Yep. I remember a physists from Standaford Uni said something along the lines of "my life/career consists of me continually forgetiing and re-learning physics." I guess the trick is to learn/memorize something when you need it (I.e. the test in 3 hours for me).
One does not forget such magnificent things. Think about it: this is a battle of merely carbon, hydrogen, nitrogen and others to develop specalized logical higher-order functions with system dynamics. That can not be forgotten, you need to witness it, observe it, breathe it, live it.
Great video thank you. Really helpful for my upcoming test tomorrow - 20% test in fact! Hopefully all goes well, will keep you updated once test is over and additionally once results come out!
THANK YOU! I read the Wikipedia article like 6 times and watched the Khan academy video and they were... things that exist, but THIS video made it click.
Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists? Or do they rather cause a more pronounced neutralization of the receptor?
An activated receptor induces a conformational change in the alpha subunit causing the GDP to dissociate. GTP which is abundant in the cytosol readily binds in place of the GDP. GTP then causes a change in G protein therefore regulating the activity of target proteins in the plasma membrane. Then the alpha subunit hydrolyzes its bound GTP to GDP, reversing. turning it off and repeating all over again as long as the signaling receptor remains stimulated.
I will use this video to teach my high school students signal transduction. It will still require a lot of scaffolding but the explanation is so clear and easy to follow! I am doing the PCR- PTC lab so I hope this video will help them to understand the mechanism.
