P450 Enzyme System (Inducers, Inhibitors, & Subtypes) 

So for some reason my brain kept saying 2E3, but to be clear it’s CYP-2E1 . Note that the mnemonic reflects this and is correct. Just ignore my brain fart

Mnemonics for CYP450 Drugs: Inducers (ASMR): Anticonvulsants, St John Warts, Modafinil, Rifampin Inhibitors (ABCDE): Antimicrobials (lots), Belly (Omeprazol, Cimetidine), Cardio (Amiodarone, Calcium channel blockers), Depression (SSRIs), Extra (Grapefruit juice)

This one belongs in the DirtyUSMLE's Greatest Hits album

You are not a simple youtuber, you are a messenger of tHE GODS, a messenger with a message that will SAVE the medical students and allow them to ascend into the godlihood status of being a professional in the field ;w; thank you

I don't listen to any music in my car anymore. I listen to you every day that I go to work. Thank you for sharing your knowledge.

I’ve been trying to remember this throughout medical school and this was just one of those topics that never stuck and all it took was this 13 and a half minute video… This was a lifesaver. Thank you!!!

You are a very gifted educator. This is the most simple explanation I've seen and I don't think I've fully understood these concepts until watching this video. Thank you for what you do.

I cannot tell you how much this video has helped me get through pharmacy school rotations! May Allaah bless you!

GOD BLESS YOU I HAVE MISSED SO MANY UWORLD QUESTIONS ON THIS

THANK YOU!!! You had me at the enzyme doesn't inhibit. My teacher just flew over this and I was so confused. You are a lifesaver.

I must say it : the best explanation i have ever heard! Thank you.

VERRRRRY HELPFUL especially for me as a pharmacy student! Please KEEP THEM COMING! Thank you!

OMG this was hilarious. My partner and I are Pharmacists and are studying for a Board Certification tomorrow. This made our day. Thanks!!!!

Thanks a lot bro. You made my medlife hell eazy....all of your videos are the best on RU-vid, such cool mnemonics - you are genius.

I'm so glad I found your channel. Foreign MD here! Studying for the USMLEs... Taking Step 1 in Spring. God bless you!!!

CRAP GPS induces my rage is so freaking good. It’s saving my life right now. I kept getting those questions wrong before!!! Thank you!!!!!!

P-3 student pharmacist in my last semester of curriculum...and this is the best CYP explanation I've seen since being in this program...God (or whoever you believe in) bless you sir!!!

Studying for the PHMNP exam next week. This was excellent, thank you!

Oh dirty! I wish I had found you sooner! Thank you for making my life easier!

Warfarin was one of the awesome memonic. GENIUS bro 😎

What a great way to simplify this concept! Really helped me put it all together. Thank you!

Well presented. Prior pharmacy student, changing major to Nursing, i have tried to understand the P 450 enzyme system, since as senior, I need to understand personally & professionally. You did an amazing explanation and presentation thank you

Phenomenal video, your mnemonics are on point as always. For some odd reason, a couple of the Qbanks like to stress out the difference between Chronic vs acute Alcohol. ChRonic Alcohol (CRAp gps) induces and acute inhibits. It has to do with the 0 order kinetics / enzyme saturation bs i think. Regardless, I just wanted to thank you for all the hard work you've put in. Recommended your channel to everyone I know lol.

Short, sweet and the to point!! Thanks a million 🙏

Thank you so much for this video!!! I always had trouble understanding P450 system, and now I totally get it!

Btw on my actual Step 1 exam I was asked about the Cytochrome Subtype that metabolizes a certain drug (which i cant remember which it was) but I HIGHLY recommend learning it from this vid, because I just guessed, because this is way too difficult to memorize without a mnemonic. Other than that this channel is truly great, and on many questions like the inheritance pattern and the cardiovascular loops I used the mnemonics and tips from DIRTYUSMLE. Thank you so much.

Holy shit, this is exactly what I needed. No one else's videos or mnemonics are as good as yours.

The P450 subtype mnemonics are absolute FIRE - thank you so much!!!

Thank you so much for this video. You explained in 13 minutes what my 2 hour lecture could not w/o confusion!

Well explained. I'm not any kind of doctor or a professional in bio-chemical or bio-genetic but I like me all about science. Thank you!

THANK YOU, THANK YOU, THANK YOU!!! I'm in nursing school and that darn text didn't explain what you just did. Now I know why Grapefruit is an inhibitor to Ca+ channel blockers ❤️

Wow, I just finished a UWorld Form 1 practice exam and got destroyed by 3 CytP450 questions. Open up RU-vid after I finish my exam and see this beautiful new upload. Pharm gods have spoken, bless your soul

I got p450 enzyme questions on Uworld correct today..! Happy tears :) Thankyou so much for relieving the pain of remembering these meds!!!!

Thank you kindly, this was extremely helpful----whatever watching videos and documentaries are for a learning style, that's me. Thanks a million for the help learning these abstract concepts in pharmacology.

Thank you for this video! If possible can you please make a video for the lab techniques? (i.e. RT-PCR, FISH)

I thank you for your teaching. You make learning enjoyable and stress free.

absolutely brilliant! love your videos and your sense of humor!!!!

You are such a lifesaver. THANK YOU THANK YOU THANK YOU I always mixed these up

I am taking my exam in 3 days... and I guarantee these videos are going to come in CLUTCH on test day. Thank you! Binge watching all of them now.

It finally makes sense! THANK YOU!!!!

Thank you so much! The FA mnemonic for this is unnecessarily hella long! :) Very much appreciated!

Thanks sir, I love the way u teach and makes big topics like nothing 🙏

This is just an interesting & informative video. So many subtypes.This video brings it down to my educational level. Pneumonics , I use so this was invaluable. Thank you Dr

Thank you so much!! This was so helpful. I’ve been getting confused a lot on the topic, thank you. 😍

I'm getting ready to take my PMHNP boards! This video is extremely helpful!

I struggled with this for a while but your video saved me so thank you!!!!

I like the way you explain things so easy!

My mnemonic is CAR GPS and when you think of CAR (carbamazapine), I think of the stick in the middle that says PRNdl = Phenytoin/Phenobarbital, Rifampin, and Nicotine (another enzyme inducer) and then dl isn't anything. GPS is Greiseofulvin, Phenytoin/Phenobarbital, and Sulfonylureas.

This video makes it so easy to understand the concept.

I love that you don't have filters

INCREDIBLY HELPFUL!

Really helpful! I understand P450 enzyme better. Thanks for making this video!

the best video i have seen in my life

This might be the most beautiful thing ever

You’re bloody incredible.

You are the common man's Dr. Sattar.

I'm literally so happy I found your channel! I feel like a doctor already and Im only in first year med LOLLL

This is excellent... Looking forward to more of u

Very well explained, thank you!

I LOVE YOU SO MUCH RIGHT NOW 🥺❤️, you explained it so damn good, have a good blessed day, you genius!

This was a very good video👌🏻 loved it. You made it so easy to learn p450 subtypes

What u are doing is amazing sir...

This is SO great! thank you

Best explanation Yet!!!! Thank you!!! 🙏💕

Excellent loved your Numonics

Love it! Thanks mate!!!

Great video! Helped me tremendously!

This video was really very helpful. Thank you!!

Thank you! It finally clicked with your video. And the fact that you cuss made it funny :)

dear sir, not only this one every one is super super ...easy to understand and super easy to remember...bundles of thanks ..keep it on sir

Wonderful explanation. Thanks so much

thank you for the great mnemonics!

Your subtype mnemonics are the best

I love this video. How do you relate these pneumonics to the rest of the drugs metabolized by the subtypes?? Or just different pneumonics to relate to those certain drugs?

THIS IS GOLD🙌🏻

Thanks man. You deserve a Nobel prize

Excellent video!! really helpful, thanks!!!

Your videos are amazing! Thanks for the help!

OMG Thanks for the video. It made it really easy to remember. Great video!

This was amazing!!!! Great mind! Will totally help.....

This information is Gold to me

The best explanation ever...♥️👍

Excellent!!! Thank you!!!

Thank you 🙏 soooo very much for the best explanation God bless you!

Thank you for the video, very helpful!

That was awesome!!!

All gods bless you man !!!!

such a life saver,.. thank you so much

This is brilliant thank you so much!

Thanks I learn the new thing, I am working on P450 enzyme.

this is brilliant! thank you.

im crying thank you for these

Simply amazing

Luv u and your mneumonics Thank you!!!

Thank you. It is a beautiful video.

Very helpful video, Thank you

thank you so much sir This video has really helped me Your mnemonics are very good Favour from nigeria

Thanks for this marvelous explanation. Are inducers also substrates ?

Helpful video! I have a question. Do the inducers and inhibitors work globally on all of these subtypes?

THANK YOU SO MUCH FOR THIS