Dat neuronal chemical messaging system fuckin wit me brain chemistry n shit fu real homie got me thinkin thoughts n shit got my brain doin dat neuroplastic shit stretchin n growin.
From what I understand, MG isn't necessarily the absence of the the receptors as much as it is that the immunoglobulins are blocking Ach from reaching its target on the receptors which is why its usually treated with indirect parasympathomimetic which block Ach-esterase from breaking down Ach and increasing its concentration at the NMJ
Some of the other neurotransmitters not mentioned in this video get really weird. My favorite is endocannabinoids because they break all the rules. They were one of the last neurotransmitters to be discovered, and we still don't know everything they do, but the short version is that they work backwards. We only discovered them because someone realized, "Hey, weed clearly does something to your brain and it doesn't seem to be interacting with any of the neurotransmitter pathways that we already know about."
I beg to differ, I consider the serotonin-dopamine pathways to the hippocampus and various areas of neurogenesis far more impactful, and novel. You know, how memories are formed and ultimately biased based upon emotional state and present focus/motivation. The endocannabinoid system is a simple regulatory system, not that different from GABA and glutamate, both able to be either inhibitory or stimulating depending on the site of the receptors. Serotonin systems (not a typo) are self-regulatory, due to stochastic distribution of receptor densities, which in turn regulates "direction" (or rather, the natural selector) of fresh neurons and their migration paths. I mean, the endocannabinoid system is pretty cool, because I have a weak spot for simple but effective systems, but the serotonin-dopamine pathways for memory formation and brain adaptability is too cool for anything to top off.
@@gandalf8216I think serotonin should be left alone. Like seriously all these SSRI antidepressants are like kicking your TV to make it work again. Sometimes it works, sometimes you make it worse and sometimes the TV just dies. Just give me opium and koka leafs for depression like in the good old days. It surely can't be that hard. All these new psych meds are easily perscribed because they feel like shit. Just give me something that makes me feel good. People could freely buy opium in pharmacy for centuries but somehow in the last 100 years everything went to shit.
@@cyan_oxy6734natural supplements like you mentioned, and deadlifts for depression. Seriously - lifting heavy weights [safely] really helps stave off depression.
You struck a great balance of discussing details of neurotransmitters while still being generally understandable to a non-chemist/non-biologist. I'd watch more videos talking about other neurotransmitters and/or talking more in depth about their functions. Also the S3RL x That Chemist crossover is as awesome as it was unexpected.
i love how i get my dopamine and serotonin is a tiny hardworking walking chemical that carries a ball of neurotransmitters to my neurons. you go lil guys!
DMT is the coolest neurotransmitter. In the visual cortex of laboratory mice, the proportional concentration of DMT compared to Serotonin, was found to be approximately 1:2 under normal conditions. :D (this is even more surprising given its short metabolic halflife of about 5 minutes.) That's why from now on, I will be referring to it as a neurotransmitter. I wish they would actually study it more. It has effects on neurogenesis, and neuron repair (at the very least by downstream activation of BDNF), and also plays a role in plasticity.
For a chemical to get the status of being a neurotransmitter it must satisfy four conditions. 1: it's synthesized intracellularly. 2: it's stored intracellularly. 3: it's activated and then consequently 4: it's deactivated. I'm not saying DMT couldn't be a neurotransmitter, but an abundance of the stuff compared to serotonin isn't sufficient to say it is.
For clarity, I presume you mean N,N-DMT in this case, as opposed to any of the common (4-PO, 4-HO, 5-MeO, 4-AcO) or uncommon analogs? IIRC there's some recent research that's found some quantities in human CSF, but the jury's out from what I've read as to if we can really call it an endogenous neurotransmitter... yet! "Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain" 2019 makes for an interesting read, regardless.
Jesus Christ... I just spent over three hours watching, pausing, digesting, and resuming a 30-minute RU-vid video about six neurotransmitters. This was so dense, probably the most well compressed info-packed RU-vid video I've ever watched. How did you do it! The writing, the editing, the animations, the research (that long ass list of references in the desc!)... and the humor sprinkled along the way💛 I couldn't be happier, I feel so immensely lucky to have this available to me- and for free? Incredible, incredible work from everybody involved, oh my goodness! Thank you all, from the bottom of my heart!Bless you!👏👏👏🙏❤️🔥🔥🔥💯
I'm glad you enjoyed it a lot! The best way to help the channel is to share the video with specific people who you think would enjoy it :) Have a _great_ day
Learned helplessness is such an important topic, I think one of the most shocking I took out of my psych studies. I didn't graduate so I'm not gonna offer any advice to anyone, but do check it out, if you have.... troubled past.
love the vid. I was curious if you would involve neuropeptides in the list such as dynorphins, enkephalins and endorphins. the opioid receptors gettin no love today.
if people are interested in the topic of neurotransmitters, we may consider making more ;) the best way to help is by sharing the video with people who you think would enjoy it!
This video was amazing! I learned so many nuances to things I thought I fully understood, and this just makes me want to pursue my biochemistry dreams even more haha. Thanks for the awesome 3d models of not only the neurotransmitters themselves but the receptors too! I had never known there are so many varieties of receptors for each neurotransmitter, Awesome content as always 😎
People say that the human brain is essentially a very advanced computer. If this is true, then deciphering the mechanisms of the brain is like trying to make sense of spaghetti code written by insane hyperintelligent chimpanzees that have drafted, redrafted, overwritten, feature-creeped, and developed one after the other, for six thousand years. And the computer runs in Terraria.
Ah yes, noradrenaline. It turns out that when treated with serotonin/noradrenaline reuptake inhibitor my heart rate rises from my "normal" 36bpm to something more traditional xD
Honestly one of the best channels I found in the past months. Sad to see that it not gets the attention it deserves. As much as it hurts to say, maybe more short form content would do a lot
I have been studying psychology and neuroscience for 5 years and failed the learning and memory course 3 times. This video taught me more than that entire course ever did.
I guess me taking Biochemistry really paid off. This is such an amazing video covering so many hyper-complex concepts in amazing detail and clarity! Can't wait for the next video.
there was so much information packed into this video, ill have to get a little stimulated and watch it again before i can reuptake all that information into my neural pathways in a couple of minutes
ah i remember getting serotonin syndrome from taking a lot of cough syrup and drinking a lot of grapefruit juice, the lady on the phone said it was only mild but by fucking god it did not feel mild lmao
Ever since I subscribed to Hamilton Morris I keep getting recommended these type of videos. Thank you Allmighty Algorithm for bringing me here, this video is incredibly concise for the amount of information it has.Alos, that quick humor works really well. :)
the chubbyemu bit got me, had to check if i was still watching a that chemist vid lol. great as always, as someone who's got an interest and chemistry, especially how things react with neurotransmitters and medication with the body as a whole, this video taught me a lot more than text books could in such a short time
bro this is probably the most amount of actual learning ive gotten in a while and you made a 30 min video of it. Props to you. Still have to pause a lot to even grasp wtf is going on. It is definitely interesting and i wish to know more.
I love these videos because you're like: *Complex and thorough explanation of dopamine*, followed by "Dopamine goes in C tier because cheese starts with 'c'."
something i legit dont understand about human bio is like how in the world is neurotransmission so insanely fast? like the diagrams make it seem like the synapse vesicles move to edge then release then the receptors receive then it decides if thats gonna continue. like okay fast transport is like mm per day okay… but you touch something and you feel it cia registering in brain in literally 50ms??? how does the math work out here?
So that's a good point, there is a pool of vesicles ready for release and it kind of rotates them in and out kind of like an airport, theres always something on standby. My explanation was more focused on how they show up in the first place not how they are released, but effectively there is a voltage gradient that runs down and triggers them faster than any protein process.
Please make more neurotransmitter videos, your explaining of what they do and how they function is so good, its also really interesting content. Loved the video :).
I love you and your videos especially those about biochemistry, I swear to god u directly hit a spot with your animations and explanations of the biochemistry. I could literally listen to a whole semester of biochemistry in a week if it was all videos of yours
Please do an addendum regarding endogenous morphine relevant to tyrosine/Ldopa production and any thoughts on endogenous morphine production in respect to parkinsons and the precursor/intermediate isoquinoline reticuline
as someone with adhd, this was quite interesting to learn about. I mean, i didn't have the attention span to get past dopamine, but it still paints an interesting picture of what might be going on inside my own head 😅
The last exposure to an AChE was only slightly less unpleasant than the alternative. Thanks and FU but thanks again to the NAAK and screw you guys that worked on the V series. (But I guess it helped with rodent control.)
Im going into my second year as a Neuroscience student and really enjoyed the video. It's very cool to see your mastery of Chemistry translate into the realm of Biology. Had to turn the speed to .75 though 😅.
Hmm... The first neurotransmitter - Dopamine. Yeah.... And then the receptors D1-D5..... Attention.... ADHD, or how I like to call it Error! Dopamine not found. It is really important that someone battling with something, also understand where their problem comes from, and what it does. This helped to explain thing a bit more.
The only downside of this video is that it was posted a few months after I was studying the underlying mechanisms of all these neurotransmitters for my Pharmacology exam
New favorite channel. Watched you a bit before but you really made a banger with this one. I love pharmacology and I love S3RL. Thank you. Thank you for putting 2 and 2 together and making an educational yet entertaining video. Never stop doing what you're doing!
coming back to this video a few weeks later. i freaking love neurotransmitters. i really like psychology and i like this channel (even though i know little to nothing about chemistry) so this video really caught my eye
Fantastic video. I had to slow it down by only 75% of the video speed and paused the video 50 times but I got there an hour or so later. But I learned a lot. Thanks! =]
As a person with Fragile X disorder (the trigger motorprotein doesnt work and ive git reeuced GABA function) So ive got hyper active nerves and oddly extra grown synapses. Would be interesting to look at receptor mutations
@That_Chemist thankfully psilocybin and novel compounds like betacaryophyllene have really assisted with modulating Mglur5 receptors to help. But you can definitely do an episode on beneficial receptor/cell mutations like sickle cell for malaria,ACE II for rona, immunity to the HIVirus etc also endocannabinoid signalling is quite a hot topic rn Then theres also BDNF and psychedelic binding affinity without serotogenic effects causing hallucinations becoming the newest neural meds. Lots of content
@That_Chemist I appreciate the good words! For years it hampered me, but getting involved in medicine has assisted me greatly , even to greater success than traditional allopathic compounds
Wanna quickly point out, when you presented the explanations for nmda, AMPA and Kainate receptors, you didnt put an explanation for AMPA. I think you accidentally re copy pasted the NMDA receptor explanation. But great video nonetheless
Appreciate it, glad you enjoyed it... it was one heck of a learning curve but I managed, hope to improve upon it more~ David here from the description!
I see you put quite some effort in the visuals, but I think the receptor protein blobs all from different angles and the weird color coding on the transmitter molecules are more confusing than helpful. apart from that you did a good job of summarizing the topic
Should've talked more about dopamine's role in pattern recognition and hallucination. Also D2 is the target of most of the mindnumbing soul crushing apathy inducing weight gaining medication that I have to take.
Ya know all this talk about neurotransmitters reminds me. What does the trace amine associated receptor do?! It seems important for the mode of action of stimulants but what is its normal healthy function in the body?
That's about 2 lectures full of neuronal biochemistry pack in 30 minutes, if you really look into those references. Geez that's a lot to pull together in a video, nice job.
