Lol, hope this video provided some more insight into p53. One area I didn't really touch on was the connection of p53 and cancer protection vs. aging, but that is because I already made a video on it last year --> ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-__yPiIBXXtU.html
As one of those asking about your own work - Thanks! I can see that you're excited about THE WORLD'S COOLEST PROTEIN and even more, WHY you're excited! Thanks again!
One question I am interested in p53 activators I know there has been a few supplements like IP6 and resveratrol that have been shown to activate and you mentioned mTor inhibitors like metformin which I used to take prescription but stopped do to it not being helpful with fitness. Is there any other activators? Would fisitin or quecertin be possibilities?
@@randenrichards5461 A Ginsenoside, one of components in American ginseng herb, increases levels of Bax protein and induces cell death, activating the p53 tumor suppressor. Knockout of p53 dramatically decreases the cell death, suggesting that p53 contributes to apoptosis induced by Ginsenoside in the cancer cells.
Using the eye 👁 as a P-53 protein molecule:Run error DNA 🧬 Through “amplification” to detect the error than “Cyclic GMP” to process the corrections Or through the electron transport chain
“Malfunctional” is the coolest word I’ve heard in a long time, thank you! It is fun to learn more about your research, thank you for sharing your progress with us!
Thank you so much for sharing your passion and making it so easily digestible! Would it be possible to make a follow up video on how p53 interacts with SIRT6?
Hi there! I'm an undergraduate biology major and while learning about the cell cycle and post translational modifications, I got stuck on "p53" when my professor said it was found to be a contributing factor to the majority of cancers. I'm so glad I found your video! I can tell this is a complicated topic, but the way you explained it was approachable and easy enough for an undergrad to understand. Congratulations on all your success!
If p53 itself gets a mutation or double-strand break from, for instance, heavy ionizing radiation produced from x-ray blasts of a CT scanner, this is when cancer is likely to occur depending on how much cumulative damage you already have, ROS accumulation, etc.
Your videos take up way too much time. It isn't the length of the video, it is the amount of time I put in to researching the ideas and potentialities they bring up. Keep them coming!
Hi Sheek, to give you a good excuse to overhype p53, could you explain its relationship with p16, another "tumor surpressor". Could nutraceutically targetting these proteins improve or, more interestingly, worsen cancer outcomes? All the best with this channel!
wow, this topic is deep. thanks for the info. i'm a non-scientific amatuer, was just curious about genetics, and found your video by way of rabbit hole. again, thanks for the making this video, very insightful.
I know what the world's coolest protein is but I don't know why because I've a small brain lol. Thankyou for your entertaining and unconventional style.
Can't wait to hear your comments on UW-Madison cancer researchers Richard A. Anderson and Vincent Cryns that discovered a direct link between the p53 and PI3K/Akt pathways.
I'm just an old lady who finds your videos fascinating, and I do my best to try and keep up with what you're trying to explain. I watched this video, and went back and watched the previous video, and I have a question; P53 is a protein- how do our bodies develop P53? Is it part of a larger protein molecule that we ingest? - or is it a protein that our bodies create on its own? Considering the information that presented that fasting has an effect on P53, I assumed it had something to do with nutrients?
look at Betulinic acid 👍 you may of heard of it b4 seeing as you did a video on mushrooms. chaga is more a fungus than a mushroom but manages to pull Betulin out of the birch tree and into the fruiting body of the fungus.
(Again thank you for your videos Questions: What is the relationship of dietary Zinc and P53? How does too little or too much zinc affect P53 expression in normal cells and cancer cells? What about other dietary nutrients? How might zinc and other dietary nutrients affect wild type and mutated differently? Just some video ideas. ;) - THANKS!
Bonus question: We see during embryongenesis at the very moment of the formation of a zygote ("conception itself!" how miraculous) - that incredible amounts of zinc radiate from the zygote - a "zinc explosion". Since zinc seems intricately related to P53 expression, and embryongenesis seems to involve tight coordination of senescence and apoptosis in shaping new tissues - is it possible we might investigate P53 in the earliest stages of human embryo development? Haha as you might be able to tell - I have limitless questions!! But unfortunately do not have a personal biochemist! Thanks! 33 year old Max Darling, Long Beach California - (High school drop out, but caregiver for my tetraplegic mother with MS for the last 17 years every day - ugh - last two years we've been having issues so I've been diving head first haha - unfortunately the healthcare system is too risk averse so I've had to become an amateur biochemist - avoidance/elimination of cancer is my primary focus - and over the last 2 years I've found P53 quite interesting in many contexts).
I have been doing research on p53 trying to understand it better. I find myself constantly referring back to your presentation to try and put what I learn into the broader perspective. I realize now what I'd like about your presentations versus some others on RU-vid. Many of the others simply provide information on recent study results. This is very beneficial but it does not provide an understanding of the why or how of the study. Without an understanding of the why or how something works you are not able to correlate the results of a specific study to other studies. This is not to denigrate the value of the other presenters but I just don't think they have the ability or sufficient understanding to correlate the results of multiple studies into a larger understanding of issues. So I now appreciate your presentations even more. By the way, does anyone know how I can print out the graphical charts from these presentations?
Do you any trials which attempt to modify P53 or target it somehow? My father has prostate cancer with a p53 variant. I realize I'm grasping a straws.. but thought why not ask. Thanks for the videos!
Thank you! I have been waiting to hear your story on this. BTW, do you have any good recommendations for a book that serves as a solid primer on P53? I love technical, but I definitely should be considered a layman.
@@TheSheekeyScienceShow Nice! It wasn't until this video that I realized how truly fascinating P53 is. Thank you for sharing. I'll check out that book.
CAN SHEEK OR ANYONE TELL ME IN WHICH FOODS IS P53 MOSTLY IN OR IN ABUNDANCE BECAUSE I HAVE A LITTLE SISTER AND I WILL NOT LET HER DIE OF BREAST CANCER LIKE MOTHER, I NEED TO FEED HER FOODS WITH P53
I LOOOOOVE P53 had no idea that some skin cells had mutant alleles 😲 on a side note, this is a real dumb question, but are there any surface proteins correlated with p53 missense? and also, we could hypothetically predict MHC peptides based on the p53 mutation right?? that would be sickkk!!! Precancer work is also super important, there might be fewer problems with transcription in early mutant p53, which means we could more accurately predict and target cells with mutant p53! also sorry another thing, but my brain is scatterbrained and I actually love p53 so much, but there were these drugs called gendicine and advexin (I believe gendicine was the first approved gene therapy! (in china)), and they would target cancer cells with an AD vector and put an extra copy of p53 in em. Apparantly they weren't too effective, and neither got approved in the US. Whydya think that was the case?
If i was diagnosed with Cancer in the early stages i would go on a 30 day fast and continued regular fasting from then on and i would hope for the Cancer to have not spread or started to reverse due to the body healing itself going into a survival state and that's were i think the cancer would struggle to spread as the body is undergoing repair at the deepest Cellular level so it could meet the cancer head on in battle. It may or may not work but it would be worth a try.
Me too, initial 2 week fasting and then keto OMAD for as long as neccessary. But I am confident that with IF autophagy and low carb as well as healthy life style cancer is unlikely to happen.
@@andyz.5431 10 days was my longest fast. I wasnt hungry but i am naturally slim and was looking very thin so i ended it. Fasting is the most potent health enhancer thats why i do it regularly.
@@TheSheekeyScienceShow yeh i wasn’t sure if there was one specific mutation that was most prevalent or researched. Are the mutations found in skin p53 deleterious in other tissues?
اللهم صل على محمد وعلى ال محمد كما صليت على ابراهيم وعلى ال ابراهيم انك حميد مجيد وبارك على محمد وعلى ال محمد كما باركت على ابراهيم وعلى ال ابراهيم انك حميد مجيد 🌿🦋
Cat 🐈⬛ is tight group shooting the entire genomics 🧬 industry. The pattern, puzzle 🧩 map 🗺 is required to know which genes 🧬 are structural variants to make the sequence of DNA 🧬 shape or the repair 👨🔧. ArkG will buy in when the lab opens. BNGO$
