No. Both types of toxins bind the active site and block the AcCh. The non-competitive binds irreversibly to the site and essentially destroys the enzyme's activity (i.e. no competition with AcCh). The competitive binds-releases-rebinds, etc. blocking the AcCh when it is on the site, but competiting with AcCh when the toxin is not bound to the site. Also, the competitive toxin is metabolized away and/or excreted more easily since it is not tied to the enzyme's active site. The enzyme remains active when the toxin is not tied to it and is available for normal function. In the case of the non-competitive, the enzyme activity is permanently gone, and the organism must wait until new enzyme is synthesized -- if it is to recover from a non-lethal dose.
the organophosphate is an irreversible anticholinergic compound so even if it is present in small concentration it will bond to the enzyme and stop it's activity that is why it is non competitive
Hi Larry Keeley, My dad is pushing a move for a Hillsborough style inquiry in organic phosphate poisoning within the UK mainly affecting farmers who used sheep dip between the 50's to the 90's, Im trying to gather as much evidence on his behalf to bring forward to the inquiry, the formal medical opinion is that organic phosphate only has short term medical affect rather than long term, my father and others have paid for private tests and they have come back with high amounts of chemical particles originated from organic phosphate still within his body. He has been paralysed on numerous occasions suffers pain and low dexterity and as a child using organic phosphate suffered fits. if you have any research that may help Id be very greatful. Kind Regards
John Wright Sorry, I did not work specifically in toxicology. I am an insect neuroendocrinologist. Try some of the people in entomology departments that specialize in toxicology.
i believe i stepped bare foot on a floor just treated with bedbug pray . it seems to have made few toes decrease sensitivity when touching something as if i had a packing tape stuck under my toes
Both. It is the action in any animal with a nervous system. It is deadly to insects because they get a larger dose per body weight, than people. But it is toxic to humans and other animals if they get a high enough dose. Toxicity for any chemical is a dose-to-size relationship and most chemicals: including water and oxygen, can become toxic if you get enough of them.
If you are asking would I make a video showing its action, I would be happy to but by the time I did you probably would not care. It takes me weeks or months to make a video plus all the background reading I do. If you just want to know its action: fipronil blocks GABA- and glutamate-responsive chloride channels to hyper-activate and disrupt the nervous system. Wikipedia has a good write-up on it as to advantages and disadvantages.
