How Enzymes Work (from PDB-101) 

I have done this in Persian. but it does not end "saving" :/ what is wrong there?! BTW your videos are great (y) I hope to translate them into my maternal language :)

FONSI!!!!!!

I want to translate this video to my native language (Turkish) but RU-vid is about remove community contribution. How do I translate it for you so its added by creator, and not the community?

@@yyyaaa3928 I believe if add them before September 28, we will be able to publish them. I believe once the community contributions go away the ones we have published will not be deleted. It means the community will not be able to contribute new ones.

@@eatemadfanaee5954 Not sure. Perhaps try again? We are glad you like the videos.

Hey it's Professor Dave!

Hello sir

He knows a lot about the science stuff...

...Professor Dave Explains...... *sound effect*.

Professor dave

It's actually easy (for scientists who are experts in this field and/or have the resources to accomplish this) to map out every single atom. One way they do this is to accumulate an amount of their target molecule (a protein for example), crystallize it, put in in an X-ray scanner then blast it with an X-ray pulse. The cristal (made of proteins) will scatter the X-ray into a specific pattern; and from there they can determine the structure of the molecule.

@@gelatinocyte6270 Thanks. Is this the technique developed by Rosalind Franklin? I read a book "In Search of the Double Helix" by John Gribbin, about the discovery of the structure of DNA, where it was mentioned too. Nonetheless, it still looks amazing to me :)

@@gelatinocyte6270 did you just say X ray cristallography was „easy“? My thousands of optimization conditions would like to have a word with you lol

well, unfortunately, while atomic positions can be routinely mapped and often with high reliability, the movements of the atoms cannot. this is one of the most severe constraints in deducing enzymatic mechanisms. animations like this one are *theories* of how the enzyme does its job. they may be supported by a great deal of structural and reactivity data of various types, but are still theories. computational modeling holds great promise for letting us envision the detailed dynamics of enzymatic mechanisms. the most plausible path forward at this point is the co-development of mechanistic theory and computation.

Me too!

@@amluzia Our minds... XD

Yeah, the amount of "knowledge" that is based on no knowledge at all, just repeating phrases others have said, is insanely high. Everyone thinks they know something, because they can repeat the words. And then ppl in school wonder why kids don't get it. Well, cause you don't really explain it! That's why. Just try to find this level of explanation on youtube. Took me 30 minutes to get through the gazillion of videos that just teach me "nomenclature" and basically descriptors, for a problem I haven't even understood yet before watching this video. How is a mind supposed to comprehend abstraction and meta layer information (like in all the other videos) when the mind hasn't had a chance to see the specific mechanics that are being abstracted.

Same

Same, thats what I expected by my biology book 😂😂😂😂

They would if they can - but to transport the sound you need to have a transporter which is normally air, but in thic case there is obviously no air sourrended. But if you move your ear close, very close ...

All the time! And that vague bubbling sound you hear in the background? That's really what it sounds like down there! 🙂

@Archaeopteryx Lithographica What are you talking about...? This is one of the only videos they have, and none of the data that I can find has any paywall. They even have a tutorial on how to make renderings of the protein structures... and the database itself is free...

Tom Jerry I tell you they are dancing. Life is a dance.

Reminds me of Tom the cat chasing Jerry the mouse

Lol

Lol

Lol

Just as mind-blowing to me the complexity of the chemistry is the observation that so many people think if you leave a can of Campbell's Primordial soup out in the sun a billion years too long, this type of stuff is eventually what you'll get. Huh?

@@Mark16v15 Just as mind-blowing to me is the observation that so many people, when faced with complexity in nature, rush to embrace specious and evidence-free teleological explanations.

@@alexross5714 Based on your comment, I think I see a difference between us with respect to our perceptions of reality, as shown in my example below. We both are walking together along the seashore and come across some seashells lined up in such a way that they spell, "Sally Loves Joey". ME: Look, someone came along and wrote "Sally Loves Joey" with some seashells. YOU: Why do you think such complexity had to come about from design or purpose? When shells wash up on the beach, they can land anywhere. Most likely, these just happened to randomly wash up together in such a way that by accidental happenstance they only appear to look like the sentence "Sally Loves Joey". It's mind-blowing to me the observation that so many people are like you, when faced with complexity in nature, rush to embrace specious and evidence-free teleological explanations. ME: Huh? Are you serious? I want to thank you for introducing the word "teleological" to me. I always like learning new words. You have a good day alex. For others reading this, wondering how I came about my response, the above is an example of exercising option 2 of Proverbs 26:4-5, noting that writing "Sally Loves Joey" is literally child's play compared to the infinitely more complex production of enzymes and proteins.

Hi

The creator of all life is Yahway.

Wonderfully designed systems, too, Jerry.

I was going to say the same thing, @@IsaacNussbaum. It's shocking that people actually believe any enzyme was designed by natural processes.

@@KenJackson_US it's shocking that after science advances more and more using the scientific method, there are still people to continue to search for the supernatural within every new discovery.

In fact, @@AleksandarKamburov, it is science that finally educated me to the fact that natural processes _can't_ produce new proteins, new molecular machines, new organs, or therefore new body plans. It wasn't a bad hypothesis back in the 19th century, long before modern science uncovered DNA or any molecular machinery. But errors (mutations) don't accumulate to form the *complex, hierarchical, interdependent* systems that proliferate through life. Life was clearly designed. The revelations of science confirm it.

@@KenJackson_US BS

Thank you for pointing it out. The closed captions were added.

I actually come up with an exercise where I had extracted the automatic closed captions and wanted them to correct the errors =) I'll come up with something else.

@@mortengrftehauge7416 ah, what a great teacher, i would love one of you for a couple semesters

Thank you!

That is what I think about every night

Microscopes, chemical analyses.

@@lionfire3359 Ok I know for a fact that microscopes are no use for figuring out biochemical pathways and looking inside the active site of an enzyme

Time resolved X-ray crystallography and NMR with either inhibiting substrate-like molecules or metallic ions.

@@ambervale6172 The work of hundrends of scientist working in biochemistry during years.

Life is beautifully complex as well :)

The Universe is elementary complex :)

The living thing said that life is complex for it's living complex brain in fact to brain