Elucidating the optimal second-line therapy in metastatic pancreatic cancer 

Sara Lonardi, MD, Veneto Institute of Oncology, Padua, Italy, explores the survival outcomes of various second-line regimens in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine plus nab-paclitaxel. Liposomal irinotecan with 5-fluorouracil and leucovorin (nal-IRI+5-FU/LV) outperformed FOLFIRI, FOLFOX/XELOX, and whilst FOLFIRINOX had a modest overall survival, it only benefits a small number of patients. Overall, nal-IRI+5-FU/LV continues to be the preferred second-line option. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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