At 14:48 you did a synthesis question where you have used SO3, H2SO4 and then HNO3, H2SO4. Wouldnt the sulfuric acid in the nitric acid act in a way to remove the SO3 on your benzene (unwanted side reaction)? If not, then I noticed that later on you use dilute sulfuric acid to remove SO3 so sounds like that might occur.
@@s.p.8508 Hello S.P.! You might very well be right. Friedel-Crafts reactions don't work on strongly deactivated rings. If the only substituent were the sulfonate group then you could conclude that the reaction wouldn't be possible. But the alkyl group is an activating group and likely counters the deactivating nature of the sulfonate group. But then you can factor in some steric issues. Acyl groups are large and here we're trying to force it to go ortho to an alkyl group. So now we have a confluence of factors which lead us to believe that the yield might not be as good as we'd like if we were to perform this reaction in the lab. You've convinced me to use a different example for the next go around of the ochem playlist (probably a couple years away). Thanks!
