Common Causes Behind the Formation of Gallstones 

First, why is the incidence of gallstones higher in women than in men, and are there any commonalities during pregnancy and after menopause? Second, why is there an excess of cholesterol in bile? Is it because we consume too much cholesterol, or does the body produce too much cholesterol, or is it due to too little bile with cholesterol being relatively too high? Third, is the inability of the gallbladder to empty properly solely due to skipping breakfast (fasting)? What, then, are the signals that promote gallbladder emptying? Fourth, are high fat and high cholesterol truly risk factors for the formation of gallstones? What are the hidden causes behind these four questions?
New Insights into the Molecular Mechanisms of Estrogen's Impact on Cholesterol Gallstone Formation
www.ncbi.nlm.n...
Even in non-obese, non-diabetic Korean men, insulin resistance is associated with gallstones
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Insulin resistance leads to impaired gallbladder motility in humans
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Reactive oxygen species and reduced gallbladder motility as targets for melatonin therapy in gallstone treatment: A review
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