How about the New Beginnings Trilogy. 8 people live\work in the Traken castle: the Denis Carey Keeper, Tremas, Kassia, Seron, Luvic, Katura, Neman, and Nyssa. At the end everyone on Traken, Logopolis, and Castrovalva is dead, and not only that, but everyone on a good 40% of the universe. Except Nyssa who only survived because she was teleported off as part of the Doctor's regeneration.