Autophagy and Neurodegeneration: Autophagy-lysosome Pathway in Neurodegenerative Disease

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Dr. David Rubinsztein discusses the basic biology of autophagy and its role in neurodegeneration as well as how certain genetic variants in neurodegenerative diseases are associated with compromised autophagy. Original Air Date: November 20, 2018. Learn more about autophagy at www.novusbio.com/research-are...

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29 ноя 2018

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Комментарии : 20

@CryoEMQueen Год назад

Dude some people are so good at presenting. This should be a skill that is much higher priority in graduate schools than it currently is. Props to Dr. R here

@pirasa5 4 месяца назад

WOW. What a wonderful talk.

@domagojbarac 4 года назад

this is dr. rubinsztein's masterpiece. can you just say if there might be way to apply autophagy in ALS? misfolded proteins should be "eaten", along with excess of glutamate (neurotransmitter). also, is there a connection between mentioned glutamine (acid) and glutamate in enormous quantities in ALS?

@bobcocampo Год назад

Any research on autophagy and retinopathy and CKD?

@toby2524 4 года назад

My father has Parkinsons, dementia and had skin/lung cancer. I am 20 years old with no signs of anything but what tests can I take to see my genetic chances of getting such issues? I'm British so would I just ask my GP for advice ect? Great video just heard of autophagy today and was recommended this video

@MasiaMaksymowicz 4 года назад

You could try going to a clinical geneticist, he/she might do some genome analysis which would tell you what is there. Then, if it's needed, they could propose you some treatments.

@DR-br5gb Год назад

How you doing/? Pretty crazy how close to the cutting edge you were for only being 20, 3 years ago lol

@ramesh123443 5 лет назад

Dr. Rubinsztein talk is very interesting. Does mitophagy proteins have any role in Huntington's disease for PolQ expansions clearance? However, it is NOVUS responsibility to take the care about the sub-titles of the video and made a lot of big mistakes about terminology spellings. Please fix for large viewership across the globe or remove the subtitles to avoid the confusion.

@NovusBiologicals 5 лет назад

Thanks for watching the video! Here is an article that you may be interested in www.frontiersin.org/articles/10.3389/fnmol.2017.00064/full for your question. Also, thanks for letting us know about the transcript, we will get that fixed! Please let us know if there is anything else that we can help you with.

@kdcruz75 2 года назад

@@NovusBiologicals Has there been any update on the study of cysteine buildup in lysosomes. .. and its clearance with cysteamine.. I beleive there are papers on kidney and cysteamine and its use in reducing aterioscheloris... I believe there are papers on neuroinflammation as well regardign cysteamine. I am lookong for natiral sources of cystramine

@joshuakuruvilla 4 года назад

44:20 bookmark

@AceKinG2024 5 лет назад

How many days someone should fast to activate autophagy?

@NovusBiologicals 5 лет назад

Thanks for your comment and interest in this video! According to Dr Rubinzstein in a BBC article (www.bbc.co.uk/news/health-44005092), we don't know yet exactly how long humans would need to fast to see the benefits (from autophagy). That said, fasting does stimulate autophagy, David said, and its benefits had also been proven by other studies. Please let us know if there is anything else that we can help you with!

@AceKinG2024 5 лет назад

@@NovusBiologicals Thanks for the heads up

@LizandSkatz 3 года назад

As I understand it, those on a standard western diet of high carb and low fat, it will take up to 72 hours of fasting to get into any decent autophagy. With low carb or keto diet we can enter autophagy as soon as 17 hours with optimum autophagy happening around 24 hours! Amazing 💕

@mayurgadhave 3 года назад

@@NovusBiologicals www.bbc.com/news/health-44005092 updated the link as it was not working

@HH-gf4hg Год назад

@@NovusBiologicals is there a name of the article in question. The link gives off a 404 error. Ty

@zebethnewton9456 Год назад

How wonderful is the body! Now I know, the body is not only the temple of GOD but it is more technically sophisticated than anything in the world. Better take care and learn the power if it.