Endocrinology | Pancreas: Glucagon Function

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Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join us for this two part lecture series where Professor Zach Murphy will be teaching you about the pancreas. During this lecture we discuss the hormone glucagon and its function to act upon the liver to stimulate glycogenolysis and increase blood glucose levels. We hope you enjoy this lecture and be sure to support us below!
Correction @ 7:16 I referred to CCK and secretin as Glucagon stimulators, but they are actually glucagon INHIBITORS due to being released during the fed state. CCK and secretin are insulin stimulators, as their action is to lower blood glucose levels. Thanks!
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#ninjanerd #Glucagon #Pancreas

Опубликовано:

25 июн 2024

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Комментарии : 269

@kmkim37 3 года назад

Regarding the relationship between low blood glucose and glucagon release... it looks confusing. But I guess the explanation by Ninja Nerd is the best at present moment. The link between low concentrations of glucose and depolarization of the cell membrane is still under debate. According to one of the hypotheses, they think ATP-dependent K+ channels (KATP) plays important roles as in beta cells but the downstream link seems to be not clear yet. At moderate inhibition of KATP (low glucose concentration), membrane is moderately depolarized to open Na+ channels, resulting in the opening of voltage-dependent calcium channels. At high glucose concentration, KATP is strongly inhibited and the membrane potential is strong enough to inactivate Na+ channels, and calcium channels cannot be activated. This is just one of the current hypothesis, and it is not still clear why this does not apply in the regulation of insulin secretion in beta cells.

@vidhivora3578 3 года назад

this part was bugging in whole video... thanks you so much

@saurabhranakoti7621 3 года назад

@@vidhivora3578 even I came to comment section just to clear that part

@Easypeasy007 2 года назад

@@saurabhranakoti7621 can u plz explain m not able to understand

@Easypeasy007 2 года назад

@@vidhivora3578 can u explain

@vidhivora3578 2 года назад

@@Easypeasy007 there's video on insulin just before watch that first and then this ..you will know why I got confused and the above explaination ..then I guess you might get answer to your doubt ..if not then I'll explain you ..

@abraxadabra4224 5 лет назад

For anyone perplexed about the Ca Channels, I think the answer is : Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA).

@damlakacmaz8743 2 года назад

Oh now it makes sense! Alpha cells, ones secrete glucagon has LVA Ca channels and beta cells has HVA Ca channels.

@unkown-uz4lp Год назад

Exectly

@fretelianadedeus7951 Год назад

Thank you! I was so confused in the beginning

@questioneverymatter5851 11 месяцев назад

Now I got it right. For Alpha cell the membrane is embedded by LVA calcium channel and for Beta cell it's HVA calcium channel. It's just a matter of cell type.

@-BhadoriyaMohitSinghN 21 день назад

You all people....Thank you so much for being involved and to initiate this kind of discussion on calcium channel...❤ Its really really very helpful...

@mohammadhossain8730 5 лет назад

He is a gifted teacher!

@shreyadixit8908 4 года назад

You are a god's gift to medical students. Thank you so much for sharing your knowledge with us. Really very grateful!

@himanshuambilkar4160 3 года назад

Pancreas- Hetrocrine Accini Islets of langerhans. Alpha cells glucagon hypoglycemia Beta cells insulin hyperglycemia. In alpha cells GLUT1.less ATP. Less membrane depolarization. Ca++ chhanel. NE CCK SECRETIN. GLUCAGON. IN blood. Liver fasting state- Glyogenolysis. Glucogenesis. Adipocytes- Hormone sensitive lipase. LIPOLYSIS. Heart- Ca++ uptake. Thank you sir

@supernovachampions 5 лет назад

I love how you added glucagons effect on the myocardium... useful in beta blocker and CCB overdose. Great review!

@rabiamaham473 Год назад

You get all the concepts together and make them understandable in a very easy manner. Great work and thank u so much for all these videos

@vatsalshah4582 6 лет назад

Comprehensive information provided here. You make life really easy in just 25 minutes. And after this, reading through text book becomes a breeze. Keep up the work and would love to see more topics covered.

@abraxadabra4224 5 лет назад

I appreciate the way you're enthusiastic about the things you explain - it makes the difference!! :D

@marshallbasumatary 4 года назад

This helped me so much in connecting the important key points and describing an overall picture of the process. So helpful .🙏🏻

@miriamcampillo7459 5 лет назад

Hey ! I am studying Biotechnology and have some exams in a few weeks. I just wanted to tell you that your videos are incredibly well explained. I could just watch them for fun. Congratulations for all the work and effort and thank you very much :)

@wardakashif2469 21 день назад

i had my endocrine exam today and it went absoleutuly great, actually i aced it, thank u sooo much for all of these videos. this whole endocrine palylist was soo detailed yet so easy to understand.

@safaaamehdar579 3 года назад

I hope you reach 10 million subscribers Very well explained, You are amazing teacher ! Lucky to have you Ninja nerd ❤️

@melieaperakis4438 4 года назад

My favorite teaching on this subject. I am definitely subscribing. I am a visual learner. Thank you so much.

@shahbaz9231 5 лет назад

hello Dr. WE need more videos of yours. start a new series of videos on any system. please keep em coming. we really love and appreciate your work.

@schuggy4408 3 года назад

I am now a fan. You are becoming my favorite RU-vid channel. I am so glad you exist as a person and you do what you do. Keep making these videos and I'll keep watching them. Look for a patreon donation coming your way.

@vinalkumar7041 Год назад

yes !! i did enjoy the video !! and thank you for keeping these for free us students to learn and always come back to!! Much appreciation from a fellow med student.

@abhisheksingh-qo1mw 5 лет назад

One thing for you is, you are my Super hero for biology, You gave me inspiration, and yeah man I am getting addicted to it. Thanks a lot for these lectures, and I gonna meet you one day Mr biologist

@loloonthelow Месяц назад

the best teacher... i wish i could pay my med school tuition to this king

@pristinepolido9225 2 года назад

You're an angel. I'll marathon your videos as prep for my licensure exam!!

@SivaS-qb2xj 3 года назад

Thank you! This summer I aim to review all my physiology following your videos!! Thank you!!

@THEWARRIOR1192 3 года назад

surprisingly during my bodybuilding prep, your content has massively helped keep me productive & focused. I've learnt so much information from your videos which will significantly help me deliver a better service to my clients as a online nutritionist coach. Thank you

@jonqn07 Год назад

AMAZING EXPLANATION! Wow, CLEAR explanation to the details! I'm a visual learner so your video really provides a complete picture for my understanding. Thank you very much! SUBSCRIBED!

@MrBalko 2 года назад

Thanks a lot for your great way of teaching.. I never thought I'd understand Biochemistry the way I start to understand it now..

@yazsam930 6 лет назад

Thank you man . Amazing as usual . Keep going my friend .

@reabitansky2769 6 лет назад

My exams are all oral and your videos are precious for explaining and connecting dotes

@2YKSS2N 4 месяца назад

thank you for sticking through the whole process of making this video

@fitrianib6563 6 лет назад

this is awesome... its helped me to more understand about glucagon.. thank you

@premedy1917 4 года назад

Awesome thank you very much. You're the gift to community and our blessing.

@freemigo 6 лет назад

Saved me. Amazing work. Love Ninja Science nerd.

@WANaval-zl5vb Месяц назад

Dude best class on glucagon on have seen so far.

@mamalhjn9258 6 лет назад

You are one of the best teacher in the world 👍

@yachiapatel Год назад

This man👨‍💼 is so firm, confident and understandable in the era where people opt for confusion related data. 🙌 Just so in love❤ with you, your teaching skills and your management skills 🙌✌🌟 Kindly keep doing what you do 😍💕🌠

@realloreal Год назад

I'm so addicted to all your vidss/ Love t them, start making shorts they actually help me even more

@SC-lj5sy 3 года назад

Beautifully explained. Awesome teacher

@ClinicalMedicinewithDrT 2 года назад

the best teacher on youtube.THank you for the effort

@vinayakkapatral4246 3 года назад

Fantastic.... man I am running out of words to comment. Still feel like having notes or prints! Zachcellent!

@garystone1252 5 лет назад

incredible lecture. Well done!!!

@genevieved6743 2 года назад

Professor Zach! You are awesome! Thank you so much!!!

@migueldelgadillo1835 6 лет назад

According to Costanzo CCK is a factor that stimulates glucagon secretion, so you were originally correct.

@fengcheng3507 5 лет назад

Excellent talk!

@whatev3857 3 года назад

Thank you for making learning so enjoyable 💓💓💓

@marcelaleyva6700 4 года назад

Every single time I feel like I had an epiphany watching your videos :D

@MaKa-dm7kh 2 года назад

U are a Hero without a cape! Greets from Germany.

@thomassmearcheck2819 4 года назад

I love your videos , you have a teaching gift .

@nisargshah8550 6 лет назад

at the end can you leave a picture of the board so it can be printed off?

@odysseyoddworld572 6 лет назад

Yes please, that would be very helpful. Thank you ninja nerd science.

@danielachavez8346 5 лет назад

Pleaseee

@frayedendsofsanity1733 5 лет назад

Omg yesssss

@Pieguts123 4 года назад

@@frayedendsofsanity1733 I go over the video, bit at a time, draw the diagrams and make notes of the explanations. I use coloured, erasable pens and this allows me to correct mistakes. Doing this means that I am re-listening to the lecture plus writing it down and then reviewing it whenever I want. This means a lot of revision of the topic: re-listening, note-taking, drawing, re-reading. I think this might help to truly learn rather than looking at a print-out?? I don't know; we all learn differently.

@drholiday4147 4 года назад

Pieguts123 same here ; )

@shahabuddin6149 4 года назад

Love you sir,,sault to your effort,,you make very easy every topic for us,,a bundle of thanks sir...keep it up,,I am only depending on your sweet lecture...

@snickerstoasted2212 Год назад

Packed with information and the drawings really help for someone like me that is a visual learner. Im actually a IT guy thus well done cruizin through the medical sections

@sarahsahibqran2198 3 года назад

Thank you so so much for this gold as always

@melissa5030 4 месяца назад

Absolutely amazing thank you so much professor i have never understood more, such an amazing explanation really simple and clear bravo ✅❤️

@wombat2379 11 месяцев назад

Great job, thank you!

@CarnivoreAnesthetist 3 года назад

Who are the 20 people that didn’t like this video? Good job! Loved the refresher!

@rippularora6366 4 года назад

Amazing work 👍👍. Thankyou so much🤗♥️♥️

@abdelraheemsalahin8537 4 года назад

Good doctor ever

@kannannatrajan6036 3 года назад

well defined and great lecture

@alfia.55 2 года назад

Ur videos are really helpful...uh did a great job...thanx for making these very informative videos 🌺✨

@priscillaperez941 3 года назад

THANK YOU FOR THIS VIDEOS YOUR AMAZING FOR DOING THIS

@shansha7364 Год назад

brilliant explanation

@redfoofan4618 3 года назад

Just amazing, good job man!

@paramecia_ 3 месяца назад

amazing explanation

@patriciavarga4084 Год назад

Laymen here. Interesting and mind challenging. Thank you

@injamamulhoque2013 3 года назад

Sir, you are great teacher, I am your big fan from India ❤️

@tsachie4822 3 года назад

you make biochemistry so simple to understand

@ninjaman302 3 года назад

Thank you my brother for the great info.😁🙏🏾🌈

@vinayakkapatral4246 3 года назад

Zachcellent!

@aparnakaranjkar1227 2 года назад

Awesome explaination 👍

@mohammedal-shrouf8238 6 лет назад

Thank you 😊

@freddiespinoza Год назад

Excellent!

@nirvanasharleen6994 4 года назад

In a short time presenting a lot of things ! If the time of lectures in this video would be one hour it would be so good to present all the information more simply & easily what you wanted to present that goes to be more understandable ! Lastly thanks a lot to present all these mechanisms deeply !!

@Fil-AmRN 2 года назад

You are a heaven sent... Thank you soo much!!!!!! now I am feeling kinda Nerdy :D Great videos! very clear ! love it all, I don't even notice the time whenever I binge watch your videos..... Hope for some printed materials to guide medical students like me as well, practice quizzes and what not :)

@linamaaref8373 2 года назад

god give u health and wealth professor ur incredible from algeria

@rosamariathol9546 3 года назад

Lovel 💕💕💕💕 your lessons you are great explaining.

@jeanlewallenmiles2842 Год назад

Cool presentation

@aaedits824 4 года назад

Thank you so much for your great videos...love them💕 Can you please make a video on oversecretion and undersecretion of adrenal hormones......pathologies.

@ahmedramadan8926 3 года назад

what an amazing explain

@komalrasheed2713 3 года назад

Great concepts bro😘😘stay blessed

@mohammadsulemansakhi7480 3 года назад

Good explanation amazing sir

@shreyaray5500 4 года назад

Secretin inhibits Glucagon secretion , while CCK stimulates it. So you were partly correct originally. Love your work, Zach just can’t thank you enough for your amazing videos ❤️

@manelkrm9159 2 года назад

thank you so much

@elizabethcharles6973 6 лет назад

Thank you so much, this is awesome! You're absolutely mind blowing in your teaching skills.

@NinjaNerdOfficial 6 лет назад

+Elizabeth Charles wow thank You so much for your kind comment!! I am so glad we were able to help!

@josephalharbi1169 4 года назад

Thank you 🙏 ☺️ 😊

@turkersoykan5695 3 года назад

Eyvallah Ninja kardeş! 🙏🏽❤️

@doc.3li 4 года назад

Thank you so much ☺️👏🏻👏🏻👏🏻

@eckhardtmilz1587 4 года назад

Amazing!

@hafsaislam6773 3 года назад

Great sir . Thank Uh 💙💙

@richardwellens8932 8 месяцев назад

Thanks!

@shreyaspattanshetty2560 2 года назад

Thank you! :)

@Mengjoanne 3 года назад

Can you do a video on fasting, glucagon and lipolysis? Key to fat loss?

@fitnessrev5014 3 года назад

thank you sir

@kubrathetoothfairy 3 года назад

You. Are. Great.

@user-cl9rv8uj9h 2 года назад

thank you sooooo much

@asadwork1623 2 года назад

thank you

@ahmadalaa6470 3 года назад

Very interesting .

@kimpyrant1204 4 года назад

Thank You

@Oktofalldown Год назад

Thnkk uu sir uu teach really really well

@kmkim37 5 месяцев назад

The α-cells and β-cells have opposite Ca+ signaling patterns in response to glucose. At low glucose concentration, the cytosolic ATP/ADP ratio is low; KATP channels demonstrate a moderate activity, which situates the α-cells to a membrane potential that allows the opening of voltage-dependent T- and N-type Ca2 + channels. The resulting increased intracellular calcium concentrations, in turn, stimulate exocytosis and glucagon secretion. On the contrary, high glucose blocks KATP channels, which depolarizes the α-cells to a membrane potential range that suppresses the voltage-dependent Ca2 + channels. Consequently, Ca2 + signaling and glucagon release are blocked. (Adapted from Anatomy, Histology, and Function of the Pancreas. C. Shi, E. Liu, in Pathobiology of Human Disease, 2014)

@myleeyenn 4 года назад

I am not a bio student but I can understand, thanks for ur video

@sayanhazra088 5 лет назад

love your videos,can you please give me biosynthesis of glucagon with structure...I found nothing good in internet,

@LHost-sx2kk 6 лет назад

Hey man I got a question, in the video on Insulin you actually said that those Calcium channels open, to stimulate the insulin release to the blood, now you say when there is too much depolarization they close, I'm quiet confused with what you mean, if you could help me get this right, thank you in advance!

@laithenani671 6 лет назад

second that, please elaborate. Thank you

@LHost-sx2kk 6 лет назад

6:00 , but maybe it has do do with the different threshold levels for that Calcium channels in alpha and beta cell's? I understood what he said but not why it doesn't happen in the beta cell as well

@teekay5166 6 лет назад

Yes same. Confused at this point

@NouziMora 6 лет назад

Same! If ATP channels close and K+ accumulates, there should be a membrane depolarization which causes Ca++ channels open. Don't understand why would positive charge close the channels?

@LHost-sx2kk 6 лет назад

Okay,clearification for you guys since this guy refuses either to admit he is wrong about this topic or he either too cool to answer to us, forget what he said, when B cells release insulin caused by hyperglycemia it also secretes glutamate, that will have effect on alfa cells Cl- receptor channels, increasing uptake of cloride by cell and hyperpolarizing it. When the stimulus is low glucose levels this action of Cl- channels is inhubited because less glutamate is comming form b-cells and the alfa cell will depolarize, giving the threshold for Ca++ release into the cell