Thank you for sounding so happy and excited, it really makes a difference in the learning experience. It makes learning these difficult details so much more pleasant. Thank you for cheering up science nerds everywhere :)
+Leslie Miller Thank you for appreciating that - it's subtle, but SO important! Science IS fun and wonderful! I love my profession and my students, so I'm so glad to hear it comes across. :)
WOOOOOW!!, this is beautiful!!. I have been reading this in my text book, my lecturer`s slides and my tutor`s notes but it made no sense!, I just couldn`t distinguish between excitation-contraction coupling, sliding filament theory and cross bridge cycling but now I get it, all thanks to you Prof!!, your work is much appreciated!.
Med school professors could not explain this easy concept and you did it in ten minutes. Great researcher does not mean great teacher. Learned that the hard way.
This video helped me out so much! I'm in a one month physiology course and it's so hard to learn all of the material before an exam in 4 days. One question - does this also happen in cardiac muscle cells?
you are an amazing professor, I love your tone of voice but what I love the most is how well you explained this. I wish my professor loved to teach as much as you do!! My respects for you ma'am.
very thankful to your exciting video, it is really informative. It provides more knowledges about DHP receptor and RyR that in my textbook doesn't exist, hope you can release more such interesting video.
This video is very awesome. However, I do have a question about the dihydropyridine receptor. Currently, have researchers been able to better understand the DHP-R (a voltage-gated L-type calcium channel) and know that it opens the ryanodine receptor by releasing calcium into the cytoplasm which binds to the RyR to open it and release calcium within the sarcoplasmic reticulum? I'm trying to piece everything together between RU-vid videos and my textbook.
I think it is important to note that there is a graded/local potential started by the nicotinic-AchR by Na influx. This in turn, propagates to activate V-gated Na channels that make a new AP. The new AP travels down the T-tuble etc.
That was very interesting. I appreciate understanding whats going on at the molecule level with muscle contractions. It adds to the mind muscle connection when weight training.
I've read recently that STAC3 has been identified as a (possible) fourth essential EC coupling protein and it may couple CaV1.1 with RyR1 for calcium release in skeletal muscle. This would explain observed myopathies in patients with STAC3 defects. Some good info here: www.pnas.org/content/114/2/E228
