You are quite literally the greatest educator that has ever graced the planet earth. You have a PhD+ level of understanding of every topic you cover, yet you know how to communicate it succinctly and simply. You were born to teach.
I agree he’s incredible - a genius for sure... not taking anything away - however, Jesus is the greatest teacher On earth ever in fact he is still teaching people worldwide how to live with purpose 🙏🏻
It was due to your teaching I passed my 1st Year MBBS with 75% and got 2nd Rank in my College. All set to ace 2nd Year with your lectures Dr. Zach. You deserve all the respect and love from all the students all over the world. A big THANK YOU to you!!!!!
You're literally teaching what's in my material (ppt), only thing you teach way better than my professor. Thank you so much for making this easy to understand.
u deserve all the best I hope this channel hits the 10 million subscribes , lots of effort and time spent while constructing it every time I meet my other medical student friends I tell them about this channel so I can help growing up this amazing work ,I hope I could help in more THANKS ALOT ❤❤❤
There is no words to say who u are how u are and what you are u r demigod u ur patience your hardwork and your teaching style words cannot describe how I felt like u know everything every topic we r blissed to have u tq so much 🙂👍🤗
An interesting fact about beta blockers is that they can be used as a doping agent on healthy elite sportsmen. During training beta blockers maintain a reasonable cardiac output and muscle perfusion increasing performance as a conditioning agent. During training under normal conditions an increased cardiac output will increase blood pressure only to a threshold where the ventricles need enough time to fill their chambers with blood. If the heart rates increases beyond the threshold the ventricles will fail to pump the 125 ml per contraction. This will reduce tissue perfusion due to a lower mean BP. The beta blockers can keep the heart rate below the threshold effectively during training. This is why beta blockers are banned in competitive sports and considered a doping agent by the IOC.
I already was passionate by phisiology and pharmacology - but u guys u made me head over heels about it. Congrats in everything you do. Helped me see things in such a easier way - even though really detailed
Great lecture overall, but one mistake at 9:48: the adrenal gland secretes epinephrine and norepinephrine at a 4:1 ratio. Thus, 80% of secretion is epinephrine and 20% secretion is from norepinephrine.
Zach - when you are talking about Alpha1 antagonist drugs on the bladder with BPH (e.g. the -osins), don't you mean the indication is urinary RETENTION (2ndary to BPH) not incontenance? I though the idea was with BPH, we get relaxation by the A1 Antagonists, allowing relaxation at the prostate and internal sphincter, which allows for easier urination...
Thank you all as always for all of your great work and effort. I have a question, wouldn't alpha blockers be treating urinary retention/obstruction in case of BPH and not incontinence ?.
Thank you so much Dr. Zach for your very informative videos,bcoz of your channel I passed the Veterinary Licensure Exam just now🥰u were such a great help to my basic understanding of physiology and pharmacology😊. I will surely share your channel with the future examinees of VLE.THANKS AGAIN AND GOD BLESS😇😇
Bro said "had to take a lil break" = returns with different haircut. LOVE THE VIDS, all the way from SPAIN. I watch your vids at 2x to get a quick recap
Thank you so much! Awesome explanation. Just an observation/question : Are alpha 1 blockers used for incontinence? Aren't they used for retention instead?
Hello and thank you for explaining everything so well. I was wondering how NE and E affects the receptors if they ever do overcome their natural affinity?
Hello! Love your videos! I think the notes on the website and the written values on the video might include a typo. In lecture and web searching we are given EPI and (80%) produced and NE (20%) in a 4:1 ratio not flipped as shown in the video. Also the notes you give on the website also show NE being produced by the adrenal medulla twice. Not a huge deal but just wanted to give that feedback. There were some other things with other lectures I have noticed (minor details), and if there is a better way to inform about these please let me know!. Great Stuff all in all though!
He made an honest mistake, and you are right, it helps in urinary retention because it relaxes the internal urethral sphincter and thia causes urination
Sir, you made a mistake at 9:41 when you tell that NE is the 80% released by Adrenal Medulla while it is the other way around. It is 80% EPINEPHRINE that is released by ADRENAL MEDULLA.
ur the best!!!!! med-1 student here:)) i literally skipped all my pharmacodynamics classes to follow along with you, and it was the best decision I ever made!
I discovered Zach's only weakness ( he spells the most famous Beta Blocker as Propanolol) ... he does not pronounce it as PropRAnolo) or even spell it. The imperfection that proves his legend.
We dont prefer alpha 1 blockers forHTN bcz it decreases BP markedly on working at urinary bladder sphincter by micturition is it right concept so we should prescribe it when HTN+ BHP together
Im on Labetalol for hypertension as mine spikes above 180/120 regularly, currently on 9 tablets aday and have to take extra when I have a hypertensive crisis, I also have Intracranial hypertension and am on Topiramate. Still being investigated for causes Im only 32 though do have multiple endocrine problems, possible Pheochromocytoma or pituitary tumour.
Sir is Harrison principal of internal medicine 19th edition is good for study medicine ? .... I mean I'm unable to buy 20th and 21st edition .... So is it okay to study from edition 19 ? ... Is there any major difference in these editions ?
