Geraldine Hamilton: Body parts on a chip 

3:01 Cameraman: "just f**king hold that damn thing still for a moment!"

"I have right here a human lung on a chip!!" *_frantically starts waving it back and fourth so the camera can't see it_*

3:00 Props to the camera operator for at least trying to catch a decent view of the chip even though failure was inevitable in this situation.

It's been 5 yrs I wonder how much of this has been integrated like predicted.

I've worked as an engineer/scientist in the bio-medical industry for decades. This technology of a cheap, mass-produced lab-on-a-chip is widespread throughout the industry because it's a versatile means of increasing efficiencies in testing. Microfluidic chemistries & bioassays can be deposited, dried & activated later with fluid injection at the time of testing. This can eliminate a complex protocol for preparing reagents for every test at the urgency of time-sensitive processes; this saves a lot of lab work & time. Channels encased in clear plastic can be used to create circuits that are isolated from contamination, while allowing non-contact fluid circuit actions urged on with localized heat, capillary action, magnetic sturrers & gates, & sound waves that do not foul the circuit. This also allows microscopy to be used in pre-calibrated instruments fitted to accept these chips. This is a new way of thinking that has many uses that imaginative engineers & scientists can exploit, though it's decades old!

I took a bunch of these organs-on-a-chip, added some motors, a Raspberry Pi 3B+ for a brain, and made a miniature cyborg boy in my basement. I named him Chip.

Pretty impressive. I can't wait to see what the future holds in medicine. Good luck towards the team working on this :D

Just amazing! Thank you so much for one more educational TED video-lecture!

This is bloody brilliant! It might be that i'm a little late but this was a real eye opener for me. The amount of possibilities of this technology is mindblowing. I knew that this kind of technology did exist but I never could have imagined that it would be this elegant and beautiful. Complicated yet simple.

Very exciting concepts for the health industry and many others. I can't wait to see how this could possibly revolutionize the treatment of diseases.

I would really love to see an update on this technology, so see how far this technology is today, 7years later

Amazing concepts to know through a great presentation .it must bring revolution in medical treatments .

Wowing. Love this Video. TED talks really keeps you up-to-date once but changing in the world. Awesome ideas. It will save a bunch of lives in the near future.

i love seeing 05:40 its incredible! visual presentation of whats happening inside our bodies

Me parece muy interesante, y sería posible diseñar el uso racional del medicamento en los diferentes pacientes

for me its pretty hard to believe that things like these are happening just at the same time as people fighting and killing because of religion.

What a great speaker

Wow this so genus and simple! I mean it's probably is very complicated to figure out and engineer but it's so much more simpler than so many other things

This blew me away. Awesome!!

Her graph at the beginning of the presentation on drugs follows the inflation curve for the US dollar exactly...

Just imagine the personalized medication we'll have in the future thanks to this tech! No more extensive lists of side effects for the drugs people rely on.

nice explanation!

wow wow wow! simply amazing what they are doing

Very cool, the next step towards better treatments

I am amazed totally!

Very ingenious! I love it.

Thanks you

simply amazing

This is so amazing omg

Consider how production of the transistor has evolved. How large it was in the beginning, and how small it is today (and getting smaller). If we see anything like that development for a technology such as this, imagine the statistical plausability you could get for medical trials at an insanely low cost. Truly exciting...

This is pure SF happening right now. Amazing.

This absolutely blew my mind when I heard this. Could you imagine how this would revolutionize the way we study cells. Amazing!!

This is amazing.

I believe this works for the early phases of a drug research, by eliminating at once the prototype drugs that don't pass this initial safety test. Further clinical trials will still be needed for those that pass. A human body as a whole is way more complex than what has been depicted in these examples. So many possible multi-organ or multi-systemic interactions, too many variables involved. In vitro still from in vivo.

Amazing!

This is awesome!

soooo informative

how about synthetic photosynthesis with these chips?

Very intresting!

Amazing!!! :)

Astonishing.

Impressive, exciting, and potentially revolutionary!

Interesting idea! But it seems that they are creating physical stress environs, I am curious, what about creating the chemical environment like ph levels, salt and juice levels which help in functioning and immune reactions? What about the neurological connections, the interconnections of nearby organs, bones, tissues etc which effect the response of a particular organ? What about creating any preconditions or deficiencies, diseases which affect bodily responses? If these can be done it will be revolutionary. Keep going! My best wishes.

please show the reference!

THIS IS AWESOME!!!!

its going to save lots of time n energy and of course if it will be used wisely, its gonna save lots of lives also.. great great great.... Hates off..

Awesome video

This technology is amazing and I can't wait to see this being used. I would like to see this technology combined with 3D printing, the possibilities are endless.

what about the reactions due to hormonal responds?

this is amazing :o

Pero muy bien

It should be able to use in Lap

fantastic

9 years later...how did this chip pan out? Is it industry standard now or ultimately did not commercialize well?

Great stuff

This is reeeaaally cool, but I think bio-printed organs have more potential. As she said herself in the beginning, we have to get the closest possible to the actual environment of the human body.

So.. does anyone know how this study is going right now during Covid-19?

That's awesome medical technology to personalized medicine.

Facinating! Medical system is going to be something else in next 10 years.

has anything happened with this in the last 9 years or can you do a follow up talk to this

I think this is all amazing, but I can't imagine how are they going to get for example cells from samebody's heart, or liver without an operation. Do you guys, have any idea?

impressive

great

It will be interesting what takes place once the technology reaches the field and the true innovation starts.

We need to fight for the feelings of these chips, it's our duty.

what institute is that ?

Amazing technology!!! But there is something about it that just doesn't feel right... I think we have to be very careful what we make of this technology

Hell yeah!

Really kool tech

Will they be able to host cancer cells also if so this is awesome

Interesting talk from Geraldine Hamilton about what can be made on a chip. Further than a Lab on a chip, now we're talking organs on a chip. This could help designing and testing new drugs but it could also be useful for ex-vivo cell culturing where cells could behave more like how they do behave in the body. Structuring the chip walls to mimick the natural environment of the cell is indeed important to ensure their culturing. And being able to feed the cell with microfluidics is also a key factor that this kind of chips permits. We'll see how this technology evolves and progresses...

The future is amazing.

I'm proud to cal who ever made that a true engineer

Brava

What a clever idea

My mind=blown!!!!!!

There are a tonne of biochemical transmitters around that we don't even know exist. How Wil be able to explain the cause for the effect they see on these isolated chip environments??.

Interesting stuff. The chips are still isolated islands of functionality though so you may not be able to recreate the conditions that only a whole body could produce.

When I eat while naked I sometimes get my body parts on my chips.

She sure says beautiful a lot!

Problem is, that the test the drug on the whole body. Drugs affect the entire machine, not just 1 part. Humans are not cars or computers. Because of how they interact and how a drug can concentrate in one location more than another, this will not be able to give the full picture. Its great if it stops heart disease, but its not any good if it concentrates and kills off your liver...

Bookmark 8:30

"Ghost in the Shell" type future anyone? Yes. That's the answer. Its no longer a question. Its only a mater of time before we begin building more complex "organs". Having them work in conjunction would, by then, be mere childs play.

I think this developed technology itself is very wonderful. However, based on the speaker's presentation, could it be that, prior to this technology, pharmaceutical companies had not fully clarified the effects of expected medicinal ingredients on the human body in the first place? Does it mean that detailed basic research on the possible negative effects of pharmacological ingredients on the human body as a whole and detailed clinical research on the negative symptoms observed as a result of these effects are hardly being conducted?

I hope this is what the medical industry needs to develop new medicines and vaccines.

This chip would revolutionize human research as we can see the exact respond to human bodies rather than animal testing

Hot topic with very cold audience !!

yay~!

The body parts on a chip is a brilliant idea, and be able to set it in a network to simulate the human body for research on diseases and other illnesses. Maybe the chip have to be more simulated as a real human, temperature and blood pressure etc.? To be able to treat different diseases we have to think of the external and internal factors of how the human body responds to diseases and non diseases. The human body is well built machine it can adapt and regulate itself for different situations of exposure to the human body. (hot, cold and diseases etc. and other factors.) Remember there are good and bad diseases (virus / bacteria) that can help the human body fight off other diseases etc. and the bad diseases is treated / fought off by the white blood cells and other treatments to cure the human body. There are treatments were the human is been put in stasis (controlled environment internal and external) to aid the human body to fight off diseases and better chance of recovery. By giving blood to others, does it mean the transferred blood's white blood cells aid the other person immune system? And is there a better way to aid the person immune system by human for human?

they didn't say anything about "brain on a chip". Too transhumanist or too impractical? I would think getting the brain on the chip would be the most important one as many of the typically perscribed drugs all usually have to deal with crossing the blood brain barrier.

And what media are you using... something like DMEM/RPMI... hardly physiological?

Would you exchange your organs with any of these chips?

Dr. Vahlen!!

9 years ago? i wonder what has been devoleped with this

Naftali benet?

This is really bugging me, does anyone what her accent is? It sounds like it's a mix of French and British but I'm not confident... can anyone place it?

I'm skeptic that a tiny chip can simualte the much more complex biological environment of a cell in the body.

I want a doll that uses these chip and we essentially have a homunculus

This is the most badass shit ever, seriously. I just really hope this project keeps moving forward in a possitive direction, for good use only... *cough cough government cough*

I am also working with microfluidic channels. The fabrication process has a lot of parameters so it is very hard to fabricate a lot of channels.