You’re honestly really good at explaining this stuff in a way that my secondary school drop out brain can understand without needing to run away and google word definitions every few seconds lol Thanks for the videos
I just discovered your channel yesterday. I am currently doing my PhD on mitochondrias and aging, this is a nice coincidence. Thanks for the very good content you are providing :)
You presentations are very well done. You have developed a wonderful way of presenting a highly complex subject...great work Sheekey. What tools do you use to create your videos.
There's also mitochondrial fission-fusion. It's how mitochondria control mitoDNA damage. Fed state promotes fission, Fasting promotes fusion. NAD+/NADH ratio determines fission-fusion ratio. It's possible the longevity benefits ascribed to NAD+ precursors are at least in part due to their role in mitochondrial quality control.
@@jamesmcintyre3456 Not sure what happened to my reply but it looks like it was deleted. Anyways I currently take over 50 supplements daily including astaxanthin, berberine, ALA, glycine, NAC, grape seed extract, glucosamine sulfate, nicotinamide riboside, CaAKG, spermidine, urolithin A, aged garlic extract, and sulforaphane. I also intermittent fast, do cold exposure, use the sauna, do aerobic exercise (no more than 30 min 4x/week), do resistance training, and practice mindfulness meditation. I'm still fairly young so I haven't experimented with senolytics yet, but I will when I get into my 40s. I will also start pulsing growth hormone then to regrow my thymus. Hopefully, by then, longevity science will have progressed to the point where gene therapy and epigenetic programming are proven safe and effective. I am also looking into rapalogues and stem cell/exosome treatment.
@@gamblinguru33can you please list all the 50 supplements? Also, does red light therapy work to increase energy of the whole body of a weak person in their 40s? Thanks in advance.
Just wanted to drop a big thank you. You are really good at teaching and you make this stuff graspable for a stupid economist as myself. Mitochondria are truly fascinating, I totally agree with you...
to me, it is pretty clear that there will be an extracorporeal treatment, correction, and breeding of mitochondria in the future, in order to energize the cells. Even further down the road, we can consider them as informational metabolomic trojan horses ... after all they get accepted by the cell as long-term guests ... Thank you very much for your videos, very fascinating... maybe, well, even quite likely, you are running the best bio research channel in this little universe here :)
Would artificial mitochondria inserted into the cells prevent aging? Or if we could find a way to prevent mitochondria from mutating and getting damaged wouldn't result in longer lifespans?
You have excellent content, but I wish you could do something about the sound quality. The audio is very bright and the upper frequencies are harsh, making the videoes unpleasant to listen to at medium to high volume. It can probably be solved easily by filtering or changing equipment or mic settings. Ask an audio technician for help.
Loved this. Next you should do a video about Lysosomes, lipofuscin, and the fascinating story detailed in chapter 7 of Ending Aging (Upgrading the Biological Incinerators)
BNGO$ Mitochondria: nucleus for parts in the cell… thought 💭 experiment 🧫. Mitochondria was always in cell. Formed. How would cell function w/o it? People wouldn’t have the energy to move. How did the first cell exchange O2 and CO2 and live?
Blood work is best work. Monitor your blood glucose. 2-3 times / week is not likely to cause significant issues (imo) unless they have a lot of sugar or you intake sugar elsewhere. It's generally good to have blueberries and the like in your diet, so if you stop, make sure you still get some. Not a doctor.
One thing that’s astounding is there is absolutely no requirement for sugar in the diet. The human liver can produce any glucose the body needs. Mitochondria can burn fat extremely well, more efficiently than sugar.
Acai has a very high ORAC value so it is a potent anti-oxidant. If the sugar content bothers you, you might switch to Chaga mushroom capsules or powder. Even higher ORAC, but without the sugar.
I lean towards thinking the mtDNA being from bacteria. In any case, I think it provides some usefulness to have some mtDNA separate from the nucleus and the superior DNA machinery in the nucleus. One being that the cell uses it to trigger apoptosis since mitochondria will be seen as “not self” when presented outside of cell. My own far-fetch longevity theory, I tend to think it’s a method to cull the aging population if no longer active. No judgement, I just think it might make sense from an evolutionary perspective and being a social animal. If contributing physically to the groups survival I think there might be some mechanisms to keep that contribution. Similarly I think that might explain why caloric restriction has longevity gains. Ideally, a member of a group would be physically active AND restricting calories to promote the survival of the group. And I would think those 2 things are more important past the reproductive age. Edit: On a side note, I think it’s pretty interesting that mtDNA has to come from the mother (the host) since there wouldn’t be a reproductive method to get any from the father. I bet there is some advantage for being female, considering they have to pass on mtDNA.
@@LTPottenger My understanding is that there's some ATP generation that occurs in the cytoplasm (outside of mitochondria) so I imagine cells could have started without mitochondria.
Great video. I don't understand something. When a cell divides (osmosis, or whatever), the DNA inside the nucleus lines up and then divides the cell into two, splitting in the middle. So presumably, half of all of the stuff in the original cell goes into the new cells. Each new cell has to therefore generate at least 50% more new stuff, including mitochondria. But since these are fresh copies, isn't their mtDNA fresh too, and therefore at least some of the mtDNA should be pristine and undamaged? I guess I don't understand how a lot of these damage mechanisms described by the hallmarks of aging perpetuate themselves, since cells must necessarily die, reproduce, etc and have mechanisms to "fix" a lot of that damage built-in anyway, at least to a degree.
So mtDNA replicates using the current as a template...so if it has a mutation it gets incorporated as the new strnad is made. But, you raise an important point about cell division and actually it seems like there could be asymmetry in whether the daughter cells inherits a higher proportion of "normal" vs. mutated mitochondria ...this is especially important to understand stem cell division!
@@SlamminGraham " lines up" is an artifact of needing presentation which can be grasped by the human · Currently I call this Schematics which is from engineering and mechanics ○ In reality we have a "soup" which is over ½ simply just water ○ Often missing in these discussions is a 5-Carbon / 6-Carbon "Outer Sheath" and the Carbon-Water resonance which would be useful in Proton Resonance MRI: Each water molecule has two hydrogen nuclei or protons. .which we now know interact with the Invisible Space Cooties" to relay plans from Aldebaran → Progress continues! Show them no fear nor mercy!
What about HeLa inmortalized cells...? If this theory was right, we couldn't reach such level of mass producing cells like we do in polio vaccine production. (i.e.). Billions and billions of divisions... Where are those guilty mutations trough so many decades? , which lead the cell to death.. There is something more that we are missing... Maybe we have to look in mtDNA of HeLa cells, and how this work with apoaptosis in those cells... Good job! I like your voice but I think you need a better microphone, at some high frequencies it sounds distorted.
…excellent detailed presentation…but you need to somewhat slow down your speech …it feels like hard work absorbing the presented detail and your fast speech…
This is not a mitochondrial theory of aging. This is a free radical theory of aging. The free radical theory of aging is wrong. But many people have made a scientific career and continue to lie. Moreover pharmaceutical companies have great benefits in selling antioxidants.The mitochondrial theory of aging was proposed in 1978.
