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Making The Sweetest Compound Known (Lugduname) 

Chemiolis
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It’s here
Find me on / chemiolis or any of the YT Chem discords
Literature:
test in pigs
sci-hub.se/htt...
2,3-dihydroxybenzaldehyde via o-vanillin + acetic acid + hbr
sci-hub.se/htt...
Methylenedioxy aldehyde
sci-hub.se/htt...
Oxime
koreascience.or...
www.rsc.org/su...
Oxime & Amine
onlinelibrary....
Biphasic isothiocyanate synth
sci-hub.se/htt...
T-Bu Gly (for boiling point)
www.orgsyn.org...
review about thioureas to guanidines
www.arkat-usa....
HgCl2 guanylation
sci-hub.se/htt...
www.sciencedir...
(alternative) aq phosphoric acid deprotect of t-bu ester
sci-hub.se/htt...
trisub guanidine acetic acids
pubs.acs.org/d...
sci-hub.se/htt...
synth of trisub guanidines (only with aryl-carbonyl group)
pubmed.ncbi.nl...
sci-hub.se/10....
makes disubstituted guanidines
sci-hub.se/htt...
pubs.acs.org/d...
Makes some guanidines, purifies them with flash column using 100 DCM 1 Methanol
sci-hub.se/htt...
Guanidines, Mentions regular column chromatography with 100% EtOAc
sci-hub.se/htt...
Mentions columning with 50% EtOAc
www.sciencedir...
ars.els-cdn.co...
Patent for these sweeteners
worldwide.espa...
Support my channel with patreon:
/ chemiolis

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11 сен 2024

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Комментарии : 621   
@andrewjin6618
@andrewjin6618 25 дней назад
Tasting products that have gone through stoichiometric mercury reactions is crazy
@UniCorneliusfan21
@UniCorneliusfan21 25 дней назад
Though it’s inorganic mercury, you would be more screwed if it was organic mercury Also I’m not sure but is mercury sulphide insoluble or smth
@Chemiolis
@Chemiolis 25 дней назад
I think it’s safe after workup and columns 🤭
@andrewdogaru6005
@andrewdogaru6005 25 дней назад
​@@Chemiolismeh, eat a can of Tuna and you're probably worse off😁
@elliotwilliams7523
@elliotwilliams7523 25 дней назад
@@Chemiolisgood job. Seeing you eat it is the best part. I always like to eat my lab chemicals whenever I get the chance.
@Rafi-qy2kl
@Rafi-qy2kl 25 дней назад
No more mercury amalgam mdma for me any more 😢
@cvspvr
@cvspvr 25 дней назад
a dutch chemistry youtuber ate lugduname. this is what happened to his tongue
@truey90s
@truey90s 24 дня назад
Chubbyemu's next video
@MatthewSuffidy
@MatthewSuffidy 21 день назад
Free trial
@crimson3522
@crimson3522 20 дней назад
@@truey90sthats the joke
@меффин
@меффин 20 дней назад
Chuььyemu ahh comment
@LucVignolles
@LucVignolles 20 дней назад
I could hear the music fading in while reading this
@jhonbus
@jhonbus 25 дней назад
I can see why it wasn't a commercial success... "300,000x sweeter than sugar" sounds great in theory but in practice it boils down to "Makes the inside of your mouth taste sweet for several hours. A hundred nanograms is sufficient to cause this effect so everything is now contaminated and everything will taste sweet forever"
@christopherleubner6633
@christopherleubner6633 24 дня назад
And now we know the secret ingredient for the ever lasting gob stopper.😂
@egominer5624
@egominer5624 24 дня назад
the ground water will have a faint sweet taste,
@Cineenvenordquist
@Cineenvenordquist 24 дня назад
I mean get the smallest amount you can measure and sweeten dutch baby or German apple pancakes.
@NoMusiciansInMusicAnymore
@NoMusiciansInMusicAnymore 24 дня назад
@@christopherleubner6633 it's actually just a marble
@NoMusiciansInMusicAnymore
@NoMusiciansInMusicAnymore 24 дня назад
Good way to make kids eat vegetables
@Jp-ue8xz
@Jp-ue8xz 24 дня назад
hydrochloric acid and lugduname... the forbidden lemonade
@isaacthedestroyerofstuped7676
@isaacthedestroyerofstuped7676 18 дней назад
Lugdumade coming to a store nowhere near you
@ericeder1693
@ericeder1693 16 дней назад
Hydrochloride not hydrochloric. They are two different bonds & not at all the same chemical. I like where you were going with the comment tho👍🏻
@ItsDatGuy969
@ItsDatGuy969 16 дней назад
@@ericeder1693I think he meant hydrochloric acid. Lemons are acidic, and using hydrochloride salt in that example doesn’t really make sense.
@catpoke9557
@catpoke9557 16 дней назад
​@@ericeder1693Hydrochloric acid lemonade is an idea that gets circulated online a bit. There's also a video where someone actually makes and drinks it. This comment is trying to make that concept more ridiculous by adding another exotic ingredient to it.
@ericeder1693
@ericeder1693 16 дней назад
@@ItsDatGuy969 ok, I'm no chemist. Only heard the chemical name & knew from chemistry that the suffix on a word like that changes the molecular bond structure. But you're saying there was a misspeak / typo then right? In that case the comment works perfectly👍🏻
@ChemicalEuphoria
@ChemicalEuphoria 25 дней назад
i bet my ass bro OWNS a solvent selling company 😭 Chemiolis be like: "ah yes, i washed the residue with 300L of dichlorobenzene" 🤣🤣🤣
@zombiekel09
@zombiekel09 25 дней назад
yesterday i learned people get high of dichlorobenzene 🧐 urinal cakes
@cvspvr
@cvspvr 24 дня назад
he's the ceo of ligma baldrich
@PuerRidcully
@PuerRidcully 24 дня назад
@@cvspvr ligma ballsdrich
@darealrulezbreaker9493
@darealrulezbreaker9493 24 дня назад
​@@cvspvr whats a ceo?
@SpaghettiToaster
@SpaghettiToaster 24 дня назад
@@darealrulezbreaker9493 ligma balls
@MrTotallyinteractive
@MrTotallyinteractive 25 дней назад
The green color is almost certainly from iron from the needle when you were adding the HCl. When I saw that you had left the needle in the flask during the reaction, I immediately knew why it was green. I know from personal experience never to leave needles in contact with HCl vapors during reactions 😂 Oh well, at least you got your daily iron 😅
@nickburgers5177
@nickburgers5177 22 дня назад
Relatable
@rizalassyfiya2133
@rizalassyfiya2133 20 дней назад
Whoa, never thought iron would be giving green colour. I only knows the one who'll be giving green color is sulphur
@anoirbentanfous
@anoirbentanfous 20 дней назад
@@rizalassyfiya2133 copper also give green color
@user-ql6dt3rr9c
@user-ql6dt3rr9c 20 дней назад
So true!!! I knew why it got green as well when I saw that 😅😅😅
@jaycenotsoanimations9216
@jaycenotsoanimations9216 20 дней назад
Green needle
@pvc988
@pvc988 25 дней назад
1:24 I like the fact that in stock footage the guy uses safety gloves to handle the stuff that he eats.
@jamesmnguyen
@jamesmnguyen 25 дней назад
What my chemistry teacher thinks we're going to do with all the dangerous chemicals in the lab.
@PartyhatRS
@PartyhatRS 25 дней назад
I mean, your stomach contains literal HCL, but you don't want that on your skin. Lol
@Loczyslaw3000
@Loczyslaw3000 24 дня назад
He have them on because of prostate exam he done before eating. I know that cause I was that one lucky guy ho was examined
@samiraperi467
@samiraperi467 23 дня назад
Chili. 'nuff said.
@Flint-Dibble-the-Don
@Flint-Dibble-the-Don 21 день назад
Melts in your mouth Not on your hand. 🔴🟡🟢🔵🟤
@eaglgenes101
@eaglgenes101 25 дней назад
0:07 Me fooling around sticking a bunch of functional groups together like some goofy kid in chemistry software
@Paul_Bedford
@Paul_Bedford 21 день назад
As you do on a slow Saturday afternoon
@KimYoungUn69
@KimYoungUn69 18 дней назад
@@Paul_Bedfordhere we are 🍬
@thebookman1036
@thebookman1036 15 дней назад
@@Paul_Bedfordwe used to do it in our school cause it was a selective school so we were all nerds
@Doctorgallium
@Doctorgallium 24 дня назад
“I tasted all the fractions” that’s the wildest way to identify the desired product 🤯 34:56
@Andreas-zm9tg
@Andreas-zm9tg 18 дней назад
Well, that's how science used to be done... I'm surprised we don't have any superheros with the amount of self experimentation
@Ambryu1
@Ambryu1 24 дня назад
Accidentally creates the most addictive drug on earth.
@audiophile75
@audiophile75 20 дней назад
What, you mean sugar?
@Ambryu1
@Ambryu1 20 дней назад
yes
@TheGenericPerson
@TheGenericPerson 19 дней назад
@audiophile75 Dunno if your comment is satire or not, but sugar is definitely not the most addictive. (Please note I am not a professional so I may be wrong, but nicotine is more addictive)
@Bizerro2000
@Bizerro2000 18 дней назад
​@@TheGenericPersonit was a joke.
@audiophile75
@audiophile75 18 дней назад
@@TheGenericPerson Ya, that should have been obvious by the way it was written. The true myriad intricacies, subjective views, the relative experienced and inexperienced, biology and pharmacology of addiction...... Oh ya, can't forget the most maligned...... and politics (judgment) of addiction, is far too long a discussion/argument to stem from the haphazard retort to a haphazard quip. Don't take A reply of the MANY THOUSANDS of comments to ONE of the BILLIONS of YT videos as the place to take time making an "unprofessional" correctional statement to someone/something (I could be a bot") whom you have no connection to. In the future just take the chuckle with thankness that you didn't waste the time trying to read an initially interesting statement that droned on only to end in some obvious misunderstanding steming from some strangers chronic inattention. So just........ take the chuckle. Oh, and yes, while smoking is stated as the hardest to kick, I would argue that's only due to extreme repetitive habituation of X smokes/day over however many decades. All the neural growth of every experience all those years being intimately interwoven with cigarettes. Nicotine, I would argue is not so difficult to kick, per say. GABA agonist, specifically benzodiazepines or barbiturates...... and alcohol (but with benzo's "if I can't have you, NO ONE CAN!!!" determination not to be kicked to the curb they're currently in the #1 spot) are at the top, then opioids, sex, stimulants, etc....
@xxdarthrevanxx7217
@xxdarthrevanxx7217 25 дней назад
36 min - must have been a lot of work- hope this performs well so you can keep delivering videos like this
@andersjjensen
@andersjjensen 25 дней назад
Almost no matter how well this video does it will not recover the cost of all that solvent :P
@doublepinger
@doublepinger 19 дней назад
Great news, now he has enough sweeteners for the rest of his life... and the rest of everyone's life. 1g is "about" 200kg of sweetener. You could BREATH across the room from a grain and taste a soda's worth of sugar
@chemdelic
@chemdelic 25 дней назад
Not as sweet as you bro🗣️❗️
@maymkn
@maymkn 23 дня назад
Yes! No Diddy.
@yahia1000
@yahia1000 11 дней назад
No homo bro
@user-uq8hw2rs2t
@user-uq8hw2rs2t 22 дня назад
I've synthesized and tried lugduname like you. When I prepared it, I could get it as a white powder after column chromatography (but small impurity always existed). Even 0.1 mg of that was enough to taste, really intence sweetness, and too much amount of that induced strong bitterness. The sweetness succeeded for 1 min and the bitterness did for 15 min. I'm happy to see who can share this experience!
@fiedel
@fiedel 19 дней назад
Since managing to remember „anhydromethylen-2-propantrikarbonsaures Hexamethylentetraamin“ from the 1-time-utterance of some dude in school I have a weird appreciation for chemistry-nerds. Please feel welcome in this world!
@friendsbrn
@friendsbrn 19 дней назад
I'm assuming you poured the 0.1mg into water, right? Why not further dilute the solution? I'm surprised soft drink manufacturers don't fund consumption safety studies (assuming it's stable in soft drinks) to give them yet another sweetener for their war chest of flavorings against the competition.
@xdkristof
@xdkristof 13 дней назад
0.1mg is 30g of sucrose, that's pretty sweet
@5thearth
@5thearth 10 дней назад
I think the reason this hasn't been commercialized is the synthesis is terrifying for a product you're supposed to eat.
@isaacthedestroyerofstuped7676
@isaacthedestroyerofstuped7676 25 дней назад
A couple weeks ago, I had a fever dream that I watched you have to use a heat gun and damp towel on a distillation apparatus while I ate fettuccine alfredo straight out of the pan. Well, here I am at 10:40pm eating my alfredo in the pan 😂
@andyv2209
@andyv2209 20 дней назад
You sure youre not just having deja vu?
@isaacthedestroyerofstuped7676
@isaacthedestroyerofstuped7676 18 дней назад
​@@andyv2209 Definitely not, but I did think that at first. I had told a friend back when I had the dream, and just confirmed the conversation with them.
@andyv2209
@andyv2209 17 дней назад
@@isaacthedestroyerofstuped7676 oh OK haha nice, i was gonna say, if it was such vivid deja vu, it could be a sign of epilepsy so I'm glad you know it wasn't xp crazy coincidence haha
@icecube-n2d
@icecube-n2d 17 дней назад
​@@andyv2209crazy vivid deja vus are a sign of 🏳🏴🏳🏴? i hope i won't develop it..
@ShiroCh_ID
@ShiroCh_ID 16 дней назад
what are the odds this kind of thing happening?
@FuRuMu
@FuRuMu 25 дней назад
A person who sacrificed his tongue to taste it! respect!
@scriabinskunk
@scriabinskunk 25 дней назад
#GetChemiolisASchlenkLineForProperDegassing
@aaronbarlow9616
@aaronbarlow9616 25 дней назад
Oh my goodness. Yes. Tbh he probably could get by with some multi-neck Schlenk flasks, though for a lot less $$$
@bardiaqasemalizadeh267
@bardiaqasemalizadeh267 25 дней назад
​@@aaronbarlow9616 500 € schlenk line vs 20 cent balloon
@antares8826
@antares8826 24 дня назад
And a rotary evaportator as well
@GeneralKenobi69420
@GeneralKenobi69420 20 дней назад
Ok furry
@stavinaircaeruleum2275
@stavinaircaeruleum2275 19 дней назад
​@@GeneralKenobi69420they know more about chemistry then you will ever know, you obtuse brainlet.
@StuckVomKuchen
@StuckVomKuchen 25 дней назад
Now make super-sweety candies with it just for a prank
@NuclearTopSpot
@NuclearTopSpot 25 дней назад
Candied almonds call em Lugduname deez nuts
@LalaLa-ld1gs
@LalaLa-ld1gs 25 дней назад
Would you eat one?
@vendetta1429
@vendetta1429 24 дня назад
Read it as super sweaty
@ghost_ship_supreme
@ghost_ship_supreme 23 дня назад
⁠@@LalaLa-ld1gsI might try one simply out of curiosity (like those beanboozled candies) and because I may never get another chance to, since it’s not typically commercially available
@ypcomchic
@ypcomchic 23 дня назад
@@NuclearTopSpot😂😂😂😂😂
@chemistrycapital
@chemistrycapital 25 дней назад
So much Methylenedioxyphenyl in Chem RU-vid right now
@ChemicalEuphoria
@ChemicalEuphoria 25 дней назад
@@chemistrycapital it's a motif to replace tho, it's known to metabolise into catecholes, which cause oxidative stress, but maybe the amount that is used is small enough? but i saw some interesting bioisosteres, time to investigate further!
@chemistrycapital
@chemistrycapital 25 дней назад
@@ChemicalEuphoria I know, I covered this in my recent video :)
@SetTheCurve
@SetTheCurve 25 дней назад
I wonder how long before all the videos are removed and the information forgotten.
@hhhsp951
@hhhsp951 25 дней назад
I swear that sounds like it's used in MDMA production.
@LaneVermilion
@LaneVermilion 24 дня назад
​@@hhhsp951That's... The point. MDMA is methylenedioxymethamphetamine, and amphetamines by definition are phenylethylamines.
@alxxander7506
@alxxander7506 25 дней назад
10:55 he thought we wouldnt notice.
@jpeglucy
@jpeglucy 25 дней назад
"Honey plorts are highly prized by food manufacturers. Though the plorts are naturally incredibly sweet, the discovery that they could be refined into an even sweeter substance made their demand soar. These refined honey plorts are said to score an unprecedented 867 on the Werner-Thompkins-Hong sacchrino "scale, just a few points shy of 'not fit for human consumption.' "
@captainchicky3744
@captainchicky3744 25 дней назад
slime rancher refernece? :^)
@Nanomusheens
@Nanomusheens 25 дней назад
​@@captainchicky3744I thought it sounded familiar
@Nelo390
@Nelo390 21 день назад
Interesting pfp O.O
@sop-job
@sop-job 20 дней назад
i almost forgot about slime rancher. damn i loved that game. such a good game. my childhood game
@leemadsen3821
@leemadsen3821 25 дней назад
I'd try nitrogen blow-down. That is, using a glass pipette, or equivalent, blow a slow stream of N2 over the solvent. The solvent will come off quicker than you think and evaporation keeps everything cool. If you want to speed it up, you can immerse the sample in a warm water bath. I'd also test for residual mercury before...organoleptic testing. Best of luck.
@RayCist.
@RayCist. 11 дней назад
Nerd.
@WhileTrueCode
@WhileTrueCode 24 дня назад
vids are always so good to watch, but ill say man, dont over-stress urself for high-bar target projects. u could make a bakingpowder&vinegar video and it would be great. u got the format nailed imho. cheers stay classy
@direwolf4937
@direwolf4937 25 дней назад
That methylenedioxybenzyl product looks EXTREMELY sussy, watchlist worthy indeed
@ChemicalEuphoria
@ChemicalEuphoria 25 дней назад
@@direwolf4937 i mean, it's in the ortho position and its a benzylamine, not a phenethylamine, so maybe we safe here 😂
@tone618
@tone618 25 дней назад
Lmao yeah bros gonna need one hell of a lawyer. He would be better off if he called a certain someone.
@tone618
@tone618 24 дня назад
Name rhymes with call
@anty.
@anty. 18 дней назад
Bro thank you for making this, i remember seeing this listed on wikipedia as the sweetest chemical but then just never being able to find anything more about it.
@captainchicky3744
@captainchicky3744 25 дней назад
ngl its genuinly impressive how you put together this synthesis and spent money testing different methods tbh hopefully the video gives back enough money to recoup everything lol
@reubenmckay
@reubenmckay 25 дней назад
Nice to see that you have access to NMR analysis to confirm your compound identity.
@MichaelK_
@MichaelK_ 25 дней назад
it has such a bizzare structure. if i just saw the skeletal formula without context i wouldve assumed its some kinda reaserch-chemical-super-stimulant, not a sugar subsitute lmao.
@mduckernz
@mduckernz 25 дней назад
Why stimulant? I’m not aware of any with a bare carboxylic acid moeity
@gaburieruR
@gaburieruR 25 дней назад
By the numbers of nitrogens, I would suspect a explosive precursor.
@tone618
@tone618 25 дней назад
For some reason explosives, drugs, and food additives always seem to have a similar structure. ​@@gaburieruR
@MichaelK_
@MichaelK_ 24 дня назад
@@mduckernzit has that 1,3-Benzodioxole at the bottom that looks a bit suspicious
@_iakvb771
@_iakvb771 24 дня назад
it looks like a SARM a little bit
@Tadesan
@Tadesan 19 дней назад
Ah. Mercury. Sweetest of the transition metals.
@ghost_ship_supreme
@ghost_ship_supreme 23 дня назад
This guy is about to have the best candy on the block when Halloween comes
@jeffrando
@jeffrando 20 часов назад
This video was super impressive chemistry. And the confidence to taste it too!
@Photon210
@Photon210 17 дней назад
To my British friends, your sweeteners almost made me swear off desserts forever. While visiting my bf in London, I came across the sweetener he and his sister uses. They were tiny little pills (about 1/4th the size of "Mini" M&Ms) that popped out the bottom of a small container via a button at the top. So I made coffee for him one morning and popped 3 of the sweetener pills into his coffee and he was like, "Oh no, what have you done? That'll make it really sweet." Curious, the next day I popped one in my mouth and, let me say, that was the most painfully sweet thing I have ever had in my life. It was so sweet, pleasure became pain and I, for at least a full minute, tried desperately to spit it all out. Bf had a good laugh walking into me brushing my tongue with my toothbrush.
@e.s.r5809
@e.s.r5809 2 дня назад
Oh, those little stevia pills? Blegh. Tell your boyfriend he can buy the loose stuff in bags and it doesn't taste like an old spoon.
@I_XuMuK_I
@I_XuMuK_I 25 дней назад
Yeah trying sweetener with mercury salt as catalyst two stages before xD Delicious
@penteractgaming
@penteractgaming 25 дней назад
With a lot of purification. And very little of the product was tasted. Its fine.
@gaburieruR
@gaburieruR 25 дней назад
As some people eat daily fish with mercury and heavy metal concentrations above the acceptable, just tasting a purified chemical is no problem.
@darthkarl99
@darthkarl99 20 дней назад
@@gaburieruR The amount doesn;t really mean much with mercury compounds. The Organic ones can be lethal in single drop sized amounts. Not an issue here, but mercury is a weird case where the elemental stuff when not fuming is shockingly safe but the organic stuff is shockingly toxic.
@gaburieruR
@gaburieruR 20 дней назад
@@darthkarl99 for any heavy metal, small amounts are always dangerous like ~50 to 200 mg of arsenic, which is about the same lethal dose of methyl mercury. The rule of thumb is to never taste compounds made in the lab, but after all purifications and proper washings, poisoning is unlikely for one in a life taste test (still unsafe, but not deadly).
@darthkarl99
@darthkarl99 20 дней назад
@@gaburieruR people have drunk entire glasses of elemental mercury whilst trying to commit suicide and been fine, it's poorly absorbed in the digestive system as pure elemental mercury. The Organic stuff is a different matter, that absolutely can be lethal in very low doses.
@caseymcvay4727
@caseymcvay4727 19 дней назад
i'm gonna be honest, i work as a chef, and have an extreme interest in chemistry, as well as quantum physics, and chemistry, resembles cooking, with more steps, by a wide margin
@e.s.r5809
@e.s.r5809 2 дня назад
I had to take a chemistry course to get onto my physics degree- those years of cake baking came in clutch. 😂 It's exactly like cooking, except instead of flat meringue the failure state is turning your eyeballs into soap.
@xfxox
@xfxox 25 дней назад
How this even be discovered in the first place!? Wth
@astrovation3281
@astrovation3281 24 дня назад
9:30 5 years of highschool and I can finally properly understand this shi
@hozd
@hozd 20 дней назад
2,3-Methylenedioxybenzaldehyde looks like a silly pentagonal mouse with a little tail
@ejkozan
@ejkozan 25 дней назад
Time for rotavap my friend. You more and more need one i see
@BWstiller
@BWstiller 25 дней назад
When and where did you start getting access to NMR to verify purity?
@Chemiolis
@Chemiolis 25 дней назад
A kind viewer analysed them for me :)
@keithjurena9319
@keithjurena9319 24 дня назад
Nile Red?
@aga5897
@aga5897 24 дня назад
@@Chemiolis That there Lone Star Ranger is definitely the NMR genius these days ;)
@markphc99
@markphc99 14 дней назад
As a chemistry grad , I'm really impressed by your dedication and lab technique , you have a new subscriber
@Damariion
@Damariion 17 дней назад
We've got sugar 2 before GTA6. Thanks for your content Chemiolis!
@trunk45000
@trunk45000 16 дней назад
It is named after the original gaulish name of the city of lyon " lugdunum "
@florencedono5978
@florencedono5978 18 дней назад
7:00 "I wet the filter with carbon tet" You did *what* now?
@SpencerYonce
@SpencerYonce 16 дней назад
All I can saw is wow. Great video, and superb filming and chemistry
@MaartenHeskamp
@MaartenHeskamp 25 дней назад
You can easily reduce oximes with Zinc powder and amonium formate in alcoholic solution with some heat. Yield is mostly quantitative and far less hassle than Pd on C.
@neon-john
@neon-john 20 дней назад
I'm really glad to see that there is still an adult in the room who still uses taste as analytical tool. Job well done.
@neon-john
@neon-john 10 часов назад
thank you
@LostLargeCats
@LostLargeCats 15 дней назад
"And then I added chloroform as a solvent." *Head hitting desk noise.*
@PlexusTen
@PlexusTen 23 дня назад
26:00 I used the AgNO3/MeOH TLC stain today and it was selective for a thioamide byproduct! Pretty cool. 😮
@beanargrowers
@beanargrowers 18 дней назад
bro even gave us a full tutorial, amazing
@h1234e1234
@h1234e1234 25 дней назад
Nice video man! You can add a little bit of sodium chloride or potassium chloride to enhance the sweetness or potassium chloride. This also get rid of the strange aftertaste.
@h1234e1234
@h1234e1234 25 дней назад
Here: ru-vid.comxetUy4s_j8U
@AstralKetamineX
@AstralKetamineX 16 дней назад
someone else replied that they made it as well, and if tasting a larger amount, the sweetness last for 1 minute and then it's bitter for 15 minutes. I wonder if the electrolyte salts would cut that time down, and also, a bit of this lugdaname mixed into miracle berry(which makes bitter and sour taste sweet) may make a novel sugar replacement. I myself like and use SugarShift probiotic to change the sugars i eat into Mannitol, which is calorically negligable and good(beneficial, not benign) for the kidneys(i have PKD).
@abracadabra6324
@abracadabra6324 23 дня назад
Crazy to watch this with no idea what I was getting myself into
@Jordan-pf9ws
@Jordan-pf9ws 19 дней назад
As the parent of a Type 1 Diabetic I wonder how it would affect blood sugar levels
@ffc1a28c7
@ffc1a28c7 25 дней назад
kind of cool that the measurement of sweetness potency is the same as the Scoville scale. Lining the scales up (pure sugar = 16 mil Sugarville scale), this would be 4.8 billion Sugarville units.
@slonismo
@slonismo 24 дня назад
I love how detailed you are with your steps!
@PlayingWithDanger7866
@PlayingWithDanger7866 22 дня назад
You can also demethtylate with Hydroxylamine HCl at 60C for 45 min with ethanol. Not sure if the DiBrMe step would work but it should(because you don't use any base during NH2OH HCl demethylation, I read about this in a paper in another synthesis), and it would make it way easier. Ethanol once started to dissolve a plastic bottle and after a year the bottle was very deformed. It contained 0.1% acetone but still wouldn't use a plastic bottle again.
@vaxfantomen
@vaxfantomen 16 дней назад
"Added all the X I just made" So many steps and one mistake makes you go back to square one. You sure have patience and dedication to your craft : ]
@ChessMasterNate
@ChessMasterNate 19 дней назад
Add it to a tooth filling, and you taste sweetness for decades.
@Zissou42
@Zissou42 20 дней назад
I have a Master's in physics and a cursory understanding of chemistry. Nonetheless, it feels like I am watching some dark alchemy with this type of video.
@gregnm369
@gregnm369 19 дней назад
I’m a total layman and have 0 chemistry experience. Watching stuff like this is like watching magic. Amazingly cool.
@metalmagerin3
@metalmagerin3 21 день назад
I know basically nothing but high school chemistry. The concept of taking all this stuff that'd probably kill someone if ingested separately and it becomes something thousands of times sweeter than sugar is wild to me.
@willmcclard206
@willmcclard206 19 дней назад
yup chemistry is weird. Take chlorine a deadly gas and get a Sodium molecule to snap on to it, and now you have salt.
@pizzablender
@pizzablender 25 дней назад
Sweetness of sweeteners depends on lots of factors. pH perhaps, but also concentration. Something might be much sweeter than sugar when used in food, but much less so when used in "candy sweetness" levels of application.
@mmmhorsesteaks
@mmmhorsesteaks 25 дней назад
In my old lab we had a Parr shaker to do these hydrogenations. Seems that works better than simply stirring. Might also be the higher pressure, i guess... Fun story, i saw some guys adding the pd/c to the flask without putting it under nitrogen first because 'the oxygen will react away very quickly anyway' - it sure did actual mad lads.
@20621393
@20621393 25 дней назад
you shouldn't let Pd/C get dry when you filter it off, it can spontaneously ignite. Keep it wet and pull the solvent through until just above the Pd/C
@mayo-neighs
@mayo-neighs 25 дней назад
why is noone talking about the beep at 19:20
@ChemicalEuphoria
@ChemicalEuphoria 25 дней назад
don't hear any lol
@user-mw6xy4rg1p
@user-mw6xy4rg1p 25 дней назад
Literally went to the comments to see if anyone else would say sum about it xd
@_TranGiaBao_A-zy8gh
@_TranGiaBao_A-zy8gh 24 дня назад
Maybe he had just said the wrong amount but was too lazy to revoice it, lol.
@smellthel
@smellthel 21 день назад
It’s at 19:08 now.
@_-noxxon-_
@_-noxxon-_ 20 дней назад
originally though he was censoring it but then saw the text, correcting himself, so I realised it wasn't censorship lol
@explosify5035
@explosify5035 19 дней назад
19:09 DUDE you cant just say that! What if there were kids watching! I am glad you censored it!
@jesse_o_tokyo9605
@jesse_o_tokyo9605 18 дней назад
Why was it censored?
@amritlohia8240
@amritlohia8240 23 часа назад
@@jesse_o_tokyo9605 Presumably he said the wrong amount, so he had to correct it with an annotation
@colelooney1430
@colelooney1430 19 дней назад
"here's how to make lugduname: *lists 40 chemicals so complicated i cant tell it's in english*"
@jmm1233
@jmm1233 16 дней назад
looking at the chemical bond of it i cant scratch that feeling this stuff will make someone hallucinate a trip
@sazxcdewq123
@sazxcdewq123 19 дней назад
Have you tried alkylating that thiourea, then reacting the isothiouronium salt with that glycine ester? That would beat using mercury to make something that's supposed to be edible.
@angus4974
@angus4974 12 дней назад
as someone will very limited chemistry knowledge youll never be able to convince me it isnt potion brewing
@geordifrere
@geordifrere 24 дня назад
Best video since cubane! Love the multi-step syntheses.
@bent8793
@bent8793 24 дня назад
I like your funny drawings magic man
@markusvogl2790
@markusvogl2790 19 дней назад
Consuming this green liquid is just insane😂
@LicoriceWasTaken
@LicoriceWasTaken 25 дней назад
lugging with the boies
@SpenceReam
@SpenceReam 25 дней назад
Mmm… licorice root 😉
@LicoriceWasTaken
@LicoriceWasTaken 25 дней назад
@@SpenceReam Yeah when are they gonna do a video about turning me into something, eh?
@RegularBiscuit
@RegularBiscuit 19 дней назад
Alchemists feeding this to a medieval serf
@CodeProto
@CodeProto 20 дней назад
The forbidden test: The taste test
@Omnis2
@Omnis2 17 дней назад
Awesome vid. Thanks for figuring out why nobody ever pursued this. A sweetener that doesn't like heat is commercially useless, lol.
@aleemrahaman-rb9mf
@aleemrahaman-rb9mf 19 дней назад
If this is safe and can be mass produced it will be the next alternative sugar in all the water and energy drinks 😂
@WhoAmDis
@WhoAmDis 17 дней назад
"After 100 years, Itis done." 🎉
@paulohsa22
@paulohsa22 18 дней назад
I swear these cooking channels are getting crazier and crazier.
@btcool08
@btcool08 21 день назад
17:00 “I mean, me too, but…”
@ContagiousRepublic
@ContagiousRepublic 16 дней назад
I cut the sound off, cranked speed to max with a firefox extension and look at the pretty colors, LOL
@Physhi
@Physhi 25 дней назад
My brother was working on this and you beat him to it. I can't tell him this information. Hopefully he comes up with a different process.
@aga5897
@aga5897 24 дня назад
Absolutely SUPERB video ! The Effort, Work, Detail ... Astounding, Incredible work. Beyond merely 'good' - another Level for sure.
@zithattack1216
@zithattack1216 11 дней назад
i could never be a chemist bruh, imagine your getting your house searched and they find you cooking lugduname, your going to be arrested.
@UltimateEnd0
@UltimateEnd0 22 часа назад
Looks like the strong covalent bonds of the sweetener would be hard on the body
@leliondemer
@leliondemer 25 дней назад
Pretty sure you could have made the 2,3-dihydroxybenzaldehyde from catechol, paraformaldehyde and magnesium (which would have been way cheaper and yielded more) Or do a vilsmeier haack instead.
@Ryukachoo
@Ryukachoo 20 дней назад
34:36 Anyone else see a human eye staring at them here? Thats super unnerving
@loganwolv3393
@loganwolv3393 13 дней назад
Next: Ingesting the most savoury compound known (???????).
@XionixZTV
@XionixZTV 7 дней назад
That thumbnail sure is something
@AlphaBeta-cf5wf
@AlphaBeta-cf5wf 23 дня назад
If the compound in your first step sublimes you can use that as a purification method. In college, i used a kugelrohr with a cold finter, but if you are cheap you can use a buchner flask with a test tube full of ice in it.
@krishkubba8207
@krishkubba8207 7 дней назад
idk what hes yapping about but i like the cool water
@Thaumius
@Thaumius 24 дня назад
Glad to see NMR spectrums to confirm products!
@janhelgetollefsen3048
@janhelgetollefsen3048 19 часов назад
Here I am, at 8 am, watching chemistry videos even though I"ve never been trusted around ant chemical stronger than vinegar in my entire life. No, im not up early.
@raykichytenshi7009
@raykichytenshi7009 13 часов назад
i can see why the benzodioxole isn't commercially distributed it is fairly close to the central part of heroin
@zekebowl
@zekebowl 17 дней назад
you know its gonna be a spicy video when he does the CCl4 reaction BEFORE the aside that there might be another way to do this reaction. lol.
@kathrineici9811
@kathrineici9811 17 дней назад
Tasting this sounds like a good way to Flowers for Algernon your tastebuds
@ceramically
@ceramically 18 дней назад
man, i love fantasy! i wish magic and potions like that existed in real life! magic and potions like that in real life:
@someone4650
@someone4650 12 дней назад
Damn... I bought neotame thinking it was the sweetest compound and have been using it for a while
@Glibiettop
@Glibiettop 10 дней назад
i believe they put this shit in prime
@joshinfantine8344
@joshinfantine8344 23 дня назад
dry loading with silica gel also a very good option, way easier to handle than celite
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