Comparison of Major Histocompatibility Complex - MHC I vs. MHC II 

its 4 am right now , I just want to say thank you for existing !!!!!

This table of comparison is extremely helpful but what I gathered that was most important that I was unaware of is that those MHCs that have class II ALSO have class I. Its important for us to really understand the idea that EVERY nucleated cells presents Class I MHC proteins because this is what determines how the cytotoxic T cell responds to each and every cell. I may recommend explaining a little about how cells that display the foreign antigen on MHC send the message to the T cells and how the T cell should react by either leaving it alone, killing all other cells that look like it, or mounting a defense against it.

I really enjoy the clarity of your communication, and information organization. Thank you for making these!

Thanks for articulating on this topic; the table really helped in simplifying the concept, and overall it actually isn't too complex (at least on a basic level). The images and explanation in the textbook where more difficult to grasp, so this was very helpful.

I've been trying to understand this for hours!!!! Your delivery and presentation made this very understandable for me. Your fantastic!!!!!! Thank you so much!!!!!!

This video was a life saver on the last exam. We didn’t talk much in class about MHC, so this video was definitely needed. How you wrote out the information made it easy to distinguish MHC I from MHC II.

Thank you for explaining the difference between the MHC receptors and the fact that APCs have both.

Thanks for providing us with a hint as to what might be a test question at the end of this video. I will now keep in mind that APC cells can have both MHC 1 and MHC 2 receptors as well.

MEDA 110 Spring 2020: Understanding the difference between these two complexes can be difficult, but you explained it extremely well.

I agree with the comment below, I was looking at MHC on the powerpoint and had no clue what it was. This video clarified it for me. You made it easy to differentiate the two classes! Thank you for making this video!

The table was really helpful in explaining the differences.

I was seeing MCH I and II on my notes and did not understand what they were or what purpose they served. You made it very easy to identify the difference between the two and the purpose they serve in the immune system!

This clarified my question from your earlier videos related to this topic of whether or not APCs had MCH I receptors as well! Thank you for making this video to further explain the differences between the two.

The table really helped me understand and break it down piece by piece. Also, if you asked me that question on the test (if APCs have MHC I receptors as well) I probably would have gotten that wrong. It was a helpful question because I just assumed that the APCs only have MHC II! Thank you!

I never understand how these "glass screen" things work. Do they write backwards?

I like how you made a table out of this information... very useful! Also, thanks for going over how most people don't think that APCs have receptors for MHC I but they actually do! Please highlight common mistakes in future videos!

Wow! Thank you so much, that was extremely helpful. That was my main thing I was so fused about, how to differentiate the MHC classes. I got confused when my teacher said that MCH 1. provides intracellular antigens and MHC 2 provides extracellular antigens. The way you explained it made it so much clearer. Thank you.

Thanks for the video! It really helped me understand the differences between the two MHC proteins.

i was introduced to this concept in micro but your video shades more light on the topic

Really great idea on organizing it like T chart I found it easier to follow and understand the difference between the 2.

I liked the chart and how it organized the differences. I also like how you talked about how some cell have both proteins

Thanks for making this video! This basically answers my last question haha

Thank you for explaining the differences with MCH l and ll .

How is this video taken? Is it done with a mirror? Content wise, it's great!

Super helpful!! Thank you for making this video!

Awesome - thank you so much.

That was extremely helpful.

Thank you so much! Great work!!!

It's greatly helpful video

cleared up something very basic but very important. thanks!

The visual chart helped calrify my understanding. Organized

Great video ty.

Perfect review

This dude is jacked

this helped so much

Thank you

So great

I’ve never heard of this before. Very interesting.

Thank you sir

Can you fully write out the abbreviated words? it is hard to keep up sometimes.

I like the way you broke down the differences between the two. I was a little confused as to where the CD8 and CD4 receptor are located--are they on the T-cells or are they recognized by the T-cells? I would also like to know about the significance of MHCs in terms of immunity.

Why lift if you’re going to wear a shirt?

This video helped me understand the differences between MHC I and MHC II receptors! Since APCs have both MHC receptors, is it possible for a cell just to have the MHC II receptor and not the MHC I receptor?

So curious, doesn't all pathogens occur extracellular? Wouldn't that mean that MHC II do more of the work in fighting of foreign pathogens? Sorry for asking so much question, I'm just curious on how MHC II really defends the cell from such things like cancers cells?

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why do we have these? im still a little confused

these cell types are interesting , but now i understand. great video! / MEDA110 (84168 - L)

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That was extremely helpful.

thank you