Join Dr. Chat Perche, MD, PhD, for a high-speed study session.
This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics.
By the end of this video, you'll have perfectly memorized about Methotrexate.
It masquerades as Folate, and induces damage to DNA.
Do you want to know the mechanism of action?
Discover the mechanism of action of Methotrexate in this concise video.
We explore its role as an antimetabolite, its interaction with folate metabolism, and its impact on DNA synthesis.
Learn how Methotrexate functions in cancer treatment, immune system suppression, and its effects on human T cells.
Ace your exams by understanding the core concepts without unnecessary complexities. Watch now and boost your knowledge efficiently! 📚✨
#cancertreatment #biochemistrynotes #pharmacologymadeeasy
【Notes】
▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations.
▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.
【Contents】
00:00 Methotrexate is an antimetabolite. What is an antimetabolite?
01:02 Methotrexate, the mechanism of action
01:06 Folate has an important role in DNA synthesis. Why?
02:25 Methotrexate is taken up by DHFR, why?
02:49 Methotrexate: as an immunosuppressor, what's the mechanism of action?
03:45 Methotrexate functions in the S phase of the cell cycle.
【Reference and figure】I express my gratitude and respect for your wonderful achievements.
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2. Koźmiński P, Halik PK, Chesori R, Gniazdowska E. Overview of Dual-Acting Drug Methotrexate in Different Neurological Diseases, Autoimmune Pathologies and Cancers. Int J Mol Sci. 2020 May 14;21(10):3483. doi: 10.3390/ijms21103483. PMID: 32423175; PMCID: PMC7279024.
3. Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J Struct Biol. 2009 May;166(2):162-71. doi: 10.1016/j.jsb.2009.01.001. PMID: 19374017; PMCID: PMC2738603.
4. Li GM, Presnell SR, Gu L. Folate deficiency, mismatch repair-dependent apoptosis, and human disease. J Nutr Biochem. 2003 Oct;14(10):568-75. doi: 10.1016/s0955-2863(03)00115-3. PMID: 14559107. (www.sciencedirect.com/science...)
5. BogHog, Folic acid compared to methotrexate. Wikipedia, 28/Feb/2015. commons.wikimedia.org/wiki/Fi...
6. Carmen Avendaño, J. Carlos Menéndez, Chapter 2 - Antimetabolites, Editor(s): Carmen Avendaño, J. Carlos Menéndez, Medicinal Chemistry of Anticancer Drugs, Elsevier, 2008, Pages 9-52, ISBN 9780444528247,doi.org/10.1016/B978-0-444-52.... (www.sciencedirect.com/science...)
7. NANCY OLSEN, MD. Low'dose methotrexate: antiinflammatory or immunosuppressive?, CLEVELAND CLINIC JOURNAL OF MEDICINE, 1990, VOLUME 57 NUMBER 3, page 245-246.
8. Cronstein, B.N., Aune, T.M. Methotrexate and its mechanisms of action in inflammatory arthritis. Nat Rev Rheumatol 16, 145-154 (2020). doi.org/10.1038/s41584-020-03....
9. Budzik GP, Colletti LM, Faltynek CR. Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line. Life Sci. 2000;66(23):2297-307. doi: 10.1016/s0024-3205(00)00559-2. PMID: 10855951.
10. Friedman B, Cronstein B. Methotrexate mechanism in treatment of rheumatoid arthritis. Joint Bone Spine. 2019 May;86(3):301-307. doi: 10.1016/j.jbspin.2018.07.004. Epub 2018 Aug 3. PMID: 30081197; PMCID: PMC6360124.
#methotrexate #folicacid #folate
11 июл 2024
