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why doesn't Tylenol come with the antidote already in it? 

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29 окт 2024

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Комментарии : 43   
@YodaWhat
@YodaWhat 2 месяца назад
*NOT double size!* If you double the content weight and it is all the same density, then the capsule would only be 26% bigger in every direction NOT 100% bigger, as stated.
@josephcharles2917
@josephcharles2917 28 дней назад
Let's go! It would be awesome to eventually see this on shelves because of that email. There are so many compounds people do not know about that are truly life saving. We live in the most interesting time as far as medicine is concerned.
@thrawn82
@thrawn82 2 месяца назад
Im sure those are all very good reasons they aren't doing it and not because it would be expensive and reduce their short term profit on the product to solve a long term problem.
@martinmorales9591
@martinmorales9591 2 месяца назад
Just take 2 250mg tylenol + 250 mg NAC, no? Size stays relatively the same. Lots of medicines ask you to take two pills.
@Drew-mm9wt
@Drew-mm9wt 26 дней назад
Some SUPPLEMENTS ask you to take 2. Medications will usually have a higher dose available (1 pill), unless the maximum is reached.
@Nobody04200
@Nobody04200 25 дней назад
You're correct but depending on the density of the nac it could actually use way less space allowing you to cram it into one pill like it's discussed in the video. 500mg of acetaminophen and 500mg of nac could have different densities this isn't being accounted for.
@juliavixen176
@juliavixen176 2 месяца назад
Take two 500mg pills (with 250mg NAC) rather than one 500mg pill (with 0mg NAC). This isn't difficult.
@LogjammerDbaggagecling-qr5ds
@LogjammerDbaggagecling-qr5ds 2 месяца назад
Are you going to fund the 100 million dollar clinical trials? Because they sure as hell aren't.
@oldmedstudent1750
@oldmedstudent1750 Месяц назад
​@@LogjammerDbaggagecling-qr5dshurrrrr derp derp derp 🫵🤡
@laoch33
@laoch33 2 месяца назад
The anti-caking agents & bulking agents in both pills might be able to be reduced for a combo pill, so could probably be the same size pill.
@ACSReactions
@ACSReactions 2 месяца назад
That's what I thought, too, but it turns out there's only about 120 mg of not-acetaminophen in a 500 mg tylenol pill, so adding another 500 mg of active ingredient, even without anything else, would make a much larger pill.
@renesanchez2210
@renesanchez2210 Месяц назад
​@@ACSReactionsremove 120 MG other ingredients Add 250mg nac It's possible.
@WillemPenn
@WillemPenn 29 дней назад
You are conflating weight and volume. You are assuming that the acetaminophen and the other agents have the same density. Do you know that for a fact? If the acetaminophen is more dense, then perhaps not.
@rinkrude1
@rinkrude1 28 дней назад
@@renesanchez2210 NAC only comes in 600mg tabs where I live...
@sebastianfletcher-taylor1024
@sebastianfletcher-taylor1024 28 дней назад
​@@rinkrude1it could be reformulated - I know compounding pharmacies could, it doesn't take a lot of resources.
@rdizzy1
@rdizzy1 2 месяца назад
I bet it would reduce it's effectiveness, either in total time the medication functions for, or in overall strength of effectiveness directly. Also, NAC is far more expensive than acetaminophen, it would triple the cost of tylenol.
@SpoodyFlopp
@SpoodyFlopp 2 месяца назад
NAC's interaction with Tyl is dose dependent. Lower doses increase the analgesia of Tylenol. When treating for Acetaminophen toxicity, high doses are administered, often via IV, to help the liver break it down faster. 250mg of NAC orally is considered a low dose. This is quite far from the 150mg/kg given during overdose, readministered every hour or so until risk of overdose passes. For me, the major issue with NAC is that it reduces glutamate function in a bellcurve that peaks around 800mg. This makes many people feel tired and/or anhedonic. If you are someone who relies on stimulant medication, like ADHD or Narcolepsy patients, NAC can completely attenuate the efficacy. It can even numb out the effects of caffeine. Seeing as how Tylenol is often used by people who are trying to get through their workday without nociception lowering their productivity, an energy/motivation crash is far from ideal. I think you hit the nail on the head with the cost increase. People don't want to pay more for something if it doesn't benefit them. Most people don't ever and won't ever experience acetaminophen overdose.
@oscarfernandoofpublicnature
@oscarfernandoofpublicnature 17 дней назад
Density and molar mass are very similar, so maybe they do need to be 1:1... But acetaminophen oral absorption can be 90%, whilst NAC is only about 10%.
@ChristopherCurtis
@ChristopherCurtis 2 месяца назад
I've never smelled my NAC, but ... yeah, uhg!
@ronmaximilian6953
@ronmaximilian6953 29 дней назад
The oroblem us alcohol. Taking NAC sfter drinking damages the liver.
@erikburzinski8248
@erikburzinski8248 27 дней назад
Add a warning to the container
@_Jess
@_Jess 22 дня назад
​@@erikburzinski8248 half the decisions in medicine are taken to protect people from themselves. We're already trying to mitigate accidental tylenol overdoses. So unless that's a massive problem, introducing yet another easy avenue for misuse could make things worse overall.
@anarchosnowflakist786
@anarchosnowflakist786 2 месяца назад
interesting, though I'm not sure what their answer meant, also even if there are disadvantages I'd wager people would prefer to have the possibility, even if it doesn't replace paracetamol that's alone in the pill
@Noneblue39
@Noneblue39 2 месяца назад
Interesting
@ross825
@ross825 24 дня назад
I have been taking them in stoichiometric equivalent amounts good to know I can lower the NAC ratio
@DrDremmel
@DrDremmel 26 дней назад
Nah. 4/3 pi r3. It's not double volume. You can pack 1g easy.
@user-Aaron-
@user-Aaron- 2 месяца назад
Who's overdosing on acetaminophen?
@juliavixen176
@juliavixen176 2 месяца назад
A lot of people overdose on Acetaminophen (Both on accident and on purpose.) I forget the statistics, but there's at least a hundred deaths every year directly attributed to Acetaminophen overdose.
@ACSReactions
@ACSReactions 2 месяца назад
In the USA, there were 28,000 visits to the emergency room in 2018 for acetominophen overdose. doi.org/10.1007/s11739-024-03555-1
@user-Aaron-
@user-Aaron- 2 месяца назад
​@@ACSReactionsThanks for the source. Most of the results described there aren't surprising but some of them are. While that's admittedly a higher overall number than I would've expected it's still quite low given the population size of the US. I'd think the fairly low rate of occurrence would be enough of a reason on its own for not including N-acetylcysteine with acetaminophen. Even just a single pill of NAC with each bottle of acetaminophen would seem like a huge "waste" if >99.99% of them are either thrown out or somehow misused.
@unteren_text5425
@unteren_text5425 29 дней назад
Acetaminophen is toxic with long term use regardless so if the addition of NAC made it safer I'd buy it just for the safety increase
@WillemPenn
@WillemPenn 29 дней назад
And acetaminophen is not terribly effective to begin with. It is no better than placebo at treating musculoskeletal pain or chronic pain. So what did they give me last time I was at the ER and they diagnosed me with back pain? Acetaminophen. Because my kidneys aren’t great and I can’t have NSAIDs. I asked to not be given anything instead since they were just going to be damaging my liver and not providing any relief, but they refused and gave me IV acetaminophen. 😖
@glitchsister
@glitchsister 2 месяца назад
there's no reason not wanting a headache should have to lead to lasting liver damage, who cares if it smells or an obtuse size its medicine
@sagarnegi9464
@sagarnegi9464 2 месяца назад
There are many who objects on the smell and size of a pill
@JosephDavies
@JosephDavies 2 месяца назад
@@sagarnegi9464 The size of the pill is an easy problem to solve: halve the size of the pill and double the prescribed dose. Or, in this case, keep the size of the pill alone (since it's half the effective dose) and double the prescribed dose.
@ivanmit3366
@ivanmit3366 2 месяца назад
Yeah, i don't get this part of the argument either. Bigger pill? Unpleasant smell? Who the f cares if safety and possible long-term health issues are negated?
@SpoodyFlopp
@SpoodyFlopp 2 месяца назад
Most people don't misuse Tylenol and dose to the point they get lasting liver damage. This might be a benefit to those who are prone to it, but the vast majority of us don't need it. If people who are prone to overdoing Tylenol and take it every day over extended periods of time, the NAC could cause a whole host of problems in of itself. It is a powerful enough antioxidant that it can actually inhibit the body's ability to use oxidative free radicals to fight things like cancer. NAC can stunt muscle development and it can cause fatigue/drowsiness and/or depression in a significant portion of the population. That's not ideal for daytime pain management.
@borandiUK
@borandiUK 2 месяца назад
Paracetamol. Not acetomenophen
@anarchosnowflakist786
@anarchosnowflakist786 2 месяца назад
same thing no ?
@JosephDavies
@JosephDavies 2 месяца назад
@@anarchosnowflakist786 AFAIK, yes.
@SuperBC10
@SuperBC10 24 дня назад
Same thing, different names used for US and UK.
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