Enzymes: Nature's Factory Workers 

Whoopsie! At 1:07 that should say 98 Fahrenheit, not Celsius! Boy would that be trouble.

This guy is carrying my semester

You explain better than my biochemistry professors 90 minute lectures. You’ve been my saving grace since I found you for organic chemistry😭👍

Enzyme binding is no longer recognized with the "Lock-and-Key" hypothesis. This is because the active site is not a perfect complement to the substrate. You do not want your enzyme to bind too tightly to the substrate or you might get stuck in the ES complex. This is to say that the difference between the transition state and a tight ES complex would be too high. Think of it more like a sock and a foot where the enzyme (like a sock) can mold to the size of the foot and thus decrease the Free Energy (G) of the ES transition state.

I'm a Brazilian student of Biological science, and I am trying to learn english. So, your videos help me a lot, cause I hear of a contents that I like at the same time that I try to understand your leanguage.

One of my undergraduate degrees is in Biochemistry. It's really nice to have this as a review. I think Dave's presentation is better than the one I got at UC Davis. Thanks Dave.

Thank you SO much! I don't know what I would do without your channel! You help me get through Biochem in undergrad and now you're helping me with the MCAT!

Love your opening. Thanks for helping me study for my biology test

I recently failed my first biochemistry test. I hope that watching these videos along with reading my chapters can help me get a much better grade on my next test. Kinda anxious tbh

At 1:19 the video shows 98°C for body temperature. I mean °C or Kelvin is the way to go but it would be 98°F or in the proper metric system 36.67°C.

A long time ago, I made a comment about how I disliked your teaching style, since it seemed as if you were reading off of some sort of prompter and weren't genuinely involved in teaching the subject. I now understand how difficult it is to put together a flawless presentation and still try to remember it all, so I commend you for that. I appreciate all of these videos because I really have learned a lot from them. Thank you professor Dave!

Your lectures are the reason im curious and excited to know more

Thank you so much for your efforts to make up this video, I am a student from Egypt and you are really helping me with your videos in studying , keep going Mr Dave 👏💛

Thank you very much for your time and clear explanation.

These videos are so unbellivvably helpful especially for me in my third college year. Thank you for everything you do

Thanks it was really helpful. I understood it very well could you please explain the enzyme kinetics related to the Michaelis-Menten constant

Thank you so much for this amazing video! Can you please also talk about inhibition and allosteric sites?

wow, this is an awesome explanation I never expected. God bless you, Professor Dave.

Thanks you are a life saver. I wouldn't have known how to write my Biotechnology test (BTH204) without you.

the residue in the active site part - that was hella interesting!

Apart from some mistakes it´s well explained. Ligases and Lyases both cleave and combine molecules, for an enzyme always catalyses the reaction foward as well as rewind. The difference is that a Ligase needs energy for example from ATP and the Lyase doesn´t. Furthermore there was a mistake about the Coenzymes and Cofactors. Cofactor is the generic term for Coenzymes and Prosthestic groups. Coenzymes are molecules the bond only for the short moment of reaction while prosthetic groups are bond covalently to the enzyme. It has nothing to do with the type of molecule or ion. The ion you´ve described for example is a prosthetic group.

I always recommend your videos to my students.

Keep up the great work!

professor Dave,... I like your videos, they really help me a lot

Thank you so much I thoroughly enjoy your videos!

Hello Dave..... Fantastic!!!!!! I look for new ideas in your videos.

Great video Dave

Professor dave gets back to me faster than my actual professors. I dont know if thats amazing or sad.

you're the best thing to every have happened to youtube!!!!!Thank you sincerely for all your videos

Professor Dave.... Thank you so much for sharing your outstanding illustrations on different facets of Biochemistry

Thank you so much, such a helpful video

People like this guy, makes science fascinating!

absolutely love love your channel

Hi prof. Isn’t there a category of enzymes called polymerase enzymes , or it belongs to one of the six groups you mentioned?

I love your videos Professor Dave thanks a bunch

I frickin love professor dave

im a high school student in north africa , and we have enzymes , proteins and such things as the subjects of the final exam , i wonder what grade americans study this , and gret video by the way , you have saved a life

I love your videos! Do you have anything on enzyme denaturation?

Thank you professor!

I'm not sure this would interest you but it would be cool to see a video about hair loss, seems like a big puzzle that no one can figure out. How can 5-alpha reductase inhibit scalp hair but increase facial and body hair. Why do some men go bald but others don't? why does hair miniaturize on the top but the side is immune? Always love watching your videos thanks ! :)

Hey Dave. Love your videos. I have one small complaint though. Somewhere around 1:12 you say "...and using only the reactions it has stumbled upon by blind chance." Being a Microbiologist (grad student, so still in school) I understand what you mean here, but technically its not 100% accurate and the statement can be used to sow confusion. I was a young earth creationist until I was 23 years old (34 now), and back then I would have jumped on this statement as a means to justify my distrust of the theory of evolution. Your recents 'debate' opponent, Ken Hovind, who was a hero of mine back then, loves these statements. The thing is, natural selection is not blind chance. Mutations are, but natural selection is not and, correct me if I am wrong, but these enzymes are the product of natural selection over time. Anyways, thanks for doing what you do and keep up the good work!

Professor Dave putting the proverbial Student Biochem Team on his back!

Thanks Prof Dave😍

Thank you prof

hello i was a former revserve officer in my country i starting to study in colege man your the best proffesor thank you . i can learn from you

I think it's like recitation of saved blocks of information without going beyond

hii, you are perfect professor ! im a dentistry student from turkey. and this video is perfect for meee

Thanx Dave

Clutchest man alive, saved my bio semester grade

I'm a layperson with a love for biochemistry. Loved the video!!!

Best of the best.....my biochemistry hero

You’re a master!

PROFF DAVE thanks for the grate work of educating the world

at 5:20 it was definitely a subliminal message for "blue balls" haha. OMG I'm dying!

really good

Can you make a video about Enzyme specifity, like bond specifik or absolute specifik etc.

Fantastic

Thank you, chemistry Jesus!

thanks a lot, i am interested . I'm a biology teacher in Rwanda

I’M 10 and I love organic chemistry & now biochemistry

Thank you for making this video. Your good at explaining these concepts. What boggles my mind is that someone with your intelligence looks at an even great intelligence of the body and believes it happened by chance...

Waiting for Carbohydrates. :) Thank you so much. You're changing the world.

Perfect

this guy is carrying my semester too

I adore this guy, brillant mind always exist.

Keep the hard work..it's very very very simple n useful 💙

thank u

Thanks, you are amazing!

At 6:14, the coordinate-covalent bonds between the ligands and the e- acceptor metal ion are polarized with a large negative dipole on the sulfurs and nitrogens and a large positive dipole on the metal, correct? This seems logical since the e- donor atoms have a greater electronegativity than the metal atom (say the metal in the picture is magnesium or zinc, for instance).

Hey Proff Dave, I love your videos ! quick question 5:54 is Lysine acidic or basic ? I got kind of confused

4:18 Bacteria do a great job of breaking it down actually, and produce quite a bit of gas 😅

Sir please make the video on transcription translation and protein synthesis

Great video, just a small precison, at 5:53, lysine is a basic amino acid not acidic

awesome !!!!!!!!I am from india

Alxamdulilah I understand this lesson Thank you teacher I come from somalia 🇸🇴🇸🇴

i am just going to watch all your videos

Hey prof! Are you a chemistry or a biochemistry major? Thanks for your awesome explanations!

professor Dave is very funny and interesting

Best!

Hey so I’m wondering what regulates Enzyme’s ??

Thanks daddy dave u saved my life

Not sure if I was listening carefully, but can an enzyme split an atom and create nuclear fission? Something like oxidoreductase or acid base catalysis

Thank you Prof.. Made me realize... GOD AlMighty, All Praises to Thou for Thou amazing creation..

What is enzyme substrate complex?

I always read my assignment (16-40 pages) and then I come here to understand what I just read. Thanks to your videos I'm an A+ Student :D Thank you!

My ALT and STC enzymes are high

Sir what is allosteric regulation of an enzyme?

OMG I love this vid 🤓🤓🤓😀😀

dude has a video on everything

Maybe you answer or maybe you don’t, but what about microorganisms and enzymes? Is there any video about that?

what tune is it at the end?

I have to correct you at 4:15. It is not a deficiency in lactase that makes people lactose intolerant, because this is the normal state of an adult. We are not designed to consume milk as adults, lactose tolerance is the exception.

A very unusual question which keep popping in my head that why Professor wear same shirt in every lecture???

If you could add verbiage like "Enzyme is a protein that serves some kind of catalytic function in the body" to your visual, that would be even more awesome! Thank you for your videos. They're very instrumental.

Wait... how did living cells do chemistry before the enzyme evolved? Never mind, that's not why I'm watching this video.

HEY THIS GUY MAKE ME REALISE! FOR ENZYME, JUST THINK OF PACMAN GAME!

Thanks jesus for the lesson ❤️

Please add a metric scale to videos :/

PROFESSOR DAVE txh

1 Différenciation des tryptophanases de cinq espèces d'Enterobacteriaceae par groupes sulfhydryle. Simard C , Mardini A, Bordeleau L M. Can J Microbiol. 1975 juin;21(6):841-5. PMID : 1097069Français.