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3.5 Keys to Improving Mitochondrial Health

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References (Instructions: Copy DOI number into Search Engine)
[1] doi:10.1076/apab.104.2.129.12878
[2] doi:10.1101/cshperspect.a029686
[3] doi:10.1155/2019/7058350
[4] doi:10.1210/endocr/bqaa158
[5] doi:10.1210/endocr/bqaa158
[6] doi:10.1016/j.biopsych.2018.01.012
[7] Salk Institute (www.salk.edu/n...)
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Original Video: • Mitochondria - The Key...
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#mitochondrialdisease #mitochondrialhealth #mitochondria

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20 авг 2024

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Комментарии : 361

@Physionic 10 месяцев назад

Here is the first video in this series: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-QX9o3G_G9SY.html

@PPP-on3vl 10 месяцев назад

FASTING

@ellie698 10 месяцев назад

Excellent! Looking forward to that. I found this video really useful. I have MS and notice that when life is working well so that I feel more positive, I do feel much better. It's nice to see that there's information and data that shows reasons why. It gives me ideas of how to incorporate more good things into my life, little and often and the motivation to do so.

@SkyRiver1 10 месяцев назад

No interest in E5? Amazing. . .

@melvillejayathissa7415 10 месяцев назад

What about supplements to boost mitochondrial health?

@littlevoice_11 10 месяцев назад

And this is exactly why I haven't owed a TV in years! (And don't even miss it). Thank you 🙏 Educating entertainment the Physionics way 😊

@dfung4351 9 месяцев назад

1. Exercise. Both strength training and cardio will help. 2. Fasting (Depends on your diet. All about maintaining 'healthy weight') 3. Be Disciplined about Staying Positive and Express Gratitude. Especially at Night.

@immers2410 4 месяца назад

Strength training doesn’t really move the needle on this, steady state cardio however is very effective. Read Inigo San-Millan

@johnlakey4983 3 месяца назад

Well written

@aaaaaa-aaaaaaaaaaaaaaa 3 месяца назад

which brand and how much does it cost?

@henrymakumbi7753 2 месяца назад

767

@roqclimber 10 месяцев назад

In the evening, my Kitty sits in my lap and purrs, in order to sooth my Mitochondria. Very intuitive animal.

@helenahandkart1857 9 месяцев назад

Cats are tremendously helpful in this way, bless'em!😸

@nevinkuser9892 2 месяца назад

Give that cat a treat

@Peekaboo-Kitty 19 дней назад

Mitochondrions love Kitties!

@mjinba07 10 месяцев назад

One of the best and easiest ways to improve mood before bedtime is making a gratitude list - things you're grateful for, whether from that day or further in the past - doesn't matter when. Also doesn't matter whether the list is written or just in your head. The key is lingering in a moment of gratitude. Surprising how many people find it difficult to do at first. It gets way easier with practice, until it's possible to get that warm feeling even when you've had a crap day.

@babyboltbark 8 месяцев назад

FO.

@eastcoastkickz4891 10 месяцев назад

Sleep good, eat better , fast for 12H every day. Lift some weights and move.

@User0resU-1 9 месяцев назад

Stay calm and carry on.

@Bully-mu1su 4 месяца назад

Eat plants also or carnivore?

@eastcoastkickz4891 4 месяца назад

@@Bully-mu1su plants too. Get carbs from plants. Like potatoes , sweet potatoes , etc.

@nevinkuser9892 2 месяца назад

Only ever eat fermented vegetables not starch.@@Bully-mu1su

@billa.2940 Месяц назад

Meat and vegetables are all you need to improve your health. If you don't like veggies, try saurkraut.

@salleone6387 5 месяцев назад

I just want to share a book from 2010 by Dr. Terry Wahls who reversed her MS to a great degree by concentrating on the health of her mitochondria as the primary focus: 'Minding My Mitochondria'. Its great that researchers are finally catching up after 14 years.

@SK-jf7dq 6 дней назад

Thanks for the referral!

@jmc8076 10 месяцев назад

@18:15 This admission alone sets you apart from others on YT and why you’re growing. Humility and curiosity make the best researchers and scientists. Thx Nic!

@Physionic 10 месяцев назад

That I'm a murderer? ;-P Thanks, JMC. Trust me, I never forget I have much to learn.

@jmc8076 10 месяцев назад

Oops, well compliment still applies but not that you don’t already have a lot to teach and share. ✌️

@abc_cba 10 месяцев назад

I use your content these days to make my health tips notebook. Thanks for the immense amount of research you compile.

@Physionic 10 месяцев назад

That's awesome, abc. I'm really glad.

@abc_cba 10 месяцев назад

@@Physionic best wishes from now rainy India heading towards autumn soon 🇮🇳 And my name is Sam.

@Physionic 10 месяцев назад

Autumn here, too, Sam. :)

@07.buddhi 10 месяцев назад

Nicolas, please make a video about supplements that really help with mitochondrial health! Such as Q10 as an electron transporter and other interesting things 🙌🏻 Maybe about cellular respiration and overall more basic bioenergetics stuff 🤓 BTW like your work a lot! Keep it going! 🙏🏻

@teddybearroosevelt1847 10 месяцев назад

Here are a few more: pqq, d-ribose, creatine, alpha lipoic acid, cumin seeds (you need to grind them or chew on them to have a chemical released that I would have to look up but that supports the mitochondria)

@melvillejayathissa7415 10 месяцев назад

Also the UBIQUINOL supplemental form of CoQ10 as well, for adults over 30 years of age! Melville from sunny Malaysia

@zahram4473 10 месяцев назад

Can you please share supplement names and brands?

@martinlang9615 9 месяцев назад

@@bejul2yes, please mention brands as I too suffer chronic fatigue

@HRVHackers 6 месяцев назад

Bejul mentioned peptides that help cfs

@TaraMae212 10 месяцев назад

The mood-feeling-mitochondrial relationship makes so much sense! Bruce Lipton talks about this is his studies of cell-environment relationships.

@gabriellew6467 10 месяцев назад

Most subscribers will probably agree with abc - but let me add that apart from informing intelligently and discussing knowledgably, you do it with the most delightful touch of humour. You are to serious information what yeast is to bread - making it lighter and more palatable 😊

@karenf9137 10 месяцев назад

Great analogy.

@Physionic 10 месяцев назад

That's really kind of you, Garbielle. Thank you.

@sallyweiner4180 8 месяцев назад

My long covid has given me post exercise flat out exhaustion that can last weeks to months. Infrared light therapy, eating right, water, gratitude, community, anti depressants, doing things I love to do that I can physically do and for me this is painting and getting outside is what is slowly helping me. I am trying to get my mitochondria to heal and increase. AND I’ve detached from the news.

@Bait1official 3 месяца назад

Ray peat baby! Forget low carb. The mitochondria LOVE glucose. The issue never was sugar, if it was our ancestors wouldn’t have sought out honey and fruit. The issue is a mitochondrial one! fix them, fix your disease. ;) Go high carb low low fat. Not forever, for now. We wanna get the body metabolising sugar instead of fat and turn your body in to an energy producing machine so it can heal itself. Kick out PUFAS too.

@vawiley4 10 месяцев назад

I’ve had a shift in focus: Instead of focusing exclusively on how to lose weight, I’m learning how to improve my mitochondrial function I think that focusing on these practices will improve my overall health and the result will likely be multifactorial

@donwinston 10 месяцев назад

Your mitochondria will take care of themselves with regular exercise and a healthy calorie restricted diet.

@r-type4945 10 месяцев назад

Same here. According to Robert Lustig mitochondrial disfunction is the main factor behind insulin resistance. Although there's a strong overlap and interplay, managing weight or blood glucose feels more like treating symptoms than causes.

@MM-qp4pd 4 дня назад

👍

@TsuchiuraBob 10 месяцев назад

Just a peripheral comment on the importance of neuromuscular junction (NMJ) maintenance in enabling exercise. An NMJ is the synapse between motor neuron and muscle fiber. There are genetic diseases as well as inevitable aging that cause the motor neuron to die back, causing fewer muscle fibres to fire, in turn weakening the muscle. Much remains unknown about this process that leads to sarcopenia (muscle weakness in the aged), but it would come as no surprise to me if mitochondrial health turns out to be one of the players in this process, possibly setting off a vicious cycle of weakness discouraging exercise, in turn leading to more die-back of motor neurons.

@billtrudell1636 Месяц назад

Martin is a great guy I've learned so much from him.

@heyyou9839 10 месяцев назад

The issue with PhD scientists is that they take their laboratory subject “mitochondria” and study and make recommendations outside of the rest of the body. If you eat in a way that is a calorie deficit, with many anti-inflammatory compounds, and increase fasting window PLUS move more PLUS sleep enough - that will help a raft of different processes such as hormonal responses to food, your body composition, and your stress pathways, which will sure probably have flow on effects to intercellular organelles including mitochondria. The constructs that focus on one particular aspect of the body are spurious

@casta9172 10 месяцев назад

Thanks for this information ❤ I'm battling cancer and I need to know more about mitochondria

@rahvastepaabel 6 месяцев назад

Study cancer metabolic treatment options, youre mind will be blown

@reggie5 10 месяцев назад

10:51 very interesting, particularly what you said about mitochondria downsizing in response to a nutrient overload. I've heard people say to continue your supplement regime during fasting - but maybe it would be more beneficial to discontinue the supplements during a 24/48 hour fast to freak the mitochondria out a bit more? rather than keeping them relatively comfortable despite the lack of food intake.

@flcps 5 месяцев назад

That's what I do in my weekly 48 fast. Nothing besides water, black coffee and a bit of water kefir

@Chaotic313 10 месяцев назад

The interweaving of science and humor in your content is sublime. More? Yes please. ❤

@Physionic 10 месяцев назад

Deal!

@HazardousHumorHQ 10 месяцев назад

Good work sir. A key takeaway from a latter part of the video, re: sleep, stress, mitochondria...for ⬆️ A.M. ENERGY, optimize stress PRIOR to sleep! Work towards consistently better mental mood prior to sleep time! Makes sense...emotionally better state during sleep onset --> more PNS-activated state during sleep onset --> positive neuro-emotive inertia starting out--> momentum carries through subsequent sleep cycles to some extent, perhaps facilitating (for example) better dreams and so on. Anyway, I'm sure findings in the field of psychoneuroimmunology would agree! Keep it up Physionic, and let's all take care of our emotional, cognitive and overall mental health and resilience, folks!

@abdelilahbenahmed4350 10 месяцев назад

Thx Physionic for this another great video. May I ask you what are your thoughts on the impact of metformin on the mitochodria. Some people say it's a mitochondrial poison, but a pretty large number of studies indicate that it increases mitochondrial biogenesis. Other researchers say that even if metformin impacts the mitochondria negatively (but slightly) it's actually a good thing because it triggers the mechanism of hormesis in the body. Excited to see how you could clarify even a litte bit this complex topic.

@mikeo2693 10 месяцев назад

This channel has been a great discovery. Thank you for providing this service.

@tobiasgarrard9271 7 месяцев назад

It's amazing people like you that make a difference with us humans. Thanks for being a great one. Keep studying and sharing⭐

@Resist.Tyranny 5 месяцев назад

Avoiding poisons and toxic substances may not be revolutionary, but someone understanding how prevalent these harmful substances are, and actually avoiding them is very rare. When umbilical blood was tested for toxins from many mothers births, OVER 200 chemical toxins were found.

@sheradenart7907 3 месяца назад

Oxytocin is connected to mitochondria, it helps balance the need for iron in electron transport and OXPHOS. So it makes alot of sense that happiness would be connected to mitochondrial health.

@rookhoatzin 10 месяцев назад

A positive attitude improves your biological function. We know that intuitively but I love to hear it from a scientist in the know....

@lostinversailles 10 месяцев назад

Aha! Suspense - more to come in part 2! What a science opera 😁

@littlevoice_11 10 месяцев назад

I wonder how issues such as chronic digestive issues such as IBS, SIBO, leaky gut etc impact mitochondrial health. I am aware these can impact mental health through the gut brain axis.

@dchildr360diurnalnutrition 10 месяцев назад

I greatly appreciate what you’re doing. You provide a valuable resource to those of us wishing to learn more.

@littlevoice_11 10 месяцев назад

Id love to hear more about mitochondria in relation to MS and post viral fatigue or fibromyalgia

@teddybearroosevelt1847 10 месяцев назад

Mitochondria play a role in almost every disease, as they do much more than just provide the body with energy

@mike7920 10 месяцев назад

Alex Howard in his book Decode Your Fatigue goes into depth on this

@rosaflorpuig3971 10 месяцев назад

Looking forward to your “senolytics” video. Please include “Qualia Senolytics” contentions that their 2-day regimen actually cleans out zombie cells. Thank you.

@MarcoBrianza 10 месяцев назад

Hi, great content as usual. I just watched it during my 20 min morning bike (fasting) exercise to start the day and apparently to multiply my mitochondria. I constantly stumble upon the effect of red/infrared light on the cell even on energy production. Is it something you plan to cover in the future?

@leepeterson2079 5 дней назад

The video was very informative and your humor is so dry, love it.

@salvadoroliveira6632 10 месяцев назад

Conventional agriculture usually uses fertilizers that contain N, P and K; the continuous maintenance of crops deplete soils and the fact that nobody. " makes number 2 " out of a toilet, prevents the recycling of minerals on soils. Is magnesium added to commercial fertilizers? Many enzymes cannot work without enough magnesium intake.

@nieczerwony 10 месяцев назад

Well this is the charm of industrial farming which is more and more spread and supported by politicians worldwide.

@DesertDog8989 10 месяцев назад

and many who take magnesium don't check their copper; this balance is critical ❤

@nieczerwony 10 месяцев назад

@@DesertDog8989 I know people who take 30 mg or more zinc a day (as they heard that zinc= better immune system), and they don't even care about taking copper and selenium. So yeah I don't expect them to do the same for magnesium

@salvadoroliveira6632 10 месяцев назад

@@DesertDog8989 Does the ingestion of magnesium affect the level of copper in the body? Or do you mean that people should also check for the level of cooper? Thanks.

@gaiacielo5090 10 месяцев назад

Yes this should go out to more people! Been following people talking about mitochondria health! Thank you good sure 👌🏾 😊

@Johnnysday 10 месяцев назад

You offer tremendous service to that greater body of knowledge.

@a_bar8579 10 месяцев назад

We wish to translate this teacher's channel so that all languages can benefit from it.

@H4KnSL4K 10 месяцев назад

Thanks for highlighting details of our incredible design!

@Bepartofthepanacea 10 месяцев назад

Amazing work and explanation 👏 thanks ❤️

@pip5461 10 месяцев назад

Could you put your analytical expertise into the study of Tinnitus...?

@sncnutrition7118 10 месяцев назад

Yes!!

@pip5461 10 месяцев назад

Thank you...@@sncnutrition7118

@drunvert 10 месяцев назад

👍

@AnneAlready 10 месяцев назад

Thanks for featuring Martin Picard and breaking down and expanding on some of his insights. Great video.

@jamescalifornia2964 10 месяцев назад

😉 May all your mitochondria be healthy 🙏 ✨️

@ambrsanford3703 10 месяцев назад

I am actually retaining this stuff. Thanks, again!

@user-hn3qc3oh5r 10 месяцев назад

being able to measure mitochonrial health and population is amazing, everyone knows extrinsics like emotion have everything to do with how we feel, now backed by this most fascinating area of research,, thank you for sharing this! you're a good man!!, despite having admittedly commiting murder in your lab

@peterazlac1739 Месяц назад

On the optimum diet my view and experience tells me that titrating glucose load against use and the ability to store it as glycogen is a key factor and this declines with age due to the inevitable loss of muscle mass. As a nutritional physiologist I find it a limitation to many of these videos and nutritional papers where they link their results to fat or protein when the cells do not recognize either but rather amino acids and fatty acids and the responses are different depending on which are involved and their ratios. This is especially true for excess omega 6 fatty acids and lack of essential amino acids, especially leucine but also other factors that determine their activity.

@SquatFull 10 месяцев назад

Thanks for the information on the mitochondria and the references to the studies.

@h0ph1p13 10 месяцев назад

Please make a video about salt (yes, NaCl). It's a very controversial topic. I read "The Salt Fix" and "Salt Your Way to Health" both present a very interesting picture. I wonder what's your take on salt in our diet and also salt as a supplement for endurance exercise and muscle strength.

@TheEngadine 10 месяцев назад

I feel proud of promoting you, Nicolas and this, your channel in each and every antiaging forum I follow. Hope it helps you and your team to reach your goals in YT. Big Thank You. 🎉

@Physionic 10 месяцев назад

Really kind of you. Thank you. :)

@larrysiders1 8 месяцев назад

If you're metabolically healthy (Healthy/Plentiful Mitochondria).... you're more likely to feel more "energetic"...or "positive". REVERSE CAUSALITY LIKELY HERE.

@ThomasAT86 Месяц назад

Dealing with severe ME/CFS, these things sadly didn't do anything and that's true for almost everybody with this illness. I hope there's WAY more research coming out in this regard. Desperate to not lose another decade.

@sleeplessforawhile 10 месяцев назад

No magic for now... but as always... great job to giving us a real landscape about mit. Just one question, talking about how phisical activity could increat mit. account... is there any study about how "mental activity" could induce similar process about increaing mit. account but in neurons?. Thank you so much for sharing you work. PD. I´m quite interested on PQQ , do you have in mind to do any video about it?.

@Appleblade 10 месяцев назад

Fred Hatfield's book, Bodybuilding: A Scientific Approach, had a section claiming (and citing studies, if I remember right) that mitochondria increase mainly when you stress muscles with 20+ slow reps... 90+ seconds of continuous tension... IOW, anaerobically (sarcoplasmic reticulum increases with 10-12 reps, actin & myocin increase with 4-6 reps). Has this information been lost among researchers? Was it speculative? IDK

@thetranscendedman 10 месяцев назад

I've heard people use inversion to talk about "not poisoning the body" when it comes to eating junk food, not exercising enough, not sleeping enough, etc. Perhaps we should extend that definition to the powerhouse of the cell!

@mitchellgould2053 10 месяцев назад

Great video, as usual. Have you by chance looked into any of the work Cohbar is doing with mitochondrial peptides?

@jamesparris4767 24 дня назад

Wow the mitochondria really is the powerhouse of the cell

@michaelstreeter3125 10 месяцев назад

15:37 There's a book, Kahneman, D. (2011) *Thinking, fast and slow.* 2nd edn. New York: Farrar, Straus and Giroux. where he says question order is super important; if you ask (1) how happy do you feel? then (2) do you have a girlfriend/boyfriend at the moment? you get _completely_ different scores compared to asking the same questions the other way around. Because "do you have a girlfriend/boyfriend?" gets the subject thinking and sets them up for the next question.

@surajitgoswami1871 9 месяцев назад

Independent of glucose is my conclusion too using a sample size of one. To redress then fasting may improve mitochondrial health in addition to reducing food overload. Thanks.

@darin7369 6 месяцев назад

People often like to major in the things that have the most minor benefit. People would be doing very well to simply cut out most high glycemic carbs, avoid a sustained calorie surplus and get plenty of exercise (especially zone 2). As far as fasting...finish whatever project you're working on and take a late lunch or dinner on occasion. The point is just to get into a state of hunger once in awhile and let the body adapt to it.

@yay-cat 10 месяцев назад

With the feelings study. I wonder if they took menstrual cycle into account. Like I feel a bit more depro in my luteal phase (2 weeks after ovulation). But like I would think the cocktail of hormone interactions over this cycle has a larger effect than the mood. Like it might be correlation not causation

@clintatk 3 месяца назад

I would also point out that the quality of movement is very important. Movement is a brain-nerve activity. The more skilled the movement the greater the brain-nerve network is developed. Just look at musicians. Their nervous system grew as they practiced playing, building a greater, more refined nervous system in their arms and fingers. The greater the skill set in exercising the greater the nervous system development.

@alqodsialmuqawim8061 3 месяца назад

Well muslims obligatory fast a whole month- the lunar month of Ramadan which actually moves by 11 days or so every year with respect a solar month- from dawn to sunset and this period of total fasting which is actually during the day time varies according to the season (day time is shortest in winter and longest in summer). Also, a Muslim can do the voluntary fasting any other day of the week if he wishes from dawn to sunset.

@antoniakotsiros2836 10 месяцев назад

Thank you so much for your amazing video. Loved every minute and can’t wait for part 2. Have an amazing day 🎁🎁🌟🥁

@homomorphic 28 дней назад

I know exactly what fasting regime is optimal *for me*. I derived that by taking labs frequently and adjusting for sustainability vs the results. For me it is 18 hrs/day. That is sustainable and produces excellent results in my labs (i have a BMI of 17.8, bp of 100/70, a1c of 5.1 and hsCRP of 0.9). I have no idea what the optimal level is for someone else, but I *know* for sure, it isn't 3 meals/day.

@ijimstopit 10 месяцев назад

Again, another information filled science lesson entertainingly delivered.

@paulpellico3797 10 месяцев назад

so everything we need to know we already learned in kindergarten??? move, play, eat well....be kind.

@FORTRAN4ever 10 месяцев назад

I have read articles that connect the dots about ME/CFS symptoms being brought about from some mitochondrial dysfunction . It is hard to imagine increased aerobics improving a ME/CFS patient's symptoms when doing so results Post Exertion Malaise (PEM).

@id9139 2 месяца назад

Yes, correct... What is the solution?

@AnP865 5 месяцев назад

It's cool that you're keeping things complicated. Some of the mitochondria people are alluding to or even explicitly stating a level of simple certainty which doesn't seem valid, more like ideology.

@krzychukula 10 месяцев назад

Your mood is causing mitochondria to be healthy or not. This seems like a big exaggeration to me. 1. We know there is small correlation. 2. But it’s much easier for me to imagine that whatever impact my mood can have impact on my body. Things like stress, getting sick (feeling unwell), vitamin deficiencies, bad sleep etc. I’m writing this because people often jump to „just feel happier” advice which helps no one.

@jeno427 10 месяцев назад

Very informational video. Would you consider making a video about exercise adaptation and antioxidants? Ubiquinol is an antioxidant yet it increases mitochondrial biogenesis, which is seemingly contradictory. There is not much info on it other than the bro science avoid antioxidants a couple hours before and after exercise.

@PaulHigginbothamSr 10 месяцев назад

Just let me say when younger my night vision was not as good as it is now. For 3 months I have been taking a supplement of taurine. I am taking 1,000 mg and have experimented with 2,000 mg on an occasion where I wished to check my night vision and it was reduced by doubling the dose. Before taking taurine at all I could see down the path 1/2 mile clearly. After taking taurine it was like everything was shut off beyond my bikes headlight beam. I could see all the way to the end of the walk clearly before taking taurine. What makes me wonder is my natural level of taurine being higher when younger reduced my night vision. I am seriously considering stopping my use of this supplement. I wish I knew the chemical reason for this reduction. I walk my dog early before light in the morning and have heard curious things in the dark. I am now 75 and many blood components have reduced significantly as I age further but night vision increase was not expected.

@helenahandkart1857 9 месяцев назад

Very interesting.. i've always had poor night vision, & it unexpectedly improved after about 18 months of drinking 300mls of cold vaccum pressed raw full cream Jersey milk, daily. I think it may possibly've been the extra bioavailable retinol.🤔

@Burnrate 10 месяцев назад

It's like having a ton of engines running at low rpms is better than having a few engines running at high rpms and overheating to do the same work. If you have too much fuel being dumped in all the time your body will remove a bunch of engines leaving you with few engines.

@carlribbegardh2723 10 месяцев назад

Ooh, this is going to be good 😊

@sq5 10 месяцев назад

I have a question regarding ME/CFS and the negative effects of exercise on patients with the condition, in relation to mitachondria health, which is known to be affected in these patients. If exercise promotes good mitachondria health in a person without ME/CFS, what effect does it have on the mitachondria of ME/CFS patients, where exercise usually causes a worsening of the condition and can cause relapses that last for days, months, and years? Is diet/fasting alone enough of a way to promote good mitachondrial health in a patient who cannot exercise? I would appreciate any insight into this matter.

@Bllackdog 10 месяцев назад

Im neither a MD nor a researcher in such a field. But maybe the capability of mitochondrial transcription or translation is in a manner affected that makes it hardly possible for the body to adapt, to the by exercise forced stress, in form of increasing the amount of mitochondria. Meanwhile existing mitochondria might lack under needed substrates to ensure proper balance in the equation of energy needed vs. energy used. Thus the overall burden of stressed mitochondria increases, since the lack of needed substrates, which already is responsible for the lack of needed energy, also leads to the incapability of a proper maintenance of the existing mitochondria. Maybe this will result in apoptosis? What actually also leads to a lower energy-production? But maybe that's completely wrong. Just like a said, im not a specialized person, just a curious & interested guy.

@SkyRiver1 10 месяцев назад

I have CFS and have for decades. It forced me to optimize everything about my life so that I could do more than get out of bed to take a pee. After such optimization exercise became a positive element, and I suffer some relapse if I become too sedentary.

@reggie5 10 месяцев назад

I am also thinking this is a good video for people grappling with ME/CFS. I guess as ever it is a very very gentle increase in movement over many months alongside diet optimisation that will ultimately help.

@sq5 10 месяцев назад

@@BllackdogFood for thought indeed. I appreciate the time and effort you put into your reply. Thank you.

@sq5 10 месяцев назад

@@SkyRiver1Really great to hear that exercise has become a positive thing for you, and how you went about making it so. Thank you for your reply. I hope today is a good day.

@MM-qp4pd 4 дня назад

Fascinating. Thank you!

@northerncoloradotransparen1454 10 месяцев назад

I wonder how animal consumption (full of hormones' and antibiotics) affects mitochondrial health?

@veniqe 10 месяцев назад

Definitely better than the pesticides and antinutrients from plants.

@northerncoloradotransparen1454 10 месяцев назад

No meat is much better for all@@rfbead321

@stefanisilva2493 10 месяцев назад

@@veniqe Pesticides more concentraded in meat, due to bioacumulation. Antinutrients that are antioxidant, anticancer etc that are the very reason plants are healthy.

@vajaindransramasamy4107 10 месяцев назад

Fascinating information. Thank you.

@truop4110 10 месяцев назад

Now that's sn amazing video ❤

@andreac5152 10 месяцев назад

What you mean when you say that the mitochondria burns fuel in an inefficient way? Why does this produce oxidative stress? Aren't free radicals a normal byproduct of mitochondrial function? Why they go awry? Another thing that can cause mitochondrial damage is fluoroquinolone. Plenty of people like me who have very high oxidative stress and high blood lactate. What should we do to improve? Can you take a look at this and give us an hand please? If the mitochondria is already stressed we cannot exercise, not considering that many people cannot even walk.

@jedwards1792 10 месяцев назад

I started a new habit recently. I now watch about 10 to 15 minutes of stand up comedy on RU-vid before I head upstairs to go to bed. I think my sleep has improved. Now I know why….

@Physionic 10 месяцев назад

I love the attitude.

@JuanLopez-sx1er 8 месяцев назад

MARVELOUS Video THANKS DR 🧑‍⚕️🙏

@MichielMortier 10 месяцев назад

And what about the additional use of CoQ10? As often used extra with statins? Do you notice results right away?

@bhut1571 4 месяца назад

Thanks. I enjoyed your previous spiel on choline. Myself being a 14 egg/ week afib person I was conserned and read this baby which you may find interesting. It doesn't seem to matter much on how much you eat, the choline metabolites seem to be independent and TMOA doesn't seem to matter. Here it is: Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study Clin Chem. 2021

@jenn1663 10 месяцев назад

Is this one way that taurine supplementation/exercise that increases taurine levels might be helpful in mitochondrial health/longevity? "Taurine deficiency and rotenone actions are similar, as both lead to reductions in complex I activity, inhibition of NADH dehydrogenase activity, reductions in respiratory activity and elevations in NADH. Because a primary physiological function of taurine is the maintenance of complex I activity, there is reason to believe that taurine therapy should reduce the severity of Parkinson’s disease (Alkholifi et al., 2015). "

@claudiomicheli3863 10 месяцев назад

Is mitochondrial fission inherently bad for energy metabolism? Its function is to only dissipate the excess energy? Can the newly separated mitochondria grow in size to match the previous mitochondria after the fission?

@EduardQualls 10 месяцев назад

We understand that you're excited to share your info, but, In your videos consider waiting a second or so before you start talking. Some Bluetooth speakers have a "lag" before they produce sound, so the first moments of your presentation are lost. For example, in this video, the words "I've been" are lost, and the first word we hear is "working." (There's an "alert" signal sent first by the source device, to "wake up" the speakers before sound-production commences, the response to which some senders don't wait for, but start sending audio data immediately. So, data sent during the speakers' handling of the "wake up" command can be lost.)

@elvistrompf317 10 месяцев назад

These summaries are great, even for those with acquired mitochondrial disorders. I have Friedreich's Ataxia, and the research is pretty sparse,and so are the treatments. The data available does suggest what works for acquired disorders works for FA to some degree

@lynnwilliams5432 10 месяцев назад

Normal weight but osteoporosis 81 yrs on cane fracture femur stem . Anterior hip replaced 10,000 steps 4 miles today going out once more to get up hill cardio. Was sprinting bf fractured occurred picking up trash. Do weight arms shoulders grip.

@arthurdolle5257 10 месяцев назад

Very informative discussion with information I haven't seen anywhere else. Do you think keeping a stiff upper lip through adversity helps mitochondrial function?

@hoffmancapote 10 месяцев назад

Thanks Nicholas for a great video. I do not comment a lot on your videos but I find it inspiring that you rely on research and not mutated opinion to make your videos. Your humorous comments are also improving

@Physionic 10 месяцев назад

I appreciate that!

@edkruzel 3 месяца назад

I think daily fastening does little more than act as a mechanism for calorie control. So many studies on a variety of nutrition and health conclude lesser results due to adaptation. If this is also relevant, then fasting sporadically would be a higher benefit.

@carloscarion1748 10 месяцев назад

Don’t worry, be happy!

@danhanks2936 10 месяцев назад

Thanks I like your science approach to health. There are a lot of questionable ideas floating around cyber space. This is an amazing time to be alive with so many wonderful people investigating our world.

@stargazerbird 10 месяцев назад

So vigorous exercise and a healthy weight. Everything always boils down to that. I hardly need to consume health info any more.

@ZappyOh 10 месяцев назад

Cheese_Cake Entered The Chat. Mitochondria Left The Chat.

@HazardousHumorHQ 10 месяцев назад

Thanks for your work!

@peaceonearth8693 10 месяцев назад

If you get enough Mitochondrians, can you train to develop The Force? And, is your Captain Picard really an expert on The Force? I noticed that he didn't bring it up. Which is understandable.

@eltarahim5859 10 месяцев назад

You are delightful! Learned so much..thank you sunshine!! Sending love from LivelyLasVegas!!

@paulpellico3797 10 месяцев назад

remember the lines actor spencer tracy spoke in the movie Inherit The Wind.... you invent airplanes, you lose the sense of distance and you fill the skies with gasoline. better living through chemistry, right? how do we avoid the mistakes that modern man makes when he himself is trying to improve life? there is no possible way to stop, or break, this vicious cycle. and this research is nothing more than monday morning quarterbacking. and making a living and keeping busy. my depressing point is this...we are fooling ourselves, we are spinning our wheels. but perhaps that really is all there is to life, the point of life itself: be born, procreate and keep busy living wash, rinse, repeat. this ain't about us, folks. it ain't about anything, really. its just about life itself and everything within it competing to keep it going and survive in the most chaotic struggle.

@mikeward9870 10 месяцев назад

Nice! One key concept that is often missing in metabolic vids (keto, ...) is that fasting/hunger (to generate mitochondria) is more than endogenous use of MCT oil (with abundant nutrients).