My lecturer had taught us this over the course of 3 hours - you gave me exactly the same information in small mini-clips. Please continue to do what you do, we appreciate you :)
No interaction weak cross linking B cell development in the bone marrow Central B cell tolerance 1. receptor editing 2. anergy 3.clonal deletion VJC receptor editing light chain loci immunoglobuline gene non self reactive migrates to periphery
perfect videos but needs much more improvements I think it's very important to enhance the voice over and it will be much greater hope you the best in shaa' allah ^^
Does anyone know what the exact fate of an immature B cell in anergy is as it leaves into the periphery? Why doesn't that autoreactive B cell activate itself (T-cell independent B cell activation) and start to proliferate?
T-cell independent B cell activation requires 2 signals 1. Clustering of BCR on multivalent Ag 2. Recognition of danger signals The 2nd signal is absent in case of self Ag and thus leading to Anergy of the B cell
Can you please send me the Power Point that you have used in this VIDEO in my E-Mail ID? Also please mention the reference book that you have used for the figures......It's really a wonderful video and your power of explanation is simply amazing - Dr Raktim Mukherjee (Head of the Department, Shree PM Patel Institute of PG Studies and Research in Science, Sardar Patel University, Anand, Gujarat, India)
