I am sure you get this a lot but I learned more in your 12-minute video than I did in a 90-minute lecture of the same exact topic by my professor. I really appreciate it, thanks.
Hey, I'm a student of biology in Brazil and u saved my life with all ur immunology videos. I've watched them all! Thank u so much, they are great, ur explanations are precise and simple at the same time. Ready for my test now! Thanks!!! (:
I wish I had watched these before my exam a few weeks ago!!! I was soooo confused before and now I understand so well in just a matter of 12 minutes and 48 seconds! Thank you for making this!!!
TdT is maximally expressed during heavy chain rearrangement, so "the addition of nucleotides" occurs generally in the heavy chain rearrangement. This process is called N-nucleotide addition. TdT acts much less on the light chain genes!!! However, in the light chain rearrangement process, nucleotide addition occurs by DNA repair enzymes, called P-nucleotide addition. N-nucleotide addition and P-nucleotide addition are quite different mechanisms.
You are welcome. I used the textbook Janeway's Immunobiology and i am quite happy with it, so keep in mind if you ever need a reference on such topics.
This video is already so old but exactly what I needed just now! Somatic recombination was one of the few topics I didn't get of my immunology class, so THANK YOU! you saved me hahah! Keep up the great work. And I love your drawing skills by the way
Thank you soooooo.... much!!!!!! Im a medical student in China, and the textbooks here are so long and difficult to understand. I even need a VPN to watch your videos on RU-vid!!!! You saved me! You are so awesome! Thank you very much for making these series, this must have taken you a long time
I just learned this in medical school and i was clueless what was happening, but your videos do a much better job at explaining some of these concepts than any of my lectures. thank you, thank you, THANK YOU!
Thanks so much for video 1 and video 2. I was lost in my lecture, and was worried I'd have to spend all weekend digging through textbooks. Not the case now! Super helpful.
So you're telling me that I was able to skip reading 15 pages of reading my textbook just by watching your thorough video?? You are such a blessing, thank you so much!
Not much people in China do this kind of drawing about medical stuff,thank u sooo much for helping us understand.Wish I can do this too to help students here.
I literally have an immunology exam tomorrow and this is the only topic I cannot seem to grasp the heads or tails of, I hope that this video becomes my saving grace because I'm positively panicking
Thats an interesting question. Antigens are chemicals in itself. But if you mean chemicals as in enzymes or inflammatory mediators, then yes some can act as an antigen. However its better to say that the chemicals usually disrupt, inhibit or enhance the antigen receptor recognition to an antigen, by binding to them somewhere.
I have a question that I was never able to figure out: Since you are adding random number of nucleotides, you may add 3+1 or 3+2 nucleotides and cause frame shift, then will new terminal codon occur frequently or not? I am asking because in most other genes, if you have a new insertion that causes frameshift, you will most likely have a premature stop codon soon after the frameshift insertion. And if the premature stop codon is before an intron, you will likely to have nonsense mediated decay of the mRNA and has nothing translated.
TdT addition of nontemplated nucleotides in the light chain is a very rare event.... fyi. more likely to occur in the heavy chain, which is why the heavy chain accounts for most of the diversity exhibited by any given antibody.
This is an important detail! Thanks for bringing it up, I was confused when I got to that segment of this video so I'm glad you had the same understanding that I do
