Special Lecture Series: Glenn F. Knoll Lecture
Simple theory predicts that the signal to noise ratio in PET can be reduced by almost an order of magnitude by using time-of-flight (TOF) information. The magnitude of the variance reduction is given by 2D/cDt, where D is the diameter of the object being imaged, c is the speed of light, and Dt is the coincidence timing resolution. The potential impact of this development is large, especially for oncology studies in large “diameter” patients, where it is sorely needed. The noise variance in conventional PET studies tends to increase linearly with the patient “diameter,” so we expect TOF PET imaging to lead to patient studies where the noise variance is independent of patient size. This talk will discuss physics behind the improvement afforded by time-of-flight PET, describe progress on a TOF-PET camera developed at LBNL whose timing resolution is a factor of two better than commercial TOF-PET cameras, and explore the fundamental physical limits of the timing resolution in PET.
This work was supported in part by the Director, Office of Science, Office of Biological and Environmental Research, Biological Systems Science Division of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231, and in part by the National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering under grant No. R01-EB006085.
Speaker Bio:
Dr. William Moses, Lawrence Berkeley National Laboratory
Dr. Moses Research Interests include:
Development of instrumentation for Nuclear Medical Imaging, primarily for positron emission tomography (PET). This includes development of: (1) new dense inorganic scintillators for gamma ray detection, (2) novel silicon photodetector array designs for measuring scintillation light, (3) custom integrated circuits containing arrays of low noise charge sensitive amplifiers, (4) new detector designs and scanner geometries incorporating the above elements, and (5) tomographic reconstruction algorithms incorporating the additional information available from these and other novel detector designs.
Dr. Moses has a BA in Physics from Dartmouth and a Doctor of Science in Physics from the University of California, Berkeley
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Sponsoring Department: Nuclear Engineering and Radiological Sciences (NERS)
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10 сен 2024
