Metabolism | Urea Cycle 

Who’s here from 2024 ??

You should know that you’ve succeeded in your goal; students everywhere now learn from your science (and wisdom 😁).

This youtube channel is so under rated...this guy is amazing.

I just figured that I dont need a textbook when I got Ninja Nerd Science. You helping massively than our actual lectures. Thank You so much

There was a small mistake at the start. Glutamate can't travel in the bloodstream because it is charged. What actually happens is glutamate will donate the aminogroup to pyruvate (which becomes alanine), then alanine will travel in the blood stream to the liver. There alanine will donate the amino group to alpha keto glutarate (which becomes glutamate). The end product is the same, but it is not glutamate that travels in the blood!

Can you just imagine his almost 1 million subscribers are probably future doctors, nurses and med tech people. Thank you sir✌🏻

U r really the best teacher ever udont know how much u helped me .i really appreciate these huge efforts u just make biochemistry fun and intersting ( a medical student struggling with biochemistry) thanks a lot

يارب يدخلك الجنة من اوسع ابوابها على هذا الشرح

Dude you are doing a great work. Heart felt appreciation from biochemists suffering from poor lecturers world over

After a lifetime of illness & disability from a young age, genetic testing showed Argininosuccinate Lyase deficiency. You have helped me understand how a buildup of ammonia could be causing many of my health issues including brain inflammation & severe fatigue. Thank you!

The spatial representation of the cycle is so helpful-I always struggle to understand the chemical mechanisms we’re supposed to know when it’s represented as a cyclical diagram without context but this makes sense thank you!!!

I'm a medical student and I'm struggling with biochemistry! I never thought that the processes could be amazing. 😆 Watching your videos enable me to understand more. Thanks!

I am never studying without watching your video about the topic first. You made it super easy and interesting. Thanks!

you have no idea how helpful (and interesting at the same time) your videos are !!! you are an actual LIFE SAVER.

u have no freacking idea how helpful this video was omg it is so great and u are hella talented great jobbbb thank you so much

The joy of finally understanding biochemistry! Thank you!

I'm sooooo glad I found you..😫😫😫 I always feel like a genius after watching your videos.. Thank you!!!!!

What a fantastic video, my son has a urea cycle disorder (citrullinemia) and this video explained everything so well. Thank you

Thank you so much. What you do is so amazing. I almost finished every video in the metabolism playlist and every single one helped me understand everything. You don't know how much your page blesses me!! Thank you so much

you have really made my life in Biochemistry so much easier. I love the way you explain concepts... God bless you so much

Yo your explanations are amazing! You explain every step, and each consequence that tags with it. Really happy I found your channel 🙏🏻

Wanted to point out two major details in the beginning of the video that are wrong. First of all, Glutamate isn't directly transported from the muscle to the blood. In the muscle, Ammonia is first added to Glutamate in the presence of the enzyme Glutamine synthetase to form Glutamine. This Glutamine is then transported to the Liver via the blood and is acted upon by the enzyme Glutaminase and is converted back to Glutamate and Ammonia. The second thing is that, while Glutamate undergoes oxidative deamination to alpha-ketoglutatarate in the liver, NAD+ is used as the co-enzyme and not NADP+. In fact, NADPH (and not NADP+) is used as a coenzyme during reductive amination of alpha ketoglutarate to Glutamine. And other tiny details, -> The Glutamate dehydrogenase reaction occurs in the liver mitochondria and not in the cytoplasm as you have drawn it. -> The Carbamoyl phosphate synthetase-1 reaction requires 2 ATP and only one bicarbonate ion, not 2 Bicarbonate and one ATP. -> The Carbamoyl phosphate synthetase-1 reaction also uses Ammonia (NH3) and not Ammonium (NH4+) ion. Ammonium ions are excreted by the kidneys whereas Ammonia can be actually transported to the liver cells. -> The name of the substance formed after incorporation of the nitrogen atom of Aspartate to citrulline is called Argininosuccinate and NOT arginosuccinate. Other than these details, Keep up the good work though 👍

Zach, I am graduating on Saturday and I can't thank you enough for all you've taught me. Half my science professors have been worthless! God bless you from Nebraska.

This video was so helpful! Thank you for explaining each step and giving a good visualization of how they work together.

I can understand the urea cycle! and it was actually fun to learn it ! Thank you very much . You really are a student's life saver ( I have a test about this subject in 4 days ). I HIGHLY recommend this channel to anyone who wants to understand biochemistry.

One of the best lecturers out there! Respect.

As usualy, you Guys are wonderfull ! I'm studying Nutrition in France, and I now tale my breakfast in front of your videos. Merci beaucoup for the quality of your explanations. Longue vie à Ninja Nerd !!!

This is absolutely fantastic, i'm in dedicated and this is taking my understanding of the interactions of all of these metabolic cycles to the next level. Phenomenal Job

I can never get enough words to describe who good you teach.👌

Well prepared and competent teacher ,highly useful educator!

Dude, can't find a word to show my gratitude. ❤️

God bless you and the whole team that's working on these videos as well. I swear when I finna graduate med.school and start earning my money, you'd be the first channel to be donated..

Honestly Zach, Ninja Nerd should be on my Financial Aid application along with my medical school :) your videos are EVERYTHING!!!

I come to this channel everyday!!! Soooooo grateful for the amazing job that you do.

You literally saved my life thank you 💙

man i wish the professors i pay for were this good at teaching.

couldn't be more thankful that I found this video!! Thank you so much! Keep it up!

Zach, your explanation is more than amazing !! 🙏🏻🙏🏻🙏🏻🙏🏻

this channel is so underrated people like you should have MILLIONS of subscribers

I just have to say that your videos on the metabolic processes are, unequivocally, THE BEST I have seen online... ANYWHERE. You will probably never know how many lives you have touched in this space, but I just had to come here to say "Thank You!" My medical school allows use of a metabolic map, but so many of my fellow peers are amazed that I hold these enzymatic mechanisms in my head alone without need of the map. I am a non-traditional student who had no background in the sciences beyond the basic sciences, let alone Biochemistry. With my background, it is nothing short of amazing that not only am I able to survive with this material, but thrive. THAT is a testament to simplicity and intuitive nature of your teaching! Thank you and your team! I would definitely like to support your work. Thank you. Thank you. THANK YOU!

Ur making doctors from every continent much love ❤

YOU ARE AN AMAZING PERSON MY PROFESSOR EXPLAINED THIS IN UNDER 3 MINUTES AND YOU DID WONDERS THANK YOU

This helps so much. way better than anything I have experienced in my biochemistry class in medical school! Thank you!

You are fabulous! I've never understood these cycles before as I've never been keen on learning this ... I could listen to him from the morning till the evening 🙈🙈🙈 .. Love the passion he talks about it

Thank you so much for your lectures. The only biochemistry lectures I actually understand 👌🏻💕

Best teacher ever... Lots of love from Bosnia, Im so happy that I discovered you. Hope that only best things happen to you! You are amazing...

Amazing video, great job, you have no idea how helpful this was, thanks a lot 🙏❤️

You can get the foundations of an entire med school education from this channel. And this is an excellent place to learn about your body and how it works at the highest and more complex levels.

The way I was waiting for you to say "urea" was the most desperate I've ever been😂😂😂

I wasn't clear about urea cycle till I watched this stuff. Now I've clear idea. Thanx alot.

Indeed I found your lecture more paramount than my lectures session in the class

After watching your lectures , biochemistry seems so easy now ,that i can now easily correlate every think. Thank you sir for this great lectures, it helps me a lot. 🙂🙂

Great teacher for all Basics

Very Clear Demonstration!!

I think this is good and fun.thank you for existing

Thankyou doc! Amazing explanation

So close to 1 mil subs... I subscribed when it was about 600 k and I'm sooooo proud of you.... You've done so well

Thank you so much for really explaining the steps in a way that is clear and understandable

he made tooo much easy all metabolism Thank you n we all love you. keep going

you def have a gift! I enjoy watching and learning! :*

Amazing as always

Best explanation I ever heard , finally i can understand !

I love that in biochemistry evry cycle is interconnected that is actually making it easy to learn and after I got your channel biochem has just become a peice of cake others make it so complex

you guys are amazing, beyond helpful. Thank you.

Learning has become easy with Ninja Nerds..🙏

Fantastic! Thank you professor you saved my academic carier

Thank u so much. Loving all your lectures.

Literally the best! Thank you thank youuuu!

You are the best teacher...😊😊😊

Super helpful! Thanks!

Sir u are amazing.....thanks alot ....all during my finals and mids....ur lectures saved me......

Thank you for such awesome videos. You amaze me with your ability to explain such difficult subjects so beautifully.

thank you for making such a dificult process so easy to understand

this really helps me understand the pathway better. thanks!

Your lecture is very much informative....

Thank you for this work. I really preciate it. You are an angel for all medical students.

Zach you are simply love

You are a fantastic teacher.

Great video. Thankyou for this channel. It has helped me throughout.

Dude i have watched every single video of yours the way u explain things its so mesmerising... Loads of love from india ❤❤

thanks to this guy i still have some hope in biochem. much love.

Thanks for this amazing video. I watch your videos like 5 times and i never forget the info.

You are very good at teaching. You have made biochemistry a lot easier for me. Thank you very much

Great explanation on the urea cycle! Thank you for sharing

I thank you so so much I literally was just scrolling throw my lecture notes but now i understand them well Thank you very much

It's such a gratitude bro. I love this channel.

Thank you so much. You are the best teacher ever

Amazing lectures

Thank you so much! You have been so helpful, love to see how these pathways relate to medical diseases! Student Dietician from London, UK!

This was fantastic!

Thank you for this blessing 🙌 -Love from INDIA 🇮🇳

شُكراً استاذي ❤

You are one of the man study making intresting really enjoyable.gratitude

Your teaching is also “beautiful” you see that!!! . Thanks for making all these awesome videos. Love u my life saver.

Thank you so much! These videos really help!!

You’re super impressive …thank you so much for your well organized explanation

Thank you so much 🥰 شكراً جزيلا

Amazing video, thank you!

you helped this dental student out big time!

Sir u made it a piece of cake . Super super easy to to be understood❤❤.