LPS Increases During Aging: Besides Calorie Restriction, What Else Can Reduce It?

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LPS increases during aging, which may explain the age-related increase for CD38 and decreased NAD+. LPS is decreased on a calorie restricted diet, but what else can reduce it? In this video, I present evidence for intestinal alkaline phosphatase's (IAP) role on LPS, and posit that interventions that increase IAP may be an important approach for increasing NAD+.

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2 авг 2020

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Комментарии : 84

@dvansoye 3 года назад

Another great video, Michael. There's no fluff here. I'm definitely now googling for the best sources of Omega-3, Fiber, and K1. I should mention that I am a hound for this type of information and haven't seen it anywhere else. So, thank you for all of the time you have taken for research and your crystal-clear and visual presentation. Woot!

@conqueragingordietrying1797 3 года назад

Thanks Darren!

@karenf9137 2 года назад

Agree. And I might add that his research seems a bit more substantial and eloquent than that of David Sinclair's... not that Dr. Sinclair doesn't have good stuff, but....🤷‍♀️

@manamsana3786 Месяц назад

This channel is an absolute gem... I'm sick of health influencers... i want to understand it myself and there's no other channel like this.... keep it up!

@conqueragingordietrying1797 Месяц назад

Thanks @manamsana3786, and will do, for the next 72+ years!

@diogobarardophd4210 3 года назад

Your best video so far. Nice work!

@conqueragingordietrying1797 3 года назад

Thanks Diogo, will do!

@peterz53 3 года назад

Important presentation. Thanks. I also like information on non-supplement interventions which help modulate aging. Seems controlling LPS and CD38 will go a long way to staying healthy, in part by avoiding the suppression of NAD+.

@gloglos100 3 года назад

Michael thank you. Just the additional details for which I was looking. Refreshing to get clean to the point presentation. Subscribed,

@trepied2058 3 года назад

Thank you! This answered my question from your previous video. This is very interesting as it is very recent research. Hopefully they'll soon establish a more direct causal link between IAP and NAD+ levels. The lifespan increase in the mouse study is huge.

@mshkt1620 2 года назад

Best & best organized / presented this far. Amazing.

@conqueragingordietrying1797 2 года назад

Thanks Ms Hkt!

@user-mt7jb8kx8u 2 года назад

Thank you very much for the video! I wrote you a new comment on the "longecity" forum.

@honeybadgeresse 3 года назад

Very good presentation!! Thank you!

@conqueragingordietrying1797 3 года назад

Thanks honeybadgeresse!

@monnoo8221 Год назад

amazing content! thanks a lot There is some interesting work about the gut barrier, stating that B1 among other things like stress management and microbiom composition is essential to maintain it.

@DanzeMusic 3 года назад

Good video! Think I have been doing everything right according to your video, lots of omega 3, soluble fibre, veggies with K1. The only problem I have is probably too much guts fermentation that causes histamine, so I will start taking DAO to see if it can improve my situations. 🧐

@iblisthemage 3 года назад

Very informative.

@johnsharnetsky9559 11 месяцев назад

If you eat wide variety of dietary fiber and maintain diversity of the gut microbiota than the increase SCFA production should keep the LPS in the intestines where they belong, not in the blood. A leaky gut is source of all disease and accelerated aging. The solution has always been diet and exercise.

@robertcaune840 3 года назад

Thank you!

@conqueragingordietrying1797 3 года назад

Thanks for watching, Robert Caune!

@aclearlight Год назад

It would help to define/show "LPS" a bit more thoroughly upfront.

@gerlachsieders4578 8 месяцев назад

excellent!

@lui8885 2 года назад

great video! Does sugar have something to do with this?

@stuartm2106 3 года назад

Sounds like we should all be eating dandelion greens - K1 and inulin in one serving! Any idea why the fish oil supplements didn't have the same effect as fish, could the oil have been oxidised?

@conqueragingordietrying1797 3 года назад

We evolved to get our nutrients from food, not supplements, so I'd bet that there are Omega-3 interactions with other nutritional components in the fish that boost its in vivo effectiveness.

@abritrn 3 года назад

Another great video. Thank you. My summary: It's desirable to increase IAP. Higher IAP leads to lower LPS which leads to less CD38 which can lead to higher levels of NAD+. Things known to increase IAP: caloric restriction, high fermentable fiber diet, increased long-chain omega-3 FA intake (and decreased n-6 PUFA, ratio of 4:1), vitamins K1 and K2, short-chain fatty acids especially C4 butyrate. Theoretically a LCHF/keto diet may increase acetate which can form butyrate.

@openmind8620 3 года назад

wonderful summary. Thanks Amy

@jarrodhockley Год назад

i wonder if Hemp seed / chia are good IAP modifiers as they are high in Omega 3 but also provide SCFA potential

@newdata 2 года назад

mild antibiotics like muchrooms or herbs may influence gut in right direction lowering lps ?

@sarathepanda2906 2 года назад

I've heard that probiotics and prebiotics lower LPS too. Is that correct?

@jbosson82 Год назад

Great work and video. Diving deep. Plant based sources like flax and walnuts will bring both omega 3s and fibers.

@someonelse48 3 года назад

would not flax and chia be the best option then? not only do you get the omega's in a good ratio but you also get a ton of soluble fiber...

@conqueragingordietrying1797 3 года назад

Flax and chia are good sources of soluble fiber, which improve gut barrier function and potential LPS translocation into the blood, so that's a good suggestion. I eat ~10g of flax/day, and make chia-date balls for my daughter frequently.

@jamesf7933 3 года назад

Thanks for this highly informative video. After seeing your prior video, I was wondering what could be done to reduce the effects of LPS. BTW I understand that besides getting K2 from food, that Bacillus indicus HU36 produces K2. Some companies sell a spore-based version of Bacillus indicus HU36 that are claimed to survive stomach acid. I don't own stock in companies that sell it. (-:

@Nmethyltransferase 3 года назад

Tiny nitpick. We're looking for fermentable fiber. Some types of fiber are "soluble" but ferment poorly, e.g. psyllium husk. I still take psyllium husk BTW, because it spreads out the fermentation (of other, more fermentable substrate) across the entire colon. Anyway, my main point is... Aren't green leafy vegetables the ideal delivery vehicle for vitamin K1? They deliver K1 to the colon, where you want it, along with non-disgestible but fermentable substrates that can feed the gut bacteria.

@conqueragingordietrying1797 3 года назад

Yes, increasing soluble, fermentable fiber is the goal. Do you have data that psyllium's soluble fiber ferments poorly? I haven't seen that. I don't know about them being ideal, but K1-rich vegetables are a big part of my approach, and fiber is one reason why: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-znX-fEF9YlY.html

@p_peja 3 года назад

1.5 mg of vitamin K would be a huge daily intake (recommended 0.075 mg). I've read somewhere that humans can synthesize vit K in intestines. Can mice do it? if not, that is maybe the reason why so huge vit K supplementation in mice is needed.

@Kayshadog 2 года назад

Not mg, mcg. So 0.5 mg.

@jskweres2 3 года назад

Is there a way to test NAD levels to confirm this?

@conqueragingordietrying1797 3 года назад

I looked online, and didn't see any companies that are measuring NAD commercially. Hopefully I'm wrong, and someone can correct me!

@dimitrichristou4889 Год назад

Do you think LPS & endotoxins have a role in IBD & being a player in driving some of the autoimmune stimulation on the intestines?

@conqueragingordietrying1797 Год назад

I’m not an expert on IBS, but I’d bet on yes

@GodfreyMann 2 года назад

Regarding the O3:O6 ratios instead of taking fish oil supplements how about reducing the O6 intake in the diet? Doing both would be awesome no? LPS is also mopped up by LDL-c, therefore is this an example of where high LDL-c has a health advantage? The worry is cardiovascular risk, but as long as one has pattern A (high proportion of unoxidised and unglycated ApoB on the LDL) then would that risk be mitigated or at least minimised?

@sabincioflec8413 Год назад

Hey, actually we need both omega 6s and omega 3s in a good ratio, so it's not just about the ratio but about the ratio and the quantity. I'd suggest looking at Rhonda patrick's interview with Bill Harris, they talk in depth about the role of it.

@MarmaladeINFP 3 года назад

Isobutyrate, similar to butyrate, can be produced on a carnivore diet.

@Avital4414 3 года назад

I’ve struggled to find a good brand of omega 3 supplement. Recommendation? Thanks.

@conqueragingordietrying1797 3 года назад

Are you vegan? If not, from my experience, omega-3 rich fish (salmon, sardines, macarel) is best. I've tried supplementing with omega-3, without any effect on my triglycerides or HDL, whereas the same amount of omega-3 from fish has an effect.

@Avital4414 3 года назад

@@conqueragingordietrying1797 do you happen to know if smoked salmon has ample fatty acids (do they survive the curing process)? thanks!!

@conqueragingordietrying1797 3 года назад

@@Avital4414 I don't know about that, but the smoking process is not good for health...

@randallhesse5011 8 месяцев назад

I hear that krill oil is high in DHA

@JohnHobitakis 2 года назад

Do a video on Akkermansia muciniphila and aging. I suspect that it blocks LPS passing through the gut.

@conqueragingordietrying1797 2 года назад

The Akkermansia story is complicated-it's a mucin-degrading bacterium, and gut mucus is essential for barrier defense, so intuitively (to me) having more of them may be bad for gut health. However, as I'm sure that you know, there are lots of studies showing positive effects for Akkermansia.

@JohnHobitakis 2 года назад

@@conqueragingordietrying1797 My understanding is that Akk degrades but also refreshes and reshapes the mucus layer: "A. muciniphila is considered to be a mucin-degrading bacteria that has the ability to continuously refresh and reshape the gut mucus layer, thus improving the integrity of the gut epithelial barrier and maintaining intestinal homeostasis (Derrien et al., 2008; Everard et al., 2013)." I recently read that Akkermansia was abundant in centenarian. I postulated that the mucus refreshing qualities of akk were protecting them from gram negative bacteria crossing their gut. So increasing or optimizing Akk can potentially be a longevity strategy.

@conqueragingordietrying1797 2 года назад

That's one possibility, but the other is that it can deplete the mucus layer, which can make it easier for microbes to cross the epithelial lining. In contrast, there's a growing body of evidence that Akkermansia are net positive for health-I'd like to see more data before saying that it might be good as a probiotic supplement.

@Battery-kf4vu 3 года назад

Wouldn't 1500mcg of vitamin K1 cause too much coagulation? I am taking close to that amount, I'm wondering about blood clots.

@conqueragingordietrying1797 3 года назад

As a supplement, that could be true, but in foods, especially from its main source, green vegetables, there is no evidence that higher Vitamin K intakes is associated with adverse health outcomes. In support of that, see this post: michaellustgarten.com/2020/07/28/eat-more-green-leafy-vegetables-reduce-mortality-risk/

@Battery-kf4vu 3 года назад

@@conqueragingordietrying1797 Thank you. Regarding your article, maybe there is no correlation between vitamin K2 intake and all cause mortality because people get their K2 from dairy products, which gives them too much calcium which leads to atherosclerosis. The vitamin K2 is not sufficient to counter the effect of too much calcification.

@conqueragingordietrying1797 3 года назад

@@Battery-kf4vu The all-cause mortality data for K2 is mixed-some studies show no association, while others show a risk reduction: pubmed.ncbi.nlm.nih.gov/24647393/

@Battery-kf4vu 3 года назад

@@conqueragingordietrying1797 The study says: "A small but significant correlation was found between total phylloquinone and menaquinone intake (r = 0.05, P < 0.001). Participants in the upper quartile of energy-adjusted dietary phylloquinone intake consumed nearly twice as many vegetables (especially leafy green vegetables and fruits) as those in the lower quartile. Increased menaquinone intake was associated with higher consumption of dairy products and meat (Supplemental Table 1)." People with higher vitamin K2 intake tend to have a worse diet than those with high vitamin K1, so K2 might be at a disadvantage. A good source of K2 might have a positive effect on all cause mortality.

@panimashalps4991 3 года назад

Супер!!!

@conqueragingordietrying1797 3 года назад

Благодаря!

@kamanashisroy Год назад

This is totally missed in mainstream medical science.

@diamond_s 3 года назад

I heard grass fed butter is rich in butyrate, and has some omega 3s, and k2. Keto breads are high in fiber, wonder how much is soluble fiber. Maybe buttered keto bread might have benefits in this area.

@conqueragingordietrying1797 3 года назад

We evolved for millions of years eating ~100g of fiber/day, (see michaellustgarten.com/2015/07/17/on-a-paleo-diet-not-if-you-fiber-intake-is-less-than/) not eating butter until the past few thousand years, so I find it hard to believe that the amount of butyrate consumed in butter will be anywhere close to that produced on a high-fiber diet. Unfortunately, no studies have compared those factors.

@diamond_s 3 года назад

@@conqueragingordietrying1797 yeah but butter still has k2 omega 3s cla and saturated fats. It can accompany high fiber breads, and keto breads, some of which should provide a good fiber source, also some people use it on veggies, and the fats should aid in the absorption of some nutrients..

@toomanymarys7355 Год назад

@@diamond_s it has negligble amounts of omega 3s or butyrate or K2. Even CLA is far below a bioactive amount.

@diamond_s Год назад

@@toomanymarys7355 oh i thought butyrate got its name from butter. but I will say I've heard that it contains such but haven't checked the actual amounts.