Lena Bazhenova.. you are absolutely right. Efferent arteriolar constriction does cause increased GFR as told by sir in video.. (appreciate much) but then again as Lena said it actually finally decreases the filtration process. It has a biphasic effect on GFR.
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I liked this video. He showed how blood pressure and flow can influence GFR, but I didn't see the other factors that can influence GFR such as Hormonal regulation (Aldoterone, ADH, Renin-angiotensin, ANP), obstruction to urine flow, and the loss of protein free fluid.
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Isn't the increase in GFR due to efferent constriction only transient? After a time, as there is less blood flow to the glomerulus and fluid is squeezed out, the oncoctic pressure in the glomerulus will build up, which will draw fluid back into the blood. So, overall, GFR would decrease. Yes?
I believe that the effect is biphasic; at moderate levels of efferent arteriolar constriction, resistance to flow and thus GFR will rise. Once resistance reaches 3x normal, you will indeed begin to decrease the GFR due to abnormally elevated glomerular oncotic pressure
this great, useful and so simple... I'm a med student from Morocco plz if u can add more videos about neural physiology it will be great... thank u so much
sir we are taught in physics that when diameter of pipe decreases the flow of water increases and so pressure decreases since blood is also a fluid isn't the renal flow constant
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Hey Guys. I am a 50 year old male, with one kidney. I donated my other kidney in 2010. Over the years, my eGFR numbers have ranged from 56 to my 2 most recent eGFR numbers -June-39, and July-44. It has been as high as 51 in September of 2015, but this 39 I got in June was the lowest ever. My kidney specialist doesn't seem concerned with this number, nor my creatinine numbers which have ranged from 1.46, to my most recent in July- 1.76 because of the fact I am working on one kidney. Is he right? Should I not be concerned about the 44 eGFR number? What is the "ideal" eGFR # for a white male, age 50, with one kidney??
