Autophagy and NAD+ for Longevity - Dr Elena Seranova

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Timestamps:
01:05 How Elena Became an Autophagy Researcher
04:00 What Is Autophagy
06:25 Why Is Autophagy Important
11:11 When Is Autophagy Not Good
12:12 What Activates Autophagy
16:50 How to Measure Autophagy
26:55 NAD+ Role in Autophagy
30:20 What Increases NAD+ Levels
31:35 Negative Effects of NAD+
36:35 NAD and Aging
41:21 Best Ways to Activate Autophagy
45:10 Melatonin and Autophagy
46:30 Trehalose and Autophagy
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Опубликовано:

3 авг 2024

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Комментарии : 87

@SiimLand 2 года назад

@CoffeeKing1 2 года назад

Once you said go, she was like so efficiently telling info with slides. She lives for this, great guest siim! Also great topic to learn about

@renatodoe6661 2 года назад

And she's a babe!

@CoffeeKing1 2 года назад

@@renatodoe6661 yeah totally, I personally think siim is a handsome manly man!

@cyndisculley5735 2 года назад

The ratio with glucose/ketones is VERY HELPFUL! It’s great to have this information. “Dr. Boz” in the USA uses this ratio & guide as well. THANKS SO MUCH!

@BigPictureYT 2 года назад

That was an excellent bird's eye view of her life's work. Please ask her back and dive deeper into the details of sleep, exercise, diet, and supplements she uses and recommends for autophagy and health. Have her talk all about her business and what products she sells and why. Thanks for introducing her to us.

@luisfernando55 2 года назад

Thanks siim ! We need more interviews about autophagy and long fasting effects

@julianaschmittjp 2 года назад

This is the kind of information I’m most interested in! fasting/exercise/supplements/-autophagy! Thank you!

@Arguseyed_ 2 года назад

I just recently came across your channel I find your content highly informative and detailed but also simple enough for the average person to understand

@AdventureTrust Год назад

❤Through, meaningful, coverage of autophagy. ❤

@SubtleReed 2 года назад

My new schedule 40+ hours no food. Then cabbage soup that evening then food the next day. Now beginning the process again - every other day sort of. Astounded by the results. I'm 63 years of age. Two weeks ago just started eating less each day. Then started this new process - see beginning. I started at the weight of 247lbs +- 3 lbs. Now I'm 233 lbs - Going for 200lbs by the first quarter of next year. I love 💘 autophagy it is healing my health issues. Now I'm dry fasting. I will drink spring water when I thirst. I do drink a little black coffee ☕😋 in the morning. But I hate sugar. However I wonder if I should put a little Trehalose in it?🤔 👍Thumbs-up for Mr. SIIM LAND.

@MaxLambrecht 2 года назад

Awesome interview, very informative!

@temporary3151 2 года назад

Thank you two. Very interesting and great to see things new

@yovanjohnson1251 2 года назад

The doctor had me on melatonin briefly for better sleep but exercised extreme caution. I sensed fear. Great video.

@Hail2MasterChief 2 года назад

Excellent! And timely, as I just got back into TIF today after a long break. Great info as always Siim.

@ligiasommers 2 года назад

Very helpful and interesting interview 👏🏻👏🏻👏🏻👏🏻👏🏻🙏🏻🌹

@special_brew 2 года назад

Super useful information thank you for a great video!!!

@lucaslevi4307 2 года назад

Great video, very useful information.

@skrajina8037 2 года назад

Dr Elena is really smart!

@Tru_G.R.I.T 2 года назад

Wow so much great information

@markveen1373 2 года назад

Probably the older you get, the more you want to fast. Even in yoga/ayurveda they recommand to only start after age 30. Fasting for children is a very bad idea. Personally, I go 2MAD, 16/8. People tend to only think about the 16h fast window. But there is also cleansing/autophagy going on in the 8h window. As long you dont snack inbetween the 2 meals. At age 60-70 everyone should be doing OMAD imho. Should also become easier as you get older, since your activity and metabolism goes down. You're simply not that hungry anymore. I know a story of a verified 111 year old male yogi, that did OMAD for decades before his dead.

@arjunapartha 2 года назад

Excellent. Please bring her back to discuss ONLY cD38 VS Sirtuin relationships. 🙏

@richardsilmai9038 2 года назад

Excellent health informations thank you so much

@Kiwi-sg1yi 2 года назад

Great discussion, would love to see you guys going deeper into the balance factor of Vit.C & D in retrospect to autophagy, is still hard for me to hear someone stay avoid to much sun...

@littlevoice_11 2 года назад

A part two please!!!!

@grantlikes2sing Год назад

I had a friend in middle school, who in 7th grade in school, about 13 years old, decided to go into business for himself selling candy bars to the other students for profit. When he didn't sell out all of his stock, he simply ate what he had left. In one year's time he became diabetic. A high price to pay for his excess sugar consumption. I don't think we "get away" with sugar consumption at any age really, but maybe it is true that when our healthy resources are high in youth, the consequences of our poor habits take a little longer to present themselves in ill health depending on the strength of our natural immunity.

@LesleyRabie 2 года назад

Can you talk more on this cancer/autophogy issue. Its the first time ive heard of this.

@Frogman214 2 года назад

What thermal environments support autophagy more? Cold, Sauna Heat? Altitude environments? Sea level? vs Mountains (less O2)? Physical Exercise: HIIT-Aggressive? Or Steady-state cardio? Timing of when to take NMN: Should NMN be taken after fasting and exercise or before? I didn't know excessive sun exposure uses up NAD. Great interview!

@jimo7068 2 года назад

I do remember her mentioning heat exposure/saunas, but not sure on cold exposure, although both are forms of hormesis. From what I know HIIT is superior to steady-state cardio in putting the body into AMPK/autophagy.

@fu2174 2 года назад

GREAT CONTENT, SHE IS AMAZING. Side note: Such a giving guest! HAVING SUCH AN IMPRESSIVE GUEST AND WE DID NOT HEAR YOU SAY : THANK YOU. Not nice:( If she or any guest contributes to your channel WE THINK YOU SHOULD THANK THEM AS THEY PROVIDE SLIDES AND STUFF. IT’S TRUE. We hope she comes back and we see a more appreciative version of you :). It’s just brings more help into your life:).

@richardbreeze7898 2 года назад

Shut up

@fu2174 2 года назад

@@richardbreeze7898 B R E E Z E OFF. 😂

@richardbreeze7898 2 года назад

@@fu2174 What are you her knight in shining armour ? She is clever and charming and pretty but she is regurgitating word for word the Dave Sinclair. Supplement promoting dialogue. Nothing new here buddy. NMN and resveratrol are ways of emptying people's pockets into yours. We already know about the benefits of energy deficient states and hormesis. Nothing new here buddy. She is fit though.

@zzzxxzzz3248 2 года назад

It would be nice if the words were spelled out that are not common ! @39:07 Like the supplements that get rid of the " do nothing cells " that accumulate in old age ! I've been interested in these health practices that were reviewed in this video ! Thanks for sharing !

@tomwoodall1463 2 года назад

So would a good strategy be to do my cardio in the morning, and take all of my autophagy enhancers after.. Then, in the afternoon, lift weights and eat in a 4 hour window to feed the weight lifting? How much negative impact would this sort of schedule have on my strength training results?

@DieCodBroz 2 года назад

Hey siim can you do a video about SARMs ? And mk - 677 ? Would be awesome. Thanks

@eman1989z 2 года назад

Any supplements such as Creatine, beta alanine, or Amino acids that help or stop autophagy?

@littlevoice_11 2 года назад

The speaker mentioned MCT can help boost autophagy, but would BHB (ketone) also help?

@smooth_pursuit 2 года назад

She mentioned exogenous ketones in the context of improving the glucose/ketone index… so I guess so. That kind of surprised me

@charliebrownlives1348 2 года назад

Great Dr. I'd like to know if autophagy has affects on: Plasma Membrane ( recycled?); on DNA; Autophagy & microtubules/cytoskeleton;

@aristidesaint-jean2322 2 года назад

Looking lean man!

@jaredallen291 2 года назад

Should nmn and resveratrol be taken before or after my morning fasted workout

@basilclarke-naturesway3165 2 года назад

Is Trehalose a better sweetner than Stevia?

@kayeszymanski6945 2 года назад

So if my friend had cancer and was treated with surgery, should he take autophagy blockers now? 6 months ago. Thanks!

@aquamarine99911 2 года назад

For me, age (>60) is the issue. And probably not just for me. I suspect older people are more interested in the topic of anti-aging than the young - you guys excepted. So it is discouraging to hear (again) that autophagy declines with age. But have we been able to quantify this? Does it gradually taper off, or fall off a cliff the way that metabolism does after 60? You mention fasting and exercise, but how useful are those techniques in older people for inducing autophagy? I'm not giving up, so I do fasting (20 hours 3x per week, plus quarterly 5-7 day fasts) and daily cardio plus bi-weekly resistance training, plus my own supplement stack (NR, Fisetin, Quercetin, some methyl thing, carnitine, Ashwagandha, NAC and phosphatidylserine). But it would be motivating to hear some confirmation that it's not too late to really benefit from autophagy. Melatonin and late evening steam saunas have become my go-to methods for assuring a good night's sleep. If it makes sense that repairs to our body - autophagy? - take place while we sleep, then techniques to promote sleep should be ipso facto promoting autophagy. So I try to be as fasted as possible going into sleep. Ideally I don't eat after 4 pm, but that's hard to do on a regular basis.

@eamonshields2754 2 года назад

Awesome routine man. I wouldn’t take everything said here to heart. I think a few things said in this vid need much further research. I would drop melatonin and try Andrew Hubermans sleep cocktail. It’s Magnesium threonate, apdigen and Theaninr. Daily melatonin can have a few weird effects and might mess with dopamine

@eman1989z 2 года назад

You sound very hardcore about autophagy, but the benefits seem to be in cycling in and out of it after your have a healthy baseline. Too much of anything can be counter productive, note they talk about how some cancers prefer to be autophagic, so for those individuals it may be better to mitigate it

@aquamarine99911 2 года назад

@@eman1989z That's for people with cancer in their family, as they say. I don't.

@ratherrapid 2 года назад

much info indeed! is there "any" evidence that low glycemic carbohydrates are in any way unhealthy?

@TBoneZone 2 года назад

No.

@pelletey 2 года назад

what about how nmn is coverted to niacinamide by the liver? why not just take niacinamide?

@tokorojj 2 года назад

Elena is also amazingly beautiful.

@renatodoe6661 2 года назад

She is. Russian women can be most beautiful

@tokorojj 2 года назад

@@renatodoe6661 Indeed. Also, in my humble experience, extremely harsh. Nice to look at but keeping the distance.

@littlevoice_11 2 года назад

But I wonder how low is to low for glucose?

@voodoochile6796 2 года назад

If one were to do a fast, just 1-3 days, but otherwise eating somewhat high carb and 6 times per day, would you recommend lowering the carbs and eating less frequent on the days leading up to it, or what way would preserve the most muscle?

@smooth_pursuit 2 года назад

I’m gonna hazard a guess here and say that what you eat is less important than when you eat in this context, and you would want to ditch the six meals and get on a time restricted feeding schedule leading up to the fast.

@voodoochile6796 2 года назад

@@smooth_pursuit I though eating lower carb/keto prior to the fast would make it easier since you're already in ketosis? I understand getting a feeding window before, that totally makes sense.

@smooth_pursuit 2 года назад

I think both - keto with time restriction- would be the ideal preparation

@betociscomani 2 года назад

Hi siim! I’m doing 4 1/2 days dry fast, eating 2 1/2 days, currently in my 3rd week , doing this after 6 (5 days water fast) and stepping on a weight plateau, and looking for lose more weight and not having lose skin by autophagy. Do you think doing to much dry fast can be dangerous ? I still have 30 pounds to lose or more thnx

@terencejamesparkinson7650 2 года назад

I would really be careful with a dry fast - I’m not a doctor but a dry fast seems quite dangerous. Abstaining from food is safe in most cases, but water is essential for our bodies; including facilitating detoxification which is something that is presumably quite important if you are fasting. Again , I’m not 100% sure, but maybe quit this one if you still have to ask if its dangerous and do more research from different sources. Look into the fasting mimicking diet with dr.Valter Longo which will give you essentially all the same benefits you are seeking in a safe clinically studied way. This may be a safer more sustainable method for you to obtain your goals without putting yourself at risk.

@BillyBob-fh5he 2 года назад

Why are Elderberries good?

@TheShaiHulud 2 года назад

How old are you Dr Seranova? I’m guessing thirties? You look very healthy.

@brianadler67 2 года назад

What is the name of the disaccharide that she mentions that can be used as a sweetener instead of sugar (that also activates an autophagy pathway)? Is it something that can be easily purchased?

@eman1989z 2 года назад

Trehalose, and it's on Amazon

@keithrichard391 2 года назад

I like a teaspoon of extra Virgin Olive oil daily

@aquamarine99911 2 года назад

Why so little? I'll take four tablespoons of EVOO in my 142 g salad. And drizzle it on vegetables generally. I probably average around 6 tablespoons/day.

@keithrichard391 2 года назад

@@aquamarine99911 can you take without food?

@eman1989z 2 года назад

@@aquamarine99911 because too much may inhibit autophagy

@aquamarine99911 2 года назад

@@keithrichard391 If the EVOO is real, then it burns your throat to take it straight. There's a lot of fake EVOO out there.

@aquamarine99911 2 года назад

@@eman1989z A keto diet is high-fat, almost by definition. As they say here, a rough and ready marker for autophagy is glucose level divided by keto level. Olive oil has no relevance to either of those measures.

@ThierryPianoSolo 2 года назад

11:24 : I don't get it. I see so much people which heal cancer with fasting (which is an accelerator of autophagy)... 🤔🤔🤔

@StarvingMyselfToLIFE 2 года назад

Fasting for 3-4hrs? is that really a fast???

@ThierryPianoSolo 2 года назад

3-4 hours of calories consumption. So 20h of fasting.

@benholland1331 Год назад

Fasting seems to be the best supplement you can do 🤣🤣and it’s free 🤣🤣🤣

@renatodoe6661 2 года назад

She's a babe

@15Robstar 2 года назад

Hi Siim. I enjoy watching your passion about IF. But I can't help noticing that you seem very uncomfortable with maintaining eye contact with your hosts. I have social phobia, and this is very apparent to me.

@theantiqueactionfigure 2 года назад

Weird comment!

@Layinginmysofa 2 года назад

If a person is thinking and processing information while listening and "thinking ahead" their eyes will move more at different directions. That is just being actively processing and "staying ahead". Nothing wrong with that..! Rather good! :-)

@gro16 2 года назад

As we get into the nitty gritty of the science of health with the scientists like the one in this video, i was horrified to see she took a swig of water from a plastic bottle. A very bad introduction to the company she is promoting selfdecode. Sorry Sim i had to say this. I love your advise always and watch everything you put out. Thank you.