Immunology - Innate Immunity (Complement System Overview) 

sigh... getting through medschool via RU-vid once again. But yolo, this video saves lives!

How tf did they discover all this

This guy is my adaptive immunity against a bad GPA thanks man

"Everything should be made as simple as possible, but not simpler." You've done just that; well explained and concise, thanks so much!

thank you. i was thinking that youtube is for wasting time but you help me a lot.

Iam a big fan from egypt Really you helped me alot Thanks

Thanks dude, this is very helpful! No unnecessary info and great illustrations!

The best overview of the complement system that I have ever seen. Thanks you!

You really make this so understandable. I can't thank you enough! From a very very grateful First Year biomedical science student.

Okay got it, so C3 is cleaved into C3b and C3a by C3-activator C4b2a which makes C3PO into C3bBb using a Ceetec p40, which means black moves his bishop to C3 and this is how it all works

Great video! thanks. A little problem, couldn't see the links at the end?

I might just pass my exams thanks to you.

thank you professor

I can't thank you enough! What do you do, Armando? Are you a physician? Thanks again!

Thank you so much! You're awesome!

Thanks for your video!

AMAZING! THANK YOU

Thank you man!

Wow , Chapeau 👏🏼❤️

thank you

Thank you 🙏

thank you !!

Thanks man that helped :)

splendid.

Thank you :)

Does someone have the links to the video's he talks about in the end of this video. The more detailed version?

C3 convertase. Isn’t C4b2b

I love the time you spend filling in the arrows :) awesome video!

Thank you !

Personally I just want to thank you for making these videos, I am predominantly a visual learner and though I love studying biomedical science, the lectures have been hard to follow. It's important to note that I'm not replacing all of my revision with these videos but you are very good at illustrating the main points, you create a clear context on which to work from. Thanks so much!

My complements to the author!

before this video i used to hate immunology and allison cameron

wow! who knew phil collins actually helps the immune response?:)

Hey, No I am not, I am a biomedical student. I amtrying to get into med next year thanks!

Took me a while to understand what you meant by checks. If you would understand the teaching method, it makes much more sense to see how the alternative pathway is related to the rest in this way. Its a wiser idea also not to give your address to the public. Thanks Armando

haha, ok, I was gonna say, I thought you were being pretty serious :/ Anyways thanks :)

I love you man... You have no idea how happy you've made me

Hi Armando. Can you please include a video on cytokines as a part of the immunology series?

Oh.. My.. God! This is VERY GOOD! Thank you so much for taking time doing it, I imagine it must have taken a lot of work, and also for sharing it with us! All the best! :D

Anyone else hear Phil Colllins?

Armando, you're a force of knowledge. Thanks for your generosity and help with a challenging, complex topic.

As a veterinary student I have to know this stuff, but it is really difficult. This video really helped me study for my test!

u r such an amazing teacher and doctor ...i can't tell u how i feel now after i saw this video ..i was so confused and so afraid that i can't understand the complements for the exam ..but now i get it well ..really really i won't forget ur help forever .....iam just so happy ..thxxxxxx so much ..

Hey, Yea I think the former is the correct one.

Hi Armando, great video but you have a mistake in C3-convertase. According to my literature and my professors c3 convertase is actually c4b2b. I would really appreciate if you answered me with your opinion and resolve my doubts. Thank you for making my life easier!

Omg, I dont understand how it takes my proffessor 2 weeks, 120 slides and an entire chapter of her own textbook to TRY to explain what you can clearly get across in 15 minutes.... mind boggling... thank you sooo much :)

Armando, I want to thank you for the video and for the graphic. It really helped me to sort out the various parts of the complementary proteins. It was getting too much when I was reading my notes, but your video laid it out very nicely.

I was reading my immunology book and notes and was trying very hard to visualize what was happening, but I couldn't because the plethora of C's and numbers and other letters really distracted me. This video was so SO helpful! Thank you!

Thank u so much for the video ,,, wow,,, i was finding it difficult to understand this top,,, i was just skipping the handout 😂,,,,, but this is more than clear thank yu so much

I want to kiss you right now Armano! You are the best!

Yes it is already on facebook under te immunology album~

Hey, sorry for late reply, I will upload muscle contraction video next week

You made a little mistake The C3 convertase is a C4b2b not a C4b2a :)

halo, i am having a doubt, why the lange review of microbiology and immunology said that is the C4b,2b complex but not C4b,2a as the C3 convertase

Armando, thank you so much, you saved my life, I didn't get any of this before I saw your video!

I thought the C3 convertase from the Classical pathway was C4bC2b, not C4bC2a....

I used to watch your videos during my high school, also during my college and even today during my postgraduate degree. Thank you so much for being my constant, incredible tutor and getting me through tough exams.

You are genius to explain this good! 5 hours spent for studying those systems and I got everything for 15 min. Thank you man!!!!!!!

A heads up for the more recent viewers: the c3 convertase for the Classical and Lectin pathway is no longer C4b2a; it is now C4b2b

u make concept very easy to understand..god bless u

where are the links that you had referred to in the video?

I love your videos man, they really make it a lot easier to understand physiology! I noticed you spelled Compliment with an I though, it's spelled Complement with an E, just thought it was nice to get that feedback to you as well, keep up the great work, it's a huge help! :)

You said that the alternative pathway is the last to begin since the C3 convertase made by the other two is needed. Now am I taught that first it's the alternative, then the lectine and final the classical, because in classical antibodies are needed and these have to be synthesized first. Also since C3 can react with water to make iC3, next CB attaches and gets cleaved. This leaves iC3Bb (also a C3 covertase). Showing the alternative can do it all on its own. Any thoughts?

hahaha. cheers sean

You, Arnando, you are the man! Before I found your videos about physiology and microbiology/immunology... I damn well thought I was going to fail.. but now I have some hope :p

If i ever meet you, I'll sing "you're beautiful" by james blunt for making us all understand such a difficult topic with this much ease.

I can't tell if he has an english accent or not!

Absolutely brilliant. My second week of med school, and this was proving a real thorn in my side. You have done such a brilliant job - I now fully understand how this integrates with the innate response, answering questions like "why does histamine get released?" etc. I will be sharing with the rest of my cohort! Kudos to you!

Honestly you are saving my life! I swear, if I pass my Immunology exam on wednesday, you have earned yourself a new patreon supporter.

The Best so far!! i had all confusion before this and now .. YEAH! i'm gonna f*ck the exam \m/ ! PEACE! :D

THE C3 CONERTASE OF CLASSICAL AND LECTIN PATHWAY IS C4b2b not C4b2a as far as i know according to medical microbiology book by jawetz,melnick and adelberg And also review of medical microbiology LANGE

I think this material is outdated. The Alternative Pathway is actually the first to be activated because C3 has a highly reactive thioester bond that spontaneously reacts with water to make iC3 when it is near a pathogen. The iC3 then binds factor B and then factor D comes in to cleave B into Bb and Ba to give rise to soluble C3 convertase -> iC3Bb. The soluble C3 convertase iC3Bb is now able to cleave and activate C3 into C3b and opsonize the pathogen. The Lectin and Classical Pathways follow in sequential order after the Alternative Pathway occurs. The Lectin Pathway requires an induce response from the body to make more MASP-1 and MASP-2 to activate C4 into C4a and C4b. Lastly, the Classical Pathway occurs last because it requires an induced response from the body to produce Ag-specific IgM/IgG or C-Reactive Proteins for the C1q heads to bind.

awesome video. made the complement system so easy to understand thnx. : )

In autoimmune, which of following statements about myasthenia gravis are CORRECT? 1. the immune system attacks the CNS 2. T-lymphocytes are involved in the inflammatory response 3. Antibodies attack proteins within the body. 4. The immune system blocks receptors at the neuromuscular junction

Annnnnnd I STILL FUCKING HATE THE COMPLEMENT SYSTEM. FUCK THESE stupid pathways... I hate all the pathways.

Btw, C1qr2s2 complex doesn't just bind to C4b2a. It gets activated when it binds to an antigen-antibody complex causing it to activate C1s and cleave it away. The activated C1s will cause C4 to cleave to C4a and C4b. The C4b now has a small part missing, to which attached C2 and cleaves itself to C2a and C2b...and removes the C2b part. There we form the C4b2a complex

Isn't the alternative always active at a low level? If I understand correctly, C3 can autolyze forming C3a and C3b, which binds non-specifically to cell membranes. The sialic acid in host cytosolic membranes inactivates (somehow) C3b. Bacterial cytosolic membranes, lacking sialic, become decorated with C3b allowing the cascade to progress.

I never seen something such complicated like this Topic ?! Thank you anyway :)

Thanks for wonderful video . 👏👏👏💪💪💪 But I think a small thing is wrong in this video. The c3 convertase is C4b2b not C4b2a (it is former nomenclauture ) ...🤔

Ur lectures are really straight forward. . N understanding. . Really explained well.. I understood it in 14mins than spending 50mins in class yet confused me..

low immunity create big problems My sister also had low immunity few years ago that why she always stay sick but then one of our relatives suggest to use Immunity care pack buy Planet Ayurveda. She used that and Now She is living with strong immunity.

For the alternative pathway, there is only one C3 convertase created: Facor D is aprotease that cleaves factor B in to Bb, which forms the final C3bBb complex. The Properin is an enhancer/ stimulating factor of the c3 convertase to create more fixed C3bs and therefore enhanced opsonization... p.s. where can I find the videos that are specific to each pathway?! :)

your lectures are awsome. i no longer need to go to my teachers or depend on them. can you make vedios on: 1.female reproductive structures 2. embryogenesis 3. developement of baby from embryo till birth. 4. biotechnology, recombinant DNA , vectors, gene library etc

your lectures are awsome. i no longer need to go to my teachers or depend on them. can you make vedios on: 1.female reproductive structures 2. embryogenesis 3. developement of baby from embryo till birth. 4. biotechnology, recombinant DNA , vectors, gene library etc

your lectures are awsome. i no longer need to go to my teachers or depend on them. can you make vedios on: 1.female reproductive structures 2. embryogenesis 3. developement of baby from embryo till birth. 4. biotechnology, recombinant DNA , vectors, gene library etc

hi, thank you for this video it`s very useful, but I have a question : how c4, c2, c6, c7, c8, c9 are related to the complement system? could you please explain and thank you so much :) .

Hey I am a huge fan of your videos. In this video you mentioned C4b2a as a C3 convertase ......it's wrong. C4b2b is the right answer. Cheers!! Keep uploading.

But doesn't the Alternative pathway activate first? This video makes it seem like the Alternative pathway is last but I'm pretty sure it's the first one to activate. There is C3 regularly in the blood and it doesn't need the other complement proteins to make its C3 convertase, just Factor B and Factor D.

I love that you are calling it Phil Collins lol this made the video even more enjoyable

Thank you for your gigantic Lecture. Can you please include a video How aptamer target to specific Bio marker and/or specific cancer cell as a immunological aspects? thank you !!!!

It may very well be possible that I am in love with your hand and voice,... erm... in the educational sense hahaha. Been watching most of your videos - just another big thanks. Very helpful indeed!

Thank you for you overview...But I am so sorry your hand is a HUGE distraction...but you draw very beautiful. Sorry I did not find it helpful with all of the hand movement.

Too busy! This guy is all over the shop, instead of just explaining something logically, he's here there and everywhere like a bee buzzing around!!

you are the best. Love from a current medical student

WHICH MELONHEAD FOUND ALL THIS OUT ABOUT BIOLOGY. so much information :'( but interesting and fun vid!

Brilliant stuff. You remind me of the great Dr.Frank Netter of The famous Netters Atlas of the Human Body. Armando Hasudungan superb tutorials.

Mr.Armando,l beleave that theory are good,but when you're an elderly person you need something more practical.If your bone marrow has been destroyed by a chemotherapy and you are in a big problems,you needed someone to teach you how to survive daily!

Just one question. Whats the difference between viral infection and bacterial infection. My friend told me it is T cells take responsible to against bacterial infection, while B cells are for viral infection. Why?

Alternative pathway activates first.. before classical pathway and lectin (reference: janeway textbook)

In the Innate Immunity response besides the barriers is inflammation,witch is a key step for the adaptive immunity ,without inflammation adaptive immunity would not function.