Coleen T. Murphy, a professor at Princeton University, specializes in genomics and molecular biology and is the author of How We Age: The Science of Longevity.
In this wide-ranging interview we discuss the significance of declining cellular repair mechanisms that over time lead to visible signs of aging. Prof. Murphy has a particular interest in reproductive aging and cognitive function during aging, considering the former as an often overlooked aspect that begins midlife. Her work with the model organism C. elegans, a nematode worm, has led to important insights into the genetics of aging due to its short lifespan and visible aging process. She believes that translating such findings into mammalian models and eventually human applications is crucial.
Prof. Murphy also expresses concern about the way longevity science is portrayed and criticizes some researchers for failing accurately to describe the true implications of their work. She says there is a need for honesty and realism from scientists to maintain public trust, especially in the field of aging and longevity where bold claims can often outpace reality. Researchers, she insists, should not over-promise results that science cannot yet deliver.
We also address the potential for 'exercise in a pill' and Prof. Murphy highlights recent research indicating that certain proteins can rescue memory function in aged mice. She also argues that without taking care of our planet and its inhabitants, the quest for longevity loses much of its significance.
Prof Murphy's book:
How We Age: The Science of Longevity
amzn.to/3HVhzNa
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Topics covered in this interview include:
Murphy provides her definition of aging, focusing on the declining efficacy of repair mechanisms. [00:01:15-00:02:25]
Personal motivations for engaging in aging research, emphasizing the interdisciplinary interest in aging and its impacts on human life. [00:02:43-00:03:53]
The central role of aging research in addressing a gamut of age-related diseases, highlighting a shared approach to dealing with these ailments. [00:10:36-00:11:29]
Skepticism around outlandish longevity claims arises, cautioning against eroding the public’s faith with unrealistic aspirations of reversing aging or achieving immortality. [00:13:55-00:14:18]
Lifestyle choices and their impact on longevity, including the practicality of harsh dietary regimens. [00:17:49-00:20:37]
Exciting translational research developments, where genetic discoveries in model organisms have potential pharmaceutical implications for extending human healthspan. [00:22:48-00:25:06]
The relevance and benefits of using model organisms such as C. elegans in aging research, and how these can lead to safer and more efficient human trials. [00:25:18-00:28:05]
Personal health strategies derived from research are touched upon, discussing the significance of exercise, diet, and emerging knowledge of mitochondrial health. [00:28:39-00:36:23]
Reflections on the need for a sustainable, livable world, tying the pursuit of longevity to the overall environmental and societal well-being. [00:41:58-00:42:54]
The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
8 фев 2024
