Elevated triglycerides are consistently linked with poor cardiovascular events. Let's discuss why that's the better marker to focus on.
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----------------------------------------Show Notes-------------------------------------
0:00 Intro
00:40 LDL reduction treatments has a minimal, marginal and inconsistent benefit with overall reduction in all-cause and cardiovascular disease mortality and incidence of stroke.
01:15 Heart disease was the leading cause of mortality, even during the pandemic. It was a leading risk factor behind age and obesity in severe COVID.
02:05 Triglycerides and triglyceride-rich lipoproteins tend to be more atherogenic. They are also linked with insulin resistance. If you are on a Statin or told to be on one, check your ApoB to A1 ratio. It is an inexpensive test.
04:40 When you are insulin resistant, there are more triglyceride molecules compared to cholesterol esters.
05:17 The Friedewald equation does not account for triglyceride-rich lipoproteins.
06:00 A decrease in triglycerides is a reflection of improvement in metabolic health.
06:36 Post-prandial increase in atherogenesis and heart disease is linked more closely to remnant lipoproteins and triglyceride-rich lipoproteins.
07:15 Triglycerides fluctuate. Levels of 60 to 70 is what Mike recommends to clients. Get a baseline. Test while fasted. Next time, do a lipid load test. Before you test, consume a typical mixed meal with 60 to 70 grams of fat.
09:00 The degree of your insulin resistance is reflected in your post-meal triglyceride level. When your liver becomes infiltrated with fat, there will be a dramatic increase in post-meal triglyceride levels.
09:36 Post-meal triglyceride levels should be under 220 mg/dl. Levels over that reflect an inability to process post-meal fats.
10:00 LDL particles also carry triglycerides. They can become enriched in triglycerides. Low LDL does not tell you about your cardiometabolic risk.
10:55 Exercise is one of the best ways to lower your triglycerides. Eat a low carb diet. Improve sleep quality and circadian rhythm. Cold exposure/thermal stress can help. Fasting and supplementing with myoinositol and berberine can help.
21 июл 2024