Adam Ruins Everything - The Problem with Lab Mice | truTV 

Her: "I've always wanted to be a laboratory mouse!" Me: ........ Why the heck would you want that? There's a reason we don't test on humans, you know....

What idiot ever thought that "testing on rodents is practically the same as doing actual human trials"? I will bet that no scientist ever.

I read that a researcher working to cure Alzheimer's said we've cured it at least 30 times in mice, but haven't been able to get the treatments to work in people.

Am I the only one who want's these Science Hero cards?

Well, Adam is right there is no federal law covering mice and rats, there is the PHS policy on humane care and use of lab animals, which covers all vertebrates (including mice and rats). Come on Adam, I wish you mentioned this.

*"ACTUALLY, THEY'RE NOT"* - "LITERALLY" Adam

I see what you did there. Pinky and the Brain

“What are we going to do today, Brain?” “The same thing we do every night, Pinky-try to take over the WORLD!!!!”

This is just turning one misconception into another misconception! Of course lab mice aren't going to have the same responses as a human, but you need to understand the concept of a "model system". Each strain of mouse is so well known itself that we can use that knowledge to learn about how something else, like a drug, works. We then pair that research with work in several other models, such as human cell lines or flies, to see if our understanding matches what we know in those systems. No scientist expects mice to mirror humans perfectly, or even all that well. But the alternatives? Avoiding testing on humans, there's primate research, but that is extremely difficult to justify in the majority of cases, as many species are endangered and they are considered more sentient than mice (See NIH and ICUAC). And you mentioned that lab mice aren't covered by the AWA, but that's leaving out the key point that all institutions that use lab mice are governed by regulations that do include lab mice under AWA. There is an extremely stringent policy involving lab mice that must always be followed and every experiment must be extremely well justified. Any scientist who doesn't understand this wouldn't be anywhere near lab mice, as in this video. Make sure to research your videos before saying things that'll make the general public distrust science. *Look up the institutional ICUAC for more information.

Mice are used as a step to clinical trials; they are never the only evidence for drug efficacy. While scientists can do research on human cancers and other conditions through immortalized cell lines and clinical samples, scientists must use models of a complete body to analyze the responses of all types of cells together. Ethically, this is best done in an animal model that resembles humans while minimizing harm to those animals. Those two variables are maximized (for most research) in mice.

This video forgot to mention that it's the only "ethical" way to do so. Human experimenting is illegal in almost every country.

4:10 Adam and his friends' faces when the mouse squeaks is just too darn funny.

0:40 Adam Ruins "Pinky and The Brain" LOL

I love how this offers no actual solution. Considering human trials would cause public outcry faster than the idea could be considered.

The only "negative" side to mice actually mentioned in this video is that results on mice don't always translate to humans, which isn't that bad even. Every other point in this video is a positive. They are cheap, so the failed trials cost less than failed human trials. The faster metabolism and shorter lifespan lets us perform things like experiments over a lifetime or multigenerational studies, and the size difference enables the use of lower quantities of drugs.

You're right Adam! So our solution should be to test on humans for more accurate results, why hasn't anyone else thought of this

I can't tell you how funny it was watching the researcher talk about mice ineffectiveness in studies and then how she talked about putting the card in a bike spoke 😂 Oh my God and they did it at 4:20 exactly.

Literally no one: Adam: *THAT’S WHERE YOU’RE WRONG*

That time when Adam became a furry.

“80% of the time, it fails with humans.” Um yeah, Adam Conover, that’s how science works. Get used to it.

The problem is that there is no beter alternative to testing on rodents that isn't very expensive or dangerous to humans. (As is said in the video). So, for now, it is the best option. I think saying that people in general believe that testing in rodents is similar to testing in humans is sort of correct (don't know the exact numbers, please correct me if I'm wrong), but suggesting that scientists don't know is nonsense. Of course scientists know this and the differences between rodents and humans are accounted for when decideing the dose for human subjects (as much as possible, some things stay uncertain). A good example of this is by using a formula to adapt the dose for the differences in weight and metabolic speed for the different species.

Therapist: Animated Mice Adam is not real, it can’t hurt you Animated Mice Adam:

I lost it when the lab mouse was cursing at the doctor!

Adam ruins the civil war I read somewhere that about Lincoln didn't want to end slavery

I used to work at a place that raised a huge number of mice for use in research. It was the most grossly mismanaged workplace I have ever seen. I sometimes felt like I had taken a wrong turn on the way to work and ended up in the Twilight Zone.

The amount of misrepresentation in this now has me questioning every other thing adam has "ruined"

i’m glad this is on youtube because i needed this info for a research argumentative paper

Just one question: What about the HeLa cells? We have an infinite amount of those, so why not use them?

Would you rather skip to human trials with no animal trials at all?

Adam is The Brain confirmed.

There's a lot of cellular testing as well. In fact, cellular testing is usually the first step for anti-cancer drug development, followed with animal models (or sometimes yeast as it is also extremely inexpensive), then human trials.

Dr. Raza: "Thanks for keeping me in mint condition" Also Dr. Raza: "If you put me in your bike spoke it will sound like a motorcycle. Brbrbrbrbrbrbrbrbrbrbrbrbrb!"

Adam low-key advocates for unethical, painful, and possibly painful experimentation to be done on humans for four and a half minutes

*mom walks in* mom: you still watch Johnny test? Me: No I'm watching Adam ruins everything and it's not always family friendly Mom: *whispers* Johnny test...

Wonderful segment.

I wonder if Dr. Raza was happy to make that motorcycle noise in the end. Very fun and very humanizing.

On the plus side, if you ever get mouse cancer, we got you covered.

Sure, but before mouse testing, there's testing on cancer cells- which is great, but doesn't accurately replicate the conditions inside a live organism. It's also possible that mice are a "fail-early" model- i.e. if we don't see any success with a trial in mice, it's not a huge stretch to say it likely won't be successful in humans- but at least we tried on mice first, since they're cheaper, instead of humans, where now a bunch of money has been wasted. Also the writing in the description implies that mouse studies could apply to humans 79% of the time, so that seems like a big error lol

Love the pinky and the brain touch

2:44 Several years ago scientists created a glow-in-the dark rabbit. They produce similar-sized litters but they ain't rodents. You can have genetically modified pets, I kid you not. Mutant rabbits aren't on the list yet.

Moira from Overwatch is an interesting character as she wouldn't mind using humans as test subjects.

**Adam Doesn't Know Anything About Medical Research

Since the TeGenero case (what he described, the 2006 fail in the clinical studies), there were some new regulations for medical testing installed in Europe. For example, you can only test substances of which you have studied the mechanism in the body and you have to show that the difference between an animal and a human does not affect this mechanism much. For example you might have to take a beagle instead of a chimpanzee in the second part of animal testing (which, in Europe, is done on rodents first but has to be done in larger mammals before getting into clinical studies)

GREAT WORK

Worked with lab mice for years doing cancer research. This is extremely biased and misrepresents just how useful mouse models can be.

*their pinky and the brain pinky and the brain one is a genius the others insane*

Pinky and the Brain reference at 0:44 I already expected it from seeing the thumbnail 😆

I love scientists getting goofy on Adam’s show

The doctor recommends using human cancer cells if studying cancer: for at least a few types of cancer, if not more, it is definitely possible to culture such cells in a lab. I'm not as sure that is possible for other illnesses, but for some cancers they grow fine in a dish if taken care of, possibly partly due to cancers being growing masses of cells that are not dying in the body. It sounds like medical research needs to find some better way than using mice

I will always remember to never do drug trials. My uncle did one and it dissolved his hip bones.

“Everyone ‘knows’ that” should be adam’s catchphrase

2:09 man's became a gmod ragdoll

I will point out one blaring problem. What's the solution to mouse research? Testing on other animals? Human experimentation? Stopping medical research all together? The history of medical research is complex and a lot of it is trial by error. Those "failed" experiments on mice were not all failures by any stretch of the imagination. So much has been learned from these failures, and by experimenting on mice, humans in dire medical circumstances have been given the BEST experimental treatments clinically available using animal testing. Animal testing is a cornerstone of biomedical research because these animals protect humans from receiving dangerous or ineffective treatments. Animal experiments were responsible for birth control, chemotherapy, antibiotics, and countless other biomedical breakthroughs that have significantly improved human lives. You could keep trying leeches, blood letting, and blowing smoke up your ass. If you eat animals, try not to be so judgmental when scientists kill them curing disease instead of just, you know, dinner.

Is it too difficult to link at least one SINGLE SOURCE?!

The scientist girl is Bryden from Project Mc2!

"Well Tell the cancer patients they have to wait PETE!!!" XD

2:59 they jumped from the cage to pipes outside the cage That's illegal

As someone who works in the region and have handled mice, this video isn't exactly accurate, it certainly feels like someone who haven't done research before trying to point fingers at things they don't understand. Mice are cheap and can be used to test a variety of drugs. For example, toxicity, while human toxicity tolerance and mice toxicity tolerance is not the same, but since both mice and human and mice are mammals and share a good amount of similarities, what is toxic to mice is almost always toxic to human. Say we have an experimental drug that may be potentially toxic to human, we wouldn't want to go test it on a human outright since we wouldn't want to kill him/her, we would go test it on a mice first to see if there are any side effects. Sure, mice experiments are not exactly the same compared to humans, but tell me where I can get almost an infinite amount of humans to do experiments on new drugs or biological theories without weighing on my conscience. You want science without morality? Check out Unit 731 (en.wikipedia.org/wiki/Unit_731). Also, there is no "effectiveness" when it comes to research (YOU CANT RUSH SCIENCE). I can test 1000 different ways and none of them are correct and I can test 1 single way and it just works. Scientific research isn't based on "how efficient you can pump out research papers" it is about the scientific method. For those who forgot what they learned in high school, it is observation -> hypothesis -> experiment -> conclusion/observation and the cycle goes on. Science is trial and error, try something, if it is wrong, figure out why and try to avoid making that mistake and try again, if something else goes wrong, figure out why and try avoiding making that mistake. When I start a research, I can't tell you I will be done in a certain amount of time or with a certain amount of money. I can only apply for funds and spend the fund as effectively as I can until you decide to stop giving me funding because the results doesn't warrant the funding or because I finished. For those think scientists are completely machines and have no remorse killing those mice, we aren't. We try to be as humane as possible when it comes to test subjects, even when it comes to animals such as mice, spiders (which a lot of people hate) and jellyfish (I'm putting this out just because I dealt with them in labs before). There are much worse problems in scientific research that needs to be fixed, but this certainly isn't one of them.

Great work with the Pinky and the Brain reference

I’m going to add this to the “useful information I’ll never use file” in my brain.

Was this reuploaded or what?

Something wrong: _exists_ Adam: _begone_

Loving the old toon reference...

'we could never get away with this on a raditz.' xd

As a Biomedical researcher, this is the most ridiculous thing I’ve seen.

Is it only me that this video reminds me of "Pinky and the brain" 😍

Music was on point!

let’s do science tests on bananas

I think that we should experiment on prison population, there are so many people who’s life can be used for a better purpose that they have ever archived themselves.

So does this mean the studies that say sugar is more addictive then cocaine are bunk?

Thanks for keeping me in mint condition. Now put me on your bike

Nice pinky and the brain reference

Reupload?

GUYS WATCH THE FULL EPISODE!! these clips only show part of the issues they represent. The episode will usually provide solutions and substitute to these problems by the end. Adam ruins everything isn't just about pointing out a problem. It's about finding solutions too

Sooo... winnies voice is very voice actor friendly.... i can absolutely see (hear) her voice in cartoons or videogames. Very pleasant.

I love the reference to Pinky and the Brain!

#project mc2

Reupload

Id never be able to be a scientist if it meant hurting animals

Heh.. that Dr. Raza is so cool.. playing along with the comedy theme.

This is so dumb. Literally no scientist thinks testing on mice is "practically like testing on humans." Otherwise you wouldn't need to do bloody clinical trials if what worked in mice worked on man. Mice studies are good because you can test the biological variables within a pathway (which 97% of the time is identical to the human pathway (i.e. in terms of the genes activated upon stimulation) - which is largely used to demonstrate cause and effect. Yes that 3% difference means if you change the pathway in the entire organism, the results between men and mice will probably vary *such as with the drug you mentioned- yes an extreme example, 99% of the time it doesn't go that way (the drug caused a cytokine storm in human subjects but not the mice, and because of the subtle differences between men and mice immunity, there is no way anyone could have forseen such a horrific side-effect)*- but this isn't something that escapes scientists. A good example of this is how the Nazis were the first to demonstrate that smoking caused cancer. They used mice, and we replicated that finding in the west- lo and behold; smoking causes cancer in humans too! You cannot discount all the good mice testing has done, it far far outweighs the negatives- and atleast from this clip, it seems you don't represent the issue fairly.

I usually like this show. But, This is a misrepresentation with a narrow perspective.

Oh God I love this show ! ! !

My favorite show Adam and winnie

How about pigs? Cheap, breeds fast and you can eat them when the testing is done? And only what 98% same DNA?

Animaniacs, nice touch.

I love the pinky and the brain reference

0:46 Cpt.America:I understood that reference

the truth about super foods please

Reupload to erase/reset the comment section.

Very Clever Reference

This came out before the Animaniacs Reboot was even written, which means this kind of hits harder knowing Brain’s backstory (which is dark)

those poor mice

I like rats, put them in a soup. It's just a prank

I study at the Royal Veterinary College in London, and we barely hear about mice in testing anymore. The big ones we use are Zebrafish and Fruit Flies. I imagine they aren't much better but they're popular for similar reasons; cheap and easy to genetically modify.

A mouse with ears that always faces you, I want that

This video is "ruining" a straw man. Whoever "researched" for this episode clearly don't understand how scientific research is done and why scientists need animal research before jumping to human trials.

the show should be renamed adam pushes his political agenda on everyone

I'm a Research Scientist at a Biotech company in husbandry and have been for 4 years. I have some notes on this video. Balbc mice aren't used that often. Black six are more commen. Currently SCID mice are used for cancer trials since they can be given human cancer. So human cancer is being studied And lastly you cannot have a drug go to human trial with only mouse studies in the us, even with orphan diseases you can only go to clinical trial with two different animal studies, normally it takes three or more animal studies plus the in vitro studies (done on the target cells).

"cancer research has become so mouse-centric". A brand new sentence.