Gleason 6

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Active Surveillance Patients International: aspatients.org
The Active Surveillor: howardwolinsky.substack.com
0:24 What is Gleason 6 prostate cancer?
2:22 If it doesn't metastasize, why is it called cancer?
4:26 Clinical study examines whether Gleason 6 prostate cancer metastasizes
6:56 Spread is something that occurs before the prostate is removed, not after
7:55 Can Gleason 6 prostate cancer transform into a higher grade?
9:31 Is 50% of all prostate cancer Gleason 6?
9:44 How can a patient know for sure that their grade is Gleason 6?
10:42 Are active surveillance patients less likely to die of prostate cancer?
11:15 How should a patient handle being advised to treat Gleason 6?
13:19 Can active surveillance continue indefinitely?
14:15 At what level is a PSA considered potentially concerning?
15:06 How often does a second pathology result in a new Gleason grade?
16:17 Is there any context in which a Gleason 6 patient should seek treatment?
17:49 Alex's conclusions
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The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.

Опубликовано:

22 май 2024

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Комментарии : 49

@insanecnc 4 дня назад

I am 61 and my Dr. recommended I get an MRI with contrast of my prostate because my PSA was at 4.4. The MRI showed a couple lesions so my Dr. recommended a biopsy. Out of the 12 or 13 core sample biopsies taken 9 of those samples came back all Gleason 6, 3+3. I am considering just doing active surveillance for now and do a PSA check every 6 months. But what makes me nervous is that 9 out of the 13 samples were considered cancerous 3+3. My Dr. went over a list of options but suggested removing the prostate may be the best option. As far as I know there is nobody in my family history with prostate cancer. My dad passed away at 90 years old but not from cancer and I do not believe he ever had a PSA test in his life.

@TERRY-cb2ku Месяц назад

I'm praying for a Gleason score of 3+3 or something benign when I have my biopsy soon.

@davidmarshall2486 Месяц назад

Thank you I’m a Gleason six getting a MRI done tomorrow needed to see this video and getting another biopsy done under Active surveillance

@monetizepresentknowledge5621 Месяц назад

I had an MRI targeted biopsy second time around instead of a regular random biopsy. Much more accurate and by the grace of God, results came back benign.

@tshelley4232 Месяц назад

I was diagnosed with 3+3. Urologist strongly recommended surgery removal of prostate. He got agitated as I deemed it not necessary. That was 5 years ago.

@colemant6845 Месяц назад

BTW... Another amazingly informative video with information that my Urologist(s) have never shared with me. THANK YOU!

@timothywest3575 Месяц назад

God bless you both for sharing this excellent info.

@afshinPROF Месяц назад

very grateful for your videos. I had a Gleason 6 diagnosis in 2017 (at 47 years old). I chose RP, which I agree may have been over-treatment. Now at 55 years old I'm having BCR (PSA .21) I had a PSMA scan (a month ago) which showed a small spot on a rib. Pelvic zone was clear. My radiologist thought the spot on the rib might be metastasis, but with the knowledge I've gained from your videos I was able to argue that "Gleason 6 doesn't spread." My team of doctors have now concluded that the PSMA spot was likely a "false positive," probably showing a spot from an old injury. I'll do an other PSMA in 6-12 months to check for any changes. A video on PSMA "false positives" might be a good idea. Thanks for all of your videos, which truly empower your viewers.

@user-ne1ql1rc1g 6 дней назад

If the radiologist assumed the spot on the rib was an old fracture and it ended up being a metastasis (prostate or other) you would sue him.

@RLTtizME Месяц назад

I am 76 and recently diagnosed (2/24) with prostate cancer with a Gleason score of 7 / 3+4. I have had my prostate digitally checked at every yearly physical for years. Diagnosed with an MRI, Fusion Ultra Sound used for the biopsy and a follow up PSA of 4.15 this month. My PSA has fluctuated between the 4's and 5's for years. I am on active surveillance for now. I don't think I would ever agree to a Prostatectomy (side effects and quality of life) unless circumstances were dire... but would explore other treatment options as discussed with my Doctor.

@markusrose9667 Месяц назад

Wish you had addressed whether it makes any sense to get one of those genomic tests after a G6 dx.

@Giovan_Nino Месяц назад

Very well put together..been watching this channel for a number of years now. However I’ve noticed you are getting so proficient and know what you are talking about so well, that you have managed to speed up your speech to a level that is now becoming difficult to follow..Just an observation with many thanks for your great work…

@joeysocks5718 Месяц назад

Thank you for the great information. I’m Gleason 6 for 2 years, and PSA remains steady. I’m in no rush to have surgery or get radiated.

@nvan78 Месяц назад

Initially considered Gleason 6 (3+3) in 2017 and been on Active Surveillance since. TURP surgery a year ago to deal with BPH issues as well, but my PSA has not diminished at all (last reading was 22). My sense is something has been missed here. Have a discussion with a radiation oncologist in about a week to see if they can shed any light on this. PSMA - Pet scan in the last two months which showed plenty of activity in the prostate and a suspicious thyroid nodule but thats about it.

@VictorDeLaCruz536 Месяц назад

In six month, my PSA drop from 213 to 163

@SeekingWisdom17 Месяц назад

PSA is very high for a GS 3+3. Do you have a high volume prostate?

@StarExplorer123 Месяц назад

What if you have Gleason 3+3 but the tumor breaches the prostate capsule? Then what?

@colemant6845 Месяц назад

This is a very confusing PCRI video for me... 11 years ago I was diagnosed with 3+3 PC. Had High Dose Radiation (HDR) and PSA declined to .2 for the last 11 years. Now my PSA has climbed to 6. The PSMA scan showed a single lymph node spread. 2 subsequent biopsies of both the Lymph node and and my Prostate were BOTH benign! Now... I have a Guided Fusion Prostate Biopsy scheduled (June 6th)... Is this the "best" next step??

@monetizepresentknowledge5621 Месяц назад

I had 3+3 and PSA 17 in 2018. I refused surgery. Last year I had PSMA PET scan and MRI targeted biopsy which was benign. My PSA was last at 15 and I am on active surveillance.

@johnstewart917 Месяц назад

In 2006 had prostectomy, pathology report gleason 6 3+3. No detectable PSA until 2016 then a slow rise. PSA now 0.2 and has been holding steady for 6 months. I have had PSMA PET and MRI (T3), nothing shows in the scans. My question, can this be a different prostate cancer? When the prostate was removed the tumor had not penetrated the capsule.

@user-ne1ql1rc1g 6 дней назад

Is Gleason 6 prostate cancer, by itself, a risk factor for developing Gleason 7 or higher cancer or is the risk the same as a man without prostate cancer, all else being equal?

@orangeguy3314 Месяц назад

Don't get the mri. I got a mri and didn't find anything. Also in the report. It said basically it wasn't good at finding for those having 3+3 or 3+4. Next time I'm going for a mri pet scan.

@fredwelf8650 Месяц назад

The issue with 3+3 as with any Gleason score is ‘why does metastasis occur?’ G6 is an ambiguous diagnosis because the underlying belief that it is not cancer belies the purpose of AS and the suspicion that the biopsy missed the cancerous tumor cells in the prostate. Furthermore, there is a skepticism about whether a g6 can become a g7, or a g7 into a g8. If cancer is a dedifferentiating process, why would it stop at 6 or 7 or 8, etc. That is, does the cancer stop with g6, or g7, etc. It’s doubtful. This implicates the “leap’ from a g score to ‘advanced’ or metastasis. In parallel, there seems to be a “leap” from cancer inside the prostate to cancer outside the prostate, to bone or lymph or elsewhere. The leaps indicate that the cause of metastasis is not well understood. Apparently, as cancer cells accumulate in the prostate, the likelihood of a breakout increases. But, might not the biopsy procedure cause cancer cells to escape the prostate. What causes metastasis; how does it occur? What is a metastatic event? Lastly, it is incomplete to claim a fact on the basis of data, as when very few g6’s out of 12,000 eventually developed PC. It is necessary to offer an explanation, reasoning. In other words, why does the probability of cancer increase for any initial condition?

@graemefraser1948 Месяц назад

“might not biopsy procedure cause the cancer cells escape the prostate?” This is a very good question. My limited research says that it’s possible, but is not considered as a relevant risk by the medical fraternity. Although there certainly seems to be support for moving away from biopsy. My semen was bloody for a month following a random/pattern biopsy….it certainly traumatized my prostate.

@cynthiabrenton9615 28 дней назад

Over the last few years my PSA has been slowly increasing. I’m 65. Last fall my PSA reached 4.0 and because of a family history of PC my urologist recommended doing an MRI & followup random 12 core biopsy if the MRI showed anything. 3 of the 12 cores came back with Gleason 6. I dropped approximately 40 lbs this spring on a low carb, no sugar, no alcohol diet. Recent PSA came back at 3.7. Can you tell me if the drop in PSA is most likely related to the weight loss?

@timstephens2866 Месяц назад

What is the ratio formula, mentioned in the video, between my PSA number and prostate size?

@TiHerr74 Месяц назад

In my case, my prostate measured 74 mL and my last PSA score was 5.7 ng/mL. So my PSA density is .077 ng/ml/cc. The lower the number, the better with .15 considered an actionable level.

@richardzelinka9411 Месяц назад

Divide the psa by the prostate size. The conventional wisdom is that any result below .15 is within the range of "normal".

@VictorDeLaCruz536 Месяц назад

I was diagnosed last year with Gleason 6 i’ve been on active surveillance for six months. I want to have the robotics surgery. I do not want to have this disease in me What you recommend.

@dondgc2298 Месяц назад

Look for a video called “why Gleason 6 is not cancer.” And relax and enjoy your life. And keep your prostate.

@bigr4655 Месяц назад

I had a 13 point biopsy (12 random plus 1 targeted) following a standard MRI that initially did not find anything but later did find a "speck" with another person looking at it. Nine of the 13 had nothing, the remainder had 3 + 3. My urologist says the volume was high at anywhere between 40 to 70% of the length of the core samples themselves. . The volume of a cancer cells never seem to be a topic of discussion, could you one day make a video discussing that aspect? Volume does not seem to be a topic of anyone's videos, and though I don't remember at the moment my urologist has stated that that my " high-volume" is a problem for me.

@bigr4655 Месяц назад

Btw, I was 59 when biopsy was taken. I'm 60 now in case you have any comments. Thanks !

@monetizepresentknowledge5621 Месяц назад

I was 56 when I had a random biopsy. That was in 2018. The problem is, it's a "random" procedure. Last year I had a PSMA-PET scan then an MRI targeted biopsy- that's where you're in the MRI during the procedure. These procedures are much more accurate. Don't depend on random medical treatment.

@monetizepresentknowledge5621 Месяц назад

Sorry, I meant 3+3, not 6+6.

@glennvergara9178 Месяц назад

I was diagnosed with Gleason 6 with pi rads 4. My psa is 4.61. I am on active surveillance now.Is my cancer serious or low risk? What are my options? I'm 74 years old.

@TERRY-cb2ku Месяц назад

I would think you're low risk. That's just my opinion. My PSA is 4.3 having dropped from 5.56 after a round of antibiotics for a UTI. I've had the MRI which shows an 8mm lesion in the left anterior portion of my prostate. But, I knew I had calcifications in my prostate 15 years ago. I'm hoping the biopsy will show the same. If that proves to be the case, or I get a 3+3, I will be an extremely happy man and will praise God to the highest. I'm almost 73 and I definitely won't have treatment unless it's absolutely necessary. I've done the research and read the comments section. A disease that affects more than half the male population at one time or another deserves better treatments with less side effects.

@monetizepresentknowledge5621 Месяц назад

In 2018 I was diagnosed with 6+6 and PSA 17. My urologist suggested radical surgery but I decided against it. Last year I had a PSMA-PET scan then MRI targeted biopsy that found nothing, even though my PSA is still elevated at 15. Be careful and don't let them rush you into anything.

@monetizepresentknowledge5621 Месяц назад

Sorry, I meant 3+3, not 6+6.

@olivergrossettolivergrosse3116 24 дня назад

Can 3+4 regress to 3+3 and From PIRADS3 to PIRADS 2?

@postmurrmerkulov9295 Месяц назад

After the biopsy, my result was 3+3. After the operation pT3a and also 3+3. And also R1

@waelfadlallah8939 Месяц назад

You shouldn't have done the surgery

@iamric23 Месяц назад

Why were so many men who were diagnosed with 3 plus 3 operated on to remove their prostate? Is this something that I should have done to me, I also have a 3 plus 3. I forgot to thank the two of you, without these videos I would be lost.

@monetizepresentknowledge5621 Месяц назад

Because it is a huge business and urologists are surgeons. Don't let them scare you into surgery when 6+6 isn't even considered cancer.

@Blanco83 Месяц назад

If Gleason 6 does not spread why do active surveillance? Seems like you waiting for the train to leave the station, then you would be dealing with a bigger problem.

@user-ne1ql1rc1g 6 дней назад

Because the train may never leave the station and the treatment could be worse than the cure.

@jamesdante2335 Месяц назад

Can 3+3 ever lead to biochemical reoccurrence?

@dondgc2298 Месяц назад

You can’t have recurrence if you have not removed anything.

@fredwelf8650 Месяц назад

@@dondgc2298. You can have recurrence if you became undetectable or negligible with ADT and the cancer returned increasing the PSA. imo

@dondgc2298 Месяц назад

@@fredwelf8650 valid point. I was really trying to get at “what are you doing to this Gleason 6 that it has disappeared to the point there can be a recurrence,” given that Gleason 6 is generally not treated. But of course you are correct.