The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1

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In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.
#Aging #DavidSinclair #Longevity
Thank you to our sponsors:
Athletic Greens - athleticgreens.com/sinclair
InsideTracker - insidetracker.com/sinclair
Levels - levels.link/sinclair
Our Patreon page:
/ davidsinclair
Lifespan book:
amzn.to/3sUqurT
Dr. David Sinclair Social:
Instagram - / davidsinclairphd
Twitter - / davidasinclair
Facebook - / davidsinclairphd
Matthew LaPlante's Social:
Twitter - / mdlaplante
Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:07:11 Acknowledgement of Sponsors
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins
00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Measuring Aging - Biological Age vs. Chronological Age
00:49:30 "No Law That Says We Have To Age"
00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths - Telomeres & Antioxidants
01:01:55 Options for Subscription and Support
Links:
Weapon fragments in bowhead whales - bit.ly/3eP7rqP
Rapamycin extends lifespan in mice - go.nature.com/3F0yud3
Targeting Aging with Metformin (TAME) Trial - bit.ly/3eU9ABk
Metformin improves healthspan and lifespan in mice - go.nature.com/3JSRZbs
Metformin reduces all-cause mortality - bit.ly/3pWNiWc
Reprogramming to restore vision - go.nature.com/335iysI
DNA methylation age - bit.ly/3sUAUYB
Genome-wide methylation profiles & human aging rates - bit.ly/3ETPXnK
Reversal of epigenetic aging in humans - bit.ly/3eUior3
Danish twins study - bit.ly/3eToU13
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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Опубликовано:

4 июн 2024

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Комментарии : 1,3 тыс.

@Gadinata 2 года назад

I have been following Dr. Sinclair since I was 33. I am 30 now.

@MyLongevityExperiment 2 года назад

😆😆😆

@jeroenkratsborn5122 2 года назад

😄😄😄

@mathew9851 2 года назад

hahahahha this one sent me

@genuineculture 2 года назад

yes

@bridgetnyambura4634 2 года назад

Hahaha

@jimparsons4312 2 года назад

He takes 1g NMN, 1g resveratrol, Vitamin D, K2, 83mg aspirin, avoid sugar, bread, pasta, skip one meal a day, get your blood tested, don't smoke, avoid plastic, excessive UV exposure, X-Rays, CT scans, sleep in a cold bedroom, do cold exposure, do exercise.👏👏👏👏👏

@johnmc2362 4 месяца назад

Thanks for the info, just have a question about the Athletic Greens? What time/amount does he take of it each day if you know? Thanks in advance ☺️

@catherinelee9130 Месяц назад

Plus Metformin or berberine for controlling blood sugar

@RickyConnelley 2 года назад

So glad he made a podcast! The fact we can listen “for free” to a Harvard professor teach is amazing! We live in cool times for self learning

@microwaveengineer6681 2 года назад

The combination of a scientist and a journalist for a podcast is just a match made in heaven. This is gonna be great!

@Corrans 2 года назад

I agree! More podcasts should be like this.

@jeffmiddlebrook5251 2 года назад

Thank God for leaders like David who genuinely want to help mankind. My wife and I are 65 yo and we want life after 65 to be our active second life not a death sentence. We plan to share this information to whomever will listen and become disciples of longevity.

@levondarratt787 2 года назад

Lol 65....that's not even old...most people live til 85 minimum these days, or even close to 100. You talking yourself old at 65, is the problem for not achieving long life if you're not careful. Madonna is 65.

@jimbeaver27 2 года назад

Hi Jeff, I am 70 and after 2 years of Keto feel 40 again. I am very interested in all that David says, even though some of it sounds expensive. I highly recommend Keto or other low carb diet!

@jeffmiddlebrook5251 2 года назад

@crazywarlord777 thank you.

@jeffmiddlebrook5251 2 года назад

@@jimbeaver27 Thank you. We are using the Mediterranean diet as our guide

@MyLongevityExperiment 2 года назад

I agree, 65 is not old anymore

@zalareverie4745 2 года назад

I have been counting down and now this podcast is finally here! I am greatly inspired by you and Dr. Huberman and i'll be forever grateful to Lex Fridman to introducing you both to me. Keep changing the world for the better!

@chrispridemore5562 2 года назад

Forever grateful, literally. :D

@zalareverie4745 2 года назад

@@chrispridemore5562 i see what you did there... or what i did there xD i tip my hat to you :D

@ioanenikoladze86 2 года назад

Same bro!!

@henriqueguarnieri9639 2 года назад

Same !!!!

@cecipalacios1007 2 года назад

Kudos to scientist like you, Huberman and others who brings this wealth of knowledge in a easy to follow format! Lectures like this and Huberman’s as well are priceless. Thank you

@LongevityPlan 2 года назад

We’re super jazzed David has his own RU-vid channel and podcast now! The future is looking great!

@odmineypiju4761 2 года назад

I am 27 and in the last few years I began to notice, that some of my peers are aging much faster than me. This observation caused me to often contemplate the topic of aging, and when I listened to Dr. Sinclair on Huberman Lab, I subscribed to Lifespan right away. Thank you for your work and for making this information accessible!

@MyLongevityExperiment 2 года назад

I wish I could have started at 30

@odmineypiju4761 2 года назад

@@MyLongevityExperiment It's never late to become 30 again :)

@tappersuzie Год назад

I started taking responsibility for my health in my early 20s. I stopped drinking - have not had one single drink since 1987, no cigarettes since 1993, I've had excellent nutrition and exercise. I have seen the amazing results for years, but now that I'm heading towards age 65, my efforts have paid off tremendously. I look and feel much better than 99% of my contemporaries. And now with all these new developments in knowledge, I benefit still. Something not mentioned by most practitioners too often is faith though. I'd be nowhere without my study of the Bible, years of pursuing that knowledge trumps everything.

@AnnTsungMD Год назад

@@tappersuzie Thank you for sharing your story and experience. Your story is very inspiring. I agree that faith plays a big role in our overall health, happiness, and longevity - and for me that is the most important THING of all. ❤

@carl8790 Год назад

@@tappersuzie whatever 7 day adventist are doing, it's working for them. On average they tend to live longer than their peers.

@BrentNally 2 года назад

I’m stoked David finally has his own RU-vid channel! Let’s all work together to solve aging ASAP!

@SallyEndinberg 2 года назад

Thanks for all your work too Brent!

@Health.First. 2 года назад

Oh hey Brent. Nice to see your comment here.

@syrupgoblin4920 2 года назад

Let's end it!

@jamesgallagher8714 2 года назад

Love your content too Brent!

@maspesasmasperras5554 2 года назад

Let's start with why he applied all botox available in the Northeast

@JumperAce 2 года назад

The same way you feel more justified in taking fitness advice from some one who is visibly in shape, David is 50 and looks 30, and he's been applying his science to himself. Such an inspiring guy

@calgaryalberta4892 2 года назад

Yes he looks younger this time

@AnnTsungMD Год назад

Agree! He walks the talk. He is visibly in shape. What he says is really worth trying.

@ChrisWillx 2 года назад

Love this. Congrats mate!

@user-sb9ml1ef4q 2 года назад

"...we can control aging very precisely at will. We can speed it up as fast as we want in an animal, and even reverse it. So aging is now controllable." What a time to be alive.

@davidlo168888 2 года назад

We can't control aging indeed without God's mercy nano-medication. If AGEs (advanced glycation endproducts) can't be cleared away from body, it's impossible for reversal of biological aging.

@user-sb9ml1ef4q 2 года назад

@@davidlo168888 god has nothing to do with this

@davidlo168888 2 года назад

@@user-sb9ml1ef4q Shut up. You don't know. In front of me, prof. Sinclair doesn't know how to reverse biological aging because God doesn't guide him. Do you know who I am? Do you know nano-medication. I've applied nano-medication to cure: Central Pontine Hemorrhagic Stroke Taiwan's medical society is so shocked. This is real Regenerative Medicine. Nano-medication is the only AGEs (advanced glycation endproducts) breaker. You go back to home for further study. You're not qualified to come here for bullshit statement.

@user-sb9ml1ef4q 2 года назад

@@davidlo168888 you should be taking meds man

@callofthedark 2 года назад

The wait is over.. My guru is Live. No words can ever comfort me to express my gratitude for all that I have received from life especially from my Guru “Dr.Sinclair”. I have been fortunate to have followed you since the past 4 years and all that I can say is that I am a 37 years chronological getting oldman but who looks like a 27-28 years young & health. It’s because of following you and your lessons on longevity I have been able to successfully reverse my biological age to live a robust & active life till a 100. As Dr.Sinclair once said “The one who will live till 150 has already been born”, I will do my best to be among the set of people who do. In the end can’t wait for your new Book and listen to the remaining 7 episodes of this podcast series. I bow before you for all that you have taught me.🙏🏻

@BlackMamba-lt8oe 2 года назад

you will be the longest living human in india 300 years

@JeffNixonComedy 2 года назад

This is going to be such a powerful podcast. Can’t wait!

@MyLongevityExperiment 2 года назад

I agree

@Beluinduh123 2 года назад

Love the dynamic, having someone to bounce ideas and questions about this topic is important! Thank you both for this platform 🙏

@Adam-nw1vy 2 года назад

Dr. Sinclair is a hero. We owe him a debt of gratitude. I have been following him and his work since 2016 like every single week. I'm so glad that there is a podcast now! The only thing that I'm worried might derail this fantastic and groundbreaking research is the political turmoil in the US. We need to make sure that this research reaches fruition no matter what.

@tonyamckimmy693 2 года назад

On my last leg of treatment for Lyme Disease. I sincerely thank you and Professor Huberman. Your teachings have given added strength to my hope that helps me carry forward.

@wednesday6018 2 года назад

I'm sure I speak for all of my fellow science lovers when I say, thank you for doing a podcast. It's so exciting! 😊

@MyLongevityExperiment 2 года назад

I agree, this is well overdue

@bredemeijer9648 2 года назад

@sneakers_guy5488 2 года назад

Thanks so much for starting this podcast series Dr. Sinclair! Matt's inclusion on this podcast is immediately evident to me to be a great decision, acting as an audience member (in a sense) asking the questions that many of us would in real time. Great format 👍

@pauloconnor1857 2 года назад

I've been so excited about this podcast....Here we go. Love your work David and thanks for bringing us this free information.

@billgarner1195 2 года назад

David, I would like to personally thank you for your life‘s work and the work that you are doing in reversing biological aging. As one of your students applying the information gleaned from your research to my personal life and to the lives of the medical practices and companies we serve. All I can say is this is a hell of a lot of fun :-)

@drewmoon3000 2 года назад

Congratulations on your official appreciated podcast. As an Aussie living abroad, you are a guiding light of inspiration. Thank you, Mate!

@edison_ryan 2 года назад

I'm 15 and I'm so fascinated by the forefront research and discoveries in the field of longevity and I'm so glad you started this podcast! Thank you so much, can't wait for future episodes!

@Edaryion 2 года назад

That is great! You have an opportunity to start mastering this early on!

@lckee820 Год назад

Good. You are starting young. I only learnt about anti ageing when I was already in my sixties! Anyway I can testify despite only half applied people still think I’m betw 50-60 years old!!! I’m nearly 80!

@HiTechFX Год назад

I'm 67 and agree with you!

@markschultz3791 Год назад

Wow you're 15! What an accomplishment!!

@tomsawyer2112 Год назад

@@lckee820 So what. at the age of 60 people thought I was at my early 40. I ever smoke, no alcool, an no sunburning, physical training for 50 years, no overeating, it as easy and has nothing to do with taking supplements early.

@danovic7822 2 года назад

Love this! Every bit of knowledge I can get about longevity I'll gladly take. Thank you David, for everyone you do for humanity!

@SatbirAulakhMusic 2 года назад

Thanks again David. Your book has changed my life and life of hundreds of my patients. I work as a GP in Darwin

@brittneytan8213 2 года назад

I can't wait for the next episode. This topic is near and dear to my heart, i want to live forever, or as long as i am able. I enjoyed the podcast, I never knew you're so funny Dr. Sinclair!

@Borromeo377 2 года назад

Happy New Year David - a long awaited podcast 🙌🏼Thrilled to find out more in the subsequent episodes. Thank you 🙏🏼

@jenniferdonnelly-montedeoc9285 2 года назад

I loved your book and recommended it to countless other healthcare professionals. Really exciting stuff! This podcast was excellent. I just can't say enough great things about you and your work. I'm so grateful that you are doing this podcast so that everyone can get as excited about these incredible advancements as I am!

@colinyoung3685 2 года назад

Looking forward to following this podcast. May it be fruitful with a long lifespan.

@minister1005 2 года назад

So excited! Thanks for doing this! We always needed more ❤❤

@farhadkhan5224 2 года назад

I’ve read Lifespan several times and been eagerly waiting for the latest updates from David Sinclair’s research. So glad to see this podcast.

@janisgs 2 года назад

Dr. David, I have been following you for ages already, so happy to see you starting your own Podcast. Looking forward to every moment with you.

@robertobenedit 2 года назад

Excellent, first Andrew, now David, life can't be better! Cheers for science! #scienceRules!

@redpilllense7125 2 года назад

This is AWESOME! Thank you, Dr. Sinclair, for doing the good that helps humanity. You are God sent!

@angelasaarloos3991 2 года назад

David Sinclair is such a bright mind but also a kind human being! I'm so inspired.

@lotfibouhedjeur 2 года назад

I'm bursting at the seams with excitement! Dr. Sinclair has an official RU-vid channel. I love how assertive he sounds talking about what he knows.

@paulcamdar4170 2 года назад

This is simply incredible. Thank you Dr. David Sinclair.

@MyLongevityExperiment 2 года назад

Well overdue

@vickydaisy_rose 2 года назад

Happy New Year Dr- David Sinclair. Thank you for developing the podcast. Amazing contents to be followed.

@luisrodrigueziii7316 2 года назад

I'm SOOOOOO happy that we finally have a David Sinclair podcast. Please keep this up, I look forward to the future of the show and the science that it'll teach.

@sammyhoffman71 2 года назад

So excited about this series, thanks for giving up some of your time to help us extend ours

@ggbrait9406 2 года назад

THANK YOU!!! This is awesome! Grateful to my favourite members of the humankind, Lex and Andrew, for introducing Dr. Sinclair to someone like me🙏❤️

@natalieaxl804 2 года назад

Love you David!! Appreciate all the study and research you do and keeping us in the loop of your discovery 🙏🎊💕 Blessings 🙏

@brosan5404 2 года назад

I watch every interview D.S. does and this is SO much better. MLP is a FANTASTIC interviewer, so grateful for this. 50:24

@lanetteglass8192 2 года назад

So happy to see this. Been following anything Dr. Sinclair does for a year or so.

@SCP-SAM 2 года назад

Amazing content! Thank you for starting these! Have purchased the book-which is amazing!

@elenateplushkina4346 2 года назад

I'm very excited about this. I've just finished the episode from Huberman Lab podcast. You and Dr. Huberman briefly touched on the topic of fertility and age-reversing. I would be happy to learn more about it and the protocols women can benefit from to extend their fertility age. Thank you!

@chiaroscural 2 года назад

Yes, I would also appreciate an episode on fertility!

@swg6443 2 года назад

Me too! Xx

@alinapaun1360 2 года назад

That would be a great episode!

@Starryskynm 2 года назад

Yes!! Yearning for more info on women’s health and fertility!

@joeblack4026 2 года назад

Nmn is responsible for longer fertility. Tested on animals and humans.

@turkishromeo83 2 года назад

Huberman Lab & Dr. David Sinclar, absolutely the Best of Best 🙌🏼 Thank you so much for sharing all your knowledge for free with us 🙏🏼

@simonfoo8684 2 года назад

Excellent way to allow layman like me to understand better about the science behind aging. I have listened many of Dr. Sinclair's talks and interviews but this podcast is really well orchestra to enable viewer to better understand the subject matter. Thank you very very much to both of you. I really enjoy watching it and forget to eat my lunch, which is a good thing to miss!

@vitalrestandrecoveryclinic7752 2 года назад

Im so excited for this podcast. Thank you!!!!!❤

@tygrera 2 года назад

I am so glad that this is happening, I've been a fan for a long time, absolutely love your book, much love from the Netherlands

@A7md02 2 года назад

Can't thank you enough for the huge amount of information we get from you Dr. Sinclair. I wish if the video was supported with pics for what was described.

@jamescarpenter2384 2 года назад

I would just like to thank you for your courageous efforts in keeping us all healthy and young if possible. I am sure that your grandmother is really proud of you now. I have been following you for several years now and find that Your explanation of your research is down to earth and clear especially for a nonscientist. I truly do hope that when you come out with formulas for the rest of us to take they will be available to all at an affordable price as you have said you would in past talks. NMN sounds very promising. Keep up the great work looking forward to all of your talks and podcast and once again I👏Applaud you

@Gunrun808 2 года назад

I eagerly await every Monday for Andrew Huberman's life-changing podcast. And now you're telling me that I get another podcast on Wednesday? Amazing!

@dylan8487 2 года назад

I discovered you thanks to Andrew Huberman, currently reading your book and am hyped for this podcast!. I have a feeling its going to be an amazing one.

@WyattFL5 2 года назад

Dr Sinclair has the rare ability to explain complex science in every day language. He’s absolutely one of my favorites, along with Dr Rhonda Patrick. Looking forward to future episodes!

@Joolz520 2 года назад

"A turning point in medical history." This is absolutely fascinating!

@MyLongevityExperiment 2 года назад

I couldn't agree more, exciting times ahead

@vladimirivanov6015 2 года назад

Awesome first episode! Really looking forward to future episodes. This field definitely needs more popularization to change people's perspective on aging.

@PA-eo7fs 2 года назад

David, please do an episode on bodybuilding and aging the trade off. Often times we want to gain muscle but do not want to activate Mtor and increase aging.

@Petewalker907 2 года назад

I have been looking forward for your podcast for a while now and I am happy it is finally here :) thank you and keep changing the world for the better :)

@markd6838 Год назад

Thanks for all the work you do, your research, your book and the podcasts etc. It's much appreciated.

@gautamnandu5420 2 года назад

Can’t believe it’s happening I’ve been waiting for this for Such a long time. He and huber man changed my lifestyle completely

@cttofr 2 года назад

Can you do a podcast on development of children? The acceleration of aging during puberty seems to be somewhat polar opposite to the idea of fasting during adulthood. What ideas come to mind when we say “skip a meal” to a 25-45 year old vs to a 7 yr old, 13 yr old, etc? How do you think about optimizing health in children that are developing in height, performance, etc? Thank you for all you guys do!

@cassieryan8839 2 года назад

I think this info applies to adults and kids just need to develop normally with a healthy diet and active lifestyle

@adityapasumamula7488 2 года назад

I think if you watch the podcast of Dr.Huberman & Dr.Sinclair @Andrew Huberman they have shet a little light on this topic/question you are asking & i think it would help you tremendously

@cassieryan8839 2 года назад

@@86FunQ I've watched a few of David's interviews and haven't heard any of this info applied to children. They are in a massive growth phase plus hormonal changes during puberty. Junk food needs to be avoided as much as possible and a sedentary lifestyle. Hopefully they can be encouraged to eat plenty of fresh veg and some healthy protein like fish or chicken. But above all I would be concerned about giving them hangups around eating and just let them enjoy being kids

@armieflores6064 2 года назад

I have been following you Dr. D. Sinclair, so excited to hear all brilliant information for longevity and healthy life.Thank you an awesome work with your team and sharing it to us.

@zafrat5727 2 года назад

What a time to be alive!!! My Goodness, I am so grateful to be learning this. Thank you Dr Sinclair and Matthew Laplante.

@larmikvonhorshley8631 2 года назад

I really appreciate Dr. Sinclair and the work h puts into making information so crucial to a long and healthy life available and accessible. The child in me can't help but see The crocodile hunter and The House of Pain guy having a casual conversation about epigenetics. We live in amazing times and are so fortunate that such dedicated people are willing to give so much of their valuable time to share their life's work with the world. I am both filled with gratitude and deeply humbled by this generosity, thank you both so much.

@seeesh_ 2 года назад

I'm so excited. And happy to see your own podcast, David. Greetings from Brazil

@fuscialilac3306 2 года назад

Very pleased that you are going to share your knowledge and experience with us in the podcast format, Dr. Sinclair! I'm looking forward to learning more and working to optimize my biology and be creative and productive for years to come. Thank you!

@arthurberry7666 2 года назад

Having lost 2 brothers at age 59, l hope to live the years they lost, and what better way than to follow Dr Sinclair and his science...which l am doing, having purchased his book and watching Lifespan podcasts, amongst others devoted to the science.

@MyLongevityExperiment 2 года назад

Don't waste another day in implementing a plan 👍

@stevelacy8342 2 года назад

This was a great podcast, thank you ,can't wait for the next one.

@j_grieshaber 2 года назад

Absolutely amazing. This was more than I had hoped for, so much fantastic, mind blowing information. I cannot wait to be able to test my biological age affordably and often. I am very much looking forward to the subsequent episodes and the upcoming book! Thank you Dr. Sinclair for taking the time out of your very busy schedule to make this happen for all of us, this is truly a gift!

@krevoyteam 2 года назад

Can't tell you how happy I am that you decided to do a podcast/youtube channel Dr. Sinclair...way overdue in my opinion but I also understand you are a SUPPER busy man and so grateful for you

@DrGayleDelaneyDreams 2 года назад

HOORAY! At last, Dr. Sinclair is unfettered by interviewers who feel they need to ask the same introductory questions and he is free to move on to the next level of explanation. Matthew is so well-informed and knows how to compliment David's points and how to ask interesting and useful follow-up questions. The lighting and sound are good, and the introduction to and the updating of the work is well thought out. THANK YOU! I shall be able to share these videos with a much broader spectrum of my friends and colleagues while learning more and more!

@volkerhiddemann7236 2 года назад

Thank you Dr. Sinclair for this insanely insightful work that you provide. It’s a pure pleasure to listen. It makes me smile to whiteness the similarities between your and Dr. Huberman’s podcast, knowing of course that he helped to ramp this up. It’s great to have such powerful people see collaborate. Matthew La Plante brings a nice twist to the topic. Highly enjoyable. Looking forward to the following 7 episodes.

@divyabhatia9916 2 года назад

Thank you so much for starting such an amazing podcast and providing amazing information free of cost. You are an amazing researcher, human being and an inspiration. And thanks so much for amazing research you do and for teaching how we can use that information and implement it in our daily lives to make it better.

@MatoMkenya 2 года назад

What a way to start 2022. This is epic. Can't wait for the other episodes. Thank you Dr. Sinclair for the info all the way from Kenya.

@braian4478 2 года назад

Finally it's here!!, congratulations David and team! And thank you very much for share such a useful information!

@prisar 2 года назад

After so much waiting, finally happy to see the first episode came up

@zinkarius7 2 года назад

Thanks for all your work Mr. Sinclair

@jaxnaturals 2 года назад

This is an eye opening moment for humanity! Completely enthralled with this and will be waiting for every episode! Subscribed!

@sunshinemittens23 2 года назад

Yeah!!! 🙌 So stoked you are doing a podcast!! Congrats & I’m thrilled to learn, learn & learn some more about health, longevity & more. Cheers! 🥂

@johnjudson8482 2 года назад

Thank you Dr. Sinclair and Mr. LaPlante for your book and now this podcast. When it comes to health, I feel like I have been stumbling around in the dark my whole life. The context and data that you have structured so beautiful is giving me hope that an actual and manageable path to health is within reach. You guys rock!

@MyLongevityExperiment 2 года назад

Very true, so much misinformation there from Governments and commercial organisations

@RodrasBurton 2 года назад

Rise and shine, it's lifespan podcast time! Looking forward to listen more of Dr. David Sinclair's precious info! 💪😁 Live long, stay fit, stay healthy!

@sleepmeditationsandrelaxat5681 2 года назад

You have touched the lives of millions and I hope the medical research breakthroughs will one day change the course of humanity for the better. Thank you and I will keep on following your work

@Bolangel 2 года назад

Mind blowing ! I have been watching videos about aging process for over a year now and I love every one of your interventions - but this is just mind blowing, the first one in which the concret biological process is so clearly explained ! Great work

@esdrasalmeida6047 2 года назад

Learned a lot on this episode, i'm definitely watching all of it! I am facinated on how much science has developed so far about aging and so enthusiastically about researching it.

@MyLongevityExperiment 2 года назад

The anti-aging field is exploding at the moment 👍

@dennis200620062006 2 года назад

Amazing dr Sinclair! Love the work you're doing.

@catmom6572 2 года назад

Thanks Dr Sinclair. I have read (listen the audible version) your book many many time， I'm so happy to hear your update after 2 years I bought the book.

@alejandraalvarezdetoledo1783 2 года назад

Thank you thank you David Sinclair and co host for speaking so clear for us that are not on the scientific world. I was a mother at 44 years so my interest in keeping alive with my best quality possible as long as i can is a huge wish so i can share with my child many things in his adulthood. Hope as what you say, devices and everything else will be more accesible for us in the future, but we can start with what´s in our hands and that i have been reading/listening over the last years and it´s what you talked about on your episode 2 which i loved too. I´m excited for the next episodes!!!!!

@aussiecfo 2 года назад

Great kickoff! Looking forward to every week.

@arupkalita2756 2 года назад

This is the podcast, I have been waiting for so long

@martinahollearn9538 2 года назад

'I've listened to all episodes and I LOVED all of them. Dr. Sinclair has a lovely voice for podcasting and it's fun to have the two hosts bounce ideas off each other an guide the conversation. Listening to the episodes have been a major inspiration for my personal and professional life and further motivates me to study neuroscience. Please keep working on new series!!

@EPFForsyth 2 года назад

Dr. Sinclair/ and Professor LaPlante you have helped me change my life. I am no longer over weight, no longer have Diabetes/DM2. And I finally feel/ look better. That was a long winded way of saying thank you.

@krizwang7378 2 года назад

Congratulations Dr. Sinclair! This podcast is going to be epic 👍

@MyLongevityExperiment 2 года назад

Epic is the right word

@mariamorris954 2 года назад

I discovered Dr. Sinclair when Andrew Huberman had him in his podcast, love and appreciate how they are informing us. Thank you, gracias❤

@denisegaliano6724 2 года назад

I CANNOT WAIT FOR THR REST!! Ibe listened to you so much and been wanting you to do this for so long. Thank you. Thank you. Thank you

@axeldaguerre8838 2 года назад

I doubted about Laplante going to be of any value at the beginning, I was wrong I love that his questions was to doubt a statement and waiting to be answered by Sinclair, he asks questions we want to ask.

@pareto3568 2 года назад

Read Lifespan and now listening to this. What a great opportunity to solidify the concepts expressed in the book and be up-to-date with new research.

@YogionaJourney 2 года назад

Such an educational podcast! Thank you so much for what you are doing 🙏 In your book you mentioned that in Hebrew there is a phrase "till 120" when people greet each other every birthday. We also say in Hebrew "Lechaym" which means "to life" every time we raise our wine and cheers. So, thank you for improving our quality and quantity of LIFE.