How to Optimize Fertility in Males & Females 

Please note: at the timestamp related to cumulative probability of pregnancy (2:01:30), I misspoke, my apologies. The data in the following graph are correct but the “120%” is not. The appropriate equation is 1-(1-p)^n where p is the probability of getting pregnant in a given cycle and n is the cycle number. Therefore the equation for this scenario is 1-(0.8^6). Using the equation, cumulative probability over 6 cycles is 73.8% (rounded to 3 significant figures). For a visual representation: www.researchgate.net/figure/Cumulative-probability-distribution-of-conception-over-time-number-of-cycles-with_fig1_10610311

A note on the probability of success conception touched on in the middle of this video. The probabilities are not cumulative. They are independent events, the rough equation is 1-(1-p)^n, where p is the probability of conception and n is the number of attempts. So if there is a 20% (or 0.2) chance of conception and there are 6 attempts the probability of conception is 1-(1-0.2)^6 or appropriately 74%. Assuming a 20% conception rate, the cumulative odds of conception are as follows: 1 attempt: 20% 2 attempts: 36% 3 attempts: 49% 4 attempts: 59% 5 attempts: 67% 6 attempts: 74% 7 attempts: 79% 8 attempts: 83%

Takeaways: -Fertilization: The process by which sperm and egg cells come together to form an embryo. -Menstrual cycle: The process in females that prepares the egg for fertilization and leads to the shedding of the uterus lining if fertilization does not occur. -Spermatogenesis: The process of how sperm cells are produced. -Embryogenesis: The development of the embryo after fertilization. -Fertility: The ability to conceive a child. -Hormones: Chemical messengers that play a key role in the onset of puberty, the menstrual cycle, and the production of hormones in the gonads. -GnRH: A hormone that activates cells in the pituitary gland, leading to the release of LH and FSH. -LH and FSH: Hormones that travel in the blood and affect the gonads, leading to the production of estrogen and testosterone in females and males respectively. -Sexual differentiation: The development of female and male genitalia. -Factors that affect fertility: Science-based tools, prescription drugs, acupuncture, and the presence of certain scents and odors. -Hormones effects on cells and tissues: Different hormones can have different effects on different cells and tissues, such as testosterone stimulating hair growth and estrogen enlarging breast tissue. -Ovulatory menstrual cycle: Triggered by FSH and to some extent luteinizing hormone. -Medical conditions that affect the menstrual cycle: Polycystic ovary syndrome (PCOS). -Understanding the biology of fertility and fertilization can help couples facing infertility issues. It is important to consult with a healthcare professional for personalized recommendations Sperm Survival and Fertilization -sperm survival after ejaculation, timing of intercourse for successful fertilization, sperm quality and concentration in ejaculate, optimal strategy for fertilization -Sperm can survive for a certain period of time after ejaculation, and couples should aim to have intercourse with ejaculation around the time of ovulation to increase the chances of fertilization. Ejaculate contains varying levels of sperm quality and concentration, and with each successive ejaculation, there is a decrease in the concentration of sperm per milliliter of semen. The optimal strategy for fertilization involves maximizing the concentration of healthy sperm within each ejaculate and timing intercourse around the day of ovulation. Factors such as the woman's age, health, and fertility also play a role in determining the best timing for intercourse. Cumulative Pregnancy Rate -probability of conception, cumulative pregnancy rate, independent probabilities, fecundability -The probability of conceiving in one month is around 20% for women under 30 years old, but independent probabilities do not apply to fecundability as it is a cumulative pregnancy rate. Fertilization is not just about the egg, but also the sperm and multiple probability events are at play. The likelihood of pregnancy depends on the independent probabilities of the sperm and egg meeting and fertilizing. Women under 30 should try to conceive naturally for at least five or six months before seeing an OB GYN, and older women may need to try for longer periods before seeking help. It is important to understand the concept of cumulative pregnancy rate to understand the process of fertilization and the likelihood of getting pregnant. AMH and AFC -AMH, antral follicles, ovaries, age, probability of successful fertilization and pregnancy -AMH (Anti-Mullerian Hormone) is a structural imaging measure of the antral follicles in the ovaries. The typical trend is for the number of antral follicles to decline over time. A woman in her 20s or 30s might have 20-40 antral follicles exiting the reserve each month, and the number of antral follicles and the levels of AMH will decline with age. It is a good idea for women interested in conceiving in the future to get their AMH levels or follicle count measured regularly. The earlier and more frequently a woman measures her AMH and follicle count, the higher the probability of successful fertilization and pregnancy. Intermittent Fasting Ovulation and Hormone Administration In-vitro Fertilization (IVF) -Egg and Follicle Collection -Sperm Collection and Washing -Embryo Creation and Implantation -ICSI and Embryo Selection -Sex Selection Cannabis Use and Fertility Behavioral Interventions and Fertility Acupuncture and Fertility Nutritional Supplements for Fertility -Coenzyme Q10 -Inositol -Myoinositol -D-chiro Inositol -Folic Acid -Vitamin D -Zinc -Selenium -Omega-3 Fatty Acids -Antioxidants Stress Management and Fertility Zinc and Male Fertility -Food Sources of Zinc -Dosage and Supplementation Recommendations Intermittent fasting is a dieting pattern where an individual alternates between periods of eating and fasting. It's important to consider whether or not you are overweight or lean when determining if intermittent fasting is right for you. Ovulation can be suppressed through the administration of exogenous hormones. Under ultrasound guidance, an OB GYN can collect mature eggs and follicles and put them in a dish. Sperm can be delivered to the dish, either frozen sperm or live sperm collected that day. The sperm are washed through a straightforward procedure. The sperm compete for the eggs and fertilize them, allowing them to advance to the early embryo stage. The embryos can be frozen and later implanted into a woman for full term pregnancy. In-vitro fertilization (IVF) is a medical procedure that involves collecting eggs from a woman and sperm from a man, fertilizing the eggs in a laboratory, and then implanting the resulting embryos in the woman's uterus. A specific sperm can be selected for fertilization through a process called ICSI. Multiple fertilized embryos can be obtained through this process. The genetic makeup and karyotype of the embryos can be examined, allowing for sex selection. Sex selection is only possible through IVF. Recent research suggests that sex selection is also possible at the sperm level before fertilization. Clinics outside of the United States have developed methods to separate sperm into fractions that give rise to male or female offspring, allowing for more reliable sex selection. Cannabis use can negatively impact egg and sperm quality. Avoid using cannabis, whether smoked or vaped, when trying to conceive or during pregnancy. Behavioral interventions, such as pelvic tilt, can improve fertility. Acupuncture is a proven effective treatment for improving fertility and pregnancy outcomes. It has been shown to be effective in clinical trials funded by government agencies such as the National Institutes of Health. Acupuncture is no longer considered fringe science. Acupuncture can also be beneficial for hormone status, stress relief, and chronic illnesses. Acupuncture works by stimulating neural pathways that link different organs of the body. Nutritional supplements such as Coenzyme Q10, Inositol, Myoinositol, D-chiro Inositol, Folic acid, Vitamin D, Zinc, Selenium, Omega-3 fatty acids, and antioxidants can improve egg and sperm quality and overall reproductive health for both men and women. Stress management can improve overall reproductive health and increase chances of conception by reducing stress levels and improving overall well-being. Zinc is a key nutrient for males to consider in terms of increasing fertility. Zinc can be found in foods such as oysters and can increase testosterone and dihydrotestosterone levels. A dosage of 120 milligrams of zinc twice per day with meals is recommended for maximum benefit. Zinc supplementation should be done with meals to avoid stomach discomfort. -It is important to consult with a healthcare professional for personalized recommendations

Been waiting for this one! I would also love an episode specifically about supporting healthy pregnancy/fetal brain development as well as infant/early child development.

After discussing so much about fertility and people wanting to have children we should definitely do deep dives on childhood development. It was adressed lightly in several episodes: attachment styles, trauma etc... but a deep dive into a child's brain development and the effects of the environment and interactions as he/she grows would be amazing. You have demonstrated that solely the conception of children can be an enormous challenge. Parents probably don't squander all that effort on purpose by messing up their child. They probably just don't know what they and their child needs.

Me and my husband were struggling to have children. After running some tests my husband sperm quality wasn't great. We sat down and watched the whole podcast and did the things recommended for male fertility. As mentioned in the podcast after 90 days we got a positive. We've now got our beautiful baby. Thank you Huberman for your time and podcasts ❤

Dear Huberman! I'm listening from Hungary. My english is not the best, but you speak so well and explain the things clearly that I can understand most of what you say (automatically generated captions are also very helpful). I always learn a lot from your podcasts and this episode was extremly helpful for me. Your enthusiasm for science and to share knowledge with others shines through every minute of your videos. Thank you very much for the valuable content!

I listen to huberman podcasts while exercising every morning to gain knowledge while improving my physical health.

Huberman should wear a cape.

It’s leg day!!! Huberman’s podcast is my favourite podcast by far. He’s such a wonderful teacher. I think he was born to do it. The amount of content he put out every week is crazy. I’m a retired RN so science and medicine podcasts and lectures (nerd) make me feel like I’m still learning which I love. I’m in my early 50s and would love a show about hormonal changes as we age. Menopause has been a complete nightmare for me and I’m sure I’m not alone.

I don’t have kids nor plan to have any but I know so many people who struggle with infertility and had to get IVF treatment. I know this information is greatly appreciated. Hormone health affects everything.

PLEASE do an episode on Women’s hormonal health issues like PCOS, insulin resistance, hashimotos and all!!! We women are tired of suffering and having so many conflicting opinions on these!!! Thank you Dr. Huberman!!

Only Andrew Huberman can make me sit over 4 hours and have my attention only on one thing: his podcast. Very informative ! Thank you for all that you do, it is a great benefit to all if us!

In a world where it can be so difficult to get good information, it’s a blessing to have podcasts like Huberman Lab to turn to. Thank you for your contribution to the public Andrew!

Me and my Mrs had our first set of IVF treatment fail yesterday, so I've made notes and hopefully something will work. This is a incredible indepth video, so thanks for all your hard work for getting it out there.

A key indicator of intelligence is being able to absorb mass amounts of information and repeat that information to another person in a way that is easily understandable and digestible. So grateful for your podcasts, I am amazed every time how you take all of this information and present it to us in a way that is engaging and actionable for the average person.

How much time did you need to record this 4 hr long episode Dr. Huberman? Such dedication and efforts to bring zero cost information to general public. God bless you.

Thank you so much for covering this topic! I'm a nurse midwife, women's health NP student and I know this topic will come up continually. I just wish I had the 4.5 hours to watch this instead of studying for my tests which won't give me a 10th of what you provide for free! A condensed version would be so so appreciated. Your are an amazing person and are changing health and wellness. Your podcasts should be required in all medical and nursing schools! Thank you!!

4 Hours ❤. It’s Huberman and chill.

Watched the whole episode (on regular speed too (I’m typically a 1.5X viewer)). Took me over a month to get through it all in a way I could digest and retain the info. Well worth it. What a great service being provided here. Thank you so much.

As someone who has studied this topic extensively, I am amazed to find that there were so many gaps in my knowledge about the process, that all were made clear with your amazing research Amazing episode. Thank you

I'm addicted to this podcast 😎 I listen to it whenever and whereever I can. Thank you for this continuous flow of high-quality knowledge 🙏

Hey,Andrew, If you are reading this, please keep reading. Please don't skip. It's a request. You are the most wonderful human being running the most wonderful podcast ❤️ . I just want to tell you that till date you haven't covered a single podcast for STUDENTS(even if you are a professor,no pun intended 😃.) I just want you to know that you should cover a whole podcast for students because you know we sometimes have a lot of issues regarding our studying. I have listened to many podcasts of you on other podcasts also (when you where a guest on other), but no one asked you a question about a student life. There are a few questions that I think every student will find helpful if they get an answer from you. I am sure there is a lot of literature out there regarding optimization of studying specifically. Here are some questions that I think you should answer if possible through a podcast 1. How students can enable themselves to study long hours such as 9 to 10 hours or 11 to 12 if needed. 2. How to be focused during all those study hours and how to not get fatigued while studying. 3. Your thoughts on the famous Pomodoro technique and studying for long without a single break. 4. How workouts or meditation might affect student performance and which workouts to follow specifically for students ( you can even ask Andy Galpin 🥲, I love that guy ). 5. How to reduce stress which causes because of constant studying, and also during exams. 6. And please give some protocols and some tools on optimizing studying (recommended by you and by science of course),with Food and Supplements ( if needed ) for better performance as a student who wants to study whole day for some intense period like 3 to 4 months or as needed. ( not trying to be selfish, but yeah, it's ok I guess 😉) So, Andrew If you have read this until now then I genuinely request you from the bottom of my heart to please record this podcast and to please reply to this comment and I am eagerly waiting for you to reply, also If you decide to do a podcast ( which I think you will ) please release that before 30 days or so from today because I have my most important exam in 3 to 4 months from now so if you release it in Feb, I will be very delighted. Thanks 😊 🫂 🙏 - A request from a student to a professor. Hope you don't ignore this.

You've an expert on so many subjects, and can relay information at such impressive speed without pausing or stuttering, it's beyond comprehension. Very impressive specimen indeed.

Your content is priceless...just to be able to receive such concise, science based information presented in such a way that a layperson can comprehend is incredible, a service to society. Thank you!

The best podcast in the world. I also have a question for the folks watching it - is there any podcast that makes you feel such a productive person than this one ? For me there isn`t. Watching something, whatever it is, often is associated with procrastination, but this one right here is like reading a book, or developing a skill. Keep up the good work Dr. Huberman, you and your team, standing behind that are amazing.

Thank you from Germany to Prof. Huberman! Your podcasts are outstanding! Thank you for your expertise for everyone! Best wishes, Franziska 🙋🏼‍♀️

Wow! Nearly 4.5 HOURS?! This much be a pretty comprehensive conversation on the topic. Looking forward to it!

A lot of the fertility information intended for laymen is directed at women and presented by women (e.g. Natalie Crawford and Mama Doctor Jones). I think that information is great, but it’s also an issue that men don’t tend to be interested in that content. Instead, their women relay the information to them and unless those women are professionals, men will naturally be skeptical about some of the things - especially things that need them to change practical habits (like having their phone in their pocket). The fact that Huberman presents this information in a way that I think is easy for men to be captured by and understand, makes it very valuable. When Huberman holds up a meta-analysis saying that having your phone near your testicles is bad for your sperm, I think men will understand that it’s not a myth. I was waiting for it while listening to this episode, because I knew it would come and when it did, I was so happy that you presented it in such a clear way. Thank you!

Very useful information on this episode. I had hoped the female hormone episode would follow up and further expound on infertility approaches for women, however I found this episode much more informative. I've been patiently waiting for both episodes. Thanks for putting so much time and effort into compiling this information. I do hope to hear an infertility expert on your podcast as well someday. However, I think the Kyle Gellet episodes have been super helpful as well. I just didn't get as much out of the Sara Gottfried episode that I hoped for; it often felt off topic or opinion based. This one was great at providing guidance and ideas to bring up to my docs, Thanks again Huberman Lab.

Thank you so much for taking the time to put together this fantastic resource. This is a topic that’s very close to my heart, and this episode is by far the most comprehensive overview of fertility that I’ve found. I’m looking forward to your future episode about embryonic development - I’d love to see you discuss chemical pregnancies and recurrent pregnancy loss.

4 hours?! You are amazing. Thanks for taking the time to make this!!!

Deserves a spot on the Top5 Huberman episodes list 🙌🏽 Thanks Doc.

As always, an abundance of knowledge! I'm so thankful I came across your first posts over a year ago. Thank you for sharing!

I can’t believe all this information is free. This is so amazing. Thank you so much!

Thank you Mr Huberman. I finally listened to the entire 4 hours over a week all while taking notes. This is a topic of interest to people trying to have children. The whole process is so complex, I wish the obgyns have a series of tests they can do to determine problem areas rather than recommend the standard, IVF. It'll be good if you can cover in more detail he various tests like the sperm test that one can do to determine their chances of getting pregnant naturally. Thank you again for sharing this wealth of knowledge.

This episode couldn’t have come at a more perfect time. Thank you as always ❤

Hallelujah! So happy to see this topic being discussed in depth. I think if society as a whole had these understandings there wouldn't be such confusion and conflict occurring around gender and identity. With the dropping of birth rates around the world, our younger generations particularly need to hear this and recognize the role they play in the survival of our species. Also our law makers need to learn this and recognize how their decisions with companies whose byproducts fatally disrupt our hormones negatively impact our future in all areas.

00:00:00 - Maximizing fertility: The science and tools 00:04:37 - Sponsors: Maui NUI Meats 00:05:57 - How to Get a Great Night's Sleep 00:07:11 - Huberman Lab: Momentous Supplements 00:08:20 - Fertility and the germline 00:13:27 - Fertility and reproduction, from conception to fertilization 00:18:27 - The biology of fertility and fertilization 00:19:49 - The causes and physics of puberty 00:23:01 - The onset of puberty and its causes 00:24:44 - The onset of puberty has been accelerating 00:28:43 - Pheromone effects on the onset of puberty 00:35:25 - Athletic Greens 00:36:24 - Ovulation and the Cycle 00:39:18 - The menstrual cycle and the lunar cycle 00:40:36 - Ovulatory cycle 6, The follicular phase 00:51:59 - Ovulatory cycle 6, The luteal phase 00:59:08 - Malaise during the menstrual cycle 01:03:00 - Sperm Health 01:04:18 - Spermatogenesis, the generation of sperm 01:13:29 - If You're Trying to conceive in the Next 90 Days, Avoid 01:15:04 - Boxers vs Briefs 01:17:19 - Spermatogenesis 1, Introduction 01:22:31 - Vasectomies 01:24:04 - Sperm physiology, morphology, physiology 01:27:30 - How often should I have intercourse with my wife? 01:28:28 - Problems of spermatogenesis in males 01:36:16 - Probability of fertilization in a human pregnancy 01:41:12 - Sperm counts decline 01:44:12 - Fertility 6, Quality of sperm and frequency of ejaculation 01:46:45 - How Often Should Couples Have Sex? 01:52:15 - Can You Feel Your Ovulation? 01:53:21 - How to predict when you'll ovulate 01:54:35 - How to manage libido before ovulation and sperm health 01:56:39 - Choosing the optimal methods for conceiving a child 01:59:50 - How long should a couple try to conceive? 02:08:08 - Miscarriage 6, Women's experiences 02:11:14 - Ovarian fertility and fecundability 02:23:08 - Sperm Analysis, importance and cost 02:28:59 - How to Get Enough Sleep to Be Fertilized 02:31:12 - Five Don'ts to Do to Hurt Your Fertility 02:36:04 - Binge Drinking and fertility 02:41:46 - Alcohol and sexual health 02:44:02 - Viral Infection during pregnancy 02:45:44 - Cystic fibrosis affects the sperm 02:47:33 - 5 Tips for Increasing Your Fertility 02:51:18 - Does Phone Use Affect My Sperm? 02:59:02 - Cold Exposure for Fertilizer 03:05:27 - Fertility 6, Exercise and stress 03:07:20 - Intermittent Fasting and Time Restricted Feeding 03:09:13 - Intermittent Fasting During Pregnancy 03:11:46 - Is Intermittent Fasting Bad for Spermatogenesis 03:14:30 - Testosterone Replacement Therapy (TRT) and How to Help Your 03:24:07 - In vitro fertilization and sex selection 03:32:08 - Do pelvic positions affect the likelihood of pregnancy? 03:39:08 - Are cannabis users Aphrodisiacs? 03:41:12 - How to Improve Your Fertility? 03:49:09 - 3 ways to maximize your fertility 03:53:52 - Coenzyme Q 10 03:56:02 - Fertility Supplements 04:00:57 - Omega 3 fatty acids 04:03:47 - Two Options for Boosting Testosterone in Men and Women 04:05:37 - How to Increase Testosterone and FSH? Sheila Gee 04:09:45 - Fertility 6, Zinc 04:12:53 - Fertility drugs, pharmacology and surgery 04:17:40 - The Human Reproductive Axis 04:20:27 - Huberman Lab Podcast Timestamps by Clippah

Is it just me or the amazing Huberman podcasts are getting longer (4hours+!), earlier and more frequent👏 but HOW do you do all these ..

I can feel ovulation, or better said i feel pain on the day of ovulation. I always record that day and when i start my period i look to my calendar and indeed, this pain always occurs 14 days prior to my period (+-0.5 days, depends on the time of the day). It’s pretty awesome to actually feel it. At first I didn’t understand it, thought it was maybe digestion or some inflammation issues, but i soon realised it’s actually ovulation.

Dr Andrew Huberman, I absolutely love your knowledge and your commitment to communicating science to us all. I work as a therapist and sometimes recommend your episodes to my patients :) I've been struggling with fertility and it was good to hear you talking on this subject, as always concrete and so interesting ... 🙏

Prof. Huberman, thank you for another amazing episode, for the wealth of information, the level of depth and nuances discussed, and the manner in which you're presenting it - you can make anyone listen even to the most complex or boring subject! Thank you! If you're planning future episodes on this topic, I would love it if you go deep into Bioidential Hormonal Replacement Therapy for women. 1) Types of BHRT - What are different types of BHRT, and what are the potential long-term side effects from different forms of BHRT - oral vs. transdermal vs. vaginal, vs. sublingual, vs. pellets, other? - T.S.Wiley protocol of BHRT - controversial among medical circles but makes sense as it tries to mimic the fluctuating levels of hormones in a normal cycle (rather than constant setady dose of hormones on standart HRT) - BHRT for young women (20+ years of BHRT) vs. BHRT for menopausal women (much shorter treatment window). Currently there is one standard treatment for all. 2) Hormonal Testing on BHRT - When you are on BHRT, what is the best way to test your hormonal levels - blood tests, vs. 24-urine test (DUTCH test), other? - When is the best time to do the tests if you're on BHRT and therefore on a steady (same) dose of hormones (example: estradiol twice a week, and progesterone 12 days a month)? Does it make sense to test progesterone levels on the days you're off your progesterone supplementation for instance? - Does it make sense to test the FSH if on BHRT, and will that give you a clue whether your hormonal levels are sufficient? 3) Optimal hormonal levels - How do you know if your hormones are optimal, when you are on BHRT? - What are optimal hormonal levels for your age, and when you are on BHRT? Reference ranges given by labs are so wide even within a cycle phase (Follicular vs. Luteal) that it is impossible to determine what is optimal. Most doctors will even refuse to test your hormones because according to them, if you are on HRT, we know your levels. That does not take into account however, the fact that HRT was designed for menopausal women, and if you are a young patient you may not get the optimal doses. 4) The different types of estrogen (estradiol, estriol, estrone) and how estrogen gets metabolized in the body - OH2 pathway, vs. OH8 pathway vs. OH16 pathway and how to fix suboptiaml metabolism? 5) In case of POI or loss of ovarian function, the standard HRT is estrogen + progesterone. However, other hormones are certainly impacted as the ovaries produce testosterone as well. What other hormones need to be tested and monitored in these cases? 6) As a subtopic, if possible, I would like to hear an expert talking about Premature Ovarian Insufficiency in which case, you have no choice but to be on HRT for 30+ years (if you're diagnosed in your teens). This is very different from being on HRT when you hit menopause. There is very little research that I could find, concerning young girls with POI. They are being treated like women in menopause. However, I believe that the levels of estrogens and progesterone they need when they are in their 20s and 30s is way higher than the level of estrogen/progesterone women in their 50s need. I have heard from Dr. Sinclair and others anecdotal evidence that NMN supplentation can restore menstrual function? How does that compute with the theory that women are born with limited amount of eggs? Do you know of any human studies on NMN and ovarian function? Apologies for the long list of questions, and thank you for your time!!

I've been waiting for this topic, thank you. You are such a blessing for this world. Thank you for keeping this information free and accessible.

This is so helpful, I had no interest in learning about this in high school but now that I am 40 and trying to conceive, it is so interesting! Thank you so much. You’re reaching so many more than you know!

I've been watching your podcasts for a few months now, and by far the biggest takeaway from everything I've heard is that our body is almost impossibly complexed and sophisticated, it's brilliant, and I regret not taking biology seriously and learning more tbh. I am learning now though, so thank you so much for opening my eyes!

My doctors told me I couldn't get pregnant but I started drinking everyday pure concentration pomegranate juice. After few months I got pregnant with a beautiful healthy girl. Supposedly in ancient times the pomegranate was known for fertility

59:08 Thank you SO MUCH for discussing the malaise that’s associated with the mid to second half of the luteal phase of the ovulatory menstrual cycle. I’ve gone decades thinking I’m just a terrible person who starts projects with high energy and then suddenly gets lazy at intervals for no apparent reason, and no amount of blaming and berating myself changes the pervasive feeling like I don’t want to do anything some days of the month. I’ve learned to just plod along and adjust my activities to more mundane work and make up for it when energy levels are higher. Was about to skip this episode - no plans for having kids - but am glad I listened to the intro and then all throughout the discussion of the female reproductive cycle, this information is better than any lecture I recall in school or cycle-tracking app I’ve seen. Thank you, thank you.

Just finished this podcast on Apple Podcasts.. probably my favourite listen so far as my wife & I have been trying for over a year. I promise one thing.. if these practices I will be implementing going forward work I will be name my son/daughter after you!

Sir, to go through this…is like the best lecture ever. You are a pure inspirational beast.

Yay!!!!! In anticipation I’ve been telling everybody who will listen to me to keep a lookout for this lecture! I am so excited! Thank you, thank you, thank you!

4 hours omg we are BLESSED 😭 Thank you so much!!!

This is so interesting! I’d love an episode about humans first food- breast milk and how it aids in neurocognitive development. Thank you as always, Andrew!

I don’t write reviews or comments. But, thank you Andrew for providing us with such incredible knowledge on a daily basis. The world is a healthier and better place because of you!

The explanations are so clear and accurate. This is amazing!

ive been waiting for so long for this episode to drop! over 4 hours of pure gold 😍😍😍😍

Perfect timing on this episode! I’ve been trying to get pregnant for 9 months while simultaneously nursing my first baby. Now that he is almost 2 and I’d really like to buckle down on optimizing fertility and balancing hormones after almost 3 years of feeling completely out of whack!

Thank you so much for taking the time out of your day to share your knowledge and explain this topic with such great detail. 3 years of TTC, this video was a great watch.

Thank you for using your platform to address this. Male Factor Infertility is on the rise - worldwide. And I love how you emphasize vitality through increasing fertility -even if a person doesn't want to have children.

Best health podcast ever, always learn from you Dr. H

You truly are the highest quality educator that I know. I appreciate the depth of research and coherent presentation! My wife and I are trying to conceive and will try some of the behavioral and dietary changes.

i'm a medical doctor and this video will be forwarded to many of my students

A 4 hour long free podcast with so much information and tools about one of the most critical issues the world is facing right now. Thank you Dr. Huberman for your contribution to the world. You're very under-appreciated. I hope the world learns more about you and from you.

Thank you so much Dr Huberman for this explicit episode on fertility.

Adding the odd image here and there to illustrate the concept while Dr. Huberman speaks would greatly help the understanding for some

Thank you for this! As a reproductive endocrinologist- I appreciate your thorough review. Incredibly detailed, accurate, but clear explanations- I’ll be sending my patients here to learn. Reach out if I can help you on fertility, IVF, miscarriage topics.

Thank you so much as always for the highly informative podcast! Always learn something new from each episode. Just a request, would you be able to do an episode on binge eating disorder please and ways to overcome it? It would be much appreciated and I think will help a lot of people 😊

An incredible service for humanity from an incredible scientist! You rock!

As someone who has used IVF to conceive (mainly male factor, but also egg quality issues), I found this episode really interesting in terms of supplements. The infertility world seems to revolve around the supplements recommended in "It Starts with the Egg" by Rebecca Fett when it comes to egg quality. The list included in that book and the supplements discussed here are quite different with the only overlap being COQ10 and myo-inositol. I also have an acupuncturist who recommends supplements (mostly based on the book) and also includes some herbs. I had never heard of using l-carnitine from her or my RE or my OBGYN. Really interesting stuff that I will definitely check out before going into round 3 for a sibling!

Andrew is a beast! Such a valuable content. Changing the game and raising the bar consistently. We hear about overpopulation, but more than likely we might face or even already facing underpopulation crisis and I know some couples that struggle with conceiving. Also, pretty sure fertility health simply cannot be not linked with general health.

You are right Andrew- it’s amazing, we are wonderfully made 🙏🙌

This is absolute gem of a podcast 💯 Greetings from Singapore🙏

Really appreciate the time you spent on this. One request: could you include visuals as well? Helps a lot in these kinds of discussion!

Andrew, any chance you are going to be doing an episode on the neurology of the developing mind? As a new father I would love to see this.

Hello Dr. Huberman! I wanted to thank you for all this info. Having two miscarriages in the past, I listened to this episode at the beginning of the year and my husband and I implemented many of the recommendations. We’re now happily pregnant! Thanks for always sharing such up to date and valuable science and research with us! ❤️ (He is also now back to his much-loved sauna protocol now that his guys have done their job 😆)

Your podcasts are absolutely amazing. Please do a podcast on how to sustain a pregancy - the dos and donts.

Small suggestion: When you’re define words that you really want the audience to remember, like GNRH, it might be helpful to place the text on the screen for a short period. I think it would help “visual” and “reading” learners a bit more. But it also depends on how much editing you want done. Just a thought! Thank you for your continued commitment to shared science based knowledge!

Haven’t had a chance to go through all the comments to see if anyone has mentioned this, but I think that there is a big chunk of the woman’s fertility that was left out. There’s a huge conversation around cervical mucus and basal body temperature tracking and how these things are related to an Impact fertility. There is a super brief mention of how to identify ovulation that I think was misleading (I think referencing the rhythm method) but there is a much more accurate way to anticipate and confirm ovulation using the two biomarkers mentioned above. I would love to hear another episode that focuses on these things! I absolutely adore this podcast.

Andrew Huberman? More like, Andrew Uberman! Thank you for this work of heart and to spread the scientific knowledge right as it is coming into consciousness. You are an inspiration and motivation, and responsible for changes in my life for the positive, by the power of knowledge. Thank you!

28 year old male, watching to learn more as my wife and I have been trying for a child for a while now. Done test and verified to be ok, just hoping to learn more with this video! Thank you in advance

Thank you Dr. Huberman really informative as usual. Impatient to see a discussion on Menopause- our risks of hormone therapy- maintaining our sexual health- our brain function-optimize bone density. You know, mature women stuff... Thank you in advance. btw love your podcast my brain insisted to write it down. 🤘

Amazing episode 😊 I am def an ongoing listener - thanks for the insight A!

55 and haven't started menopause yet. My OBGyn who delivered my 3rd took a looksie and said it's all looking like the average 35 yo woman today. That is sad for young women of today.

Merci merci merci Andrew!! I was waiting since long for this one! Thank you for sharing. Please one day a podcast with Adriene Mishler about yoga and neuroscience!! ❤

When planning my family in the 90s I purchased a book which suggested Y sperm swam faster but lived shorter and X sperm swam slower and lived longer. I followed the method suggested and produced the son and daughter which was my ideal family. Sorry I haven’t details of the author as I lent it to my friend who also produced a daughter to complete her family after having two sons!! . Keep up the good work I’m learning so much. 🇬🇧

He really did focus on the mechanisms, like said in the description, but I was missing the psychological or let's just say humane part of conception in this talk. There are so many people who are doing everything right, the eggs and semen are fine, they don't drink wine, don't keep phones in the front pocket and what not, but still it's not happening (as fast) as they'd like. Huberman only mentioned it not happening quickly on statistical terms, but often the solution is to just live your live without limiting yourself in every step of the way for the fear of not doing it right. E.g finally relaxing and having that wine that you graved could result in healthy pregnancy better than following all the do's and don'ts if that leads you to live a life where you're never relaxed or happy really

Thank you for your effort and time, Sir. Sending more Love!

Suggestion: have you ever thought about doing an episode on top 10 health/performance related studies of 2022? Or similar episodes where you cover studies/ literature reviews that yield actionable advice? It would be like an online journal club.

Hhmm coincidence, I just had a miscarriage and started looking into my own fertility, I have 3 perfect girls, but am now 41 so fertility was never an issue before. My last child is 10 so this was unexpected but embraced pregnancy. I've gotten more information from your podcast than all articles podcasts, studies ect I've read and watched this last month. I've obsessed over this because I haven't accepted that I'm "infertile". Anyway, I appreciate this and I will be a regular listener of yours now, thank you😁❤️

I love the graceful way Dr Huberman handles the most sensitive topics! I believe that every mother should explain the physiology covered in this podcast to her daughter, and every father should do the same for his son as the children get into puberty. One point that I dare disagree with Dr Huberman on is cold exposure for female fertility. With no disrespect to the dopamine release triggered by cold exposure, cold exposure itself is very often a cause of cystitis, which, in turn, is a pathway to infertility. I believe it would have been beneficial to mention that on the podcast so that women know to be particularly careful with cold exposure and would make informed choices between additional dopamine and risk of cystitis. Otherwise, another brilliant podcast and a beautiful example of perseverance and commitment to a cause by Dr. Huberman. Thank you.

Thank you so much Andrew Huberman for making this podcast. I’m a huge fan! As an addition to this podcast, it might be interesting to invite Norbert Gleicher from the center of human reproduction in New York. He specialized in fertility, and with a particular focus on androgens in women and immunology. Very interesting speaker!

I wish I had this podcast 15 years ago! Thank you Dr H!

Thats a splendid explanation. It is how science is made. I also have an idea to strengthen the explanation the part of fertilization. If there could be an animation playing on the screen which is also showing very detailed in the maybe a microscopic level what is happening during, while Dr. Huberman is telling about it, that could help to imagine how it works. Beside this, I understood the processes very well. I really appreciate the podcast and I admire it, thank you so so much.

Amazing teacher , love the detailed science. From a Retired RN

Inositol and choline restored my daughters' cycle after months of 45 days or more. We never eat any choline foods and started taking Biosil twice daily and eating 350 grams cantaloupe every day. The results was astonishing and she is back to 29 day cycles. Her skin cleared up completely too.

Great podcast. After going through my own journey with fertility issues, I completely agree with the statement said about wishing I had done things sooner. I was diagnosed with unexplained infertility after trying for 2 years to become pregnant naturally. After 4 failed IUIs, I was able to conceive after my first round of IVF. I researched everything under the sun during that time. My husband and I took many of the mentioned supplements to improve our success (and even a few additional more targeted to IVF success). We are now beginning a second round of IVF and I really enjoyed the podcast to refresh on the subject. Two books that I found incredibly helpful that may be a help to others - (1) on egg quality and focus on supplements/environmental factors: It Starts With The Egg by Rebecca Fett, and (2) on the role of inflammation, it's impact on fertility, and immunotherapy to improve conception success: Is Your Body Baby Friendly? by Alan Beer. Looking forward to a future podcast on ART and IVF.

First of all I'd like to express my sincere gratitude for sharing your wealth of knowledge with the world - people like you restore my faith in humanity! Secondly I'm curious to know about the effect of caffeine on fertility and pregnancy. Thanks again!

thank you so much for this precious clip i wanted this the most n searched for that everywhere

Wooow ich schau ihnen aus Deutschland zu ! Was für ein toller Vortrag. Vielen lieben Dank für das teilen ihres Wissens. Sie helfen so vielen Menschen mit Kinderwunsch! . ❤🎉 Danke

This was absolutely amazing, thank you, I love this!