Thank you for explanation But why is it indicated to give H2 Blockers in AKI rather than PPI to prevent GI bleeding due to inc serum urea if Cimetididine causes Inc in S.Creatinine levels ?
Thanks but I have a Question Why dobwe say the amount of Urea increases in the Blood in case of AKI because of the reduction of filtration , when at a normal state it will come back to the blood anyway through Absorption ?!
Good question. Although we normally filter 100% of urea from blood into nephron and then reabsorb the urea in the nephron, we do not reabsorb ALL 100% of it. Normally 20-50% of urea ends up being excreted out in urine, which is why our blood urea nitrogen levels normally do not rise as high as they do in AKI(how urea is normally handled is explained more in detail at bottom). In the case of AKI, AKI causes reduction of filtration that leads to less than 100% of urea from blood filtered into nephron, which means more urea will bypass filtration and remain in blood, leading to increased blood urea levels. The reduced filtration will also lead to less urea excretion in nephron due to there being less urea in the nephron from lack of filtration. Hope this helps! Normal urea handling(can google "urea handling" if you want to confirm my info) 100% of urea is normally filtered, 50% of that filtered urea reabsorbed in proximal tubule, 0-30% reabsorbed in medullary collecting duct, 20-50% excreted out in urine.
@Naj Nahar you seem to know this, ~ a month ago my creatinine was 0.95 and my BUN was off the charts on the low end (6). they had it highlighted in red. are my #s good or bad? no one ever got back to me to explain the test results. i'm male, more than 90% of the time my systolic is 100 to 110 and over 90% of the time my diastolic is under 75
