Hi I am a Pathologist and I should say that that video is one of the best, clear and easy to learn video of somatic recombination I have ever seen. You must be so clear in your concepts to make something like this. Excellent work. Hats off to you.
I like the way you present your explanation of the topic, so easy to follow, fast paced (in a good way) and succinct. Good job, man - I will be visiting here a lot more in prep for my mid-sem.
Also, thanks, your explanation made this MUCH easier to understand...everyone said immunology would be a breeze after biochem and cns. I got a 400 page book to learn in 2.5 weeks.
Just used this video for a presentation at University of Rochester School of Medicine, it's awesome! We wanted to point out one minor error for the sake of clarity - the big antibody, drawn at 2:17, has the structure of an IgG (with 3 constant regions). Armando is correct in stating that it is an IgM antibody, so the drawing should show 4 constant regions (with THREE constant regions before the hinge region, and 1 after the hinge region). Thanks! My class and my professor loved it!
Thank you, this is the best explanation ever. You are saving lives with these videos, I don’t know what I’d do without your explanations, (my lecturers are hmm useless sorry to say).Thank you infinite times. I’ll pass it forward.
Thanks, this is great. The only thing is for VJ recombination of the light chain (around 6:30) you leave the leader segment in the complete spliced segment that makes up the final light chain.
Hey! This video is awesome. I'm really gratefull. Just have a question that I can't find anywhere, why the variable, diversity, and joining region are called like that? Thank you.
Same question as James Mallon. Could you please explain a little about constant region selection? Is there anything that happens prior to everything else in terms of selecting the class of antibody?
this video literally saved my soul but i do have one question. since an igm antibody has 4 constant regions, and the big antibody drawn in 5:01 only has 3, is that an error? Also, why was the second C region colored in with red... does it not participate as a constant region subunit, and thats why there were only 3 drawn in the antibody?
can you explain a little about constant region selection? You just say these are IgM's, I know you just chose one as an example, but, is there anything that happens prior to everything else in terms of selecting the class of antibody?
Hi thank you. I have a question to ask. If the antibody of IgG and IgM have the same specificity, the constant region will still be the same, but what about the variable segment?
Shouldn't there be a fourth C segment in the ab heavy chain?? cause it is an IgM, and both IgM and IgE got four C segments in their heavy chain, you drew only three :/
