MDMA's Neurotoxicity: What the Research Shows & How to Reduce Your Risk

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The neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA) has been a controversial topic for decades. Even though a lot of research has been published, we still don't fully understand what the harm potential is. As it currently stands, there's good evidence for serotonergic dysfunction (not necessarily neurotoxicity) with heavy use.
A lot of problems exist with the literature. Despite that, animal and human results suggest heavy use (total use and/or frequency) is likely connected to some form of serotonergic disruption and potentially toxicity.
There's reason to believe certain behaviors and supplements may be able to reduce the risk.
TDC page (a lot more information & references): thedrugclassroom.com/video/md...
Reddit discussion: / mdmas_neurotoxicity_wh...
-Timestamps-
03:43 - Main claims about MDMA's effects
04:24 - Animal research
06:02 - Examining the different interpretations of the animal research
07:57 - Looking at whether MDMA is actually "neurotoxic"
11:18 - Human research
13:40 - How MDMA might be causing dysfunction
18:11 - What you can do to reduce your risk
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The Drug Classroom (TDC) is dedicated to providing the type of drug education everyone should have. Drugs are never going to leave our society and there has never been a society free from drugs.
Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!

Опубликовано:

26 мар 2017

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Комментарии : 936

@Scrawlerism 7 лет назад

Please don't stop making videos. This is all important.

@steventhigpen9750 5 лет назад

Even testing drugs is irrelevant if it's implied effect isn't understood....

@lilgryps 3 года назад

@@MEN101 i read this as “please stop making videos” lol

@cooldudelol9186 3 года назад

@@njiendam3673 lol DEA getting desperate (fr tho don’t use these links)

@Kushcloudzz 3 года назад

469th

@julieshort8088 2 года назад

My daughter is at a club currently overdosing from this as we speak. She's already almost died beforehand and was in a coma for her 17th bday. 😭

@zoneomega1872 5 лет назад

yes let me just pop these 380 mg tabs twice a day for 4 days straight

@BoobPlateYolo 5 лет назад

i laughed LMAO

@jordan7721 5 лет назад

That's like drinking 4 bottles of wine everyday for 4 days straight

@TomTomTomTom538 5 лет назад

@@jordan7721 yeah harmless

@tomshull9257 5 лет назад

I used to sell and took mdma in excess. It fucked up my personality up permanently for sure.

@connerd2183 5 лет назад

@@TURK_182 I'm sorry, but when was the last time you had 4 bottles of wine for 4 days in a row? I'd imagine after the wine most people probably would feel similary f'd up. Heavy users of course wouldn't be as effected. I never tried these substances in such super high doses, 4 days in a row or both. But i can imagine that both would fuck you up pretty bad, alcohol probably more on a physical level, mdma probably more psychological.

@reshapinvapin5908 4 года назад

You're an absolute hero. There are millions of us avid drug users that are still above the status quo in means of intelligence and wisdom, of whom direly rely on unfiltered or bias research. I've been doing loads of research on my own about molly in order to make an informed decision on usage of said substance, and you did a beautiful summation of my own research plus much more which had me very intrigued and wide eyed. Thank you so much for what you do!

@AvatarRoku999 3 года назад

I found out that MDMA was safe cuz people I knew did it and sold it and were completely fine.

@reshapinvapin5908 3 года назад

8 months later and I'm doing just fine, pure product never gave me a bad time. hell, the experiences were divine! They helped open my mind! Two beautiful women enhanced the good times😎 I've chosen to limit consumption and used It..mostly responsibly! I know im not looking into buying again though. Thank you for your part in helping keep me safe! If I ran into this and didnt have the info I do because of the available, unbiased and well backed knowledge, an encounter with this substance could be devastating. The way it made me feel was truely Devine. But I know the costs of repeative usage, and refuse to cross that bridge. It's not even a second thought, I've had my fun and will cherish the memories. Plenty of other sustainable avenues!

@wavfly2828 2 года назад

lol people trying too fool themselves

@pwnage783 2 года назад

@@AvatarRoku999 yes same but i also know people who have abused said substance and have absolutely ruined their life they are not "happy" anymore. all drugs come with consequences never call a drug safe, a drug is only safe in moderation out of that they and all of them are very dangerous

@Grandmaster-Kush 2 года назад

@@wavfly2828 LSD and DMT and Shrooms only trust natural extracts and chemically pure compound brahs

@sinceremage9 7 лет назад

I'm a once a year kinda guy so seeing these people with 200+ uses is mind boggling, it's hardly surprising that using such a powerful chemical so often damages the parts of the brain it interacts with. These people probably have an underlying issue if they're so reckless with their safety I'd say.

@allstar4life3000 5 лет назад

EDC?

@engladtur 5 лет назад

Once to twice a year here. And I'm good. Means I REALLY look forward to it when I do it and that I'm ready and in a good state of mind.

@Nemanoid 5 лет назад

2 to 4 times a year for 4 years now, all good

@Xzy666 5 лет назад

I've probably taken 200+ and some silly high doses. For me personally I was just young and reckless, started taking them at 17 and never really thought about the future. It was just so fun and there was nothing else to do, wasn't many jobs going in 2008 where I lived. Me and my mates would take them probably on average once a week but sometimes multiple times in a week for 2-3 years, only really stopped taking them because they didn't get me high anymore. Looking back I'm pretty sure I did some damage there but fuck it, what's done is done.

@lsadxmthcdphdayum2452 5 лет назад

MDMA is way worse than dxm or lsa

@TheDrugClassroom 7 лет назад

One of the primary things I didn't explicitly discuss is usage frequency. We have effectively no data to tell us anything more than: less use is better and even less use is even better. So, any specific frequency recommendation is largely just a hypothesis. That being said, I think it's highly unwise to use MDMA weekly and even monthly use should be avoided. The typical 3-month recommendation is a good starting point, but if you can reduce your use even further, that's certainly not a bad thing. If you're using the drug in settings that are far from ideal (e.g. festivals), you should have an even greater focus on restricting your use.

@timdavids4091 7 лет назад

Great Vid! What do you have in Mind when speaking about an ideal Setting?

@ptadisbander7959 7 лет назад

Why is a festival considered far from ideal place to use?

@TheDrugClassroom 7 лет назад

The downside to festivals is often the local temperature, ambient heat from crowding, and high activity levels. Those can contribute to increased body temperature and likely through some pathway to a higher potential for toxicity. So, it's not that you cannot try to make your use safer in festival settings, but I don't view it as ideal when compared to a relaxed/cool indoor/outdoor environment with the substance taken early enough to not infringe upon sleep. On one end of the "ideal/not ideal" spectrum are clubs/festivals and on the other end is a MAPS therapy-like setting. I just feel it's worth mentioning that using it further on the latter side of the spectrum is a good idea when possible. Most people who regularly attend festivals are still going to despite hearing this. That's understandable. As such, I'm often just focused on harm reduction in those settings (drug checking, take breaks, limit redosing, don't overdo the water, etc.)

@radioffvoicesnoysyvisionna7643 7 лет назад

The Drug Classroom what you say is true...nothing to add...as you said people would still do it despite what you said

@BigNateDoggOG 5 лет назад

Just stay hydrated all throughout the roll, I've heard stories of people taking Molly at raves and dying in the crowds because they overheated

@TheDrugClassroom 7 лет назад

Timestamps 01:23 - Overview of the topic 03:43 - Main claims about MDMA's effects 04:24 - Animal research 06:02 - Examining the different interpretations of the animal research 07:57 - Looking at whether MDMA is actually "neurotoxic" 11:18 - Human research 13:40 - How MDMA might be causing dysfunction 18:11 - What you can do to reduce your risk

@reptilespantoso 7 лет назад

PLEASE contact these people? I worked for them (as researcher) and they're trustworthy. A parallel toxology study has been done (decades ago). There are a number of simular studies in Europe. They can help you further. www.drugresearch.nl/Ecstasyinhetuitgaanscircuit

@cyrilio 7 лет назад

The Drug Classroom +

@mrnanners6540 7 лет назад

The Drug Classroom h

@fishersofmen4727 6 лет назад

Wow, you sound just like Gbay99

@ante2409 6 лет назад

First thing, awesome channel, keep up the work dude :). Now, i'm curious about dopamine changes caused by MDMA use, how much dopamine is released compared to non-drug users, how permament it is, if there are significiant drops in dopamine after use how long until it gets restored to normal levvels, and feel free to add any otheer dopamine.relatedinfo you deem important.If you have already covered it that extensively, sorry, i seem to have skipped that particular video. Ty in advance.

@d3ly51d 5 лет назад

Also worth mentioning magnesium supplements, which completely combat bruxism. Your teeth will thank you.

@JoshCarterWeb 5 лет назад

How many mg of magnesium do you use & for what dose of mdma?

@EI_Greko 5 лет назад

I love moving my jaw tho

@EI_Greko 5 лет назад

and rolling my eyes back

@ATiGaming1 5 лет назад

in my experience it doesn't do anything, but magnesium is always good to consume anyway, whether you're taking MDMA or not

@d3ly51d 5 лет назад

@@JoshCarterWeb Not sure exactly, but for a typical dosage of about 100mg you could try taking one magnesium tablet which is usually 400mg, then your symptoms should subside within a few minutes. If after a few hours you feel like you need to, you could take another Magnesium tablet.

@rikke7098 7 лет назад

Thank you Seth, this was one of your most intresting, well-crafted videos so far!

@Monotropism0 7 лет назад

I can't believe this video only has 12,000 visits, it should be many more! Seth's work is amazing!

@RobinCawthorne 5 лет назад

Dude, your videos are incredibly informative and really easy to digest. Thanks for sharing.

@OpenMind3000 7 лет назад

Great video.

@xyilxyil 6 лет назад

OPEN MIND wär mal interessant sich genauer anzuschauen, welche der Substanzen zur Risikoreduzierung am Besten wirken und anwendbar sind.

@shoulders-of-giants 5 лет назад

great guy

@painfultruth1846 3 года назад

Wen man hier alles findet xD

@christanch.8829 3 года назад

Geh Mal selber auf Deutsch auf dieses Thema ein, da viele die Dinger weghauen wir Tic-Tacs und sich nicht bewusst sind was dadurch geschieht 😬

@FreeZerXD 3 года назад

@danashannon8234 5 лет назад

Can't wait for MAPS to get MDMA with psychotherapy approved for treatment of PTSD. The results are amazing.

@SinergiaAlUnisono 4 года назад

Yeahhh , though it sounds like a lot to wait for me. Good luck Dana

@Thebusysuperhuman 4 года назад

Yes I do too and I hope it’s not ridiculously expensive for people who need it

@SireBag 3 года назад

Maps? Like the pedophiles? I’m confused

@Cbd_7ohm 3 года назад

@@SireBag lol

@sigmamale4147 2 года назад

Bruh i hope you're not talking about the pedopophiles

@Zack-Dean 2 года назад

I hope you know the magnitude of how much people you help and have probably saved on a day to day basis. Keep doing the great thing you are doing.

@ginabrogan1825 Год назад

found the guy rolling

@TheDrugClassroom 7 лет назад

I've gone through and summarized nearly all of the relevant studies I read on the TDC website. The website page is a work in progress and will be updated in the coming days, weeks, and months with more information. You can view it here: thedrugclassroom.com/video/mdmas-neurotoxicity-research-shows-reduce-risk-detailed/

@KaySeeyen 6 лет назад

Thank you for putting so much research into your videos, they're great.

@TheDrugClassroom 7 лет назад

The Drug Classroom is exclusively funded by donations. If you'd like to support educational content about drugs, please considering supporting here: patreon.com/TheDrugClassroom

@jobla7124 5 лет назад

I over did it for a few years. I've dealt with periodic anxiety and depression issues ever since, as well as brain fog and memory problems. It's been about 8 years or so and I'm only now starting to slowly recover, although I still have noticeable issue with my memory and will forget words. I believe mdma is great if used responsibly but don't be doing it every weekend. My largest dose I beleive was 8 pills at a rave (not all at once but still). I dont recall but I probably took more the next night. Before I get called an idiot, trust me I know. I havnt taken pills in years (well once last year for old times sake. Turns out they don't work the same on me anymore anyway) and have generally got my life together now but the damage still lingers. Stay safe out there!

@thehypest6118 5 лет назад

yeah man, i'm 3 years clean and the brain fog is real, I worry I'm losing my mind sometimes and I still get those serotonin spikes, gods speed with your recovery mate I wish you the best

@LongTanAndHandsome1 5 лет назад

6 years here. Just live a healthy life style. It helped me a lot. The gym killed my addiction and my whole life change but the first year was rough mentally but don’t fall into man. You’ll grow out of it. The body is amazing and it will recover from the damage👍

@napakamu9670 4 года назад

Jorvo Blatano Ty for sharing. Have you noticed any sleep related problems from the MDMA abuse? Does your depression include anhedonia?

@napakamu9670 4 года назад

@@LongTanAndHandsome1 Did you struggle / do you still struggle from anhedonia due to your MDMA use?

@meriska2268 3 года назад

I'm so glad that you're all in recovery!

@danielkopaee9241 3 года назад

I found it fascinating what Anne shulgin said about extremely frequent mdma use. Apparently the effects of it switched to being very dysphoric after a couple of years.

@angryktulhu 2 года назад

It depends

@coleburns5497 2 года назад

You are a blessing! We need unbiased & educated videos about psychedelics. Thank you!

@Tom17ire 7 лет назад

Seriously well done video. Keep up the good work

@randomguy93984 4 года назад

As someone who has rolled quite a lot. Overuse definitley causes short term (and some long term) memory damage. I'm talking popping a half gram rock to start the night kind of use. Also it could be because of the use of mda rather than mdma aswell. Not sure used both but it definitley made me feel slow and forgetful after rolling for 2 weeks straight (it's been 2 months since). I'm not a habitual user in that way it was a binge and after seeing the effects it had in such a short time I think I caught the message. It's only every once in a while from now on.

@stalin-grade2081 Год назад

Can someone help me please? I had lung issue and did mdma i year ago, and i had a big seizure because my lungs couldn't follow my heart beat and im pretty sure i escaped death just by chance, but after that seizure i had panic attacks and brain frog and very bad respiration and i cant even work normally because of continious panick attacks and seizure after i took that mdma please im suffering any suggestions on what to do? Ps: i did go to countless doctor's without any real solution

@lagrangiankid378 Год назад

@@stalin-grade2081 don't do any more MDMA, refrain from the consumption of other psychoactive substances as well, and just wait some time to get back to normal. It's gonna take some time, but it's gonna get better if tha anxiety was caused by your MDMA exposure.

@ansismaleckis1296 5 лет назад

Nothing is for free except cheese in a mousetrap. One way or another you will pay for everything.

@almiralower 5 лет назад

Amen!

@Coliocoliocolio 5 лет назад

Yrs

@wildfireman13 5 лет назад

Second mouse gets the cheese.

@egemensuzgun4208 5 лет назад

wow

@Thebusysuperhuman 4 года назад

Love this quote about the cheese and mouse trap

@moochee22 3 года назад

Amazing video. Everyone should watch this multiple times. Thank you.

@Thebusysuperhuman 4 года назад

Great video, very useful, thought out and informative

@jeronimuspompeus624 5 лет назад

It's insane how many of the pills in the photo's I've seen in real life xD

@hasnieking 5 лет назад

Explains your last name

@drunkensailor112 5 лет назад

Me too and I'm still alive!

@cancerishere.3362 4 года назад

Not really... people are going to use the same presses.

@AaronNazzy 3 года назад

ur cool

@marshian__mallow2624 3 года назад

Sorry u cool guy

@tjacksondolph4026 2 года назад

The fact that long term users can quit ecstasy and still have the same tolerance means it permanently diminishes your natural serotonin production. Same thing with opiates and dopamine production in my opinion, I can stop taking them for a year and I still need at least 30 mg to feel anything.

@MrMenoupload 7 лет назад

I love your videos man keep up the good work

@stop7556 5 лет назад

I definitely believe from anecdotal evidence as a history myself and peers with such. That mdma itself is not neurotoxic to a notable amount unless the person is 1. Overheating 2. Dehydrated 3. Are not properly fueled for the resources that are used/repaired. 4. Dosage/polydrug although I dont believe many will hit dosage constraints unless you're thinking of festival setupsm I wholeheartedly that the heat impact is the biggest correlation to whether neurotoxicity happens or not. Reminder this is anecdotal and is not scientific.

@mynameisreza1 4 года назад

This is some good shit. Thank you for all the effort you put into this educational video.

@wemustkungfufite 5 лет назад

I used to be drug dealer for 3 years, from age 22-25. I've sold and taken drugs at over 40 different festivals; EDC, Coachella, Mysteryland, LiB, you name it, and some on back to back weekends. also not counting club events and partying literally every single weekend for those 3 years. I must have taken at the very least 500 points of MDMA(125mg each) during this time period, not to mention all the LSD that I would often combine it with. I've stopped dealing and I'm pursuing a career in computer science now, and I have to say.... I feel perfectly fine. In fact, I would say I'm the smartest and healthiest I've ever been. It might just be genetics, or if the MDMA was just that pure(it was) but one thing I avoided at all costs was doing cocaine + MDMA + Alcohol together or stacking more than 2 substances together in general. I've also never done more than 100ug of LSD at a time. I honestly believe that if you don't take more than 2 drugs at a time, you should be fine. Purity is also a big issue; I'd much rather do molly than ecstacy, which has other mystery drugs in it.

@TheDrugClassroom 5 лет назад

The science on MDMA toxicity is based on pure MDMA, purity is not a notable factor in neurotoxicity. You also cannot necessarily feel damage, so simply feeling fine doesn't mean something was healthy.

@illbehaviour9785 5 лет назад

Your 2 drug rule is not safe, coke and alcohol is really bad for you it forms a toxic chemical in your body that messed someone I knew up. heroin and alcohol killed my friend (age 19) and many die from mixing opiates and benzo's. Party drugs are possibly safer to mix...hell we all did it lolz, but if you want to be sure don't mix stuff.

@Mc96P 5 лет назад

@@ianwiatric2861 MDMA is Molly. Ecstacy (or XTC) is just MDMA pressed into a pill together with a binding agent so the pill doesn't fall apart. However because it's a pill it's easier for dealers to put other garbage into the pills instead of MDMA because it cuts the cost. If you buy MDMA in crystal form you can be pretty sure there's no other bullshit in it, that's why it's generally safer.

@Mc96P 5 лет назад

@@ianwiatric2861 It all depends on the dosage of active drugs that's being consumed. If you were to consume 120 mg of MDMA in crystal form it would cause the same amount of damage if that 120 mg crystal was grinded into a powder and put into a pill (granted of course that there's no other harmful stuff in the pill). If you were planning to try MDMA once (you don't have to answer that, just trying to help you out, but let's say hypothetically) it's always best to get crystals because it's the easiest way to know it's "safe". Darkweb is always safer to buy quality drugs than from a random dude on the streets. However I recommend you buy reagent testing kits online (it's legal in I think every western country) to make sure that you actually bought MDMA and not an other substance because the rocks won't have MDMA written over them haha. An other important thing to have is a milligram scale. If you live in America you can get the Gemini 20 for like $20 and it's great quality. Always weigh out and test your drugs. Harm reduction is very important. Drugs can be a wonderful thing but if you don't respect them they will fuck up your life. So be smart, and if you like it and plan on doing it more than once, then please keep at least 3 months between drops to minimize damage to your brain. That's of course hypothetically, because we don't do drugs, do we? We are children of Jesus ;)

@Mc96P 5 лет назад

@@ianwiatric2861 No problem mate, glad I could help.

@nickmagrick7702 5 лет назад

the real dangers of drugs like this is if your not really getting the real thing. Which in some places, most from what I hear, is more common than not. I think I was lucky enough to get pure stuff, but idk if ill ever even be able to do that again. I still don't think its a drug your supposed to do frequently

@Alesij 7 лет назад

please, keep up good work, this type of content is very rare and it should not be... Thanks for it

@waltersobchak7275 2 года назад

A friend of a friend said, “I can tell you what you want to know. From the early 90s I was surrounded by massive quantities. Although it lost its magic for me I’ve noticed no long term detrimental effects. Lost its magic because I indulged in it every night every other night for years. Guys these days got it easy PMK glycidate. We had to put in long hours, tedious hours, for our precious ketone. We done it the hard way. I couldn’t imagine having an on-demand ketone of unlimited supply.” That’s according to him

@pairadice3186 5 лет назад

Man......you really know ur shit!!!! That's awesome, I wish I had a friend like you in my 20s when I was getting stupid high on just about everything I could!!!

@jonandbrooklynn6361 7 лет назад

Great videos. Would like to hear this same toxicity report on Iboga/Ibogaine

@conorhennell2623 5 лет назад

I went through a phase of snorting 0.1-0.3g every weekend for about 8 months, i don't recommend it. It took about 18 months-2 years to feel 'normal' and happy after i stopped. It definitely has serotonin damaging effects if you abuse it but if you stick to a 2-3 per year dosage it probably doesnt have much damage.

@napakamu9670 4 года назад

Conor Hennell thanks for sharing. Did you suffer from anhedonia or sleep issues due to the abuse?

@lucian5389 2 года назад

@@panther666 ok John McAfee

@nomnom2969 5 лет назад

In my first year of mdma use (used 4 times with around 3 months between uses that year, doses between 150 and 200mg) I did experience somewhat higher levels of anxiety. I'm not sure how much the mdma contributed though, as I was also having college-issues and my dad had a stroke which caused a lot of stress for the whole family. Nowadays I use even less frequent (3 months up to more than a year between uses) and haven't had any severe anxiety issues.

@jamalydude 2 года назад

I took mdma about 160mg each day for 9 days in a row it fucked my brain for a week straight I was insanely depressed, would break down crying, had days where I had NO feelings of anything just bleakness, and had those weird dizzy off feeling moments you gave ON molly for a long time after stopping that. Fucking stupid

@jemoeder5701 2 года назад

@@jamalydude yeah man I took around 300mg daily for a week. I was hella depressed for an entire month

@jamalydude 2 года назад

@@jemoeder5701 shit is terrible 😫 I also was having insanely real sleep paralysis attacks where I really thought people where there with me then when I would actually wake I was so confused like you were here in the room and holding me down ect and they’re like wtf?

@pellenorder7172 2 года назад

@@jemoeder5701 Bro je voelt dan toch niets meer na 2 keer gebruiken 🤣🤣🤣

@restartrestartreboot7838 Год назад

Yeah, all you guys suffered some bad neurotoxicity. Who knows what it changed

@based9069 4 года назад

I am a recovering mdma addict stay safe mdma addiction is no joke

@gladenvfx532 4 года назад

how often did you roll when you were at your peek?

@zipho5935 3 года назад

I did MDMA 3 days in a row , I took 3.5 pills in those 3 days it was my first and only time ,does it get better?

@zipho5935 3 года назад

@saxon I took it for 3 days I'm fried in my brain

@zipho5935 3 года назад

@saxon yeah I didn't know FAM it was my first day doing it

@w0y4k15 3 года назад

@William MellowCash4Life Ooh wow, internet tough guy that claims he can pop pills like they're Flintstones Vitamins. So cool bro. Get a life.

@danielt9656 2 года назад

We want more, we want more, we want more !!!! Please make more videos the world needs you !

@gdfan618 5 лет назад

Great one!

@fish9468 5 лет назад

I don't know what you're saying, but I like it.

@rezzmans7109 3 года назад

I like your funny words magic man

@youknow6607 2 года назад

The most messed up thing I heard was just killing the rats. Evil

@jorythespader 5 лет назад

Very informative. Thanks.

@sdkfz2512 5 лет назад

I love your videos, Your method of delivery Is very entertaining, And packed with information

@FullFledged2010 5 лет назад

Serotonin deficient is no joke! Trust me, been there.. You get depressed and get panic attacks... Now the depression i could kind of handle but panic attacks literally feels like you're dying so its up to you to take that risk 😑

@azizamdouni5811 3 года назад

Do you still feel the same way?

@michaelemouse1 7 лет назад

So, do I take it that Piracetam and other related substances are not much good to boost the effects (thus requiring a smaller dose which would be safer) or minimizing the harms? You mention not mixing MDMA with stimulants or alcohol. Quite right. But we know the more interesting combinations are with psychedelics like DMT, LSD, 2CB, AL LAD or shrooms. Could one of your future videos be about that? I understand drug combinations are a complex topic but a very interesting one.

@sertu1462 7 лет назад

Well I really liked the combination of 2C-B and MDMA. As I took quite a lot of MDMA because I underestimated how strong sniffing MDMA is, I mostly felt the MDMA experience. However, the visuals from the 2C-B made it a bit better, and it felt more "mature", if you can put it that way. I don't know how else to explain it, but the psychedelics made me a bit more aware. Usually MDMA makes you very overexited, naive and optimistic, I mean this effect was still there, but the psychedelic part could be the voice of reason, if necessary. I have to adnmit that I did way too much of both substances. First I took 20 mg of 2C-B orally and then 20 mg intranasaly (I don't know if "intranasaly" is the right word, english isn't my mother tounge) several hours later I took 210 mg MDMA intranasaly, I do have a high tolerance, but it was still a lot for me.

@KommentarSpaltenKrieger 5 лет назад

It's as always - within the right set and setting, with moderate dosage and with the right supplements and especially not too often, almost any drug can be consumed (maybe except for heroin or crack). Unfortunately, those things matter a lot and not everybody will consume those drugs in the right environment and with enough short- and long-term moderation.

@bisty111 4 года назад

Crap a friend of mine took it three days ago and has been taking multiple supplements the days following. One of which was l-tyrosine because he thought it would help with bringing his emotional fitness back by increasing dopamine activity, only to find out that it’s probably doing more harm than good. He was also taking DLPA but will stop taking that as well as a precaution as it also affects dopamine. Wish him luck!

@ginabrogan1825 Год назад

good luck chris

@southof.nowhere6096 7 лет назад

I was wondering, do any phenethylamines have neurotoxicity evolved? I have not seen anything saying this but was wondering if you have heard different. (Specifically I was wondering about the phenethylamines 2c-b, mescaline but if you know of others that do this I would be interested to hear about it.)

@Artiqx 5 лет назад

Wondering why 5-HTP is not mentioned. It does have some effects on mood and deeper REM-sleeping phase, but not sure if it benefits serotonine rehabilitation. Someone got an idea?

@CreativeGTX 5 лет назад

Art Iqx Was was the day that. B

@d3ly51d 5 лет назад

There is some evidence that it might, but make sure to not take it until long after the high, otherwise there is a danger of triggering serotonin syndrome.

@maricampari3970 5 лет назад

It's a building block for seratonin. It helps you make up what you wasted when you were high and all your seratonin was released at once. It helps replenish it.

@ob1934 4 года назад

@@maricampari3970 no. 5-htp is a precursor to serotonin that converts to serotonin when crossing the blood brain serotonin. In short it directly makes you produce serotonin

@hamstercow6219 4 года назад

@@ob1934 thats literally what they said

@RK-ej1to 2 года назад

They should keep track of who smokes pot or drinks alcohol in the cognitive tests because those both reduce verbal memory as well.

@nodnerbdrofsoc603 2 года назад

I used MDMA quiet heavily in the early 2000s, haven't touched it in 10 years and my jaw is still swinging

@its_robbietime1333 5 лет назад

this sounds exactly like The Stupendous Wave

@edschleck2722 7 лет назад

Very good video, thanks! Do you have any informations how mdma can trigger acne rash? My skin isn't very great and every time i roll i get very bad acne 3-4 days later. No of my friends has this condition, so i must be predestined for acne.

@pannoci2049 5 лет назад

Probably from sweating balls.. I get it to

@euphoric5172 Год назад

I have tested Vitamic C and THC myself for harm-reduction from MDMA, and from my experience vitamin C actually makes it last a bit longer and reduced some of the severity of the side-effects, and using THC after MDMA felt like it also helped reduce the severity of the side-effects and even made some of the euphoria come back slightly. I would definately reccomend not taking it again for at least a minimum of 3 months to allow serotonin to recover, 1 month is often reccomended but it is not enough, and taking it when it is hot is certainly dangerous and could be fatal due to overheating, but if you decide to do it in warm weather anyway, please avoid direct sunlight exposure, stay in the shade, drink water regularly to replenish from water loss due to sweating, and take regular breaks to cool down. Also a good tip i have found to prevent temptation to re-dose, is just only take enough for 1 dose for each person, trust me, when this stuff comes down youre gonna want to keep taking it until you dont have any left, once i took 3 doses in one session and it was the worst comedown i have ever had, just dont re-dose at all, ever. The 2nd dose was only about 10% effective, and the 3rd was basically nothing, it seems that tolerance builds up very quickly with this substance so re-dosing is pointless and you wont get what you want from the 2nd dose, so just never re-dose and save yourself from the intense depression caused by taking too much of this stuff.

@237.x Год назад

In my experience I enjoy the come down after being wired all day once the effect starts to wear off my brain just feels calm and I feel really sedated and chilled out

@lordbeebus9842 2 года назад

Salts impair memory via dehydration. Cellular destruction from salts literally come from depletion of water. They literally shrivel the cell post water a so soon swelling once purged and excreted if not dehydrated correctly post consumption.

@vemundfurre6895 7 лет назад

I have abused mdma for a long time in ridiculous dosages which have left me pretty depressed and anxious for a long time. Do you have any opinion if it is a good or bad idea to try an ssri or any other antidepressant or if it will disturb the healing process? I know its a very complex and difficult question to answer but if you have any thoughts I would appreciate tremendously! Keep up with the good work!

@TheDrugClassroom 7 лет назад

We don't know exactly what the interaction would be. SSRIs haven't been associated with quite the same "neurotoxic" concerns. If your depression/anxiety is severe to the point that it's infringing on your life *and* non-drug therapy doesn't work, utilizing an SSRI to see if it helps likely isn't a bad idea.

@vemundfurre6895 7 лет назад

Thanks for answering!

@topolo19 5 лет назад

Bro its one year later. Stay away from drugs, just meditate. Believe me, it changes the functioning of our brains. I hope you read this, if you do please reply

@thehypest6118 5 лет назад

I agree with the guy above me, I abused ridiculous doses almost every weekend from 18-20 and then some, I was using it as a means of escapism, meditation and creating a calm and peaceful environment in which to heal is key, it'll sound like internet hippy bullshit until you start trying it and if you're patient enough to stick it out until the results start coming in you'll see how beneficial the simple stuff is

@michaelsanders8961 5 лет назад

eat mushrooms the majic kind. ssris will fuck you up worse than e.

@Napsssy 4 года назад

I've taken my first pill just last night, there was a moment when I felt weak and had to leave the club for something like an hour I might have taken too much, or it was the heat an the dihydration. Is it ok to take something like 4 a year? Specially taken the precautions listed in your video and the supplements as well.

@TheDrugClassroom 4 года назад

Four times per year should not be particularly dangerous so long as you test your pills/powder with reagents to ensure they are likely MDMA (not another drug), take common doses (100-150 mg), and try to stay cool either by not using it during crowded, hot events or by at least taking regular breaks during those events. The supplements may help if you have the money to spend on them, though I view them as an accessory to those other recommendations.

@teakaymania 5 лет назад

Two questions about end recommendations: 1) Why ALA instead of DHA or just a general "Omega-3 is good for you"? Is there a specific biochemical way ALA is significant? Omega-3 is significant in MDMA use? 2) Why NAC instead of recommending a straight up ingestion of glutathione? Is NAC that much better absorbed/converted than straight glutathione?

@TheDrugClassroom 5 лет назад

You're thinking of a different ALA, α-linolenic acid (the Omega fatty acid), not α-lipoic acid, the antioxidant being discussed in the video. As to NAC, it's been specifically studied for its effects on MDMA and is generally a well validated method of increasing glutathione activity, superior to that of oral glutathione.

@kookieless 7 лет назад

Great vid to come home to.

@rayray1993 7 лет назад

What is your opinion on combining a complex b vitamin, magnesium and a 5htp supplement for a post load? It seems to help me, but there isn't much research done on it. Some people say it is placebo, but I believe in it because it works for me and others.

@TheDrugClassroom 7 лет назад

At best, those supplements on the following days will be useful in alleviating the after effects. At worst (for the most part), you wasted a little money. I don't think it's bad to try things like 5-HTP on the initial days after MDMA. Granted, if you're otherwise healthy, use in a good environment, and take a common dose, the after effects shouldn't be too significant anyways.

@muscularclassrepresentativ5663 4 года назад

Use n-acetylcolene

@eray9934 5 лет назад

Wow, great informative video! One question--you showed how NAC conjugates of MDMA metabolites also produced ROS and could be neurotoxic. So it seems as if NAC could cause more harm, but it is still recommended for possible harm reduction in the end. Can you explain this? I must have missed something...

@TheDrugClassroom 5 лет назад

We don't currently have reason to believe NAC will change toxicity for the worse via that route. It may only potentially come into play if MDMA's secondary metabolism is significantly limited under normal conditions in the absence of supplemental NAC, like occurs with a paracetamol (Tylenol) overdose, where NAC detoxifies a toxic metabolite that otherwise builds up if NAC is not given. Yet with MDMA the body's natural amount of glutathione, cysteine, etc will probably do everything needed to produce a normal amount of those NAC/glutathione-conjugate metabolites, so adding extra NAC isn't doing anything notably negative, i.e. the harm has already been done. And since it's unlikely to be harming via that route, we can gain the benefits of NAC as an antioxidant, where we have evidence it is effective. I think it is fair to be confident in this since NAC's efficacy has been confirmed in mammals, who would be experiencing both the neuronal antioxidant benefit of NAC *and* its hypothetical harm as a promoter of metabolism, which appears to be negligible or absent in practice. Great question though, on the surface it is curious that NAC would be effective as a treatment for toxicity caused by glutathione and NAC-involved metabolites.

@juant6229 Год назад

@@TheDrugClassroom. .....?

@kynanverwimp847 9 месяцев назад

@@juant6229low iq

@jasonjackson3114 3 года назад

I'd more than happy to be in a long term MDMA study.. So long as it's not in the control group however.

@xx7secondsxx 2 года назад

Therapeutic levels is a MASSIVE key to the usage. It's like Oxycodone, Alprazolam, Diazepam or kloznopam. I've known people to eat so much X to BLOW DOORS!!! (that's really stoned on the substance) so yes, reasonable dosage I'd key to any substance you put in ur body

@maxpower6110 5 лет назад

Are there natural ways to increase serotonin production/release? I remember reading an article once that said that exercise increased the size/density of the raphe nuclei in the brainstem - any truth to that?

@madmadpussymonster 5 лет назад

I would really like to know more on this too

@slowfeetdonteat 3 года назад

Aerobic exercise like running does, thats where the term "runners high" comes from...

@p.rabbitt4914 5 лет назад

The glimpse into higher dimensions of spiritual consciousness is absolutely worth it- for personal growth & the ultimate salvation of the planet. But it would be 100% better if MDMA was legal & formulated by highly enlightened professionals!

@Mopsie 5 лет назад

P. Rabbitt true, but just don’t abuse it and use it more than once every 6 months or so. I only use it once a year.

@samskill9626 3 года назад

3-methyl adenine also prevents autophagy of SERT neurons in a paper I read

@rchasecampbell3 5 лет назад

So if I'm understanding correctly, glutathione potentially increases negative effects? I have a micronized glutathione spray supplement that is absorbed through the mouth and has been shown to effectively increase glutathione. I've considered using this before and after rolling simply based on the fact that glutathione is a very powerful antioxidant. I've read that antioxidants help prevent or repair damage from rolling since it causes oxidative stress. But you're saying the opposite seems to be true? That an increase in glutathione would cause an increase in negative effects from mdma?

@TheDrugClassroom 5 лет назад

Glutathione is likely to be helpful, as shown via the beneficial effect of NAC.

@mattb9054 3 года назад

Whenever I take MdMa I always get this intense anxiety as I'm coming up, then I puke, and then I'm fine and high as a kite, it's so weird why do you get come up anxiety like that?

@zenman805 3 года назад

You are overdosing on MDMA. Your body has too much of the chemical, MDMA, and is purging (Getting rid of it), by throwing up. Just like when you drink too much alcohol, you will throw up. Your body is getting rid of too much of the chemical. Unfortunately, when this happens, you also throw up the half dissolved bean. So you are not getting all of the drugs, because you threw it up and will not get any higher.

@givgonti7877 3 года назад

the come up for mdma is arguably worse than most other substances

@nahmastay3300 3 года назад

@@givgonti7877 it’s probably one of the most brutal comeups I’ve experienced so far. More so than acid and shrooms

@zuthula3847 3 года назад

@@zenman805 That is complete bullshit. Many drugs cause nausea well below the dose required for an "overdose". This comment feels just like when people say "mushrooms make you trip because they give you food poisoning and the trip is your body fighting the food poisoning." Just complete nonsense with no basis in reality.

@badrobot114 3 месяца назад

you are experiencing nausea because most of the body's serotonin receptors are located in the gut and stimulate the smooth muscles there(think causing contractions) When you take MDMA it activates those receptors in your gut. Anxiety is related to the abrupt increase in cortisol and adrenaline.

@xzxjessxzx 5 лет назад

I feel like I've been affected by ecstasy use. I took 2 or 3 pills a week on average from age 18-20. Then just a few random times between the ages of 21-25. I'm now almost 30 and i haven't taken it for the last few years. I forget a lot, even important events like my first dates and milestones with my partner, i forget people, i forget small things people told me 30 minutes ago, i forget words (e.g. "fridge" will become "that cold thing the food is in". I also have anxiety (i think I've always had it, but it feels worse now). I also feel like my general understanding of information is worsening too. I have to re-read things to try to process the information properly. Maybe this would have happened anyway as my memory has never been amazing, but ecstasy use could be to blame.

@BigNateDoggOG 5 лет назад

It's different for everybody but these people are usually fried before they even took the drugs or at least in my experience I mean they're fried but are still coherent

@jobla7124 5 лет назад

I have similar issues. I don't doubt it was the xtc. The forgetting words is the worst.

@thehypest6118 5 лет назад

@Kevin Scully move off you tit, we'll repent for our sins in our own time no need to go pissing everywhere

@jjunit207 5 лет назад

haha you're just getting old

@NoahRexroad 5 лет назад

how much weed do u smoke

@TomTomTomTom538 5 лет назад

Do a video on GBL abuse, withdrawal and long-term use damage

@benfrancois7150 5 лет назад

Very informative

@kookamunga2458 5 лет назад

I think it effects the way your body regulates heat . I won't do it any more because there isn't any quality control .

@XDMineman117XD 7 лет назад

Could you do Deschloroketamine?

@TheBic4 6 лет назад

Ben Garrison shitty body high at high doses. Don’t try to hole on it

@ssjgrey Год назад

So is the higher your metabolism the safer mdma is?

@jerzmi 3 года назад

15:31: You said that NAC + quinone can form toxic chemicals but later at 19:49 you said that NAC can reduce the MDMA related dysfunction. So is it safe to take NAC with MDMA or not?

@TheDrugClassroom 3 года назад

Based on the available information, the beneficial effects of NAC seem to outweigh whatever possibility there is of NAC supplementation increasing the formation of metabolites associated with toxicity. This has been shown in vitro (isolated cells) and in rodents [1,2]. [1] link.springer.com/article/10.1007/s11011-014-9598-0 (full text: sci-hub.st/10.1007/s11011-014-9598-0) [2] link.springer.com/article/10.1007%2Fs11011-013-9423-1 (full text: sci-hub.st/10.1007/s11011-013-9423-1)

@kaeseistcool 7 лет назад

The Drug Classroom is drug bea

@tomcollins7677 7 лет назад

I took MDMA twice every week for around 10 weeks. Now I can really feel the side affects. My memory has suffered baddd. Quite young as well so that is probably why :(

@animeanime400 6 лет назад

Do you notice anything else, besides your memory being damaged? Like depression? And have you stopped using? Thank you in advance for answering.

@ali_mxun5444 5 лет назад

I did it 8 times in 5 months with like 2 week breaks in between each roll, ngl I feel like i feel a slight difference and am about to start takin 5htp, thyroxine, and L-theanine and hopefully that helps

@membersonly_wavynavy 10 месяцев назад

@@ali_mxun5444For future reference I recommend NAC and Glycine

@kynanverwimp847 9 месяцев назад

Please update

@SinergiaAlUnisono 4 года назад

I do not understand very well how to take those supplements... doses, timeline, etc. I want to be safe but I find it hard to follow...

@kinggav5402 7 лет назад

Great channel

@jookaipoon7795 7 лет назад

Could you do a video on Semax?

@leonardlapaz2707 3 года назад

and semenax lol

@joshafflu1 5 лет назад

I’m 170lbs or 77kgs. A 5mg per kg in my case would be a dose of .385g. I can def see how doing that twice a day would lead to permanent dysfunction😂

@TheDrugClassroom 5 лет назад

As discussed in the video, the dose must be adjusted for humans, 5 mg/kg in rats equals ~0.8 mg/kg in humans.

@Thebusysuperhuman 4 года назад

joshafflu1 yes exactly, when you look at it like that .... would be like 3 pills for breakfast then 3 more for afternoon tea......everyday

@triple_gem_shining 2 года назад

doesnt this mean that mdma use can decrease psychedelics effects overall for long after stopping mdma dosing

@corruppy 3 года назад

I think it might depend on the person because one of my friends did MDMA or ecstacy maybe it was something else but she was always told it was MDMA and she did it pretty much every week with SSRIs and isn't completely fucked or get serotonin syndrome

@Justanobodybro Год назад

trust me she will get it

@primitiveenergy8655 4 года назад

Hi, 4 days ago i took an high quality ecstasy pill (i know its high quality cuz it kicked in in like 35 minutes) and i had a really good time actually i was manic, for a solid 8 hours. I took one half then 2 hours later the other half. This was my first time in 1,4 years. Also i came in my pants when it kicked in, now i have some questions and i would really appreciate if u could reply. I am wondering how long it will take for my serotonin levels to recover, and im wondering how long it will take till my sert density has returned to its former levels. I was well hydrates the whole time and in.a cool environment outside. Also, will 5htp speed up the process of recovery? Thanks BTW i felt down when it was done working but the following days till now i feel good actually not depressed or anything

@Zen_Power 5 лет назад

The short and long term risks are not fully conclusive therefore taking MDMA is gambling with your health and well being. The question you should ask before consumption: is short term social highs more valuable than the potential deterioration of short and long term health? And - Why do I need to take MDMA?

@NZ.YouTube 5 лет назад

Because life sucks

@maurunmal1422 3 года назад

What's your opinion on MDMA mixed with racetams like piracetamor noopept? there is evedence that Noopept protect against Excitotoxicity. Buw woulden't the extra stimulation via AMPA increase excitotoxicity?

@keithnorris6348 3 года назад

QC aliquots used typically to calibrate analysers give a distinct and uniform effect even in high doses I have found. Where as pills ( from the black market ) claiming to be 3,4, MDMA do not produce the same effect and only occasionally resemble the factory product in my experience.

@darrylbrady8841 3 года назад

Adderall, Percocet, Xanax, Oxycodone are all pain meds and other drugs. The only place to get hold of it without prescription is at👇 darkfax.com They are good and their services are awesome💯✅.

@Neon-lt5jl 4 года назад

0:14 would you say they've . . . _raved_ about it?

@thepdw 3 года назад

Boooooo!

@animeswitch 5 лет назад

my memory has been fucked from it, be careful

@dexterlacroy4132 3 года назад

What was your use frequency?

@DNA9099 5 лет назад

the best dose for humans is 1.5 x your weight in kg (1.3 for women) so if you weight 70kg your dose shouldn't ecxeed 105mg (that's half a pill in my region). with this rule and 3-6 weeks pause in between consumation your brain will be just fine and the trips will be smooth with a minimum of side effects, if you don't have a genetic disposition.

@Addoagrucu 7 лет назад

At the 7:03 mark, one statistic you use is 0.6 celsius centigrade temperature increase for dosage in mg/kgs. Isn't using an absolute temperature increase flawed since the cause and effect are in relative units. Shouldn't the statistic under scrutiny be a change in body temperature in relation to total body heat?

@TheDrugClassroom 7 лет назад

That section is referring to the mg/kg dose in two different species that yields a similar effect, in this case a body temperature increase. By no means is that an ideal measure of drug exposure, but trying to match effects is one way to get closer to figuring out what kind of dose scaling is needed. Whether that's the threshold for serotonin syndrome, the threshold for a temperature increase, or the threshold for any variety of other effects. That specific functional measure was deemed relevant as the dose it yields fits with some of the other interspecies scaling doses. that have been mentioned in the literature.

@dmt4992 5 лет назад

i took mdma 5 times in a month and realised i was getting addicted to this shit. Just stay away from it

@spritemultipack 7 лет назад

5mg per kg multiple times a day for 4 days is FUCKING CRAZY what human would even come close to that

@squidlover7615 7 лет назад

Jack Duck lmao Danny brown

@pedromiguel9852 6 лет назад

Festivals, bro. Many people do that in festivals.

@jasonwalker6285 6 лет назад

ave done that a lot like 6mg/kg over week course I'm fine like others not so lucky mixing speed and pure MDA 5 year coma... I miss me mate John but I'm fine trying to quid MD but I'm quite ok in the long run happyness gone down in long run but I'm sound like quality

@bigcrunch1971 5 лет назад

You are helping. Thank you.

@joefarrow1599 4 месяца назад

Any advice on repairing long term damage after usage has been stopped?

@swampfrog195 7 лет назад

Can you please make a video on dxm neurotoxicity, there's isn't a single video on RU-vid that covers dxm neurotoxicity

@Duck-tm4bi 7 лет назад

Swamp Frog This is because a lack of studies i think. We don't have any real evidence for it being neurotoxic and it hadn't been studied as much as MDMA's neurotoxicity if it has been studied at all. So the only thing we have are anectotal reports which isn't really enough to really conclude much about it. As long as you don't overdo it it should be pretty fine. But again: It hasn't been studied enough yet.

@tonydanis1480 5 лет назад

Oddly, it sees like many people who obviously take these drugs to excess nevertheless have keen insights into their condition and are remarkably articulate in describing their symptoms and effects. The comments from all the supposedly brain-damaged burnouts below sound more like a discussion between neuroscientists than RU-vid comments from drug abusers. Whatever the damage these drugs may or may not incur, they do intellectually heighten users' minds on a very evident level.

@thedragonofdojima2172 2 года назад

why is science such a blessing and curse at the same time? like this is so fascinating but proper scientific method is fucking obnoxious, but also necessary. i can't tell if i love or hate it or i hate to love it or love to hate it or whatever else. amazing.