How science can reverse aging - and why we’d want to

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I believe that aging is our greatest humanitarian challenge, and that science can help us solve it. Find out more about my book, Ageless: The new science of getting older without getting old, at ageless.link/
Where to buy
US
Amazon: ageless.link/amazon-us
Apple Books: ageless.link/apple-books-us
Barnes & Noble: ageless.link/barnesandnoble
Books-A-Million: ageless.link/booksamillion
Bookshop.org ageless.link/bookshop.org
Penguin Random House ageless.link/prh
Audiobook on Audible: ageless.link/audible-us
UK
Support independent bookshops by ordering from Hive: ageless.link/hive
Waterstones: ageless.link/waterstones
Amazon: ageless.link/amazon-uk
Audiobook on Audible: ageless.link/audible-uk
Australia
Amazon: ageless.link/amazon-au
Audiobook on Audible: ageless.link/audible-au
Other countries
Ageless is also available in other countries around the world-just search for Ageless wherever you get your books, and you should be able to find a copy in English. It’s also in the process of being translated into (so far) ten different languages. I’ll add links here when these become available!
Some links are affiliate links and I will receive a small payment if you choose to purchase through them. Thanks!
Video chapters
00:00 Introduction
00:57 Why aging is our largest humanitarian challenge
05:24 How science could help
06:07 The hallmarks of aging
06:22 Senescent cells
08:55 Preventative treatments for aging
11:04 Where to get Ageless
Sources
Here are some of the sources I used when researching this video:
Calculation of number of deaths caused by aging based on Human Mortality Database data. You can find a report explaining the calculations, and the code behind it, on GitHub: github.com/ajsteele/ageless
Calculations of disease risk with age based on World Health Organization Global Burden of Disease (WHO GBD) statistics. Calculations also available at github.com/ajsteele/ageless
Coronavirus mortality with age (technically the age-specific infection fatality rate) was extracted from Figure 2(A) in this paper: O’Driscoll, et al., Nature (2020). doi.org/10.1038/s41586-020-29...
The hallmarks of aging I list are the ones I used in Ageless. They’re based on a paper called the Hallmarks of Aging, published in 2013, which enumerated nine hallmarks. I added two and combined two together, giving one extra hallmark overall. López-Otı́n et al., Cell 153, 1194-1217 (2013). doi.org/10.1016/j.cell.2013.0...
The 2011 paper in which scientists removed senescent cells with a ‘suicide gene’: Baker et al., Nature 479, 232-36 (2011) doi.org/10.1038/nature10600
The 2015 paper describing the first ‘senolytic’ drug combination, dasatinib plus quercetin: Zhu et al., Aging Cell 14, 644-58 (2015) doi.org/10.1111/acel.12344
Thanks
Thanks to Tran Nguyen for her help with this video! / @drmedtran / drmedtran

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24 июл 2024

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Комментарии : 109

@Blackmark52 Год назад

1:25 *"What this looks like is a rather terrifying graph."* Guess that is a matter of perspective. As a 70-year-old I want the last bit to go fast. The curve MUST be steep at the end, the steeper the better. Worrying about the length of the flat part is a waste of time when you start to realize how long you've lived.

@MsYoutuebchen 3 года назад

Like I’ve always said: I want to die as healthy as possible as late as possible.

@therabbithat Год назад

Yeah 20 years life extension just raises eyebrows. Even 5 extra years of health would be world changing. If the average age of all age related illnesses was 5 years later, or 10 years, or hell, 1 year! That's what is exciting, that why what's being researched is so exciting.

@TSutton 3 года назад

Honestly Andrew these videos have the production value of a channel 100x your size, you have such an impressive clear and concise way of explaining complex topics. Give it a few months of producing more content like this and you’ll be at 15K subs I can guarantee! Keep it up!

@DrAndrewSteele 3 года назад

Thank you! I will keep at it so I hope you're right! :)

@seasong7655 3 года назад

I hope the medication is released soon. I don't want to live pratically forever without my parents.

@raysonlogin 3 года назад

Losing someone sucks! :(

@mikewade1604 3 года назад

Agreed, I love my parents.

@aneki3394 3 года назад

Dont worry, in 20 years, humanity will have some therapies to extend our lifes

@nicholasaurus 3 года назад

@@aneki3394 She said she doesn't want to live without her parents.

@aneki3394 3 года назад

@@nicholasaurus do you think her parents will die in 20 years?

@therabbithat Год назад

If rabomycin is THE med (forgive my spelling? ) how long before there are generic forms?

@SilverFan21k Год назад

This video deserves more views..... people need to appreciate this subject more compared to your Wordle one, etc.

@DrAndrewSteele Год назад

Fully agree, I make videos about fun stuff to try to get views for this kind of stuff! (Which I do also think is fun!)

@minapatel1737 3 года назад

Just watched you on Sunday Brunch, I was captivated by you, you come across as a very important person, thank you for sharing this important topic with us, am looking to reading your book

@DrAndrewSteele 3 года назад

Thanks Mina! Hope you enjoy the book. :)

@VOLightPortal Год назад

Is there a source reference for that graph at 1:50

@DrAndrewSteele Год назад

Yes, my sources are always in the video description! In this case: Calculation of number of deaths caused by aging based on Human Mortality Database data. You can find a report explaining the calculations, and the code behind it, on GitHub: github.com/ajsteele/ageless

@DonAlonzo 3 года назад

I'm looking forward to reading your book!

@DrAndrewSteele 3 года назад

Thank you! Hope you enjoy it!

@CheriLyn-music 3 года назад

Nooooo wayyyyy the book has arrived. Yesss i am sooo excited 🥳

@DrAndrewSteele 3 года назад

Woooooo :)

@supernaturalawesome1 3 года назад

At what age would you stop aging and how long until you die. Heart just stops, no getting old? Me: 25 Life Span: 1000 years

@SebastianNiemann 3 года назад

A great book! Thank you very much! A great overview of the whole field. Love it 🙏🖖

@DrAndrewSteele 3 года назад

Thanks very much, that's very kind :)

@anon-il9qf Год назад

@@DrAndrewSteele didn't you do a ted-x presentation? aren't you in the market for self promotion? tsk tsk, guess i now have a license to dismiss any single thing you put up online. pro tip: be less smug and less phoney online and maybe you'll make more friends and actually put up information that has good substance vs good packaging.

@vaibhavpatel7910 3 года назад

Can anybody please tell me , how can I buy this book in canada?

@DrAndrewSteele 3 года назад

It should be available in most bookshops in Canada! It’s coming on March 23rd. :)

@LiveForeverorDieTrying 3 года назад

So excited to have my hands on the ARC Andrew. Thank you for spreading the good word!

@DrAndrewSteele 3 года назад

I hope you enjoy it! :)

@LiveForeverorDieTrying 3 года назад

@@DrAndrewSteele I've heard great things, I'm sure i will!

@Danuxsy 3 года назад

Great video Andrew.

@classicrock1027 2 года назад

Ok so I have 2 questions Can this med be like if you were 60 and you would take this would it be like you would look and feel 20 again (I’m not 60 tho lol) 2 : when do you think this med will be released

@aliimran8479 3 года назад

Great video as always..

@andrewhobbs5268 2 месяца назад

A cure for ageing is somthing we should all want for us family pets and older relitives we can do this its just when for me

@psiphisapiens 2 года назад

Brilliant job!

@SnikieViniciose Год назад

Loved the video !!! If I may, I think the video would benefit from a few images/videos/clips to visualize a few of the cells, subjects, etc. I think it could keep the viewer implicated longer in the video, for a longer watch time.

@jacobdaboss8413 Год назад

Can't believe granny lost a dice roll she never lost at dice.

@marianbadea369 Год назад

6:27 Ageing is only one thing... Oxidative stress caused by toxicity and other forms of stress. All the 10 on your list stem from this!

@thegoodlydragon7452 3 года назад

I think that WHY we should cure aging is obvious. The real question is HOW to do it, and how we can hurry up to be in time for most of us who are around now!

@DrAndrewSteele 3 года назад

You might be surprised how many people aren’t sure about the why! I agree though, I hope these treatments are available ASAP. :)

@andrewhobbs5268 4 месяца назад

i agree i want this so i can save family pets and older relitives i dont want to lose them and we wont have to not if we cure ageing hope it happens sooner

@samiraly07 3 года назад

As I m watching you now on today show from INDIANA state I searched your name on RU-vid and I m a new subscriber So happy to find your channel

@DrAndrewSteele 3 года назад

Thank you! Happy to be spreading the word in the US!

@shivamrichhariya4343 3 года назад

Very good Sar ,God bless you .

@lakestreet3951 Год назад

You’re so tense. Relax man. 🧘🏼‍♀️

@DrAndrewSteele Год назад

THIS COMMENT REALLY HELPED ME RELAX THANKS!!!!!

@treeeva 11 месяцев назад

@@DrAndrewSteele😂😂😂 Thanks for the chuckle.

@pavelbaidurov228 3 года назад

Like from Russia, I'm very optimistic about future innovations because if nothing will happen - social and medical sectors will collapse with a current demographics, also people live so long even today - children have no place to live, property is so costly for many, people in Japan and in Russia as well sometimes work&live with parents up to 35-40yo just to collect some money and live in their own house. After first million of ultra rich will use these new methods like epigeneric rollback/AGEs breakers/etc - it will be cheaper than a phone. Also to be 80 and look and feel 30-40 it will be ultra popular, it will be a market x10 bigger than current cosmetics. Also sound quite futuristic and new.

@Ars-vb7tm 3 года назад

I have been thinking the same from my 24 years to today in my 30s and over to have my grandmother longer 🙂

@larubisco4074 2 года назад

Still waiting for it in Argentina. Have a great year!

@conversascontroversas7384 3 года назад

Cure aging please

@andrewhobbs5268 3 месяца назад

i agree with you iwant this so i can save family pets elderly relitives i dont want to lose them and we wont not unless we cure ageing hope it happens sooner than later

@megacodex2597 Год назад

death is unstopeble, and there is a reason why.

@patrickjos8922 2 года назад

Hello M.Steele we would like to hear you also talk about cryonics. There's no life extension strategy possible without it. Why it's so critical to fund,improve,advocate for cryonics? When science today says "nothing can be done so let's burn or bury this body"cryonics reply that we will pause the process to bring you to the future when science and technology hopefully could be able to revive you. By being alive means we can die at any moments,having the option of cryonics is crucial. There's a tremendous work to be done to put cryonics as a viable option for anybody who wish it.

@AidanRatnage 3 года назад

If we do solve all 10 hallmarks could immortality be plausible?

@DrAndrewSteele 3 года назад

I suspect after we solve these ten hallmarks we'll find more that aren't such a problem in current human lifespans, or we've just missed… But human biology is finite, so eventually I'm pretty confident we'll crack it. Immortality is going to be a tough nut to crack because there will still be buses to fall in front of, an infectious diseases, but we'd certainly live a lot healthier for longer!

@AidanRatnage 3 года назад

@@DrAndrewSteele I meant the sort of "soft immortality" like you'd need to be killed to die, but wouldn't naturally die.

@DrAndrewSteele 3 года назад

@@AidanRatnage If we really did cure ageing and make people's death rates the same as a young adult, we could perhaps get close. There are still a few 20- or 30-somethings who get cancer/have a heart attack etc, but it's obviously very rare. What I hope for is ‘biological immortality’-death rates that don’t depend on how long ago you were born. :)

@SlamminGraham 2 года назад

Please save us, science.

@RyanLawless 2 года назад

It's interesting how aging and death are seen as inevitable results of life, but they're no more impossible to mitigate as deep sea or space exploration. It's all a matter of applying resources to the study of each with a corresponding redesign of how we view the process of aging and whether death represents more than just the cessation of cellular activities in living organisms.

@andrerodrigomaitamedrano1338 2 года назад

felicidades para los paises anglosajones , el resto del mundo nos iremos al diablo pero hey asi es el mundo

@Dr_Oleg_Kulikov 2 года назад

The main cause of aging is stiffening of the extracellular matrix (ECM). And it is not even in the list of hallmarks of aging! My big dislike to the video.

@DrAndrewSteele 2 года назад

It is actually! I list it as a sub-hallmark under ‘protein problems’ in Ageless-maybe you’d enjoy the book where I’ve got a bit more than 12 minutes to go into more detail. :)

@Dr_Oleg_Kulikov 2 года назад

@@DrAndrewSteele Stiffening the ECM is the MAIN cause of aging. All the rest is a consequence of it. Even accumulation of trash in the ECM is going because macrophages cannot migrate through the stiff matrix amd eliminate the trash. So, if you don't understand it then I believe your book is a kind of trash that only mislead people.

@DrAndrewSteele 2 года назад

@@Dr_Oleg_Kulikov I don’t think that’s fair. The ECM is certainly neglected as a cause of ageing, but to say it’s the main one is to misrepresent the science. Even the two two ECM ageing experts I interviewed for the book didn’t say it was the main cause of ageing! Perhaps you’d learn more by reading it that you think. :)

@Dr_Oleg_Kulikov 2 года назад

@@DrAndrewSteele Wow. Did you just deleted my reply to you? It tells a lot about you as a scientist. Congratulations. I believe your book will have a commercial success in this clown world.

@DrAndrewSteele 2 года назад

@@Dr_Oleg_Kulikov No, your reply is right there! See the full comment thread (if you clicked on the notification it sometimes only shows the latest comment)

@Portia620 Год назад

This guy is like more morbid an the virology dudes I watch!! lol

@iantroggs 3 года назад

Meanwhile Intermittent Fasting Ketogenic Diet Fasted Cardio Simples

@howin9235 3 года назад

Are u also biologist ?? U also physicist And how u write book so fast I think u 👽

@leftysheppey 3 года назад

Honestly, I'd rather die than live forever. Life is already long enough. Maybe that's just depression speaking though 😅

@DrAndrewSteele 3 года назад

It's not about living forever! It's about reducing disease, which is a huge source of depression in older people. :) Take care!

@altargull 3 года назад

Removing aginig doesn't mean you'll never die. It means you'll live much healthier and for as long as you want (or until you get in an accident)

@ruffryderprabhu6206 3 года назад

I am poor pls give me it for free i badly want to know and learn abt this

@DrAndrewSteele 3 года назад

Request your local library order a copy :)

@ruffryderprabhu6206 3 года назад

@@DrAndrewSteele thanx sir

@GrimDarkHalfOff 2 года назад

Look this all sounds wonderful, but let's be honest the poor will never have access to these treatments even if they begin to exist in the future. Fix income inequality and the wealth gap then I'll care. When the future looks like everyone being long lived instead near immortal billionaires and street urchins who die in their 20s I'll support you. I think that's fair.

@DrAndrewSteele 2 года назад

I agree it’s only fair to support these ideas if there’s good access for everyone, not just the rich-and I think it’s very likely to be the case, or I wouldn’t be promoting it! I’ve got a full video on the way about this, and will also be releasing a free extra chapter of my book soon to go into more depth about the ethics of treating ageing. It’ll be available at ageless.link/ethics As a really quick summary: the treatments are unlikely to be that expensive (most drugs can be produced pretty cheaply once off-patent and, while more advanced treatments will probably cost more, the economic benefits of treating ageing will encourage governments to make sure they’re available to reduce healthcare costs overall); and billionaires don’t want to be the only people taking these drugs! The only way to be sure they work is huge clinical trials and reliable measures of biological age, which mean billionaires, even if they were being selfish, would support the development of an industry around this, rather that brewing their own risky bespoke cocktails in an underground lab. :)

@GrimDarkHalfOff 2 года назад

@@DrAndrewSteele thank you