Leah4sci.com/Grignard presents: Grignard to Alcohol Synthesis Shortcuts when reacting with formaldehyde, aldehyde, ketone and ester
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Grignard reagents are useful for chain elongation of carbonyl compounds in organic synthesis and retrosynthesis questions.
This video will give you tips, tricks, and shortcuts for predicting the specific alcohol products of Grignard reactions with aldehydes, ketones, and carboxylic acid derivatives such as an ester.
You’ll see a quick overview of the mechanism for each of these reactions, with an emphasis on the similarities and differences between the alcohol products, including degree of substitution and symmetry.
Finally, you’ll learn a shortcut for predicting which Grignard reagent was used, when given the product, in a retrosynthesis.
↪ Links & Resources Mentioned In This Video ↩
▸Grignard Series + Cheat Sheet Leah4sci.com/Grignard
▸How to Tackle Organic Chemistry Synthesis Questions Leah4sci.com/synthesis
▸A Simple Approach to Retrosynthesis Leah4sci.com/retrosynthesis
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⏱ In this video:
[0:32] Formaldehyde + Grignard Mechanism
[1:41] Aldehyde + Grignard Mechanism
[1:57] Ketone + Grignard Mechanism
[2:20] Ester + Grignard Mechanism
[3:57] Overview of Alcohol Products
[4:42] Retrosynthesis Examples
[6:16] Shortcuts for Grignard Retrosynthesis
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4 апр 2022
