Your Microbiome: The Invisible Creatures That Keep You Alive!

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Learn more/references:
Fujimura, Kei E., et al. "House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection." Proceedings of the National Academy of Sciences 111.2 (2014): 805-810.
Strachan, David P. "Family size, infection and atopy: the first decade of the 'hygiene hypothesis'." Thorax 55.Suppl 1 (2000): S2.
Gerrard, J. W., et al. "Serum IgE levels in white and metis communities in Saskatchewan." Annals of allergy 37.2 (1976): 91-100.
Kuleshov, Volodymyr, et al. "Synthetic long-read sequencing reveals intraspecies diversity in the human microbiome." Nature biotechnology 34.1 (2016): 64-69.
Li, Junhua, et al. "An integrated catalog of reference genes in the human gut microbiome." Nature biotechnology 32.8 (2014): 834-841.
Elahi, Shokrollah, et al. "Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection." Nature 504.7478 (2013): 158-162.
Gibbons, Deena, et al. "Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants." Nature medicine 20.10 (2014): 1206-1210.
German, J., et al. "Human milk oligosaccharides: evolution, structures and bioselectivity as substrates for intestinal bacteria." Personalized Nutrition for the Diverse Needs of Infants and Children. Vol. 62. Karger Publishers, 2008. 205-222.
Sela, D. A., et al. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."Proceedings of the National Academy of Sciences 105.48 (2008): 18964-18969.
C-section statitics: www.oecd-ilibrary.org/social-i...
Kroiss, Johannes, et al. "Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring." Nature Chemical Biology 6.4 (2010): 261-263.
Zaneveld, Jesse, et al. "Host-bacterial coevolution and the search for new drug targets." Current opinion in chemical biology 12.1 (2008): 109-114.
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Опубликовано:

7 авг 2016

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Комментарии : 413

@thespycrab8305 7 лет назад

Teleportation like this seems like a incredible cool way to brush your teeth.

@AtheistCitizen 7 лет назад

it was metaphorical, as any good teleporter would carry along all of your baggage.

@3uujh656 7 лет назад

+AtheistCitizen Beaming is Killing

@AtheistCitizen 7 лет назад

05x32 LOL, "beaming" does not exist, and may never..

@NickFisherman 7 лет назад

In my stories, they use this indigo mist that's actually a collection of nanites that are capable of sanitizing everything they touch and then teleporting away. They use it for cleaning so they don't have to waste water.

@AtheistCitizen 7 лет назад

***** only said that it was absurd to try to describe the outcome [death] of a technology that does not exist. I'd sure hope, but not expect it. Cart before the horse..

@robspiess 7 лет назад

Pap: That tasty treat from "down under".

@therealzackrunkle 7 лет назад

I see what you did there

@sciencepower608 7 лет назад

So they toss their mom's salad

@dylanflynn1895 7 лет назад

+Science Power coprophagy

@doubler906 7 лет назад

yep, pooped out (literally)

@robspiess 7 лет назад

***** Yep, I have a South-Side-Up map (from odt.org) I use that reminds me of that. "Downunder" is just a popular nickname, though. I don't actually think New York is a large apple.

@jasminenightlock8971 6 лет назад

Ooh.. betrayal! "From your first day on Earth, these microbes helped build, protect, and feed you, and on your last day, they'll be the first to take you apart." Well, at least we get what we need, and they get what they want.

@AlyssaMcNeil 7 лет назад

Basically we are incomplete robots that needs smaller robots to made up for our insufficient functions.

@Rafael57YT 7 лет назад

It's kinda like robots with nanomachines

@CorpusOrganic 7 лет назад

Ever watch that episode of star-trek where the ship lost its crew. Its kinda like that. To compare us to robots is innacurate. A better comparison would be a factory or corporation. We are millions of different parts that are there to complete only one function. They are there to do their job and do it well. and the Corporate Board keeps messing up the company.. From the mitochodria to the e-coli. We are one, we are many, we are legion, you didn't even have a chance to be assimilated. You started that way.

@jonnenne 7 лет назад

I would rather say that we are robots that smartly use smaller robots since they offer some functions for cheap. Like using a subcontractor for parts of a project.

@Blu3Jao 7 лет назад

NANOMASHEENS, SON!

@communistcat3240 7 лет назад

yuuuuuuuuuuuuuuuuuuuup

@VicodinElmo 7 лет назад

I'm still fairly sure that Crohn's Disease (which I suffer from) and other immunological disorders are partially attributed to better hygiene in developed nations. It's strange that these places have higher levels of immunological disorders despite having generally better healthcare. I also have a feeling (though this is more of a passing thought of mine) that people who eat more pickled and fermented food have less chance of developing immunological disorders. It only occurred to me when I noticed that countries like Japan and South Korea, which are still developed, have had lower levels of immunological problems in the past, yet the growth of a western diet in recent decades and a subsequent shift away from more traditional foods (such as the aforementioned pickled and fermented goodies) seems to be correlated with an increase in immunological disorders. I know, I know. Correlation is not causation. Although it could simply be the western diet itself that's the problem...

@VicodinElmo 7 лет назад

Also, I'm not seriously suggesting that any of this has any scientific merit so please don't take it as such. It's just one of those passing curiosities of mine.

@yellowdockooo5907 7 лет назад

Pickles are very good and are anti parasitic.

@moguldamongrel3054 3 года назад

It's not at all odd. They teach you at a young age that healthcare will keep you healthy but what it does is inhibit your immune system. You trade the capacity to self heal with the pharmacutical/medical industry that profits off of your illness. It's not so much the fault of doctors/nurses as it is the mindset of capitalistic profiteering that drives treatments over cures, over isolating genetic disorders and reconstructing dna strands, etc. Not to mention I have yet to see one study on the effects of sanitizers, antibacterials, anti anything on your microbiome both short or long term...

@aia1190 3 года назад

also eating meat and dairy from animals that were injected with antibiotics, the antibiotics make their way into us as well causing more disturbances in our gut microbiome modern meat and dairy is not as healthy as it used to be before introducing cows to corn feed, and pasteurisation. The modern diet also causes crowded teeth and jaw development issues in the west

@yoshikagekira6166 3 года назад

@@aia1190 Pasteurization is definitely needed otherwise you can have salmonella, E.Coli, Campylobacter and can cause food poisoning.

@mrnice4434 7 лет назад

Thx little guy living in me for keeping me alive!

@Master_Therion 7 лет назад

I suspect that many illnesses potentially can be treated by adjusting our microbiome. Soon we might go to the doctor, not to treat an infection, but to be treated WITH an infection.

@DemRat 7 лет назад

That is called a vaccine.

@Master_Therion 7 лет назад

RasRas342 Not really. That's a completely different thing. The goal of a vaccine is not to introduce a viable colony of bacteria.

@keonder4884 7 лет назад

+Master Therion pretty sure it is a vaccine is like here are some prisoners check out their weaknesses so we can fight em if they invade

@Master_Therion 7 лет назад

Vaccines prime the immune system to PREVENT a microbe from growing inside the body. Microbiome therapy will be used to ENCOURAGE a microbe to grow. Not all microbes cause disease, some are actually helpful.

@iout 7 лет назад

so, are you proposing to engineer bacteria that fight off specific viruses, then introduce them into our systems so that they can grow and effectively become our immune system? And if so, then there come a few problems, such as making sure the bacteria can't mutate to become harmful, plus they'd have to be introduced when we're still babies, otherwise our immune system might reject the bacteria, and depending, it might give you fevers and stuff anyways as it attempts to take down the new bacteria.

@JMCote112 7 лет назад

Interestingly, I've recently read a study claiming a child born by cesarean instead of natural birth might have a higher chance of obesity later in life due to the fact they did not receive those birth canal microbes. I love science! Always learning, always changing!

@TheMinecraftMan757 7 лет назад

Hmm... the invisible creatures that keep you alive... Wait- you don't mean gremlins?

@mvsawyer 7 лет назад

Angels

@myherpesitch7763 7 лет назад

+Michael S No. Something that's not made up.

@MusiCaninesTheMusicalDogs 7 лет назад

Not if you feed them after midnight... 😮

@Kenneth-lj4cf 7 лет назад

To everyone reading this, have a good day or night!

@ziggystardust123 4 года назад

*3 years later* you too!

@ARC87 3 года назад

The relationship between the microbiome and your psychology/behavior is also fascinating...

@DungeonBricks 7 лет назад

*microscopic laugh*

@AtheistCitizen 7 лет назад

best comment [all day]

@venkatkotti 7 лет назад

Extraordinary channel with mind blowing presentation skills...Love your work...Best of youtube 👍

@FreePalestine460 7 лет назад

Are orphaned koalas unable to eat eucalyptus leaves?

@william41017 7 лет назад

Nice question! Wanna know it too

@bradskurt5334 7 лет назад

in theory no ?

@DarkArcticTV 7 лет назад

bernie is a sellout

@tiyas5378 7 лет назад

yes, probably just more susceptible to infections

@thedarkmessiah874 7 лет назад

everything that is orphaned wont survive for long,sorry for my bad english

@xenotronia6681 7 лет назад

I love this show because it is kid-friendly and educational and I watch it all the time!When my best friend watched it he just kept on staring at the tv!

@Leticiapais_ 7 лет назад

Microbes are so underrated...

@disrxt 7 лет назад

Damn, they just mean very small, not invisible. I was hoping magic was real.

@iout 7 лет назад

well technically, it is invisible. From our perspective at least. Invisible just means, "not visible". and I don't know about you, but I've never seen a microbe without a microscope.

@myherpesitch7763 7 лет назад

Haha!

@myherpesitch7763 7 лет назад

+IOUT Damn. What a joke killer.

@TheAlienFleet 7 лет назад

+IOUT WOOSH!* did you hear that? It was a joke going right over your head!

@needpit1 7 лет назад

You deserve much more views

@sudeshnakar5332 2 года назад

This is such an amazing channel .....with amazing content. ❤

@Faafelue 7 лет назад

Hi ! I just wanted to tell you that your videos are really awesome ! I don't like science, but all your vids are captivating and speaking about topic that are very interesting, thank you very much to teach us about all thoses littles things everywhere ~ ! -I'm sorry I don't speak English very well, because I'm French, aha ^^-

@veganchaatparty 7 лет назад

Super Superb!! Super Superb!! Super Superb!! Thanks.

@Lion_TurtIe 7 лет назад

Great video never knew about most of what you said in this video

@kristinandaya7812 7 лет назад

So fascinating! This is the optimist's version of Guns, Germs and Steel. Thanks

@kishaloych 7 лет назад

awesome video ... the knowhow is just great ...

@thxdts1999 7 лет назад

Great video thanks

@m17guy 7 лет назад

great vid man, I loved it

@jamesdeininger3759 6 лет назад

Can you do a video on how the gut microbiome creates serotonin and influences the foods we crave?

@wasifabbas7357 7 лет назад

You are genius man you are great

@abheeshtarao3592 5 лет назад

You are a living legend

@jericcayoung4087 4 года назад

So beautiful

@MD-cy7hs 7 лет назад

awesome channel

@nanothefruit8063 7 лет назад

This guys amazing

@mindspongeshow 7 лет назад

You could have discussed whether actions taken as adults can help this process, or whether it is only the exposure as babies that affects us later in life

@Parietal-Polymath 6 лет назад

Nailed it! 🖒

@Liquoricilicious 7 лет назад

I love the background music

@Dogsrule777 2 года назад

I can’t wait to give back to the bacteria that helped me from day one. 👊🏽☮️

@Pablo_Gubin 7 лет назад

whoever named the Beewolf Wasp should name all animals.

@LarryPhischman 7 лет назад

I was the only one of 4 children born via C-section, and I'm also the only one with severe allergies in adulthood.

@Linkous12 7 лет назад

I'm in a similar boat. I was born via c-section, and overly protected and coddled as a child. While none of them are serious, I ended up with chronic allergies, sinus problems, and Irritable Bowel Syndrome.

@hussainattai4638 7 лет назад

I was born in my own home, I was a few hours early and got out. However, I never had any allergies, and in the past few months the last time I got sick was because of a food poisoning, and I was ok in half a day. So maybe because I was naturally born in a relatively dirtier environment, I got a better immune system today. However, I had my fare share of colds and flus as a kid.

@Damnagoras1 7 лет назад

During my young years I lived on the country-side among animals, playing outside in the mud, getting my hands dirty. My parents have never considered an overly clean home to be desirable. I have no allergies or other medical diagnoses. So far, the pattern in these comments seem to match the information in the video.

@nolanwestrich2602 6 лет назад

On the plus side, you can kill Macbeth.

@sudhanshuvinayak5492 3 года назад

😇👍

@robertosata 7 лет назад

Ad comment: I prefer these ads in the video vs the crappy ones we skip at the beginning

@jacobnair6707 7 лет назад

And as always, thanks for watching

@elizabetharcher8762 7 лет назад

cut from my mom who then "dried up" two weeks later, now I'm 33 and have nearly died from blood clots twice, with no explanation other than everyone missing my diabetes for around 15 years.

@NaseemAhmed-uv5xt 3 года назад

Microbes on birth day: Help you to be protected and fed. Microbes on your death day: Eat your corpse. Me: RANK: THE BETRAYED

@matthewray6008 6 лет назад

Gotta love nerdy Daniel Tosh :)

@grapes6461 6 лет назад

So how do I get more diseases listed down in my library so I could be prepare for them?

@Elora445 6 лет назад

Born by Cesarean section, born lactose intolerant...was sick as hell the first ten to twelve years or so. Think I've finally figured out why. ^^

@someguy2135 3 года назад

It is important to eat a wide variety of whole plant foods for fiber (pre-biotics) to get the healthiest microbiome possible. When you feed the beneficial microbes, they grow and crowd out the dangerous ones.

@spiderartmc3912 7 лет назад

I bet you $16,723,427,O56 you did not see the letter in that sentence the first time. 😜

@lifebeforedeath1788 7 лет назад

Alright, pay up, buddy

@tanktheta 7 лет назад

I. So, pay up bro. I need some funding to get out of Australia.

@functionparameter 7 лет назад

Australia's good

@T0YCHEST 7 лет назад

seen it cause my o and zero are different Gimme that money

@ourlordpapajohn4370 7 лет назад

What letter?

@skyadventurer7574 7 лет назад

MY GOSH STOP SWAYING

@ThatFluffySheep 7 лет назад

4:54 did you just reference\steal that line from thoughty two

@yourmother9834 5 лет назад

This episode is sponsored by audible. I forgot to cancel my free trail and had for 4 months straight 😂😂 I paid for my own view on this one

@Rithene 7 лет назад

I always feel a bit cheated whenever I hear about how infants develop resistance to allergies. I wasn't born via c-section or fed formula. I had a dog and later a rabbit. I played outside a lot. I had both an older and a younger sibling. And yet I'm STILL allergic to pollen, household cleaners, and artificial scents. Come on, biology, you could have thrown me this one bone...

@harrykelly4665 7 лет назад

I'm having to learn about microbiomes to help cure my eczema, I've settled my digestion problems significantly by introducing probiotics from Goats Kefir, but I'm still not all the way there, it can be frustrating

@v-gc7257 2 года назад

Nice

@NickFisherman 7 лет назад

On the show Earth 2, children are suffering from a condition due to being born into the pristine conditions of space. They don't have very healthy microbiomes, so they're in constant danger of disease.

@ahears1 4 года назад

@It's Okay To Be Smart: What is the source of your soliloquies per episode? Am I to assume your soliloquy is sourced from College Thesis Papers?

@philiprachtman1217 Год назад

It was also noted comparing west and east Germany after WW2 the children in east germany had a better immune response than in West germany due to the lack of cleaning products

@edwinbalbuena6540 7 лет назад

your close too 1 million

@ozdergekko 7 лет назад

Around their 1st birthday toddlers eat earth/dirt. Probably need some microbiota in it. never use "hygiene cleaners" in your household, perhaps with the exception of in the washing machine every now and then.

@greenman5255 7 лет назад

Holy Squat! We're like Kurt Russell in *Guardians of the Galaxy 2*!!!!

@jenniferrobinson8759 7 лет назад

He sways a lot xD

@ArgonneLab 7 лет назад

Excellent video! We've always wondered about how pets (and other people) contribute to our own microbial health here. Resident microbe warrior Jack Gilbert is one of those researchers hot on the trail, here's his breakdown of dogs and the microbiome. bit.ly/2b3BtXK

@besmart 7 лет назад

Great video! Jack Gilbert does awesome research, great to see him featured so much on your channel

@mollof7893 7 лет назад

+It's Okay To Be Smart oh sh¡t! You replied!

@Giga_Pudding 7 лет назад

Wait... Our brains are partly constructed from bacteria poo? That explains so much...

@LordofSyn 7 лет назад

Love the videos, keep it up. However, the little smudges and black dots in your background made me think I had stuff on my phone screen. Yes, I tried to wipe them away at first. :-)

@westzapwood8697 6 лет назад

Does this mean, "safety is not number one priority"?

@4G12 7 лет назад

This video has conveniently neglected to mention that in reality, our microbial symbiotes far outnumber our own cells. Each individual human being is an ecosystem, not just one individual creature.

@besmart 7 лет назад

+4G12 That's actually not the case according to more recent estimates. New studies in 2016 put our microbial population about 1:1 equal to our own cells

@4G12 7 лет назад

I see, though in reality microbial population numbers may vary quite a lot depending on exact environmental situations. I also wonder how their estimates are made as well. I would much appreciate if you could provide some links to references too. ;-) Either way, that does not change the fact that we are still ecosystems in on ourselves as "individual humans" though. We all transfer microbes between ourselves and our environment all the time unless we somehow got locked up in some hypothetical sterile environment and somehow got all microbes purged from our bodies, something I would not personally recommend. The hygiene hypothesis actually reminds me of the parasite hypothesis too, which says something along the lines of we evolved to tolerate parasitism to a degree and as long as parasites don't run amok, they may benefit us by reducing the chance of autoimmune diseases. Personally, I find the notion of an organism considered in a vacuum to be an inherently invalid concept. And organism cannot possibly exist without the environment it emerged from in the first place. An organism only makes sense within the context of its environment. Thanks, I sincerely appreciate your efforts to educate and inspire scientific curiosity.

@I_am_a_cat_ 7 лет назад

+4G12 Jesus dude. you just wrote paragraphs that 1 out of 10,000 people will read, if that. you really gotta try that hard to be right?

@Goreuncle 6 лет назад

+Cat Do you really think 4G12's reply was long? ^^ You haven't seen some of my replies, you'd probably consider them short novels ^^ Btw, nobody is forcing you to read comments...

@piemammoth5065 7 лет назад

Interesting

@madsterlof7948 7 лет назад

I have a small question my dad did a flushing. ( don't know the medical term, in english but its like flushing you intestines with salt water or something ) And i told him that it wouldn't do much good unless you have a certain medical conditions, and it could be bad for him becaus i knew that you have a kind of ecosystem in their that helps your body and that it maybe would damage the balance. I am curious if that is true or i am overreacting ? great video btw learned a lot, but it did give me a new weird view on star trek LOL

@PurpleCoin7777 7 лет назад

I just realized pressing the up and down arrows change the volume on RU-vid... Cool.

@jaymzcross7927 6 лет назад

Finally another genius! Yay!

@lovelyluna3518 7 лет назад

I have a question, what would happen if we were still alive after the Mayan calender ended would we die no shelter food and the gasses and chemicals from the disasters kill us? or what it we could use the broken pieces ir buildings and build farms reproduce more, but then again something else would happen :0

@ethoslai1367 7 лет назад

a.. My I Ask Why Does Singapore Have Monsoon season?

@Xydes 7 лет назад

Forgot to mention Midi-chlorians :)

@magmarios369 7 лет назад

I wish George Lucas forgot to mention midi-chlorians.

@kjell159 7 лет назад

This reminds me of that nice video I once viewed called "two koalas, one tree".

@user-wv8kr3yn6l 7 лет назад

Luckily, this video isn't about midi-chlorians.

@collinperry4206 7 лет назад

I have 2,000 in every blood cell

@nolanwestrich2602 6 лет назад

You mean "sadly"?

@NymphetaminexXxGrrrl 6 лет назад

I always wonder when you see moms constantly scolding babies, and saying "dont touch that" "thats dirty" "dont put that in your mouth" "now we have to wash your hands all over again" etc.. Are they unknowingly hurting their babies? Should we be letting kids crawl on public floors and put strange items in their mouth? I know i always rolled in mud, played with snakes, sucked on everything i could, and just generally exposed myself to many germs as a kid. I don't have any allergies to anything, but i do have a horrible immune system. I wonder if early exposure made things better or worse? Is there any benefit to continuing to expose oneself to germs as an adult, or is there only benefit for babies? Just curious as to how clean is too clean when it comes to cleaning and just generally being alive.

@brianflores662 7 лет назад

same as the coala cows to I think

@jenniferrivas7138 7 лет назад

How is there different Blood types?

@marcelfil 7 лет назад

*whispers into ear: audible has over 200.000 books

@brainarwhaltheillogicalpar6739 7 лет назад

Woah, last time you were at like 110,000,000 subs, not its 910,000.

@Kenneth-lj4cf 7 лет назад

Legend says if you make a useful comment, he will reply. Nice video!

@naturalistmind 7 лет назад

I was allergic to milk as a baby, but my i.q is a tiny bit above average (122) so what's up with that? are you saying if I hadnt been allergic to milk I would have been a genius or something?

@guineapigsarecute6104 2 года назад

So in the Netherlands, people (especially older people) call some types of dessert pap

@animalia5554 6 лет назад

How quickly would you die if the microbes were taken out?

@timbuktuks1 6 лет назад

Tell me how to totaly drop drinking

@ollekennedy9141 7 лет назад

My mum was sick when i was a baby so i never got any breast milk will that affect me?

@dacrazyfox6768 7 лет назад

Ur almost at 1 mil subs

@filida 7 лет назад

When I was a child on countryside, there was this city kid whose parents were sterilizing everything for him to protect him from microbes. They came to visit and the first thing that the kid did was to eat chicken poop. Oh the horrified faces of his parents, while we were all laughing... But even at that time we knew that the joke was on the parents, not on the kid.