Dr. Robert Lustig | Obesogens: The Hidden Driver of Obesity | The Metabolic Link Ep. 44

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In this episode of The Metabolic Link Podcast, host Dr. Dom D'Agostino sits down with Dr. Robert Lustig to discuss groundbreaking research unifying different models of obesity. They dive deep into the flaws of the traditional energy balance and carbohydrate-insulin models and introduce a compelling integrative theory encompassing the impact of obesogens, redox biology, and reactive oxygen species (ROS) on metabolic health. The conversation navigates through a review article by Dr. Lustig and others on obesogens from the International Journal of Obesity, dissecting specific obesogens like bisphenol A, phthalates, and glyphosate, and examining how different foods and lifestyle choices can mitigate their effects. This episode is a must-listen for anyone interested in nutritional science, metabolic health, and the future of obesity research.
About Dr. Lustig
Robert H. Lustig, M.D., M.S.L. is Emeritus Professor of Pediatrics in the Division of Endocrinology, and Member of the Institute for Health Policy Studies at UCSF. Dr. Lustig is a neuroendocrinologist, with expertise in metabolism, obesity, and nutrition. To learn more about Dr. Lustig, please visit: robertlustig.com
Special thanks to the sponsors of this episode:
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Referenced Papers:
Obesogens: a unifying theory for the global rise in obesity: www.nature.com...
Do We Need a New Unifying Theory for Obesity?: academic.oup.c...
In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!
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Follow us on social media @metabolichealthsummit for the latest science on metabolic health and therapy. Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

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5 окт 2024

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Комментарии : 54

@MrScaramoosh 3 месяца назад

Dr. Robert is an encyclopedia of scientific facts and has no problem exposing the corrupted food industry and educating the curious.

@MickiGlenn-wu4ty 2 месяца назад

I like both of you a lot but DUDE! You’re interviewing Dr. Lustig! Let him talk. Your interruptions are highly irritating.

@cag19549 2 месяца назад

They're not corrupt they're trying to make money. That's what companies do. If you want corrupt, look at the American Heart Association and the American Diabetes Association. They're supposed to be looking out for our health, but they're taking money from the food industry.

@sylvestervoigt9836 2 месяца назад

Dr Robert is more like the new MCAT's though in that now it's all about Critical Thinking and less of Memorizing Terms (Questions will often be defined in the Passage)

@Fufushinxgdch Месяц назад

I have not seen anyone else like Dr. Lustig as amazing ENCYCLOPEDIA of knowledge in medical biology. Yet he is not arrogant. He explains complex things in easy to understand language. A really nice person, too.

@CarnivoreScott 3 месяца назад

Once again you have presented a treasure trove of data points and critical information that each of us really do need. Thank you!

@MetabolicHealthSummit 2 месяца назад

We're so glad you enjoyed the episode! Thanks for watching!

@reimaravalk7679 3 месяца назад

Thank you very much, Dr. Dom and Dr. LUSTIG for this insightful podcast. I can utilise the insights well in the case report I am writing about a man who after 10 years of battling,, overcame his obesity through lifestyle changes . Looking forward to your next podcast in which you both share your wisdom. Best wishes, miss Reimara

@hiljim01 3 месяца назад

I want to put it out there that everything dr lustig says, explains nicely everything what i have been trying to figure out about autism for my patients. So many things that we are doing, are not just making adults sick but kids and even the unborn. We need to change the diet in pregnancy and the first 30months of life.

@elizabethcollins1548 2 месяца назад

What can you tell me about how ..or what type of good should be given to an Autism adult female

@elizabethcollins1548 2 месяца назад

Food

@iahfranc2215 3 месяца назад

Would’ve been super interesting if Dr Lustig wasn’t interrupted that much. Sorry.

@tweety7353 2 месяца назад

Agreed!

@TravelsByTrike Месяц назад

Yes, the interruptions were annoying and made the conversation confusing.

@murraymahaffey6398 3 месяца назад

Another great discussion of metabolic health. Several years ago, there was several articles stressing the benefit of complex 2 vs complex 1 entry into the electron transport chain in the mitochondria, one benefit being less ROS formation when the complex 2 entry is predominant. This concept seems to have disappeared from the metabolic health discussion. Is the concept of improved metabolic health when complex 2 is predominant valid?

@Zuzana-no2nq 3 месяца назад

npc1 L1 what is this? Even R.Lustig as humble he is, told us ´I didn´t know this.´ Why so many interruptions by Dr. Dom?

@DominicDAgostino 2 месяца назад

NPC!L! causes cholesterol hyperabsorption ((target of Zetia) www.ncbi.nlm.nih.gov/gene/29881 Agree, rude on my end, should have let him speak more.

@MementomoriPTP 3 месяца назад

Can you let dokter Robert speak please! 😒

@DominicDAgostino 2 месяца назад

Apologies, rude of me, but appreciate the feedback

@Bass.Player 3 месяца назад

Can we get to the point please?

@DominicDAgostino 3 месяца назад

Obesogens mentioned here are factoring into the obesity crisis. It is NOT clear to me of their magnitude, but some people seem more vulnerable. Importantly, food selection, exercise, and lifestyle choices can largely mitigate their effects.

@JoseMagurra 3 месяца назад

Omg, stop man, let the guest speak!

@KenJackson_US 3 месяца назад

I'm very pleased to hear Dr.Lustig's comments on the carnivore diet. I was curious.

@PropheticCoachTheresa Месяц назад

What a freaking awesome conversation. My geeky ADD brain lived the science talk. Subbed and can't wait to listen to more!

@larisam6755 3 месяца назад

Very interesting and informative podcast, great guest! It was hard to follow for a lay person, but I managed to get some interesting information. Needless to say the story about NESTLE made my blood boiling.

@MickiGlenn-wu4ty 2 месяца назад

Question: Regarding infant average weight, do they take into consideration the number of surviving preemies today? If they exclude them, then the average weight is actually way higher than half a pound.

@tanpeng2884 3 месяца назад

should have spoken lesser and let robert speaks, so distracting

@HereDiianas 2 месяца назад

Saying that you are on a ketogenic diet does not mean you are actually on this diet. That's what he meant. You can think you are but your biological markers shows you're not. It's not about what you think you're doing it's about what your biological markers shows in the end when it comes to this diet. If we take a sample of a thousand random people on this diet and check their biological markers....how many people will actually be on this ketogenic diet after 2 months, 4 months, 6 months.... Since that's what he has been doing in his clinic for some patients for years he knows that it's less easy than people think to actually be on this diet especially long term if you don't have the possibility to check those markers and most people claiming to be on a ketogenic dier do not.

@mark-c802 3 месяца назад

the biggest cause of oxid stress and ros is excess, unbound iron due to a lack of regulation and recycling from bio avail Cu, ceruloplasmin and ferroxidase

@lindajones4849 3 месяца назад

Only 15 minutes in and this podcast and i need to comment . You need alot more definitionof terms for the lay person listening. I have fairly strong science background and I am have ng trouble: what the heck is NNT????

@DominicDAgostino 2 месяца назад

Good feedback. We will work to define terms up front. NNT = number needed to treat

@lindajones4849 2 месяца назад

@@DominicDAgostino Thanks for definition of NNT. I should have known that but my brain doesn't do well with acronyms.

@markrw5964 2 месяца назад

I have a couple of questions; 1) do the gut microbes damage the intestinal membranes during prolonged fasting? 2) Societies that thrive on an exclusively carnivore diet with no ill effects: what sustains their microbiome?.

@tomandersen7343 3 месяца назад

Is it generally acknowledged that DAGE’s can pass the digestion system and become problematic regarding ROS/ redox processes?

@quisge 3 месяца назад

Link to the Kevin Hall paper that's mentioned?

@DominicDAgostino 2 месяца назад

www.ncbi.nlm.nih.gov/pmc/articles/PMC7946062/

@mariafranciscamorales2102 Месяц назад

I watched 13 minutes and had to stop. It’s unnerving how much he keeps interrupting. Let dr. Lustig finish a sentence, please!

@davidpitchford6510 10 дней назад

A "Questversation" is a modern plague. The questioner feels the need to compete with the speaker for time, attention and authority. A proper interviewer asks concise questions of ten words or less and then shuts up until the speaker is ready for the next question. Also, only the speaker should be in view, not the questioner. This plague started with women in media who can never shut up and always want the spotlight of attention and feel insecure unless they are attempting to demonstrate that they are on the same level with the speaker (which they are not). You see it everywhere. We come 100% to hear the speaker and he winds up getting interrupted because the examiner needs to invade the presentation.

@nefertitib4313 2 месяца назад

148 g broccoli = 3.8 g dietary fiber according to USDA, so 1 lb of broccoli only has about 12 g of fiber, not even half of 25 g. Not sure how he got 25 g of fiber from 1 lb of broccoli.

@rawmilkmike Месяц назад

Convince me obesity isn't caused by calorie restriction.

@kenadams5504 3 месяца назад

Imo, the time I stay on my ketogenic diet is directly proportional to how much my health symptoms disrupt my life ,when I stop keto/carnivore. (and I'm 21 months on a ketogenic diet.) Keto for a health condition is different to keto for weight loss etc. .Please don't hesitate to start keto if you have a health condition ,because you will find the motivation to sustain it when it helps significantly ....,I assure you.

@lindak5036 3 месяца назад

Too many adds!

@dannykay3598 Месяц назад

Robert just schooled this guy along the lab’s PHD chick.

@ahmedsabry3909 3 месяца назад

thx

@christinehuman3967 Месяц назад

Don,stop talking about your stuff. You were rude, interrupting you guest. He NEVER had a chance to give coherent, logical explanation about this fantastic subject. I wish he could have a chat with a better host!.

@nivleusone Месяц назад

The interviewer seems to be more interested in displayibg his knowledge rather thab listening to Dr. Lustig... keeps on interupting line of thought

@TravelsByTrike Месяц назад

This interview was annoying. You were antagonistic from the start and wouldn’t let Dr Lustig explain the topic.

@1timbarrett 2 месяца назад

If I have understood correctly, both doctors believe that eating fiber (in broccoli for instance) is a good idea for all humans…? 🤔

@stubloom4870 3 месяца назад

Really, Dr. Lustig? Nobody can sustain a ketogenic diet for more than two months unless they are doing it with medical supervision? With no qualifications at all of that statement? There are hundreds of thousands of who are doing just that, many of us not only without medical supervision but contrary to the advice of our clueless physicians.

@rawmilkmike Месяц назад

It's ridiculous to talk about or chase the microbiome. It will balance itself to the food you eat. A carnivore requires no microbiome at all. Meat is digested before the colon.