Aging, Rapamycin, Metformin, Resveratrol, Longevity Supplements, David Sinclair, Anti-Aging Myths

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About the guest: Matt Kaeberlein, PhD is a Professor of at the University of Washington and CEO of OptiSpan. His research focuses on the biology of aging and longevity.
Episode summary: Nick and Dr. Kaeberlein discuss: the biology of aging; mTOR, FGF1, growth & metabolism; sirtuins, NAD & NMN; longevity drugs like metformin & rapamycin; facts & myths about longevity molecules like resveratrol & taurine; controversies in aging research related to prominent Harvard researcher David Sinclair; epigenetic clocks; healthspan & lifespan; and more.
*This content is never meant to serve as medical advice.
All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel:
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ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
#Science #Podcast #Biology #Metabolism #Aging #Longevity #Genetics #Resveratrol #Metformin #Rapamycin

Опубликовано:

13 сен 2024

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Комментарии : 17

@MindAndMatter 4 месяца назад

All M&M content is available on Substack. Podcast, writing, free weekly newsletter: [mindandmatter.substack.com] If you enjoy M&M content and want to provide further support, read this: [mindandmatter.substack.com/p/how-to-support-mind-and-matter?Fsearch%2Fsupport&] Thanks!

@IAMMANIFEST 2 месяца назад

I literally only listen to Kaeberlein and Attia these days! It's so good to see him spreading his no nonsense good sense. I literally love how passionate he is and I share his annoyance re 'health influencer misinformation' so it's great to see him debunking.

@sportsdude2828 4 месяца назад

Cool podcast, but I would suggest adding topic timestamps to the description, so we know what to expect

@MindAndMatter 4 месяца назад

Thanks! mindandmatter.substack.com/

@tonystewart7624 4 месяца назад

This is an interesting conversation. Thank you.

@workingTchr 3 месяца назад

We don't want to make longevity the only standard for taking supplements. For instance, long term NMN was shown in a 2022 study to prevent the progression of age related hearing loss in mice. If you're old and losing your hearing, that's reason enough to take it. One other thing I just found, "(Metformin) reduced the need for health care services for severe COVID-19 by 42.3% after 14 days and the risk of Long COVID by 41.3% during a 10-month follow-up." For this to work you have to take the Metromin "early on" the Covid infection. That, in effect, means, taking it all the time.

@jpjames8044 4 месяца назад

The suggestion is that to improve Healthspan, the factors for genomic instability, telomere dysfunction, epigenetic alterations, loss of proteostasis, compromise of autophagy, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication and deregulated nutrient sensing should be targeted. So how do we prioritize the many supplements some charismatic influencers with impressive qualifications has urged us to take? The Science. Astaxanthin Maritime pine Matcha NAC Nattokinase Resveratrol Taurine Creatine Berberine Magnesium Potassium Omega 3s Silybin Amla Glycine GTF Chromium alpha-lipoic acid Benfotiamine NAD+ L-citrulline NMN NMNH Nitric oxide Flaxseed Pomegranate Hibiscus Cranberry Beetroot Betaine anhydrous Metformin Rapamycin Vitamin K2 Fisetin Sodium butyrate forskolin Alpha Ketoglutarate Spermidine urolithin A DHEA Rhodeola L-theanine

@JoseSolis-q4h 3 месяца назад

Honestly shocking to hear how resveratrol has practically no longevity benefit

@szghasem 4 месяца назад

Thanks for the awesome podcast! I'm hooked on Dr. Kaeberlein's talks, this one introduced me to his insights on Vitamin D, B12, and Omega 3. I've heard that people on very low carb diets might need less Omega 3. Would love to get Dr. Kaeberlein's thoughts on this!

@MindAndMatter 4 месяца назад

Thanks! mindandmatter.substack.com/

@mynorby206 4 месяца назад

I do though actually lose weight from taking Nicotinamide Riboside (300mg/ daily) around 1 kg a month, I only took it to live longer and then found that I lose weight without changing anything else , and I used to not to be able to lose weight easily: 9 kg in 7 month now

@Schu2505 3 месяца назад

Why the deliberate placement of Sinclair's book?

@NicholasOdinson Месяц назад

That’s my copy, I work at Optispan and put it there for fun 😊

@mynorby206 4 месяца назад

you are certainly right about doctors not measuring peoples level of vitamin D even in Denmark where we pay all health system over our tax and don´t have to pay anything going to our GP except for the medicine which is also supported economically from our state