Wow. I was a young nurse in the early 90s, attending an Apheresis conference in Houston, Texas. I can vividly recall s speaker introducing a modern plasma machine and mentioning the system to be the answer to finding the fountain of youth. Years later, I was working with a machine harvesting stem cells for cure in a research stage. I am now retired, and hearing these presentations indeed, pointing to yes, near the fountain of youth? Until this day, I only had seen the Trevi fountain 😂😊
I am layman. I just wanted to bring into your notice there is something in UDST (Urine Devrived Stem Cells0 which helps longivity. Former Indian Prime Minister, Mr. Morarji Desai used to drink his own Urine every day and he became PM at a very late age and lived more than 100 years without any major health problem. His interview on this subject is available on BBC. Make sceientific studies if you can! There is a branch of study on this subject in ancient India, called Shivambu. Some literature is still available.
Stem cells have taken a long time to get their day, a lot of false starts, but finally they are. Now that AI has come into the picture in medicine, who knows what the coming decades will bring. And we NEED it. By 2050, the number of 65+ year-olds will have doubled, and the number of 85+ year-olds will have quadrupled. And that's in the best-case scenarios of countries like the USA with lots of immigrants. So what do we do? Get serious about this research right now.
In terms of the gentlemen asking about timing - it’s ignorant to laugh. It’s not funny. For example, in ARPA-H, one criteria for funding is the - so what? And is your research going to have a real impact on peoples’ lives in a reasonable period of time? And as far as “you didn’t know cancer survivors before, and now you do” goes - we used to use rotary phones and now we have cell phones. Point is - now we have tools like epigenetic clocks, AI / ML, models on protein folding, better imaging technology, not to mention knowledge of bioelectricity (which also ties into cell differentiation), epigenetic reprogramming, mitochondria, quantum biology, etc. We don’t need studies about the limitations of rotary phones. It’s 2024, not 2004 or 1984. Different times, different measuring stick. Same for biomedical R&D, tech transfer, distribution.
@36min. Why the stem cells are near the lyfatic system. Maybe it is because it is the drainage. (There is no garage, almost all lymfatic fluids are recycled). The drainage will tell the stem cell about the health of the tissue and thus if repair is needed.
Well yeah but before we had No idea why yet what aging exactly is, we now have a relatively clear Definition as well as Most Major causes with Rough strategy plans which future developments will contribute to slowing or even Stopping and reversing aging
According to Matt Kaeberlein (rapamycin researcher), calorie restriction doesn't extend lifespan in all lab animals. He said that CR actually shortens lifespan in some lab animals, depending upon the individual genetics of the animal. And he suspects that the same thing would happen in humans. That's probably why Dr. Roy Walford (one of the first proponents of calorie restriction, back in the day) emphasized that his calorie-restriction protocol (CRON) was NOT recommended for people who are naturally lean, have low bodyfat, and can eat anything and as much as they want, without gaining weight.
I have never talked to the stem cells, cells, mitochondria, or white blood cells in my body, and I have never told them what to do, but they do their jobs on their own. Are they autonomous robots?
what teleology? He presented on stem cells. How was his talk out of place in 'the scientific endeavor' ? Your comment should be clarified if it is to be considered.
I thought and felt he did a remarkable presentation with just the right balance, presenting the landscape, drilling down into a few details, inspiring viewers to broaden their view, and leading directly into the talk by his colleague. Examining all the factors, rational ( for that which is still being discovered), and various directions and co-factors is a plunge, first fired by inspiration.
If by teleology you mean the graphics used in the explanation, I think it simplified the complex scientific processes to something familiar that the lay person can grasp. I found it efficient, personally. I have always believed stress, physical emotional and mental has something to do with aging.
Even wear full body suit gloves boots helmet I still got TBI Thematic Brain Ingery, I don't remember what happened but I was told I was going too fast 😞 I had a Ducati 1299 PANIGALE S...
Talk one - great! But what ARE old super stem cells, and how do you make them? Is this published anywhere? That was the most important part. Is this in mice or people? Talk two - ok, so the supporting lymphatic / vasculature for the stem cells is more important than just the stem cells alone. So if there is no way to fix the lymphatic / vasculature - who cares? This talk is premature and irrelevant to people. Come back when you have a solution to fixing the lymphatic / vasculature for stem cells - or at least learned something that does not work so it’s not repeated. Otherwise this was a waste of time to watch, and a waste of funding to do unless the goal is to just sit and look at stem cells not performing well because of lymphatic vasculature. Pretty irritating actually when scientists think the point is their own self indulgence.
