Thanks so much for the comprehensive update. Mammal to mammal would include my fur baby species, the Canine. In North Texas we have been slammed with Canine influenza (H3N2, H3N8) since November 2022 and it's still going strong. I've received multiple notices about high risk areas such as groomers, vet clinics, dog parks and day care centers, the typical places that dogs visit. I would imagine that all eyes are watching this one. Hope it goes away and soon.
I’d be interested in information around transmission. The human cases, as I recall, are mostly poultry farm workers. The minks, and perhaps the seals (if it spread in a colony), were in close conditions with dense populations. That seems to indicate the probability of mammalian spread, but perhaps a higher infectious dose than other influenza viruses that have adapted to mammals or humans. (As a side note, the (caged) mink farm strongly suggests aerosol spread, barring something like aggressive spray down cage cleaning.) I wonder if anyone has studied infectious dose in susceptible birds/mammals? Also, if that is potentially relevant, whether there is knowledge regarding the likelihood of mutations that lower infectious dose (as appears to have happened relatively consistently in COVID, at least according to most reports). One might think there is at least a high-level tendency for that to happen, all other things being equal (which of course they aren’t : )
Why do you say it is uncommon? Please don't get the conspiracy theorists started about it being created in a lab for some bizarre purpose. Wikipedia notes, "The most widely quoted date for the beginning of recorded history of avian influenza (initially known as fowl plague) was in 1878 when it was differentiated from other diseases that caused high mortality rates in birds." That is before even the discovery of the structure of DNA.
@@flagmichael Go look up who was studying this virus and let me know if they weren't playing with variations that might be more likely to infect humans.
In 2013 they performed gain of function on H5N1. They have a discussion on this at the NIH. It was stopped 4 years ago and there isn't much information after that.
Thank you for explaining the history of H5N1. It’s interesting to learn it started with a domestic group of birds. With all the sub-variants we have seen with SARS-2, it is easier to understand how H5N1 has evolved over time.
Love the deep dives. Thanks! Interesting and informative. I agree with your current conclusion. Oh, and it probably came to you when off camera... word you were looking for: reputable. Happy days off when ya' have 'em, and workdays(nights) in the meantime!
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According to WHO, temperatures of 140°F to 150°F are enough to kill most viruses, and boiling water makes it safe from pathogens like bacteria, viruses, and protozoa.
Just starting hopefully you acknowledge Plumb island's contribution. It was early on when the East coast was starting rumbling about illness from a tick. 🤔I just realized don't know why they called it Lyme. Bird flu was released in 90's .. Lyme was named around same time to appease the East Coast make it look like they were doing something .., anyway bird flu was rt b4 they moved from Plum island to manhattan Kansas .. Rt after their move was swine cow and Hand foot mouth . I'm sure lots more but I only remember the big obvious releases. ...
My daughter is finishing her residency at Colorado University Hosp .. a bunch of "prepared units" got Malaria and Plaugue/salminila-ecoli vax ... so did Minnesota and Oregon so expect lots malaria and Black Death from plague ....
❤ I really want to thank you for sharing this video on RU-vid! I'm not a Physician but, I chose to view your video because I was almost certain, that you could help me better understand the Bird Flu contagion vs. an uneducated RU-vidr, who's only concerned about "Clicks". I'm glad that I watched this and was provided factual information & research from an educated doctor! It's a great video so, thanks again, & I will share this with my family & friends. ❤
Do we know whether the mink farm employees wore PPE or at least masks when they did the culling? I would think they would have been careful not to be infected. In vitro testing of this variant on its ability to infect on human cells or humanized mice would be telling.
I know when this video was posted it didn't have human to human transmission. Since the video has posted there was a case of human to human. Can you re visit this video. Sorry for asking so soon after you just posted this.
I'm not a virologist so this is out of my knowledge base but when looking at C-19 I did wonder if the spike protein is a more advanced form of HN ( Hemagglutinin-neuraminidase) as found in human influeza virus.
Interesting! The reports we saw from CDC and WHO reported that it occurred in April in Colorado (linked below) www.cdc.gov/media/releases/2022/s0428-avian-flu.html
Tell me something, doctor...was the US doing any gain of function research in China in the mid-nineties?? Wonder what was being concocted in the research facilities in the Ukraine.
