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How Traumatic Brain Injury (TBI) Affects Brain Cells - New Research Could Lead to New Treatments 

University of Maryland School of Medicine
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Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability, and neurodegenerative diseases, such as Alzheimer's Disease.
University of Maryland School of Medicine (UMSOM) researchers wanted to better understand what happens in the brain during injury, so they conducted a study in mice to determine how different types of brain cells in mice react to severe trauma. The recently published results could lead to new treatments.
The University of Maryland School of Medicine serves as the anchor for a large academic health center which aims to provide the best medical education, conduct the most innovative biomedical research and provide the best patient care and community service to Maryland and beyond.
#traumaticbraininjury
#neuroscience

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1 май 2023

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Комментарии : 106   
@jonkas4542
@jonkas4542 6 месяцев назад
At 21 I hit my head hard. 45 lbs intracranial pressure. Took years before I could read a page in less than 15 minutes. Mid twenties I fell into the machine shop industry. People would get in my face and scream at me when I asked them to repeat instructions two or three times as I struggled to process information. Now I'm 52. I do my job well. People come to me to solve problems. But I still struggle. It's like traveling in my own lane, at my own pace. To merge with the traffic has been too difficult. I live this life as best as I can for myself.
@Tantemify
@Tantemify 6 месяцев назад
sorry to hear sir
@inelics
@inelics 4 месяца назад
You are a hero in my eyes
@jonkas4542
@jonkas4542 4 месяца назад
@@inelics there were SOME people who could understand I was struggling with an injury that you can't see. No scars. The best advice I got was from a Marine. He said, "Embrace the suck. Ride the wave, make adjustments, move forward".
@wyfarfoclaj8643
@wyfarfoclaj8643 4 месяца назад
​@@jonkas4542when did u recover from it?
@polishherowitoldpilecki5521
@polishherowitoldpilecki5521 3 месяца назад
Did you get concussion or was it just a hit.
@tinman1952
@tinman1952 7 месяцев назад
Living with brain damage is a real suffering course because there is no escape, not even a moment's respite. It follows you everywhere like a shadow, even in your dreams where it takes the form of bizarre personifications and strange, broken landscapes.
@jonkas4542
@jonkas4542 6 месяцев назад
Yup. It's like being a nomad hitching a ride on spaceship Earth and feeling a million miles away from everyone around.
@grandfarter3855
@grandfarter3855 6 месяцев назад
How did u get this damage and how long does it take u to completely recover?
@kimberlymiller333
@kimberlymiller333 6 месяцев назад
yes
@dwargonedragon794
@dwargonedragon794 2 месяца назад
​@@grandfarter3855You don't recover fully from a brain damage. Once your brain cells are gone, they are gone. Sure the brain can work harder and rewire itself but it can't keep that up forever so you end up with increase risk of dementia and other brain disorders.
@peacelovejoyandhappiness
@peacelovejoyandhappiness Месяц назад
@@grandfarter3855my father had a brain bleed and they are blaming the blood thinners he took in the ER. Who really knows right? The CT scan may have missed the bleed in the ER, it could have been quite possible it was a slow bleed at home due to a stroke or an injury to his head? I’m quite baffled myself and heartbroken. Thank God there is a God who knows all of these answers. The one thing I need to know if the magnificent love we had for each other. Rest in peace Dad.
@MrKuljitssandhu
@MrKuljitssandhu Месяц назад
I had brain injury and concussion three years ago and feeling it’s improving every day
@datsuntoyy
@datsuntoyy 8 месяцев назад
They'd love me. I've had 10 concussions, 3 skull fractures and knocked unconscious 5 times. 3 years ago I had a stroke to further compound the situation. Memory issues, depression, mood swings, anger issues, balance problems, concentration and learning problems.
@davidbadihi3915
@davidbadihi3915 8 месяцев назад
How do you cope with this?
@datsuntoyy
@datsuntoyy 8 месяцев назад
@@davidbadihi3915 Very difficult and not very well. On a few meds which help but I don't relate well with people and it's hard to focus anymore.
@brianthompson1137
@brianthompson1137 8 месяцев назад
Hi my wife fell on and landed on the back of her head she had a brain bleed it took them 30 minutes to drain the blood from her head .When i rushed her to the hospital she heard the nurses so she was trying to push the nurses off of her and when they tried to lay her down she was sitting up trying to resist the nurse but she wasn’t talking or opening her eyes thats when i rushed her.She started opening her eyes a hour after the surgery is she going to make a fast recovery
@datsuntoyy
@datsuntoyy 8 месяцев назад
@@brianthompson1137 I'd say it's likely since they got it rather quick. The brain is a weird thing and not everybody reacts the same to TBI. I wish her and you the best.
@alexfahey6733
@alexfahey6733 7 месяцев назад
I have a tbi… my eyes shake during the day sometimes and gotta concentrate to see strait tbi really sucks… brain tingles are normal that’s what I call it… def can’t think sometimes and depression episodes along with memory loss feels like things sometimes are spaced out it’s not a fun problem to deal with but for ten years now I’ve dealt with it… I feel for ya tho
@Dom.Perignon123
@Dom.Perignon123 5 месяцев назад
I had my severe tbi when i was 20 from mva, 35.5yrs ago. Frontal & temporal lobe injury; glasgow 5 on presentation; up to 7 within 24hrs. 3wks coma, chronic mental, pysch, physical pain. I've learned to walk, talk, move, think, interact, go back to school, graduate college, work full time, wife, kids, house... pressure, stress, anger, etc... keep going a million mph... lose wife, house, kids, severe depression, anxiety, hate work, life... i've always felt that i probably have a greater chance of dementia/alzheim as i age... in a sense i've accomplished a significant amount considering the place i came from, but i couldn't manage to maintain it... it all got too much and i ended up losing it... was it worth my working so hard??? i'm near the end of the show (will be 56yrs old) and wonder how much more i can go on... i'd like to eventually donate my brain to research
@Operation-homeless
@Operation-homeless 3 месяца назад
Don’t give up whatever you do don’t give up!!!
@cornbread5151
@cornbread5151 Месяц назад
Not crying because this is me now n pushing everyone one way n the angry ffffffffkkk that will kill u by itself…
@CubeAnimator
@CubeAnimator 19 дней назад
I survived 3 nuclear bombs while having brain damage, got shot, got electrocuted, got burned and ran over 12 times by a drunk driver. Now i lost all my limbs and is still walking to this day.
@bradbrowne4987
@bradbrowne4987 3 месяца назад
One year for me since my TBI last May ‘23 I was 24. I was in a coma fully brain dead for 2 months craniotomy then cranioplasty 4 months later 40% of my skull is PEEK (thermodynamic plastic). I’ve been back in work since January and the only side effect I cant kick is the tiredness and anxiety
@VirginiaSwann-pn6kf
@VirginiaSwann-pn6kf 19 дней назад
Had a TBI, 2 Skull Fractures and In A Coma for 6 weeks and 3 days at Baylor Hospital Dallas Texas in 1974. I'm 60 years old and suffer from GAD, Panic Attacks, Depression, PTSD, Total Memory Loss Prior To Wreak, Headaches Everyday unless I take my Headache Medicine From Neurologist and Paralysis on my left side for 13.5 mths. I've struggled with my life ups and downs since the wreck. Where I was hit by a DRUNK DRIVER ON BIKE AND MY BODY WAS UNDER HER CAR FOR 500 FT. MY BODY LOGGED BETWEEN UNDER CAR AND MY BICYCLE. HAD BLEEDING FROM MY LEFT EAR, MY NOSE AND MOUTH. HAVE ANY QUESTIONS ANYONE. I'D BE HAPPY TO HELP IF I CAN... GOD BLESS YOU ALL VEE...
@Corrieri85
@Corrieri85 18 дней назад
I was in a motor vehicle accident in 2005 at the age of 20 and collapsed the whole right side of my brain. I struggled with memory issues along with anxiety and severe depression since. I have worked the whole time since the accident and my anxiety and seizures have just gotten to bad and i have 38 of thw 40 credits needed as well as 20 years of medical records and rhey are denying me. I am awaiting my appeal now and cant find an attorney because i files everything myself. When i see rhe judge it will have been almost 30 months.
@stuartjones6669
@stuartjones6669 Месяц назад
A few bad concussion in my life mixed with longcovid in 2020 and I am haveing a lot of trouble. Its difficult to simply make dinner or remember how to work with a power tool. ❤
@jamesdemoruelle7731
@jamesdemoruelle7731 6 месяцев назад
In someone tried to steal my car and punch me really hard. And I fell backward in a parking lot onto the cement. And my head cracked open. I lost almost all my blood and I almost died. But had surgery end. Recovered quite nicely. I hope no long term effects now
@Karin-qv5mq
@Karin-qv5mq 19 дней назад
You're doing great! Stay positive
@danielsykes7558
@danielsykes7558 5 месяцев назад
I'm glad we're learning these things, but I'm starting to feel bad for the mice
@MissSkyeDoll
@MissSkyeDoll 4 месяца назад
I had a TBI when I was 3, I’m 31 now. Would love to see a head scan & talk to a specialist.
@polishherowitoldpilecki5521
@polishherowitoldpilecki5521 3 месяца назад
What happened?
@hellyahhh7590
@hellyahhh7590 18 дней назад
I hadn't a tbi when I was 3,I'm not 31 now.wouldnt love to see a head scan and talk to a specialist
@namitgaur
@namitgaur 5 месяцев назад
Thank you. Can big left frontal lobe meningioma cause TBI
@Idontknow-tz2lw
@Idontknow-tz2lw 3 месяца назад
When I got hit on the head with barbbell, I don't know if I had concussion or not because I didn't passed out or vomit instead I my head bleed so much. For the first months I had PTSD symtoms and very painful headeache on the area I got hit the most which is the right side. the very prominent effects of my head injury is I got severe headeache everyday, eventually the headeache reduced to a few time a month and now I only got that headeache when I got stressed. The least prominent but very noticeable to me is I can't get focused like I used to be. I got diagnosed as an autistic kid when I was 2 or 3 years old, when it came to school assignments and chores I would always do it one time and I used to have social anxiety. After I got that head injury, I neglect my college assignments and chores and I do it when it was near the deadline or if really need it to. I tried to get assignments done with music for adhd people and it only helped me for the first few times, I tried cigarette same case, I ended up focus enhancing drugs from drug store but still the same case. I would say this effect of my head injury stil persist even after 3 years, I would like to get diagnosed for ADHD beause of the similar symtoms. I don't know if this effect was also because mental trauma I had after that head injury. Well I guess I just need to wait it up 😕
@dwargonedragon794
@dwargonedragon794 2 месяца назад
I had a heavy object fall on the back of my head thanks to an autistic coworker. I hope it wasn't too bad as I wanted to go back to college. I had vomiting and reoccurring headaches. Also have a headache when I'm stressed or when my head is exposed to extreme temps. I'd say we should visit a doctor. Not like they can do anything bec once your brain is damaged, it's done. No cure for now. But hey, we both need closure so we can tailor our life around it. No more engineering degree and take, I dunno, janitorial degree. Fck life.
@skylerplumb4065
@skylerplumb4065 Месяц назад
When I was 19 I hit my head in a car wreck and was in acoma for a month. I woke up blind in one eye no sense of smell and the front of my skull was removed. Now I barely remember anything and nothing is the same. And now I'm 30.
@brendak.wallace2348
@brendak.wallace2348 4 дня назад
I also had spinal fliid leaking out of my nose when I tipped my head forward. But for many many many years couldn't verbalize anything I was going thru but the present moment.
@4242Chasity
@4242Chasity 4 месяца назад
Sometimes it doesn't go away last a lifetime
@lauralaplace9945
@lauralaplace9945 6 месяцев назад
Multiple car wrecks , hit by a car on foot , hit on the head by other objects . Severe head pain , nausea, vomiting . CT’s left and right . Still waiting on the Neuro Dr
@user-if3fv9of5f
@user-if3fv9of5f 7 месяцев назад
My BTI is already 11 years from my accident the injured part is in my right part of the brain, according to my neurologist doctor a white spotted been seen in my MRI he said thats a blood cut been healed but the connection or function is no longer normal, he have a medicine recommended it's "COLINERVE" 500mlgrm I remember 😅 first it's 1,000mlgrm 😊. But now it's already 11 yrs. My left hand still can't forced well the strength and really the problem of moving normal I can't close open in normal, holding some things and counting on my left hand. Help me/ guide me please doctor. Thank you 😊
@lfdab34
@lfdab34 7 месяцев назад
I ve had misdiagnosed rightt leg extension and curls and calf raisrs.I can t run,skip, jog,jump.. I have problems walking and hobbling.I also have problems with lifting and carrying groceries.
@fleefleer2326
@fleefleer2326 4 месяца назад
As a kid i would purposly slap my head multiple times with my palm. For some reason is caused problems. Because i did it all time, but now i completly changed as a person. Now i always feels this sensation on my head that feels reslly weird. Its like my body is swimming in air. And i lost personality and evreything. Now people and all my old friends are lost because i can work like a being or anything. Feel emotion or yk normal daily activites and thinking and all that its hell
@gamma4053
@gamma4053 24 дня назад
does head movement brain damage like in shadowboxing?
@psychfred
@psychfred 2 месяца назад
Fasting, walking, red/infrared light got about 70% back after TBI hit by car.
@kp3509
@kp3509 17 дней назад
After reading the comments section, I never had a head injury. However I respect the helmet law all if a sudden. I am 53 and did all BMX stunts and riding without a helmet because I couldn't afford one. Now I respect the helmet law, and I always have my kids wear a helmet.
@user-ui5cm1jd4o
@user-ui5cm1jd4o 17 дней назад
That one boxer died after boxin he still kept punching random stuff while his brain ain’t functioning 😢
@mmttpp4477
@mmttpp4477 10 месяцев назад
Nice
@Jayjay-jw9nf
@Jayjay-jw9nf Месяц назад
I was 4 years old. My grandmother was driving somewhere... but I don't know why or where. Maybe just to get out. But any ways we got T-boned on a four lane road right behind my sisters school while she was still in school. I was sat in the the direct spot the truck hit
@juanalderetedelapena5161
@juanalderetedelapena5161 5 месяцев назад
i sustained my tbi 4 years ago and i am afraid of future issues
@WahlVids
@WahlVids 5 месяцев назад
I'm 14 years post TBI and still having Executive Disfunction. Still seeing specialist for coping mechanisms (speech, OT) but all brain injuries are different in terms of degrees of symptoms.
@juanalderetedelapena5161
@juanalderetedelapena5161 5 месяцев назад
@@WahlVids my most difficult symptoms are my left leg and left arm numbness which is challenging when I play my music instrument. My memory is also challenged severely because I can’t recall a lot since sustaining my tbi
@DCGreenZone
@DCGreenZone 3 месяца назад
Look into palmitoylethanolamide and perhaps specialized pro resolving mediators.
@revelacion3241
@revelacion3241 3 месяца назад
i have 4 year with my tbi and since first day with tbi i have depresion anxiety alucinations anger personaly changed and more things is a hell live with that all days are diferents and i never get peace sometimes i feel only drinking beer i going to get peace but i won t i had 14 year no alchol and anything always i fought in two weeks or two month everthing disappear but not now is 4 yeae and everthing is worses
@juanalderetedelapena5161
@juanalderetedelapena5161 3 месяца назад
@@revelacion3241 I HAVE CHANGED for the worse...my wife filed for divorce because we dont have any kids but she raises me kike i am a kid now because my memory issues.
@kellyroup4262
@kellyroup4262 15 дней назад
At 11 years old I had a pony kick me in the head and folded back a piece of skull about 2 inches in diameter on my right temple. I survived it and even got to look into my head with myoms compact mirror before they closed and stitched it up.. Then in about 2017 I was working on my porch/deck and had stood up a 12 foot 4x4 and then forgot about it and I walked about 5 feet away to dig a hole for another post. While I was digging the post I had stood up fell over and knocked me to the ground. It caught the rest right side of my head giving me what I know now as a severe concussion. My wife and I lived by ourselves and we're pretty independent so when this happened she got the garden hose and helped me to wash the blood off my head and finally got it to stop bleeding. The cut was about 7 inches long and she wanted to take me into the hospital but seeing as I was standing and talking to her I said that we would just bandage it up and I had long hair so I had her tie it together like stitches and after a bit I finished digging the hole and nailing up that freaking 4x4 then went to take a shower because I still had quite a bit of blood on me. When I got into the shower I tried to wash out the cut and when the water hit in the cut I couldn't remember anything but she found me kneeling in the shower just rocking back and forth and she helped me snap out of it and got me standing again. It healed with the help of some herbal treatment that I made myself at the time with mullein but now years later I think I'm having issues because of it. 4-5 years after this I was watching TV and I can't tell you what show it was but all of a sudden I had tears streaming down my face! I shouted at her and she came running in to see what was wrong and I remember the look she gave me because I rarely saw that look of fear and confusion. She asked what happened and I told her that I didn't know,! I just started crying! This time, not knowing what the issue was I agreed to go see the doc. When I did and he asked me if I'd hit my head or something and I told him about it and he felt it he got all pissed off and said that I should have went in and had it looked at then. He was used to us and knew we generally doctored ourselves and agreed that many times that was a good thing but explained how this should not have been one of those times and that perhaps this caused my tears because of pressure but said that nothing could be done about it since it was already healed solid now. Know I have shortness of breath issues and the years happen a couple of times a week and I get these tense moments which I guess could be considered panic attacks yet no reason for any panic. I'm wondering if this breathing problem could be related to that and if anyone else has had this issue. I don't as far as I know have any type of personality changes but she passed away and I'm kind of a loner now so maybe I just don't see it. I can talk to people all day when they're around but when they leave I really don't miss them and can spend several weeks alone literally enjoying the MY TIME! LOL But I'm trying to simply find out if this could be the cause of my breathing issue because I've been to the doctor many times now and just gave up and am using herbals to treat a possible lung infection with no real success but I had no success )o
@josebelisario6050
@josebelisario6050 23 часа назад
That’s a gnarly story man, keep your head up, you’re a warrior. I use to suffer from panic attacks and depression, now just depression but if it is just panic attacks and not like anything physical, you just got stop over thinking and try to relax.. the brain is a strange thing if u panic it’s gna panic. Stay strong.. & about the socializing I think you’re like me we are just introverted , but remember being that isn’t bad its just part of our personality.
@jeremyanthony6625
@jeremyanthony6625 4 месяца назад
I had bleeding on the brain for 160 hours. I haven't felt right since that
@peacelovejoyandhappiness
@peacelovejoyandhappiness Месяц назад
Do you mind if I ask you what happened? Thank you.
@john1boggity56
@john1boggity56 3 месяца назад
I was seven years of age when I fractured my skull - not a depressed fracture but enough to keep me in intensive care for a while. I don't really have a before and after the incident awareness that everyone else does. But I can see that emotional control is difficult. My short-term memory is affected, and I suffer from Persistent Depressive Disorder which is treated with pharmaceuticals. I have an ambitious goal to live an ordinary life. I am lucky to be in an excellent marriage, I have good contact with my adult children, I am studying again at uni, I have a few good friends and I have worked consistently for twenty years in roles that require some cognitive effort. But...I cannot convince my family of my life success. I am sure everyone on this site can relate!!
@DCGreenZone
@DCGreenZone 3 месяца назад
Consider Mg Threonate, Palmitoylethanolamide, DHA, Pycnogenol, Specialized Pro Resolving Mediators.
@Dan-xo9ly
@Dan-xo9ly 3 месяца назад
The question then is how does one promote autophagy? I know intermittent fasting is a thing. Vitamin D?
@drayincommandadw544
@drayincommandadw544 9 месяцев назад
Don't u wanna test on someone who has worked with the natives to make are system better I let myself get hit for reasons like I was getting ready for the world ,I was training to become a hip hop artist that went through the struggles of protest an today I stand with the people not being fairly treatment when u break ur arm or even tear muscle or ware muscle or disturb any part of ur body it will affect ur brain ur spine sends the message up to ur brain when ur spine an ur everywhere is hurting u need something for the pain an in my experience drinking liquor an smoking weed isn't going to work for me this time I'd love to help the people just in coincidence the people who need life saver medicine need it thank you
@4242Chasity
@4242Chasity 4 месяца назад
That's good
@sjdbfi
@sjdbfi 7 месяцев назад
Search sapien med brain regeneration
@sudhanshuchandra1866
@sudhanshuchandra1866 2 месяца назад
Actually I am thinking that I had suffer or not many times I had hit my head with something hard object and you know you know you know my actually my friends were very very crazy b they usually hit the brain just for a fun but now have knowledge and I encourage not to do that..
@astrostar4181
@astrostar4181 Год назад
That way my room is messy I had a concussion?! I’m wondering if my lifestyle is the reason to my concussion.
@armandoaguilera2969
@armandoaguilera2969 9 месяцев назад
I think so, I had a tbi in a car accident 2 years ago and i have a messy room as well.
@drayincommandadw544
@drayincommandadw544 9 месяцев назад
Same I'm a bare knuckle boxer like fight club except more honor an love don't get me wrong tho getting ur shit pumbled is never fun tho especially with violent people all in love yeah know cousins friends consensual fighters but what we did as kids is starting to mess with me badly an sometimes u might mess up so u gotta rise the lighting an they could hold u under an make u get hurt every year or they could hurt you really badly then I got the shit kicked out of me an my head stomped early an there lots of injurys between then a now last one being hit by a car an one before punched in the head by a huge person more receiving punishments for things as I did what I was doing or little ones through the years like my eldest cousins would have my little cousins to hurt me cause my grandfather knows Barry an berry would know Darcy an Darcy berry would tell Darcy drayin hurt someone in our community not understanding we have consensual fights an more than that community building look at me everything I'm doing u can't say that what ive chosen to help this community I never hurt anyone have u ever got hit by a weak kid it's like a fever dream had sex with a dream where you can't punch hard an sometimes it's be that matter that my cousins were stronger I just wanted to see how they would defend themselves an holsome stuff for native bros
@grandfarter3855
@grandfarter3855 6 месяцев назад
​@@drayincommandadw544 Yooooo what are you saying use full stops and commas bro
@WahlVids
@WahlVids 5 месяцев назад
Look up Executive Disfunction. That's exactly what I struggle with daily as a result from TBI
@Mevc94
@Mevc94 7 месяцев назад
My classmate slipped on the floor and hit his head very hard on the wall and I saw his head bleeding and his skull was exposed and me and my classmate we called his dad so his dad can take him to the hospital and stitch it.
@mefor3
@mefor3 7 месяцев назад
You should have called 911
@katherinegabriel1419
@katherinegabriel1419 6 месяцев назад
Thank you for your care and devotion 🧠👩‍🌾🌸
@bettyrose5387
@bettyrose5387 6 месяцев назад
The same thing happened to me but how is your friend doing now! My doctors didn't do any tests for me they just asked if I vomited or lost consciousness I said no and they stitched my forgead and told me to go.
@Tanjaamazon
@Tanjaamazon Месяц назад
Why don't doctor listen to there patients and just say physical therapy
@VirginiaSwann-pn6kf
@VirginiaSwann-pn6kf 19 дней назад
Watch channel 4 news on Traumatic Brain Injuries
@VirginiaSwann-pn6kf
@VirginiaSwann-pn6kf 19 дней назад
On RU-vid
@VirginiaSwann-pn6kf
@VirginiaSwann-pn6kf 19 дней назад
What they have now discovered about Traumatic Brain Injuries from the beginning and through our life for those who have been effected by TBI, Concussions and Comatose if it last longer than a few days as mine did the long term effects are now discovered to be TETRIMENTAL FOR SOME NOT EVERYONE BUT THE MAJORITY OF US.
@RR_DM
@RR_DM 3 месяца назад
Oh heck no, if anything he took more care of me the I did him. Honestly I think he (my father) is still alive but was upset over the advertisements for annuities 🍔🌭🍕
@peternolan5632
@peternolan5632 2 месяца назад
Me brain head
@_MaxNeon_
@_MaxNeon_ 4 месяца назад
Walk it off. Your body will regenerate.
@one-day-at-a-time4134
@one-day-at-a-time4134 4 месяца назад
Paraplegic? Nah, walk it off lol. Smh.
@N0rth.glo45
@N0rth.glo45 День назад
Naw man this shit hurts and might need surgery there is no full recovery
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