Cori Cycle | Lactic Acid Metabolism | Purpose and Importance in Anaerobic Metabolism

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Lesson on the Cori cycle, introducing the importance and purpose of the Cori cycle and discussing how the Cori cycle can recycle lactic acid, produced from anaerobic metabolism in skeletal muscle, in the liver to form glucose through gluconeogenesis. Intensive exercise and other hypoxic conditions induce anaerobic metabolism in muscle cells, which leads to the production of lactic acid from pyruvate via the enzyme lactate dehydrogenase (LDH). If this lactic acid is left in the muscle cell, the pH of the muscle cell can decrease and cause detrimental effects to the muscle. Therefore, the lactic acid is transported out of the muscle cell through specific transporters located in the muscle cell membrane. The hydrogen ions from the lactic acid are then buffered by the blood and/or removed from the blood in the form of carbon dioxide. The remaining lactate is transported into the liver, where it can be used as a precursor for gluconeogenesis.
Hey everyone! Here is a lesson on the Cori cycle and lactic acid metabolism. In this lesson, you will learn the differences between aerobic and anaerobic metabolism in skeletal muscle, and how lactic acid is produced. You will also learn how that lactic acid is transported out of the cell and into the blood, and how the blood buffers and removes excessive hydrogen ions (protons) produced from lactic acid hydrolysis. This video then discusses how the lactate is transported into the liver hepatocyte, and how the lactate is used as a precursor for gluconeogenesis.
I hope you found this video helpful! If you did find this video helpful, please like this video and consider subscribing to my channel to show your support for my medical education videos :)
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I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe! JJ
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DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.

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29 сен 2024

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Комментарии : 60

@bokangmotlhatlhedi2873 4 года назад

Imma need a lot more people to start liking this man’s videos and giving him the coin he deserves. Big ups brother, your content is very helpful, you are highly appreciated!🙏🏽🙏🏽

@vedangisekra9399 2 года назад

This video was so damn conceptual. Loved it. Keep it up man! You doing great

@joecanti5944 6 лет назад

Thanks - but one thing I don't understand is why lactic acid production causes an increase in acidity when the reaction that turns pyruvate into lactate is a h+ ion acceptor? Lactate then dissociates, but is the net effect an increase in h+? From what I am reading lactate is an important fuel, especially for the heart and brain, and not just in hypoxic conditions.

@ralphhancock7449 6 лет назад

Hi Joe, just stumbled in to this presentation and I can't answer your question, but I think this article does: www.ncbi.nlm.nih.gov/pmc/articles/PMC4343186/

@ittimani 5 лет назад

Hi JJ and Ralph see Understanding Lactate - Paul Marik from Royal North Shore Hospital & UTS smacc.net.au/2016/05/understanding-lactate-paul-marik/ Acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and Pi, a proton is released. Lactate saves the day by becoming Lactic acid and removing the proton.

@mohitjesani2797 Год назад

Can cori cycle result in liver glycogen formation?

@eduardozamora2182 6 лет назад

Clear explanation. Thanks for helping us with these issues ! 🤓

@GeorgeRon 4 года назад

Is the pyruvate to lactate formation in the presence of LDH a proton consuming or proton releasing reaction? What is the latest research on this?

@mahanteshgouri2931 3 года назад

Hi sir my son is 2 and half years suffering from elivated lactatic acid ( IEM) by birth what is life sir my son tell me pls 🙏

@mahanteshgouri2931 3 года назад

Explain me sir my son problem life long ya some time

@myprettygirl91 6 лет назад

Wow, best explanation ever. Thank you!

@NurulFatinIrwana 4 часа назад

very helpful video thank you so much :)

@venkatramanan6518 Год назад

HI SIR. awesome lecture you explainded the reason behind these steps, cleared so many of my doubts. thank you from the bottom of my heart. please continue the good work. you rock champ

@mennaamin5079 3 года назад

i found this channel randommly and it became one of my favourites

@alexbraun5573 2 года назад

Maybe I understood your explanation wrongly, but the truth is that lactate is produced as a buffer for protons generated in non-mitochondrial ATP production (Robergs et. al). otherwise good!

@sonya1500 2 года назад

Liver has high oxygen meaning ETC can proceed hence the high levels of NAD in the liver. Writing this down helps my thought process so i might as well share it ! Pls correct me if im wrong and b nice abt it

@mr.ssj3847 3 года назад

why doesnt the regenerated pyruvate from the lactic acid go into the mitochondria for cellular respiration? going all the way back into glucose via gluconeogenesis seems inefficient.

@shinn-tyanwu4155 3 месяца назад

Excellent presentation 😊

@سارا-ج9و 3 года назад

Please keeeeep going I really like your explanation 😩💕💕💕

@hedemeatry4854 2 года назад

when pyruvate is converted to lactate, why there is a proton released? I think the proton should on the pyruvate side.

@jacobhernandez953 3 года назад

EXCELLENT explanation... understood perfectly ... God bless you!

@yogayantra 6 лет назад

Thank you so much, so clear, and so useful.

@GeorgeRon 4 года назад

Does lactic acid exist in human metabolism? What is the latest research on this?

@marcus00077 5 лет назад

Immensely useful ! Thank you!

@billypho1232 5 месяцев назад

BEST CORI CYCLE EXPLANATION ON YT THANK YOUUUU

@muvideo757 4 года назад

How much atps are formed in fermintation??

@mehmetaliyavuz9917 3 года назад

Thanks a lot. those are great videos to memories all thing.

@andilemabika7690 2 года назад

Is the cori cycle the same as homolactic fermention?

@jermaineguynn4348 3 года назад

Well Explained.Thank you!

@alianasser7084 3 года назад

very simplified and clear enough! thank you for your efforts.. please keep going

@hasanhas00n1 3 года назад

can we supplement mtc1? what increases it?

@idkanaccountname Год назад

Bravo!

@nikeshbiswal6656 3 года назад

thank you. great informative video

@abhijitchatterjee7408 Год назад

Great!

@5602KK 4 года назад

Solid video, but I think there’s a mistake towards end? On the skeletal muscle side NADH is getting oxidized and on the liver side, it shows NAD+ getting reduced for the same reaction

@CosmoH0103 4 года назад

Because the reaction is going in the opposite direction.

@khoinguyenlehoang6000 2 года назад

thank you so much for this lecture

@jaym9846 2 года назад

Are lactate levels increased in T2 diabetics? If so, what is preventing pyruvate (for glycolysis) from entering the TCA/Kerb Cycle?

@marky5493 Год назад

Yes, inflammation in diebetics restricts blood flow(oxygen),leading to hypoxic areas which make the cori system work harder,to clear the lactic acid being formed. You can have both anorobic and areorobic energy production happening at the same time in your body, the problems start happening when it becomes more anaerobic for longer periods. Hope that helps

@jennpineapple9408 4 года назад

this video helped me a lot thank you.

@noshushaikh617 3 года назад

Very clear explanation

@cherlynseleky9392 2 года назад

5:52

@prcho8605 6 лет назад

How does pyruvate overcome pyruvate kinase, since that enzyme only proceeds in one direction?

@jjmedicine 6 лет назад

You're right. Pyruvate kinase is an irreversible enzyme, so the cell needs to bypass that step in order to "recycle" pyruvate back to glucose. I talk about this in detail in my Gluconeogenesis video - but briefly, the cell uses pyruvate carboxylase to convert pyruvate to oxaloacetate in the mitochondria. Oxaloacetate gets converted to malate by malate dehydrogenase, and that malate leaves the mitochondria and enters the cytosol. In the cytosol, malate gets converted back to oxaloacetate by malate dehydrogenase again, and then the oxaloacetate gets converted to phosphoenolpyruvate by PEP carboxykinase. There are two other irreversible steps in the glycolysis pathway that are also bypassed by the cell - please check out my Gluconeogenesis video for more details on that. Hope that explanation helps :)

@abhipatel8890 4 года назад

exceptional video!

@alessiamartina 3 года назад

thank you!!

@peony286 2 года назад

Too many ads

@anonymousperson8222 4 года назад

worth to watch

@031harshsingh7 5 лет назад

Excellent

@nyawirawaithaka4993 5 лет назад

Thank you

@olenapo4895 4 года назад

didn't get, where exactly came a proton H+ in reaction "from pyruvate to lactat". can someone provide a link with an explanation of mechanism this reaction?

@ivanmateev 4 года назад

I think he got it wrong with the H+. H+ should have come from the Glycolisis. Glucose forms 2 pyruvates, 2H+ and the electrons from the H go to NAD+ to NADH. Those H+ cause acidic conditions and need to be taken care of. In absence of oxygene, they join the pyruvate to form Lactic Acid. Correct if I am wrong. I'm still getting to know this stuff.

@ivanmateev 4 года назад

Form wikipedia/glycolisis: "The overall process of glycolysis is: Glucose + 2 NAD+ + 2 ADP + 2 Pi → 2 pyruvate + 2 NADH + 2 H+ + 2 ATP"

@ivanmateev 4 года назад

And then: Pyruvate + NADH + H+ → lactate + NAD+. I don't think H+ gets into the bloodstream. Never found a source telling MCT1 is resposible for that. Lactic fermentation is the process to get rid of H+ and recover NAD+ from NADH

@yogayantra 4 года назад

Does the transformation of lactic acid back to glucose require oxygen? It is not mentioned here. Thank you very much.