*NOT double size!* If you double the content weight and it is all the same density, then the capsule would only be 26% bigger in every direction NOT 100% bigger, as stated.
Let's go! It would be awesome to eventually see this on shelves because of that email. There are so many compounds people do not know about that are truly life saving. We live in the most interesting time as far as medicine is concerned.
Im sure those are all very good reasons they aren't doing it and not because it would be expensive and reduce their short term profit on the product to solve a long term problem.
You're correct but depending on the density of the nac it could actually use way less space allowing you to cram it into one pill like it's discussed in the video. 500mg of acetaminophen and 500mg of nac could have different densities this isn't being accounted for.
That's what I thought, too, but it turns out there's only about 120 mg of not-acetaminophen in a 500 mg tylenol pill, so adding another 500 mg of active ingredient, even without anything else, would make a much larger pill.
You are conflating weight and volume. You are assuming that the acetaminophen and the other agents have the same density. Do you know that for a fact? If the acetaminophen is more dense, then perhaps not.
I bet it would reduce it's effectiveness, either in total time the medication functions for, or in overall strength of effectiveness directly. Also, NAC is far more expensive than acetaminophen, it would triple the cost of tylenol.
NAC's interaction with Tyl is dose dependent. Lower doses increase the analgesia of Tylenol. When treating for Acetaminophen toxicity, high doses are administered, often via IV, to help the liver break it down faster. 250mg of NAC orally is considered a low dose. This is quite far from the 150mg/kg given during overdose, readministered every hour or so until risk of overdose passes. For me, the major issue with NAC is that it reduces glutamate function in a bellcurve that peaks around 800mg. This makes many people feel tired and/or anhedonic. If you are someone who relies on stimulant medication, like ADHD or Narcolepsy patients, NAC can completely attenuate the efficacy. It can even numb out the effects of caffeine. Seeing as how Tylenol is often used by people who are trying to get through their workday without nociception lowering their productivity, an energy/motivation crash is far from ideal. I think you hit the nail on the head with the cost increase. People don't want to pay more for something if it doesn't benefit them. Most people don't ever and won't ever experience acetaminophen overdose.
Density and molar mass are very similar, so maybe they do need to be 1:1... But acetaminophen oral absorption can be 90%, whilst NAC is only about 10%.
@@erikburzinski8248 half the decisions in medicine are taken to protect people from themselves. We're already trying to mitigate accidental tylenol overdoses. So unless that's a massive problem, introducing yet another easy avenue for misuse could make things worse overall.
interesting, though I'm not sure what their answer meant, also even if there are disadvantages I'd wager people would prefer to have the possibility, even if it doesn't replace paracetamol that's alone in the pill
A lot of people overdose on Acetaminophen (Both on accident and on purpose.) I forget the statistics, but there's at least a hundred deaths every year directly attributed to Acetaminophen overdose.
@@ACSReactionsThanks for the source. Most of the results described there aren't surprising but some of them are. While that's admittedly a higher overall number than I would've expected it's still quite low given the population size of the US. I'd think the fairly low rate of occurrence would be enough of a reason on its own for not including N-acetylcysteine with acetaminophen. Even just a single pill of NAC with each bottle of acetaminophen would seem like a huge "waste" if >99.99% of them are either thrown out or somehow misused.
And acetaminophen is not terribly effective to begin with. It is no better than placebo at treating musculoskeletal pain or chronic pain. So what did they give me last time I was at the ER and they diagnosed me with back pain? Acetaminophen. Because my kidneys aren’t great and I can’t have NSAIDs. I asked to not be given anything instead since they were just going to be damaging my liver and not providing any relief, but they refused and gave me IV acetaminophen. 😖
@@sagarnegi9464 The size of the pill is an easy problem to solve: halve the size of the pill and double the prescribed dose. Or, in this case, keep the size of the pill alone (since it's half the effective dose) and double the prescribed dose.
Yeah, i don't get this part of the argument either. Bigger pill? Unpleasant smell? Who the f cares if safety and possible long-term health issues are negated?
Most people don't misuse Tylenol and dose to the point they get lasting liver damage. This might be a benefit to those who are prone to it, but the vast majority of us don't need it. If people who are prone to overdoing Tylenol and take it every day over extended periods of time, the NAC could cause a whole host of problems in of itself. It is a powerful enough antioxidant that it can actually inhibit the body's ability to use oxidative free radicals to fight things like cancer. NAC can stunt muscle development and it can cause fatigue/drowsiness and/or depression in a significant portion of the population. That's not ideal for daytime pain management.
