Hi, thank you so much for this video! I just have a question that I can't seem to answer: why can't the lagging strand synthesise continuously toward the helicase on the left of the bubble?
And dsDNA are antiparallel and when there is a 5"end in the strand in one place, the related other place on the other strand there is 3" end. This is the reason for synthesis of leading and lagging strand
Sure! The "origin of replication" is where the polymerase enzyme starts laying down new strand. It goes off in the 5'-3' direction to make the lagging strand, but *behind* the origin of replication, that's where the lagging strand gets laid down as the replication fork goes on unwinding the double helix. :-)
