I have the original edition + requiem expansion. Can I mix all of the cards from those in with the second edition + the 3 booster packs that came out recently? Or do the two editions have to be kept apart?
Great questions and I'm honestly not sure. But if you head over to Board Game Geek and post in the game's forum the community will help you out for sure boardgamegeek.com/boardgame/336844/the-binding-of-isaac-four-souls-requiem
Yes this box lets you play with 1-4 players. Whether or not the other players are your friends is entirely up to you. Thanks for watching and commenting!